Q5F5W1 (DADA_NEIG1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
D-amino acid dehydrogenase small subunit
EC=1.4.99.1

Gene names

Name:	dadA
Ordered Locus Names:	NGO1808

Organism

Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)

Taxonomic identifier

242231 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	419 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Oxidative deamination of D-amino acids By similarity. HAMAP MF_01202
Catalytic activity	A D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor. HAMAP MF_01202
Cofactor	FAD By similarity. HAMAP MF_01202
Pathway	Amino-acid degradation; D-alanine degradation; NH(3) and pyruvate from D-alanine: step 1/1. HAMAP MF_01202
Subunit structure	Heterodimer of a small and a large subunit By similarity.
Sequence similarities	Belongs to the DadA oxidoreductase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	D-amino-acid dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 419	419	D-amino acid dehydrogenase small subunit HAMAP MF_01202		PRO_1000066100
Regions
	Nucleotide binding	3 – 17	15	FAD Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5F5W1 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: F435775806AABDE3	FASTA	419	46,845
	10 20 30 40 50 60 MKVLVLGAGV AGVSSVWYLA EAGHEVTVID RTEGVAMETS FANAGQLSYG YTTPWAAPGI 70 80 90 100 110 120 PTKALKRLFK SHPPLLFRPD GGLYQIEWLW RMLQNCTATR YQINKERMVR ISEYSREMFR 130 140 150 160 170 180 RFEAQTDMNF EGRKKGTLQI FRQTEEVEAA KQDIAVLERY GVPYRRLKPE ECAEFEPALA 190 200 210 220 230 240 RVTAKIVGGL HLPADATGDC RLFTENLYKL CQEKGVRFYF NQTISRIDHN GLRIKAVETE 250 260 270 280 290 300 TGRFETDAVV CALGCFSRTV LAQLDLNLPI YPVKGYSLTL PVTNSDGAPV STVLDESYKV 310 320 330 340 350 360 AITRFDNRIR VGGMAELSGY ETKLPEKRRE TLALVVNDLF PEGGDLSQAL SWSGLRPMTP 370 380 390 400 410 DSTPLIGRTR FENLFLNTGH GTLGWTMSPG SAKLTADIVS GKDTEIRSDD LSLSRYQKL

References

[1]

"The complete genome sequence of Neisseria gonorrhoeae." Lewis L.A., Gillaspy A.F., McLaughlin R.E., Gipson M., Ducey T.F., Ownbey T., Hartman K., Nydick C., Carson M.B., Vaughn J., Thomson C., Song L., Lin S., Yuan X., Najar F., Zhan M., Ren Q., Zhu H. , Qi S., Kenton S.M., Lai H., White J.D., Clifton S., Roe B.A., Dyer D.W. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700825 / FA 1090.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004969 Genomic DNA. Translation: AAW90426.1.
RefSeq	YP_208838.1. NC_002946.2.
3D structure databases
ProteinModelPortal	Q5F5W1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5F5W1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBNEIT00000003334; EBNEIP00000003175; EBNEIG00000003334.
GeneID	3282307.
GenomeReviews	Gene locus NGO1808 in contig AE004969_GR.
KEGG	ngo:NGO1808.
NMPDR	fig|242231.4.peg.1391.
PATRIC	20337268. VBINeiGon24812_2169.
Phylogenomic databases
eggNOG	COG0665.
GeneTree	EBGT00050000020907.
HOGENOM	HBG729204.
OMA	NCTAAHY.
PhylomeDB	Q5F5W1.
ProtClustDB	PRK00711.
Enzyme and pathway databases
BioCyc	NGON242231:NGO1808-MONOMER.
Family and domain databases
HAMAP	MF_01202. DadA. [Tree]
InterPro	IPR023080. D-aa_DH_ssu_DadA. IPR006076. FAD-dep_OxRdtase. [Graphical view]
KO	K00285.
Pfam	PF01266. DAO. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DADA_NEIG1

Accession

Primary (citable) accession number: Q5F5W1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	March 15, 2005
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program