Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

DNA mismatch repair protein MutL

Gene

mutL

Organism
Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutLUniRule annotation
Gene namesi
Name:mutLUniRule annotation
Ordered Locus Names:NGO0744
OrganismiNeisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Taxonomic identifieri242231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000000535 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000100461 – 658DNA mismatch repair protein MutLAdd BLAST658

Structurei

Secondary structure

1658
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi469 – 474Combined sources6
Turni475 – 477Combined sources3
Beta strandi478 – 483Combined sources6
Beta strandi486 – 491Combined sources6
Helixi492 – 511Combined sources20
Beta strandi516 – 526Combined sources11
Helixi529 – 544Combined sources16
Beta strandi548 – 550Combined sources3
Beta strandi556 – 563Combined sources8
Helixi571 – 582Combined sources12
Helixi595 – 602Combined sources8
Beta strandi606 – 608Combined sources3
Helixi616 – 627Combined sources12
Turni630 – 633Combined sources4
Beta strandi640 – 646Combined sources7
Helixi647 – 652Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NCVX-ray2.40A/B460-658[»]
ProteinModelPortaliQ5F8M6.
SMRiQ5F8M6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5F8M6.

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutL/HexB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000256550.
KOiK03572.
OMAiQFLFINN.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
HAMAPiMF_00149. DNA_mis_repair. 1 hit.
InterProiIPR013507. DNA_mismatch_repair_C.
IPR014762. DNA_mismatch_repair_CS.
IPR002099. DNA_mismatch_repair_fam.
IPR020667. DNA_mismatch_repair_MutL.
IPR003594. HATPase_C.
IPR014790. MutL_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF01119. DNA_mis_repair. 1 hit.
PF08676. MutL_C. 1 hit.
[Graphical view]
SMARTiSM01340. DNA_mis_repair. 1 hit.
SM00853. MutL_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR00585. mutl. 1 hit.
PROSITEiPS00058. DNA_MISMATCH_REPAIR_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5F8M6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRIAALPDH LVNQIAAGEV VERPANALKE IVENSIDAGA TAVDVELEGG
60 70 80 90 100
GIRLIRVGDN GGGIHPDDIE LALHRHATSK IKTLNDLEHV ASMGFRGEGL
110 120 130 140 150
ASIASVSRLT LTSRQEDSSH ATQVKAEDGK LSSPTAAAHP VGTTIEAAEL
160 170 180 190 200
FFNTPARRKF LKSENTEYAH CATMLERLAL AHPHIAFSLK RDGKQVFKLP
210 220 230 240 250
AQSLHERIAA IVGDDFQTAS LEIDSGNSAL RLYGAIAKPT FAKGKTDKQY
260 270 280 290 300
CFVNHRFVRD KVMLHAVKQA YRDVLHNALT PAFVLFLELP PEAVDVNVHP
310 320 330 340 350
TKTEIRFRDS RQVHQLVFHT LNKALADTRA NLTESVSNAG EVLHDITGVT
360 370 380 390 400
PAPMPSENDG ENLFDSASNH PTGNKPDTRN AFGSSGKTAP MPYQAARAPQ
410 420 430 440 450
QHSLSLRESR AAMDTYAELY KKTDDIDLEL SQFEQARFGN MPSETPAHKT
460 470 480 490 500
DTPLSDGIPS QSELPPLGFA IAQLLGIYIL AQAEDSLLLI DMHAAAERVN
510 520 530 540 550
YEKMKRQRQE NGNLQSQHLL IPVTFAASHE ECAALADHAE TLAGFGLELS
560 570 580 590 600
DMGGNTLAVR AAPVMLGKSD VVSLARDVLG ELAQVGSSQT IASHENRILA
610 620 630 640 650
TMSCHGSIRA GRRLTLPEMN ALLRDMENTP RSNQCNHGRP TWVKLTLKEL

DTLFLRGQ
Length:658
Mass (Da):71,602
Last modified:March 15, 2005 - v1
Checksum:i5B95436331D8C422
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004969 Genomic DNA. Translation: AAW89461.1.
RefSeqiWP_003698476.1. NC_002946.2.
YP_207873.1. NC_002946.2.

Genome annotation databases

EnsemblBacteriaiAAW89461; AAW89461; NGO_0744.
GeneIDi3282588.
KEGGingo:NGO_0744.
PATRICi20334628. VBINeiGon24812_0886.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004969 Genomic DNA. Translation: AAW89461.1.
RefSeqiWP_003698476.1. NC_002946.2.
YP_207873.1. NC_002946.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3NCVX-ray2.40A/B460-658[»]
ProteinModelPortaliQ5F8M6.
SMRiQ5F8M6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW89461; AAW89461; NGO_0744.
GeneIDi3282588.
KEGGingo:NGO_0744.
PATRICi20334628. VBINeiGon24812_0886.

Phylogenomic databases

HOGENOMiHOG000256550.
KOiK03572.
OMAiQFLFINN.

Miscellaneous databases

EvolutionaryTraceiQ5F8M6.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
HAMAPiMF_00149. DNA_mis_repair. 1 hit.
InterProiIPR013507. DNA_mismatch_repair_C.
IPR014762. DNA_mismatch_repair_CS.
IPR002099. DNA_mismatch_repair_fam.
IPR020667. DNA_mismatch_repair_MutL.
IPR003594. HATPase_C.
IPR014790. MutL_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF01119. DNA_mis_repair. 1 hit.
PF08676. MutL_C. 1 hit.
[Graphical view]
SMARTiSM01340. DNA_mis_repair. 1 hit.
SM00853. MutL_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR00585. mutl. 1 hit.
PROSITEiPS00058. DNA_MISMATCH_REPAIR_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMUTL_NEIG1
AccessioniPrimary (citable) accession number: Q5F8M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 15, 2005
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.