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Protein
Submitted name:

Capsid protein

Gene
N/A
Organism
Norwalk virus
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei299 – 2991GalactoseCombined sources
Binding sitei381 – 3811FucoseCombined sources
Binding sitei382 – 3821N-acetyl-D-glucosamineCombined sources
Binding sitei385 – 3851FucoseCombined sources
Binding sitei449 – 4491N-acetyl-D-glucosamine; via carbonyl oxygenCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Capsid proteinImported
OrganismiNorwalk virusImported
Taxonomic identifieri11983 [NCBI]
Taxonomic lineageiVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeNorovirus

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ONUX-ray1.40A/B225-538[»]
3ONYX-ray1.85A/B/C225-538[»]
3PA1X-ray1.48A/B224-538[»]
3PA2X-ray1.48A/B224-538[»]
3Q38X-ray1.28A/B224-538[»]
3Q39X-ray1.25A/B224-538[»]
3Q3AX-ray1.40A/B224-538[»]
3Q6QX-ray1.43A/B224-538[»]
3Q6RX-ray1.40A/B224-538[»]
3RY8X-ray1.40A/B225-538[»]
3V7AX-ray3.30A/B224-538[»]
4X7EX-ray2.11A/B224-538[»]
4X7FX-ray1.70A/B224-538[»]
ProteinModelPortaliQ5F4T5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5F4T5.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni355 – 3562Fucose bindingCombined sources
Regioni400 – 4012N-acetyl-D-glucosamine bindingCombined sources
Regioni451 – 4522Fucose bindingCombined sources

Family and domain databases

Gene3Di2.60.120.20. 1 hit.
InterProiIPR004005. Calicivirus_coat.
IPR013643. Calicivirus_coat_C.
IPR029053. Viral_coat.
[Graphical view]
PfamiPF00915. Calici_coat. 1 hit.
PF08435. Calici_coat_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5F4T5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMASNDAAP SNDGAAGLVP ESNNEVMALE PVAGASLAAP VTGQTNIIDP
60 70 80 90 100
WIRMNFVQAP NGEFTVSPRN SPGEVLLNLE LGPELNPYLA HLSRMYNGYA
110 120 130 140 150
GGMEVQIMLA GNAFTAGKLI FAAVPPHFPI ENLSPPQITM FPHVIIDVRT
160 170 180 190 200
LEPVLLPMPD IRNSFFHFIQ RDEPKMRLVA MLYTPLRSNG SGDDVFTVSC
210 220 230 240 250
RVLTRPTPDF DFTYLVPPTV ESKSKPFTLP ILTLGELTNS RFPLPIDVLY
260 270 280 290 300
TNPNESAIVQ CQNGRCTLDG ELQGTTQLLP TGICAFRGKV TQQVQDEHRG
310 320 330 340 350
THWNMTVTNL NGTPFDPTED VPAPLGTPDF SGQIYGVISQ RNTNTVPGEG
360 370 380 390 400
NLPANRAHEA VIATYSPKFT PKLGNIQFST WETQDVSSGQ PTKFTPVGLA
410 420 430 440 450
SVDANSHFDQ WTLPSYSGAL TLNMNLAPSV APVFPGECLL FFRSFIPLKG
460 470 480 490 500
GYGNPAIDCL MPQEWVQHLY QESAPSLSDV ALVRYVNPET GRTLFEAKLH
510 520 530 540
RNGFLTVARN SAGPVVAPTN GYFRFDSWVN QFYTLAPMGN GSGRRRMQ
Length:548
Mass (Da):59,900
Last modified:March 14, 2005 - v1
Checksum:iFDB134B87D09A39B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF504671 Genomic RNA. Translation: AAT12445.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF504671 Genomic RNA. Translation: AAT12445.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ONUX-ray1.40A/B225-538[»]
3ONYX-ray1.85A/B/C225-538[»]
3PA1X-ray1.48A/B224-538[»]
3PA2X-ray1.48A/B224-538[»]
3Q38X-ray1.28A/B224-538[»]
3Q39X-ray1.25A/B224-538[»]
3Q3AX-ray1.40A/B224-538[»]
3Q6QX-ray1.43A/B224-538[»]
3Q6RX-ray1.40A/B224-538[»]
3RY8X-ray1.40A/B225-538[»]
3V7AX-ray3.30A/B224-538[»]
4X7EX-ray2.11A/B224-538[»]
4X7FX-ray1.70A/B224-538[»]
ProteinModelPortaliQ5F4T5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ5F4T5.

Family and domain databases

Gene3Di2.60.120.20. 1 hit.
InterProiIPR004005. Calicivirus_coat.
IPR013643. Calicivirus_coat_C.
IPR029053. Viral_coat.
[Graphical view]
PfamiPF00915. Calici_coat. 1 hit.
PF08435. Calici_coat_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Detection of norovirus and sapovirus infection among children with gastroenteritis in Ho Chi Minh City, Vietnam."
    Hansman G.S., Doan L.T., Kguyen T.A., Okitsu S., Katayama K., Ogawa S., Natori K., Takeda N., Kato Y., Nishio O., Noda M., Ushijima H.
    Arch. Virol. 149:1673-1688(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Vietnam 026Imported.
  2. "Crystal structures of GII.10 and GII.12 norovirus protruding domains in complex with histo-blood group antigens reveal details for a potential site of vulnerability."
    Hansman G.S., Biertumpfel C., Georgiev I., McLellan J.S., Chen L., Zhou T., Katayama K., Kwong P.D.
    J. Virol. 85:6687-6701(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) OF 224-538 IN COMPLEX WITH FUCOSE; GALACTOSE AND N-ACETYL-D-GLUCOSAMINE.
  3. Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) OF 225-538.
  4. "Structural basis for broad detection of genogroup II noroviruses by a monoclonal antibody that binds to a site occluded in the viral particle."
    Hansman G.S., Taylor D.W., McLellan J.S., Smith T.J., Georgiev I., Tame J.R., Park S.Y., Yamazaki M., Gondaira F., Miki M., Katayama K., Murata K., Kwong P.D.
    J. Virol. 86:3635-3646(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.30 ANGSTROMS) OF 224-538.
  5. "Nanobody binding to a conserved epitope promotes norovirus particle disassembly."
    Koromyslova A.D., Hansman G.S.
    J. Virol. 89:2718-2730(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 224-538.

Entry informationi

Entry nameiQ5F4T5_9CALI
AccessioniPrimary (citable) accession number: Q5F4T5
Entry historyi
Integrated into UniProtKB/TrEMBL: March 14, 2005
Last sequence update: March 14, 2005
Last modified: March 31, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.