Q5F6L9 (MURC_NEIG1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-N-acetylmuramate--L-alanine ligase
EC=6.3.2.8

Alternative name(s):
UDP-N-acetylmuramoyl-L-alanine synthetase

Gene names

Name:	murC
Ordered Locus Names:	NGO1532

Organism

Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) [Reference proteome] [HAMAP]

Taxonomic identifier

242231 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria › Neisseria gonorrhoeae

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cell wall formation By similarity.
Catalytic activity	ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP-Rule MF_00046
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00046
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the MurCDEF family.
Sequence caution	The sequence AAW90168.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP UDP-N-acetylmuramate-L-alanine ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 468	468	UDP-N-acetylmuramate--L-alanine ligase HAMAP-Rule MF_00046		PRO_0000242566
Regions
	Nucleotide binding	112 – 118	7	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5F6L9 [UniParc]. Last modified June 27, 2006. Version 2. Checksum: CB32AB59652B38B0	FASTA	468	50,194
	10 20 30 40 50 60 MKNRVSNIHF VGIGGVGMSG IAEVLHNLGF KVSGSDQARN AATEHLSSLG IQVYPGHTAE 70 80 90 100 110 120 HVNGADVVVA STAVKKENPE VVAALERQIP VIPRALMLAE LMRFRDGIAI AGTHGKTTTT 130 140 150 160 170 180 SLTASILGAA GLDPTFVIGG KLNAAGTNAR LGKGEYIVAE ADESDASFLH LTPIMSVVTN 190 200 210 220 230 240 IDEDHMDTYG HSVEKLHQAF IDFIHRMPFY GKAFLCVDSE HVRAILPKVS KPYATYGLDD 250 260 270 280 290 300 TADIYATDIE NVGAQMKFTV HVQMKGHEQG SFEVVLNMPG RHNVLNALAA IGVALEVGAS 310 320 330 340 350 360 VEAIQKGLLG FEGVGRRFQK YGDIKLPNGG TALLVDDYGH HPVEMAATLA AARGAYPEKR 370 380 390 400 410 420 LVLAFQPHRY TRTRDLFEDF TKVLNTVDAL VLTEVYAAGE EPVAAADSRA LARAIRVLGK 430 440 450 460 LEPIYCENVA DLPQMLMNVL QDGDVVLNMG AGSINRVPSA LLELSKQI

References

[1]

"The complete genome sequence of Neisseria gonorrhoeae." Lewis L.A., Gillaspy A.F., McLaughlin R.E., Gipson M., Ducey T.F., Ownbey T., Hartman K., Nydick C., Carson M.B., Vaughn J., Thomson C., Song L., Lin S., Yuan X., Najar F., Zhan M., Ren Q., Zhu H. , Qi S., Kenton S.M., Lai H., White J.D., Clifton S., Roe B.A., Dyer D.W. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700825 / FA 1090.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004969 Genomic DNA. Translation: AAW90168.1. Different initiation.
RefSeq	YP_208580.3. NC_002946.2.
3D structure databases
ProteinModelPortal	Q5F6L9.
SMR	Q5F6L9. Positions 3-465.
ModBase	Search...
Protein-protein interaction databases
STRING	242231.NGO1532.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAW90168; AAW90168; NGO1532.
GeneID	3281507.
KEGG	ngo:NGO1532.
PATRIC	20336560. VBINeiGon24812_1828.
Phylogenomic databases
eggNOG	COG0773.
HOGENOM	HOG000256031.
KO	K01924.
OMA	YQPHRYS.
ProtClustDB	PRK00421.
Enzyme and pathway databases
BioCyc	NGON242231:GI2G-1396-MONOMER.
UniPathway	UPA00219.
Family and domain databases
Gene3D	3.40.1190.10. 1 hit. 3.40.50.720. 1 hit. 3.90.190.20. 1 hit.
HAMAP	MF_00046. MurC.
InterPro	IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. IPR000713. Mur_ligase_N. IPR016040. NAD(P)-bd_dom. IPR005758. UDP-N-AcMur_Ala_ligase. [Graphical view]
PANTHER	PTHR23135:SF5. PTHR23135:SF5. 1 hit.
Pfam	PF01225. Mur_ligase. 1 hit. PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view]
SUPFAM	SSF53244. Mur_ligase_C. 1 hit. SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMs	TIGR01082. murC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURC_NEIG1

Accession

Primary (citable) accession number: Q5F6L9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	May 1, 2013
This is version 64 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program