Q5F6F7 (AROE_NEIG1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	NGO1602

Organism

Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)

Taxonomic identifier

242231 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000021311
Regions
	Nucleotide binding	130 – 134	5	NADP By similarity
Sites
	Active site	68	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5F6F7 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 07FFD1FCF1A5FDD9	FASTA	269	28,649
	10 20 30 40 50 60 MHALPRYAVF GNPAAHSKSP QIHQQFALQE GVDIEYGRIC ADIGGFAQAV STFFETGGCG 70 80 90 100 110 120 ANVTVPFKQE AFHLADEHSD RALAAGAVNT LVWLEDGRIR GDNTDGIGLA NDITQVKNIA 130 140 150 160 170 180 IEGKTILLLG AGGAVRGVIP VLKEHRPARI VIANRTRAKA EELARLFGIE AVPMADVNGG 190 200 210 220 230 240 FDIIINGTSG GLSGQLPAVS PKIFRDCRLA YDMVYGEAAK PFLDFARQSG AKKTADGLGM 250 260 LVGQAAASYA LWRGFKPDIR PVIEHMKAL

References

[1]

"The complete genome sequence of Neisseria gonorrhoeae." Lewis L.A., Gillaspy A.F., McLaughlin R.E., Gipson M., Ducey T.F., Ownbey T., Hartman K., Nydick C., Carson M.B., Vaughn J., Thomson C., Song L., Lin S., Yuan X., Najar F., Zhan M., Ren Q., Zhu H. , Qi S., Kenton S.M., Lai H., White J.D., Clifton S., Roe B.A., Dyer D.W. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700825 / FA 1090.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004969 Genomic DNA. Translation: AAW90230.1.
RefSeq	YP_208642.1. NC_002946.2.
3D structure databases
HSSP	HSSP built from PDB template 1NYT based on UniProtKB P15770.
ProteinModelPortal	Q5F6F7.
SMR	Q5F6F7. Positions 5-267.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5F6F7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBNEIT00000002293; EBNEIP00000002134; EBNEIG00000002293.
GeneID	3281609.
GenomeReviews	Gene locus NGO1602 in contig AE004969_GR.
KEGG	ngo:NGO1602.
NMPDR	fig|242231.4.peg.1691.
PATRIC	20336740. VBINeiGon24812_1916.
Phylogenomic databases
eggNOG	COG0169.
GeneTree	EBGT00050000020137.
HOGENOM	HBG553408.
OMA	GRICADI.
PhylomeDB	Q5F6F7.
ProtClustDB	CLSK877516.
Enzyme and pathway databases
BioCyc	NGON242231:NGO1602-MONOMER.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_NEIG1

Accession

Primary (citable) accession number: Q5F6F7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 15, 2005
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program