ID Q5F4T5_9CALI Unreviewed; 548 AA. AC Q5F4T5; DT 15-MAR-2005, integrated into UniProtKB/TrEMBL. DT 15-MAR-2005, sequence version 1. DT 27-MAR-2024, entry version 79. DE SubName: Full=Capsid protein {ECO:0000313|EMBL:AAT12445.1}; OS Norwalk virus. OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; OC Picornavirales; Caliciviridae; Norovirus. OX NCBI_TaxID=11983 {ECO:0000313|EMBL:AAT12445.1, ECO:0000313|Proteomes:UP000157806}; RN [1] {ECO:0000313|EMBL:AAT12445.1, ECO:0000313|Proteomes:UP000157806} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Vietnam 026 {ECO:0000313|EMBL:AAT12445.1}; RX PubMed=15593412; DOI=10.1007/s00705-004-0345-4; RA Hansman G.S., Doan L.T., Kguyen T.A., Okitsu S., Katayama K., Ogawa S., RA Natori K., Takeda N., Kato Y., Nishio O., Noda M., Ushijima H.; RT "Detection of norovirus and sapovirus infection among children with RT gastroenteritis in Ho Chi Minh City, Vietnam."; RL Arch. Virol. 149:1673-1688(2004). RN [2] {ECO:0007829|PDB:3ONU, ECO:0007829|PDB:3ONY} RP X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) OF 224-538 IN COMPLEX WITH FUCOSE; RP GALACTOSE AND N-ACETYL-D-GLUCOSAMINE. RX PubMed=21525337; DOI=10.1128/JVI.00246-11; RA Hansman G.S., Biertumpfel C., Georgiev I., McLellan J.S., Chen L., Zhou T., RA Katayama K., Kwong P.D.; RT "Crystal structures of GII.10 and GII.12 norovirus protruding domains in RT complex with histo-blood group antigens reveal details for a potential site RT of vulnerability."; RL J. Virol. 85:6687-6701(2011). RN [3] {ECO:0007829|PDB:3RY8} RP X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) OF 225-538. RX PubMed=22031945; DOI=10.1128/JVI.05909-11; RA Hansman G.S., Shahzad-Ul-Hussan S., McLellan J.S., Chuang G.Y., RA Georgiev I., Shimoike T., Katayama K., Bewley C.A., Kwong P.D.; RT "Structural basis for norovirus inhibition and fucose mimicry by citrate."; RL J. Virol. 86:284-292(2012). RN [4] {ECO:0007829|PDB:3V7A} RP X-RAY CRYSTALLOGRAPHY (3.30 ANGSTROMS) OF 224-538. RX PubMed=22278249; DOI=10.1128/JVI.06868-11; RA Hansman G.S., Taylor D.W., McLellan J.S., Smith T.J., Georgiev I., RA Tame J.R., Park S.Y., Yamazaki M., Gondaira F., Miki M., Katayama K., RA Murata K., Kwong P.D.; RT "Structural basis for broad detection of genogroup II noroviruses by a RT monoclonal antibody that binds to a site occluded in the viral particle."; RL J. Virol. 86:3635-3646(2012). RN [5] {ECO:0007829|PDB:4X7E, ECO:0007829|PDB:4X7F} RP X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 224-538. RX PubMed=25520510; DOI=10.1128/JVI.03176-14; RA Koromyslova A.D., Hansman G.S.; RT "Nanobody binding to a conserved epitope promotes norovirus particle RT disassembly."; RL J. Virol. 89:2718-2730(2015). RN [6] {ECO:0007829|PDB:4Z4R, ECO:0007829|PDB:4Z4S} RP X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 224-538 IN COMPLEX WITH FUCOSE RP AND ALPHA-D-GALACTOSE. RX PubMed=25980740; DOI=10.1016/j.virol.2015.04.006; RA Koromyslova A.D., Leuthold M.M., Bowler M.W., Hansman G.S.; RT "The sweet quartet: Binding of fucose to the norovirus capsid."; RL Virology 483:203-208(2015). RN [7] {ECO:0007829|PDB:5BSX, ECO:0007829|PDB:5BSY} RP X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 224-538. RX PubMed=26295280; DOI=10.1016/j.virol.2015.07.009; RA Koromyslova A.D., White P.A., Hansman G.S.; RT "Treatment of norovirus particles with citrate."; RL Virology 485:199-204(2015). RN [8] {ECO:0007829|PDB:5HZA, ECO:0007829|PDB:5HZB} RP X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 224-538 IN COMPLEX WITH FUCOSE RP AND GLUCOSE. RX PubMed=26889023; DOI=10.1128/JVI.03223-15; RA Weichert S., Koromyslova A., Singh B.K., Hansman S., Jennewein S., RA Schroten H., Hansman G.S.; RT "Structural Basis for Norovirus Inhibition by Human Milk RT Oligosaccharides."; RL J. Virol. 90:4843-4848(2016). RN [9] {ECO:0007829|PDB:5O03, ECO:0007829|PDB:5O04} RP X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 224-538. RX PubMed=29095961; DOI=10.1371/journal.ppat.1006636; RA Koromyslova A.D., Hansman G.S.; RT "Nanobodies targeting norovirus capsid reveal functional epitopes and RT potential mechanisms of neutralization."; RL PLoS Pathog. 13:e1006636-e1006636(2017). RN [10] {ECO:0007829|PDB:6GY9} RP X-RAY CRYSTALLOGRAPHY (1.83 ANGSTROMS) OF 225-538. RX PubMed=30071731; DOI=10.1021/acs.biomac.8b00829; RA Bucher K.S., Yan H., Creutznacher R., Ruoff K., Mallagaray A., RA Grafmuller A., Dirks J.S., Kilic T., Weickert S., Rubailo A., Drescher M., RA Schmidt S., Hansman G., Peters T., Uetrecht C., Hartmann L.; RT "Fucose-Functionalized Precision Glycomacromolecules Targeting Human RT Norovirus Capsid Protein."; RL Biomacromolecules 19:3714-3724(2018). RN [11] {ECO:0007829|PDB:6GW1, ECO:0007829|PDB:6GW2} RP X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 225-538. RX PubMed=30355683; DOI=10.1128/JVI.01581-18; RA Kilic T., Koromyslova A., Hansman G.S.; RT "Structural Basis for Human Norovirus Capsid Binding to Bile Acids. ."; RL J. Virol. 93:e01581-e01518(2019). RN [12] {ECO:0007829|PDB:8EN2} RP X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 224-538. RX PubMed=36971561; DOI=10.1128/jvi.01833-22; RA Kher G., Sabin C., Lun J.H., Devant J.M., Ruoff K., Koromyslova A.D., RA von Itzstein M., Pancera M., Hansman G.S.; RT "Direct Blockade of the Norovirus Histo-Blood Group Antigen Binding Pocket RT by Nanobodies."; RL J. Virol. 97:e0183322-e0183322(2023). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF504671; AAT12445.1; -; Genomic_RNA. DR PDB; 3ONU; X-ray; 1.40 A; A/B=225-538. DR PDB; 3ONY; X-ray; 1.85 A; A/B/C=225-538. DR PDB; 3PA1; X-ray; 1.48 A; A/B=224-538. DR PDB; 3PA2; X-ray; 1.48 A; A/B=224-538. DR PDB; 3Q38; X-ray; 1.28 A; A/B=224-538. DR PDB; 3Q39; X-ray; 1.25 A; A/B=224-538. DR PDB; 3Q3A; X-ray; 1.40 A; A/B=224-538. DR PDB; 3Q6Q; X-ray; 1.43 A; A/B=224-538. DR PDB; 3Q6R; X-ray; 1.40 A; A/B=224-538. DR PDB; 3RY8; X-ray; 1.40 A; A/B=225-538. DR PDB; 3V7A; X-ray; 3.30 A; A/B=224-538. DR PDB; 4X7E; X-ray; 2.11 A; A/B=224-538. DR PDB; 4X7F; X-ray; 1.70 A; A/B=224-538. DR PDB; 4Z4R; X-ray; 1.80 A; A/B=224-538. DR PDB; 4Z4S; X-ray; 1.80 A; A/B=224-538. DR PDB; 4Z4T; X-ray; 1.80 A; A/B=224-538. DR PDB; 4Z4U; X-ray; 1.89 A; A/B=224-538. DR PDB; 4Z4V; X-ray; 1.80 A; A/B=224-538. DR PDB; 4Z4W; X-ray; 1.80 A; A/B=224-538. DR PDB; 4Z4Y; X-ray; 1.80 A; A/B=224-538. DR PDB; 4Z4Z; X-ray; 1.80 A; A/B=224-538. DR PDB; 5BSX; X-ray; 1.78 A; A/B=224-538. DR PDB; 5BSY; X-ray; 1.60 A; A/B=224-538. DR PDB; 5HZA; X-ray; 1.35 A; A/B=224-538. DR PDB; 5HZB; X-ray; 1.55 A; A/B=224-538. DR PDB; 5O03; X-ray; 2.19 A; A/B=224-538. DR PDB; 5O04; X-ray; 2.30 A; A/B=224-538. DR PDB; 5O05; X-ray; 2.00 A; A/B=224-538. DR PDB; 5OMM; X-ray; 1.70 A; A/B=224-538. DR PDB; 5OMN; X-ray; 2.68 A; B=224-538. DR PDB; 6GW1; X-ray; 1.90 A; A/B=225-538. DR PDB; 6GW2; X-ray; 2.05 A; A/B=225-538. DR PDB; 6GY9; X-ray; 1.83 A; A/B=225-538. DR PDB; 8EN2; X-ray; 1.85 A; A/B=224-538. DR PDBsum; 3ONU; -. DR PDBsum; 3ONY; -. DR PDBsum; 3PA1; -. DR PDBsum; 3PA2; -. DR PDBsum; 3Q38; -. DR PDBsum; 3Q39; -. DR PDBsum; 3Q3A; -. DR PDBsum; 3Q6Q; -. DR PDBsum; 3Q6R; -. DR PDBsum; 3RY8; -. DR PDBsum; 3V7A; -. DR PDBsum; 4X7E; -. DR PDBsum; 4X7F; -. DR PDBsum; 4Z4R; -. DR PDBsum; 4Z4S; -. DR PDBsum; 4Z4T; -. DR PDBsum; 4Z4U; -. DR PDBsum; 4Z4V; -. DR PDBsum; 4Z4W; -. DR PDBsum; 4Z4Y; -. DR PDBsum; 4Z4Z; -. DR PDBsum; 5BSX; -. DR PDBsum; 5BSY; -. DR PDBsum; 5HZA; -. DR PDBsum; 5HZB; -. DR PDBsum; 5O03; -. DR PDBsum; 5O04; -. DR PDBsum; 5O05; -. DR PDBsum; 5OMM; -. DR PDBsum; 5OMN; -. DR PDBsum; 6GW1; -. DR PDBsum; 6GW2; -. DR PDBsum; 6GY9; -. DR SMR; Q5F4T5; -. DR UniLectin; Q5F4T5; -. DR ABCD; Q5F4T5; 10 sequenced antibodies. DR EvolutionaryTrace; Q5F4T5; -. DR Proteomes; UP000157806; Genome. DR CDD; cd00205; rhv_like; 1. DR Gene3D; 2.60.120.20; -; 1. DR Gene3D; 2.40.30.120; Positive stranded ssRNA viruses; 1. DR Gene3D; 2.40.510.10; Positive stranded ssRNA viruses; 1. DR InterPro; IPR004005; Calicivirus_coat. DR InterPro; IPR013643; Calicivirus_coat_C. DR InterPro; IPR033703; Rhv-like. DR InterPro; IPR029053; Viral_coat. DR Pfam; PF00915; Calici_coat; 1. DR Pfam; PF08435; Calici_coat_C; 1. DR SUPFAM; SSF88633; Positive stranded ssRNA viruses; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:3ONU, ECO:0007829|PDB:3ONY}. FT DOMAIN 12..275 FT /note="Calicivirus coat protein" FT /evidence="ECO:0000259|Pfam:PF00915" FT DOMAIN 307..546 FT /note="Calicivirus coat protein C-terminal" FT /evidence="ECO:0000259|Pfam:PF08435" FT CARBOHYD 355 FT /note="Fucose" FT /evidence="ECO:0007829|PDB:3ONY" FT CARBOHYD 356 FT /note="Fucose" FT /evidence="ECO:0007829|PDB:3ONY" FT CARBOHYD 385 FT /note="Fucose" FT /evidence="ECO:0007829|PDB:3ONY" SQ SEQUENCE 548 AA; 59900 MW; FDB134B87D09A39B CRC64; MKMASNDAAP SNDGAAGLVP ESNNEVMALE PVAGASLAAP VTGQTNIIDP WIRMNFVQAP NGEFTVSPRN SPGEVLLNLE LGPELNPYLA HLSRMYNGYA GGMEVQIMLA GNAFTAGKLI FAAVPPHFPI ENLSPPQITM FPHVIIDVRT LEPVLLPMPD IRNSFFHFIQ RDEPKMRLVA MLYTPLRSNG SGDDVFTVSC RVLTRPTPDF DFTYLVPPTV ESKSKPFTLP ILTLGELTNS RFPLPIDVLY TNPNESAIVQ CQNGRCTLDG ELQGTTQLLP TGICAFRGKV TQQVQDEHRG THWNMTVTNL NGTPFDPTED VPAPLGTPDF SGQIYGVISQ RNTNTVPGEG NLPANRAHEA VIATYSPKFT PKLGNIQFST WETQDVSSGQ PTKFTPVGLA SVDANSHFDQ WTLPSYSGAL TLNMNLAPSV APVFPGECLL FFRSFIPLKG GYGNPAIDCL MPQEWVQHLY QESAPSLSDV ALVRYVNPET GRTLFEAKLH RNGFLTVARN SAGPVVAPTN GYFRFDSWVN QFYTLAPMGN GSGRRRMQ //