Q5F8B4 (TRPE_NEIG1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate synthase component 1
EC=4.1.3.27

Alternative name(s):
Anthranilate synthase component I

Gene names

Name:	trpE
Ordered Locus Names:	NGO0872

Organism

Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)

Taxonomic identifier

242231 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 491	491	Anthranilate synthase component 1		PRO_0000154101

Sequences

	Sequence		Length	Mass (Da)
	Q5F8B4 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: A810F7B2304FE47F	FASTA	491	54,748
	10 20 30 40 50 60 MISKQEYQAQ AAQGYNRIPL VQELLADLDT PLSLYLKLAN RPYTYLLESV VGGERFGRYS 70 80 90 100 110 120 FIGLPCSHYL KAGGKHVDVY QNGEIVEQYD GNPLPFIEAF HNRFKTPEIP SLPRFTGGLV 130 140 150 160 170 180 GYFGYETVYN FEHFAHRLKN TAKANPLGTP DILLMLSQEL AVIDNLSGKI HLIVYADPSQ 190 200 210 220 230 240 PDSYERARER LEDIRTQLRQ SCAIPLSLGS KQTQAVSEFG EEPFKACVDK IKDYIFAGDC 250 260 270 280 290 300 MQVVPSQRMS MEFTDNPLAL YRALRTLNPS PYLFYYDFGD FHIVGSSPEI LVRRERDDVI 310 320 330 340 350 360 VRPIAGTRLR GKTPAEDLAN EQDLLSDAKE IAEHVMLIDL GRNDVGRISK TGEVKVTDKM 370 380 390 400 410 420 VIEKYSHVMH IVSNVEGCLK EGVTNMDILA ATFPAGTLSG APKVRAMEII EEIEPEKRGI 430 440 450 460 470 480 YGGAVGVWGF NNDMDLAIAI RTAVIKNNTL FIQSGAGVVA DSDPTSEWQE TQNKARAVVR 490 AAQMVQEGLD K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The opcA and (psi)opcB regions in Neisseria: genes, pseudogenes, deletions, insertion elements and DNA islands." Zhu P., Morelli G., Achtman M. Mol. Microbiol. 33:635-650(1999) [PubMed: 10417653] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The complete genome sequence of Neisseria gonorrhoeae." Lewis L.A., Gillaspy A.F., McLaughlin R.E., Gipson M., Ducey T.F., Ownbey T., Hartman K., Nydick C., Carson M.B., Vaughn J., Thomson C., Song L., Lin S., Yuan X., Najar F., Zhan M., Ren Q., Zhu H. , Qi S., Kenton S.M., Lai H., White J.D., Clifton S., Roe B.A., Dyer D.W. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700825 / FA 1090.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ242839 Genomic DNA. Translation: CAB45014.1. AE004969 Genomic DNA. Translation: AAW89573.1.
RefSeq	YP_207985.1. NC_002946.2.
3D structure databases
ProteinModelPortal	Q5F8B4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5F8B4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBNEIT00000002489; EBNEIP00000002330; EBNEIG00000002489.
GeneID	3281838.
GenomeReviews	Gene locus NGO0872 in contig AE004969_GR.
KEGG	ngo:NGO0872.
NMPDR	fig|242231.4.peg.238.
PATRIC	20334917. VBINeiGon24812_1028.
Phylogenomic databases
eggNOG	COG0147.
GeneTree	EBGT00050000020301.
HOGENOM	HBG507440.
OMA	PSQRMSM.
PhylomeDB	Q5F8B4.
ProtClustDB	PRK13565.
Enzyme and pathway databases
BioCyc	NGON242231:NGO0872-MONOMER.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR019999. Anth_synth_I. IPR006805. Anth_synth_I_N. IPR005256. Anth_synth_I_PabB. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
KO	K01657.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
SUPFAM	SSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMs	TIGR00564. TrpE_most. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_NEIG1

Accession

Primary (citable) accession number: Q5F8B4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	March 15, 2005
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program