Q5F5W6 (LPXD_NEIG1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-3-O-acylglucosamine N-acyltransferase
EC=2.3.1.-

Gene names

Name:	lpxD
Ordered Locus Names:	NGO1803

Organism

Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)

Taxonomic identifier

242231 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00523
Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein]. HAMAP MF_00523
Pathway	Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. HAMAP MF_00523
Subunit structure	Homotrimer By similarity. HAMAP MF_00523
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxD subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transferase activity, transferring acyl groups other than amino-acyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 347	347	UDP-3-O-acylglucosamine N-acyltransferase HAMAP MF_00523		PRO_0000264398
Sites
	Active site	241	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5F5W6 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: F9CD31A824E08AC0	FASTA	347	36,269
	10 20 30 40 50 60 MIPATCTLSQ ITARLGGEWR GEDISVTAVR PLADAQAEHI SFLANPKYKA EVHDSSAGAI 70 80 90 100 110 120 IVSAKAADGF EGRNLIVADD PYLYFAKVAR LFSPVVKARG GIHPTAVVEP GATVPASCEI 130 140 150 160 170 180 GANAYIGANT VLGEGCRILA NAVVQHDCKL GDEVVLHPNA VVYYGCTLGR HVEIHSGAVI 190 200 210 220 230 240 GADGFGLAFA GDSWFKIPQT GAVTLGDDVE IGSNTNIDRG AMSDTTVGNG TKIDNQVQIG 250 260 270 280 290 300 HNCKIGSHTV IAAKTGISGS VTIGSYCIIG GGVGTVGHIE IADKTTIGGG TSVTHSITES 310 320 330 340 GKHLAGIFPM SEHKEWARNA VYIHRLSEMN KRLKTLEQQL SDSKDTQ

References

[1]

"The complete genome sequence of Neisseria gonorrhoeae." Lewis L.A., Gillaspy A.F., McLaughlin R.E., Gipson M., Ducey T.F., Ownbey T., Hartman K., Nydick C., Carson M.B., Vaughn J., Thomson C., Song L., Lin S., Yuan X., Najar F., Zhan M., Ren Q., Zhu H. , Qi S., Kenton S.M., Lai H., White J.D., Clifton S., Roe B.A., Dyer D.W. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700825 / FA 1090.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004969 Genomic DNA. Translation: AAW90421.1.
RefSeq	YP_208833.1. NC_002946.2.
3D structure databases
ProteinModelPortal	Q5F5W6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5F5W6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBNEIT00000003644; EBNEIP00000003485; EBNEIG00000003644.
GeneID	3282536.
GenomeReviews	Gene locus NGO1803 in contig AE004969_GR.
KEGG	ngo:NGO1803.
NMPDR	fig|242231.4.peg.1386.
PATRIC	20337256. VBINeiGon24812_2163.
Phylogenomic databases
eggNOG	COG1044.
GeneTree	EBGT00050000020532.
HOGENOM	HBG469615.
OMA	CFVGKNT.
PhylomeDB	Q5F5W6.
ProtClustDB	PRK00892.
Enzyme and pathway databases
BioCyc	NGON242231:NGO1803-MONOMER.
Family and domain databases
HAMAP	MF_00523. LpxD. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR011004. Trimer_LpxA-like. IPR007691. UDP-3-O_GlcNAc_AcTrfase. IPR020573. UDP_GlcNAc_AcTrfase_non-rep. [Graphical view]
KO	K02536.
Pfam	PF00132. Hexapep. 4 hits. PF04613. LpxD. 1 hit. [Graphical view]
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01853. Lipid_A_lpxD. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPXD_NEIG1

Accession

Primary (citable) accession number: Q5F5W6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	March 15, 2005
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program