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Q5F5D6

- SYC_NEIG1

UniProt

Q5F5D6 - SYC_NEIG1

Protein

Cysteine--tRNA ligase

Gene

cysS

Organism
Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi28 – 281ZincUniRule annotation
    Metal bindingi209 – 2091ZincUniRule annotation
    Metal bindingi234 – 2341ZincUniRule annotation
    Metal bindingi238 – 2381ZincUniRule annotation
    Binding sitei285 – 2851ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. cysteine-tRNA ligase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cysteinyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciNGON242231:GI2G-1891-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine--tRNA ligaseUniRule annotation (EC:6.1.1.16UniRule annotation)
    Alternative name(s):
    Cysteinyl-tRNA synthetaseUniRule annotation
    Short name:
    CysRSUniRule annotation
    Gene namesi
    Name:cysSUniRule annotation
    Ordered Locus Names:NGO1993
    OrganismiNeisseria gonorrhoeae (strain ATCC 700825 / FA 1090)
    Taxonomic identifieri242231 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
    ProteomesiUP000000535: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 473473Cysteine--tRNA ligasePRO_0000240924Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi242231.NGO1993.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5F5D6.
    SMRiQ5F5D6. Positions 1-414.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi30 – 4011"HIGH" regionAdd
    BLAST
    Motifi282 – 2865"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0215.
    HOGENOMiHOG000245250.
    KOiK01883.
    OMAiVTWYTCG.
    OrthoDBiEOG6RVFXC.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00041. Cys_tRNA_synth.
    InterProiIPR015803. Cys-tRNA-ligase.
    IPR015273. Cys-tRNA-synt_Ia_DALR.
    IPR024909. Cys-tRNA/MSH_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view]
    PANTHERiPTHR10890. PTHR10890. 1 hit.
    PfamiPF09190. DALR_2. 1 hit.
    PF01406. tRNA-synt_1e. 1 hit.
    [Graphical view]
    PRINTSiPR00983. TRNASYNTHCYS.
    SMARTiSM00840. DALR_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    TIGRFAMsiTIGR00435. cysS. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5F5D6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAIYNTLTR QKEPFAPIDP ENVRMYVCGM TVYDYCHLGH ARVMVVFDMI    50
    ARWLRECGYP LTYVRNITDI DDKIIARAAE NGETIGELNA RFIQAMHEDA 100
    DALGVLRPDI EPKATENIPQ MIAMIETLIQ NGKAYPAANG DVYYAVREFA 150
    AYGQLSGKSL DDLRAGERVE VDGFKRDPLD FVLWKAAKAG EPAWESPWGN 200
    GRPGWHIECS AMSENLFGDT FDIHGGGADL QFPHHENEIA QSVGASGHTC 250
    GHDHAQTHHG QSIASHVKYW LHNGFIRVDG EKMSKSLGNF FTIREVLKQY 300
    DPEVVRFFIL RAHYRSPLNY SDAHLDDAKG ALTRLYTTLK NTPAAEFDLS 350
    ENANGYTRRF YAAMNDDFGT VEAVAVLFEL AGEVNKTNDA HLAGCLKALG 400
    GIIGLLQRNP IEFLQGGAVS DGLSNEEIED LIARRKQARA DKNWAESDRI 450
    RDLLNEHKII LEDSAGGTTW RRG 473
    Length:473
    Mass (Da):52,804
    Last modified:March 15, 2005 - v1
    Checksum:i43042DFF3BD373E8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004969 Genomic DNA. Translation: AAW90601.1.
    RefSeqiYP_209013.1. NC_002946.2.

    Genome annotation databases

    EnsemblBacteriaiAAW90601; AAW90601; NGO1993.
    GeneIDi3282631.
    KEGGingo:NGO1993.
    PATRICi20337755. VBINeiGon24812_2404.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004969 Genomic DNA. Translation: AAW90601.1 .
    RefSeqi YP_209013.1. NC_002946.2.

    3D structure databases

    ProteinModelPortali Q5F5D6.
    SMRi Q5F5D6. Positions 1-414.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 242231.NGO1993.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW90601 ; AAW90601 ; NGO1993 .
    GeneIDi 3282631.
    KEGGi ngo:NGO1993.
    PATRICi 20337755. VBINeiGon24812_2404.

    Phylogenomic databases

    eggNOGi COG0215.
    HOGENOMi HOG000245250.
    KOi K01883.
    OMAi VTWYTCG.
    OrthoDBi EOG6RVFXC.

    Enzyme and pathway databases

    BioCyci NGON242231:GI2G-1891-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00041. Cys_tRNA_synth.
    InterProi IPR015803. Cys-tRNA-ligase.
    IPR015273. Cys-tRNA-synt_Ia_DALR.
    IPR024909. Cys-tRNA/MSH_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    [Graphical view ]
    PANTHERi PTHR10890. PTHR10890. 1 hit.
    Pfami PF09190. DALR_2. 1 hit.
    PF01406. tRNA-synt_1e. 1 hit.
    [Graphical view ]
    PRINTSi PR00983. TRNASYNTHCYS.
    SMARTi SM00840. DALR_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    TIGRFAMsi TIGR00435. cysS. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of Neisseria gonorrhoeae."
      Lewis L.A., Gillaspy A.F., McLaughlin R.E., Gipson M., Ducey T.F., Ownbey T., Hartman K., Nydick C., Carson M.B., Vaughn J., Thomson C., Song L., Lin S., Yuan X., Najar F., Zhan M., Ren Q., Zhu H.
      , Qi S., Kenton S.M., Lai H., White J.D., Clifton S., Roe B.A., Dyer D.W.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700825 / FA 1090.

    Entry informationi

    Entry nameiSYC_NEIG1
    AccessioniPrimary (citable) accession number: Q5F5D6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3