Reviewed, UniProtKB/Swiss-Prot Q5F836 (PNCB_NEIG1)

Names and origin

Protein names

Recommended name:
    Nicotinate phosphoribosyltransferase
      Short name=NAPRTase
    EC=2.4.2.11

Gene names

Name:	pncB
Ordered Locus Names:	NGO0962

Organism

Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) [Complete proteome] [HAMAP]

Taxonomic identifier

242231 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	402 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00570
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP MF_00570
Subcellular location	Cytoplasm By similarity HAMAP MF_00570.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP nicotinate nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 402	402	Nicotinate phosphoribosyltransferase HAMAP MF_00570		PRO_0000205832

Sequences

	Sequence		Length	Mass (Da)
	Q5F836-1 [UniParc]. Last modified July 5, 2005. Version 2. Checksum: 87785B369B2D9AA0	FASTA	402	46,265
	10 20 30 40 50 60 MTGIIHSLLD TDLYKFTMLQ VVLHQFPQTH SLYEFRCRNV STVYPLADIR EDLEAELDAL 70 80 90 100 110 120 CRLRFTHDEL GYLRSLRFIK SDFVDYLELF QLQRRFVEVG TDDKGRLNIR IEGPMIQAMF 130 140 150 160 170 180 FEIFILAIVN ELYFRRLETP AVIEEGERRL QAKAARLKEI AAAQNPDEPP FLISDFGTRR 190 200 210 220 230 240 RYKLAWQEHV IRTLLEAAPS IVRGTSNVYL AKKLGITPIG TMAHEFLQAF QALDVRLRNF 250 260 270 280 290 300 QKAALESWVH EYRGDLGVAL TDVVGMDAFL RDFDLYFAKL FDGLRHDSGD PYVWGDKAYA 310 320 330 340 350 360 HYQKLKIDSR TKMLTFSDGL DIERSWALHQ YFKGRFKTGF GIGTNLTNDM GHTPLNIVLK 370 380 390 400 LVECNGQSVA KLSDSPGKTM TNNSTFLAYL RQVFGIPEPR TP

References

[1]

"The complete genome sequence of Neisseria gonorrhoeae." Lewis L.A., Gillaspy A.F., McLaughlin R.E., Gipson M., Ducey T.F., Ownbey T., Hartman K., Nydick C., Carson M.B., Vaughn J., Thomson C., Song L., Lin S., Yuan X., Najar F., Zhan M., Ren Q., Zhu H. , Qi S., Kenton S.M., Lai H., White J.D., Clifton S., Roe B.A., Dyer D.W. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004969 Genomic DNA. Translation: AAW89651.1. Different initiation.
RefSeq	YP_208063.1.
3D structure databases
SMR	Q5F836. Positions 3-396.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5F836.
Genome annotation databases
GeneID	3282612.
GenomeReviews	Gene locus NGO0962 in contig AE004969_GR.
KEGG	ngo:NGO0962.
NMPDR	fig|242231.4.peg.472.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1488.
HOGENOM	HBG325503.
OMA	LYKFTML.
PhylomeDB	Q5F836.
Enzyme and pathway databases
BioCyc	NGON242231:NGO0962-MONOMER.
Family and domain databases
HAMAP	MF_00570. NAPRTase. [Tree]
InterPro	IPR006406. Nic_PRibTrfase. IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. [Graphical view]
PANTHER	PTHR11098:SF1. NAPRTase. 1 hit.
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
TIGRFAMs	TIGR01514. NAPRTase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PNCB_NEIG1

Accession

Primary (citable) accession number: Q5F836

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	July 5, 2005
Last modified:	February 9, 2010
This is version 37 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)