Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5F5D6

- SYC_NEIG1

UniProt

Q5F5D6 - SYC_NEIG1

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Cysteine--tRNA ligase

Gene

cysS

Organism
Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).UniRule annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi28 – 281ZincUniRule annotation
Metal bindingi209 – 2091ZincUniRule annotation
Metal bindingi234 – 2341ZincUniRule annotation
Metal bindingi238 – 2381ZincUniRule annotation
Binding sitei285 – 2851ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. cysteine-tRNA ligase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cysteinyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciNGON242231:GI2G-1891-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine--tRNA ligaseUniRule annotation (EC:6.1.1.16UniRule annotation)
Alternative name(s):
Cysteinyl-tRNA synthetaseUniRule annotation
Short name:
CysRSUniRule annotation
Gene namesi
Name:cysSUniRule annotation
Ordered Locus Names:NGO1993
OrganismiNeisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Taxonomic identifieri242231 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
ProteomesiUP000000535: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Cysteine--tRNA ligasePRO_0000240924Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi242231.NGO1993.

Structurei

3D structure databases

ProteinModelPortaliQ5F5D6.
SMRiQ5F5D6. Positions 1-414.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi30 – 4011"HIGH" regionAdd
BLAST
Motifi282 – 2865"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0215.
HOGENOMiHOG000245250.
KOiK01883.
OMAiVTWYTCG.
OrthoDBiEOG6RVFXC.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00041. Cys_tRNA_synth.
InterProiIPR015803. Cys-tRNA-ligase.
IPR015273. Cys-tRNA-synt_Ia_DALR.
IPR024909. Cys-tRNA/MSH_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR10890. PTHR10890. 1 hit.
PfamiPF09190. DALR_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view]
PRINTSiPR00983. TRNASYNTHCYS.
SMARTiSM00840. DALR_2. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00435. cysS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5F5D6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTAIYNTLTR QKEPFAPIDP ENVRMYVCGM TVYDYCHLGH ARVMVVFDMI
60 70 80 90 100
ARWLRECGYP LTYVRNITDI DDKIIARAAE NGETIGELNA RFIQAMHEDA
110 120 130 140 150
DALGVLRPDI EPKATENIPQ MIAMIETLIQ NGKAYPAANG DVYYAVREFA
160 170 180 190 200
AYGQLSGKSL DDLRAGERVE VDGFKRDPLD FVLWKAAKAG EPAWESPWGN
210 220 230 240 250
GRPGWHIECS AMSENLFGDT FDIHGGGADL QFPHHENEIA QSVGASGHTC
260 270 280 290 300
GHDHAQTHHG QSIASHVKYW LHNGFIRVDG EKMSKSLGNF FTIREVLKQY
310 320 330 340 350
DPEVVRFFIL RAHYRSPLNY SDAHLDDAKG ALTRLYTTLK NTPAAEFDLS
360 370 380 390 400
ENANGYTRRF YAAMNDDFGT VEAVAVLFEL AGEVNKTNDA HLAGCLKALG
410 420 430 440 450
GIIGLLQRNP IEFLQGGAVS DGLSNEEIED LIARRKQARA DKNWAESDRI
460 470
RDLLNEHKII LEDSAGGTTW RRG
Length:473
Mass (Da):52,804
Last modified:March 15, 2005 - v1
Checksum:i43042DFF3BD373E8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004969 Genomic DNA. Translation: AAW90601.1.
RefSeqiYP_209013.1. NC_002946.2.

Genome annotation databases

EnsemblBacteriaiAAW90601; AAW90601; NGO1993.
GeneIDi3282631.
KEGGingo:NGO1993.
PATRICi20337755. VBINeiGon24812_2404.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004969 Genomic DNA. Translation: AAW90601.1 .
RefSeqi YP_209013.1. NC_002946.2.

3D structure databases

ProteinModelPortali Q5F5D6.
SMRi Q5F5D6. Positions 1-414.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 242231.NGO1993.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW90601 ; AAW90601 ; NGO1993 .
GeneIDi 3282631.
KEGGi ngo:NGO1993.
PATRICi 20337755. VBINeiGon24812_2404.

Phylogenomic databases

eggNOGi COG0215.
HOGENOMi HOG000245250.
KOi K01883.
OMAi VTWYTCG.
OrthoDBi EOG6RVFXC.

Enzyme and pathway databases

BioCyci NGON242231:GI2G-1891-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00041. Cys_tRNA_synth.
InterProi IPR015803. Cys-tRNA-ligase.
IPR015273. Cys-tRNA-synt_Ia_DALR.
IPR024909. Cys-tRNA/MSH_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
PANTHERi PTHR10890. PTHR10890. 1 hit.
Pfami PF09190. DALR_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view ]
PRINTSi PR00983. TRNASYNTHCYS.
SMARTi SM00840. DALR_2. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
TIGRFAMsi TIGR00435. cysS. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of Neisseria gonorrhoeae."
    Lewis L.A., Gillaspy A.F., McLaughlin R.E., Gipson M., Ducey T.F., Ownbey T., Hartman K., Nydick C., Carson M.B., Vaughn J., Thomson C., Song L., Lin S., Yuan X., Najar F., Zhan M., Ren Q., Zhu H.
    , Qi S., Kenton S.M., Lai H., White J.D., Clifton S., Roe B.A., Dyer D.W.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700825 / FA 1090.

Entry informationi

Entry nameiSYC_NEIG1
AccessioniPrimary (citable) accession number: Q5F5D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 15, 2005
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3