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Q5F5D6 (SYC_NEIG1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteine--tRNA ligase

EC=6.1.1.16
Alternative name(s):
Cysteinyl-tRNA synthetase
Short name=CysRS
Gene names
Name:cysS
Ordered Locus Names:NGO1993
OrganismNeisseria gonorrhoeae (strain ATCC 700825 / FA 1090) [Reference proteome] [HAMAP]
Taxonomic identifier242231 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

Protein attributes

Sequence length473 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). HAMAP-Rule MF_00041

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_00041

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00041

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00041.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcysteinyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

cysteine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 473473Cysteine--tRNA ligase HAMAP-Rule MF_00041
PRO_0000240924

Regions

Motif30 – 4011"HIGH" region HAMAP-Rule MF_00041
Motif282 – 2865"KMSKS" region HAMAP-Rule MF_00041

Sites

Metal binding281Zinc By similarity
Metal binding2091Zinc By similarity
Metal binding2341Zinc By similarity
Metal binding2381Zinc By similarity
Binding site2851ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5F5D6 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 43042DFF3BD373E8

FASTA47352,804
        10         20         30         40         50         60 
MTAIYNTLTR QKEPFAPIDP ENVRMYVCGM TVYDYCHLGH ARVMVVFDMI ARWLRECGYP 

        70         80         90        100        110        120 
LTYVRNITDI DDKIIARAAE NGETIGELNA RFIQAMHEDA DALGVLRPDI EPKATENIPQ 

       130        140        150        160        170        180 
MIAMIETLIQ NGKAYPAANG DVYYAVREFA AYGQLSGKSL DDLRAGERVE VDGFKRDPLD 

       190        200        210        220        230        240 
FVLWKAAKAG EPAWESPWGN GRPGWHIECS AMSENLFGDT FDIHGGGADL QFPHHENEIA 

       250        260        270        280        290        300 
QSVGASGHTC GHDHAQTHHG QSIASHVKYW LHNGFIRVDG EKMSKSLGNF FTIREVLKQY 

       310        320        330        340        350        360 
DPEVVRFFIL RAHYRSPLNY SDAHLDDAKG ALTRLYTTLK NTPAAEFDLS ENANGYTRRF 

       370        380        390        400        410        420 
YAAMNDDFGT VEAVAVLFEL AGEVNKTNDA HLAGCLKALG GIIGLLQRNP IEFLQGGAVS 

       430        440        450        460        470 
DGLSNEEIED LIARRKQARA DKNWAESDRI RDLLNEHKII LEDSAGGTTW RRG 

« Hide

References

[1]"The complete genome sequence of Neisseria gonorrhoeae."
Lewis L.A., Gillaspy A.F., McLaughlin R.E., Gipson M., Ducey T.F., Ownbey T., Hartman K., Nydick C., Carson M.B., Vaughn J., Thomson C., Song L., Lin S., Yuan X., Najar F., Zhan M., Ren Q., Zhu H. expand/collapse author list , Qi S., Kenton S.M., Lai H., White J.D., Clifton S., Roe B.A., Dyer D.W.
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700825 / FA 1090.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004969 Genomic DNA. Translation: AAW90601.1.
RefSeqYP_209013.1. NC_002946.2.

3D structure databases

ProteinModelPortalQ5F5D6.
SMRQ5F5D6. Positions 1-414.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING242231.NGO1993.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW90601; AAW90601; NGO1993.
GeneID3282631.
KEGGngo:NGO1993.
PATRIC20337755. VBINeiGon24812_2404.

Phylogenomic databases

eggNOGCOG0215.
HOGENOMHOG000245250.
KOK01883.
OMAVTWYTCG.
OrthoDBEOG6RVFXC.

Enzyme and pathway databases

BioCycNGON242231:GI2G-1891-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00041. Cys_tRNA_synth.
InterProIPR015803. Cys-tRNA-ligase.
IPR015273. Cys-tRNA-synt_Ia_DALR.
IPR024909. Cys-tRNA/MSH_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR10890. PTHR10890. 1 hit.
PfamPF09190. DALR_2. 1 hit.
PF01406. tRNA-synt_1e. 1 hit.
[Graphical view]
PRINTSPR00983. TRNASYNTHCYS.
SMARTSM00840. DALR_2. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
TIGRFAMsTIGR00435. cysS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYC_NEIG1
AccessionPrimary (citable) accession number: Q5F5D6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 15, 2005
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries