Q5F7V9 (SURE_NEIG1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE
EC=3.1.3.5

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	NGO1058

Organism

Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)

Taxonomic identifier

242231 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	248 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 248	248	5'-nucleotidase surE HAMAP MF_00060		PRO_0000235627
Sites
	Metal binding	8	1	Divalent metal cation By similarity
	Metal binding	9	1	Divalent metal cation By similarity
	Metal binding	39	1	Divalent metal cation By similarity
	Metal binding	91	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5F7V9 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 16CA6A2CECD221A2	FASTA	248	27,057
	10 20 30 40 50 60 MNVLISNDDG YLAEGIAILA RVASEFANVR VVAPERDRSG VSNSVTLDRP LQLKQAQNGF 70 80 90 100 110 120 YYVNGTPTDC IHVGQFALPD FKPDVVFSGI NRGANMGDDT LYSGTVAAAT EAYLMGMPAV 130 140 150 160 170 180 AFSLNDASGR YWATAEKALW TLLAHFFKKP PSAPVLWNVN IPAVAPEDVR GIKITRLGRR 190 200 210 220 230 240 HHEQNIVPSR NPRGEQIYWI GPVGEVSDRE EGTDFGECGA GFITVTPLQI DLTAYPDMAE TAAFWHTD

References

[1]

"The complete genome sequence of Neisseria gonorrhoeae." Lewis L.A., Gillaspy A.F., McLaughlin R.E., Gipson M., Ducey T.F., Ownbey T., Hartman K., Nydick C., Carson M.B., Vaughn J., Thomson C., Song L., Lin S., Yuan X., Najar F., Zhan M., Ren Q., Zhu H. , Qi S., Kenton S.M., Lai H., White J.D., Clifton S., Roe B.A., Dyer D.W. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700825 / FA 1090.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004969 Genomic DNA. Translation: AAW89728.1.
RefSeq	YP_208140.1. NC_002946.2.
3D structure databases
ProteinModelPortal	Q5F7V9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5F7V9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBNEIT00000003582; EBNEIP00000003423; EBNEIG00000003582.
GeneID	3281758.
GenomeReviews	Gene locus NGO1058 in contig AE004969_GR.
KEGG	ngo:NGO1058.
NMPDR	fig|242231.4.peg.1239.
PATRIC	20335348. VBINeiGon24812_1240.
Phylogenomic databases
eggNOG	COG0496.
GeneTree	EBGT00050000021428.
HOGENOM	HBG600532.
OMA	NGFYYVN.
PhylomeDB	Q5F7V9.
ProtClustDB	PRK00346.
Enzyme and pathway databases
BioCyc	NGON242231:NGO1058-MONOMER.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_NEIG1

Accession

Primary (citable) accession number: Q5F7V9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	March 15, 2005
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program