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Q5F4T5 (Q5F4T5_9CALI) Unreviewed, UniProtKB/TrEMBL

Last modified January 22, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
OrganismNorwalk virus EMBL AAT12445.1
Taxonomic identifier11983 [NCBI]
Taxonomic lineageVirusesssRNA positive-strand viruses, no DNA stageCaliciviridaeNorovirus

Protein attributes

Sequence length548 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region355 – 3562Citrate binding PDB 3RY8
Region355 – 3562Fucose binding PDB 3PA2 PDB 3Q38 PDB 3PA1 PDB 3Q39 PDB 3ONY
Region400 – 4012N-acetyl-D-glucosamine binding PDB 3PA2
Region451 – 4522Fucose binding PDB 3PA2 PDB 3Q38 PDB 3PA1 PDB 3Q39 PDB 3ONY

Sites

Binding site2991Galactose PDB 3Q3A
Binding site3811Fucose PDB 3PA2
Binding site3821N-acetyl-D-glucosamine PDB 3Q3A
Binding site3851Citrate PDB 3RY8
Binding site3851Fucose PDB 3PA2 PDB 3Q38 PDB 3PA1 PDB 3Q39 PDB 3ONY
Binding site4491N-acetyl-D-glucosamine; via carbonyl oxygen PDB 3Q3A
Binding site4511Citrate; via amide nitrogen PDB 3RY8

Sequences

Sequence LengthMass (Da)Tools
Q5F4T5 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: FDB134B87D09A39B

FASTA54859,900
        10         20         30         40         50         60 
MKMASNDAAP SNDGAAGLVP ESNNEVMALE PVAGASLAAP VTGQTNIIDP WIRMNFVQAP 

        70         80         90        100        110        120 
NGEFTVSPRN SPGEVLLNLE LGPELNPYLA HLSRMYNGYA GGMEVQIMLA GNAFTAGKLI 

       130        140        150        160        170        180 
FAAVPPHFPI ENLSPPQITM FPHVIIDVRT LEPVLLPMPD IRNSFFHFIQ RDEPKMRLVA 

       190        200        210        220        230        240 
MLYTPLRSNG SGDDVFTVSC RVLTRPTPDF DFTYLVPPTV ESKSKPFTLP ILTLGELTNS 

       250        260        270        280        290        300 
RFPLPIDVLY TNPNESAIVQ CQNGRCTLDG ELQGTTQLLP TGICAFRGKV TQQVQDEHRG 

       310        320        330        340        350        360 
THWNMTVTNL NGTPFDPTED VPAPLGTPDF SGQIYGVISQ RNTNTVPGEG NLPANRAHEA 

       370        380        390        400        410        420 
VIATYSPKFT PKLGNIQFST WETQDVSSGQ PTKFTPVGLA SVDANSHFDQ WTLPSYSGAL 

       430        440        450        460        470        480 
TLNMNLAPSV APVFPGECLL FFRSFIPLKG GYGNPAIDCL MPQEWVQHLY QESAPSLSDV 

       490        500        510        520        530        540 
ALVRYVNPET GRTLFEAKLH RNGFLTVARN SAGPVVAPTN GYFRFDSWVN QFYTLAPMGN 


GSGRRRMQ 

« Hide

References

[1]"Detection of norovirus and sapovirus infection among children with gastroenteritis in Ho Chi Minh City, Vietnam."
Hansman G.S., Doan L.T., Kguyen T.A., Okitsu S., Katayama K., Ogawa S., Natori K., Takeda N., Kato Y., Nishio O., Noda M., Ushijima H.
Arch. Virol. 149:1673-1688(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Vietnam 026 EMBL AAT12445.1.
[2]"Crystal structures of GII.10 and GII.12 norovirus protruding domains in complex with histo-blood group antigens reveal details for a potential site of vulnerability."
Hansman G.S., Biertumpfel C., Georgiev I., McLellan J.S., Chen L., Zhou T., Katayama K., Kwong P.D.
J. Virol. 85:6687-6701(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.25 ANGSTROMS) OF 224-538 IN COMPLEX WITH FUCOSE; GALACTOSE AND N-ACETYL-D-GLUCOSAMINE.
[3]"Structural basis for norovirus inhibition and fucose mimicry by citrate."
Hansman G.S., Shahzad-Ul-Hussan S., McLellan J.S., Chuang G.Y., Georgiev I., Shimoike T., Katayama K., Bewley C.A., Kwong P.D.
J. Virol. 86:284-292(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) OF 225-538 IN COMPLEX WITH CITRATE.
[4]"Structural basis for broad detection of genogroup II noroviruses by a monoclonal antibody that binds to a site occluded in the viral particle."
Hansman G.S., Taylor D.W., McLellan J.S., Smith T.J., Georgiev I., Tame J.R., Park S.Y., Yamazaki M., Gondaira F., Miki M., Katayama K., Murata K., Kwong P.D.
J. Virol. 86:3635-3646(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.30 ANGSTROMS) OF 224-538.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF504671 Genomic RNA. Translation: AAT12445.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3ONUX-ray1.40A/B225-538[»]
3ONYX-ray1.85A/B/C225-538[»]
3PA1X-ray1.48A/B224-538[»]
3PA2X-ray1.48A/B224-538[»]
3Q38X-ray1.28A/B224-538[»]
3Q39X-ray1.25A/B224-538[»]
3Q3AX-ray1.40A/B224-538[»]
3Q6QX-ray1.43A/B224-538[»]
3Q6RX-ray1.40A/B224-538[»]
3RY8X-ray1.40A/B225-538[»]
3V7AX-ray3.30A/B224-538[»]
ProteinModelPortalQ5F4T5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR004005. Calicivirus_coat.
IPR013643. Calicivirus_coat_C.
[Graphical view]
PfamPF00915. Calici_coat. 1 hit.
PF08435. Calici_coat_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ5F4T5.

Entry information

Entry nameQ5F4T5_9CALI
AccessionPrimary (citable) accession number: Q5F4T5
Entry history
Integrated into UniProtKB/TrEMBL: March 15, 2005
Last sequence update: March 15, 2005
Last modified: January 22, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)