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Q5F5Y6 (LPXB_NEIG1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:NGO1782
OrganismNeisseria gonorrhoeae (strain ATCC 700825 / FA 1090) [Reference proteome] [HAMAP]
Taxonomic identifier242231 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Protein attributes

Sequence length390 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 390390Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_0000255200

Sequences

Sequence LengthMass (Da)Tools
Q5F5Y6 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 8327E2A576E565BF

FASTA39043,064
        10         20         30         40         50         60 
MWGQTNMVDK KSPLIAVSVG EASGDLLGAH LIRAIRKRCP QARLTGIGGE LMKAEGFESL 

        70         80         90        100        110        120 
YDQERLAVRG FVEVVRRLPE ILRIRRELVR DLLSLKPDVF VGIDAPDFNL GVAEKLKRAG 

       130        140        150        160        170        180 
IPTLHYVSPS VWAWRRERVG KIVHQVNRVL CLFPMEPQLY LDAGGRAEFV GHPMAQLMPL 

       190        200        210        220        230        240 
EDDRETARKT LGADVGIPVF ALLPGSRVSE IDYMAPVFFQ TALLLLERYP AARFLLPAAT 

       250        260        270        280        290        300 
EATKRRLAEV LQRPEFAGLA LTVTDRQSET VCRAADAVLV TSGTATLEVA LCKRPMVISY 

       310        320        330        340        350        360 
KISPLTYAYV KRKIKVPHVG LPNILLGKEA VPELLQSEAK PEKLAAALAD WYEHPDKVAA 

       370        380        390 
LQQDFGALHL LLKKDTADLA ARAVLEEAGC 

« Hide

References

[1]"The complete genome sequence of Neisseria gonorrhoeae."
Lewis L.A., Gillaspy A.F., McLaughlin R.E., Gipson M., Ducey T.F., Ownbey T., Hartman K., Nydick C., Carson M.B., Vaughn J., Thomson C., Song L., Lin S., Yuan X., Najar F., Zhan M., Ren Q., Zhu H. expand/collapse author list , Qi S., Kenton S.M., Lai H., White J.D., Clifton S., Roe B.A., Dyer D.W.
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700825 / FA 1090.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004969 Genomic DNA. Translation: AAW90401.1.
RefSeqYP_208813.1. NC_002946.2.

3D structure databases

ProteinModelPortalQ5F5Y6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING242231.NGO1782.

Protein family/group databases

CAZyGT19. Glycosyltransferase Family 19.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW90401; AAW90401; NGO1782.
GeneID3282347.
KEGGngo:NGO1782.
PATRIC20337208. VBINeiGon24812_2140.

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018003.
KOK00748.
OMARRSEIRH.
OrthoDBEOG6FBWZR.

Enzyme and pathway databases

BioCycNGON242231:GI2G-1680-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_NEIG1
AccessionPrimary (citable) accession number: Q5F5Y6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 15, 2005
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways