Reviewed, UniProtKB/Swiss-Prot Q5F694 (G6PI2_NEIG1)

Names and origin

Protein names

Recommended name:
    Glucose-6-phosphate isomerase 2
      Short name=GPI 2
    EC=5.3.1.9
Alternative name(s):
    Phosphoglucose isomerase 2
      Short name=PGI 2
    Phosphohexose isomerase 2
      Short name=PHI 2

Gene names

Name:	pgi2
Ordered Locus Names:	NGO1668

Organism

Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) [Complete proteome] [HAMAP]

Taxonomic identifier

242231 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	547 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 547	547	Glucose-6-phosphate isomerase 2 HAMAP MF_00473		PRO_0000180690
Sites
	Active site	351	1	Proton donor By similarity
	Active site	382	1	By similarity
	Active site	508	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5F694-1 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: FAD6BFEE1FD7D6F3	FASTA	547	60,317
	10 20 30 40 50 60 MDAFTRAWYA LERHYQDTCH ILLRDRFAAE PDRFERMHER LDGMLFDYSK NRFGEDTLQL 70 80 90 100 110 120 LCRLAETADL EGKMRALRTG AKVNGSEGRA ALHTALRLPD GADAVYADGR DVLPEIRREL 130 140 150 160 170 180 NRALKFAHSL DDGLYQGITG KRIADFVHIG IGGSDLGPAM CVQALEPFRR QISVHFVSNA 190 200 210 220 230 240 DPACLDEVLC RLNPETTMFC VASKSFKTPE TLLNAEAVKA WYRGAGFSES ETAHHFCAVS 250 260 270 280 290 300 ADTEAAQSFG IAAERVFAMY DWVGGRYSVW SPVGLPVMVA VGGARFRELL AGAHAMDSHF 310 320 330 340 350 360 FHTPPRRNIP VLMALIAVWY NNFQHADGQT AVPYSHNLRL LPAWLNQLDM ESLGKSRASD 370 380 390 400 410 420 GSPAACKTGG IVFGGEGVNC QHAYFQLLHQ GTRLIPCDFI VPMTAQGAED GRSRFTVANA 430 440 450 460 470 480 FAQAEALMKG KTLDEARAEL ADLPEAERER LAPHKEFPGN RPSNSILLDR LTPCNLGMLM 490 500 510 520 530 540 AAYEHKTFVQ GAIWNVNPFD QWGVEYGKQL AKTIIGELEG GTSVHDASTE GLMAFYRECR LKGGGAA

References

[1]

"The complete genome sequence of Neisseria gonorrhoeae." Lewis L.A., Gillaspy A.F., McLaughlin R.E., Gipson M., Ducey T.F., Ownbey T., Hartman K., Nydick C., Carson M.B., Vaughn J., Thomson C., Song L., Lin S., Yuan X., Najar F., Zhan M., Ren Q., Zhu H. , Qi S., Kenton S.M., Lai H., White J.D., Clifton S., Roe B.A., Dyer D.W. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004969 Genomic DNA. Translation: AAW90293.1.
RefSeq	YP_208705.1.
3D structure databases
SMR	Q5F694. Positions 5-540.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5F694.
Genome annotation databases
GeneID	3281318.
GenomeReviews	Gene locus NGO1668 in contig AE004969_GR.
KEGG	ngo:NGO1668.
NMPDR	fig|242231.4.peg.1809.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HBG352954.
OMA	STEGLMA.
PhylomeDB	Q5F694.
Enzyme and pathway databases
BioCyc	NGON242231:NGO1668-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI2_NEIG1

Accession

Primary (citable) accession number: Q5F694

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	March 15, 2005
Last modified:	January 19, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)