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Protein
Submitted name:

Transient receptor potential cation channel, subfamily M, member 3

Gene

Trpm3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation, ReceptorImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Transient receptor potential cation channel, subfamily M, member 3Imported
Gene namesi
Name:Trpm3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:2443101. Trpm3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei865 – 88420HelicalSequence analysisAdd
BLAST
Transmembranei932 – 95019HelicalSequence analysisAdd
BLAST
Transmembranei962 – 98019HelicalSequence analysisAdd
BLAST
Transmembranei1001 – 102121HelicalSequence analysisAdd
BLAST
Transmembranei1079 – 110426HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ5F4S6.
PRIDEiQ5F4S6.

Expressioni

Gene expression databases

BgeeiQ5F4S6.
GenevisibleiQ5F4S6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084857.

Structurei

3D structure databases

ProteinModelPortaliQ5F4S6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini871 – 1113243Ion_transInterPro annotationAdd
BLAST
Domaini1207 – 126256TRPM_tetraInterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3614. Eukaryota.
ENOG410XR5B. LUCA.
HOVERGENiHBG055663.
KOiK04978.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR029583. TRPM3.
IPR032415. TRPM_tetra.
[Graphical view]
PANTHERiPTHR13800:SF7. PTHR13800:SF7. 2 hits.
PfamiPF00520. Ion_trans. 1 hit.
PF16519. TRPM_tetra. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5F4S6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKWRDAGE LERGCSDRED SAESRRRSRS ASRGRFAESW KRLSSKQGST
60 70 80 90 100
KRSGLPAQQT PAQKSWIERA FYKRECVHII PSTKDPHRCC CGRLIGQHVG
110 120 130 140 150
LTPSISVLQN EKNESRLSRN DIQSEKWSIS KHTQLSPTDA FGTIEFQGGG
160 170 180 190 200
HSNKAMYVRV SFDTKPDLLL HLMTKEWQLE LPKLLISVHG GLQNFELQPK
210 220 230 240 250
LKQVFGKGLI KAAMTTGAWI FTGGVNTGVI RHVGDALKDH ASKSRGKICT
260 270 280 290 300
IGIAPWGIVE NQEDLIGRDV VRPYQTMSNP MSKLTVLNSM HSHFILADNG
310 320 330 340 350
TTGKYGAEVK LRRQLEKHIS LQKINTRIGQ GVPVVALIVE GGPNVISIVL
360 370 380 390 400
EYLRDTPPVP VVVCDGSGRA SDILAFGHKY SEEGGLINES LRDQLLVTIQ
410 420 430 440 450
KTFTYTRTQA QHLFIILMEC MKKKELITVF RMGSEGHQDI DLAILTALLK
460 470 480 490 500
GANASAPDQL SLALAWNRVD IARSQIFIYG QQWPVGSLEQ AMLDALVLDR
510 520 530 540 550
VDFVKLLIEN GVSMHRFLTI SRLEELYNTR HGPSNTLYHL VRDVKKGNLP
560 570 580 590 600
PDYRISLIDI GLVIEYLMGG AYRCNYTRKR FRTLYHNLFG PKRDDIPLRR
610 620 630 640 650
GRKTTKKREE EVDIDLDDPE INHFPFPFHE LMVWAVLMKR QKMALFFWQH
660 670 680 690 700
GEEAMAKALV ACKLCKAMAH EASENDMVDD ISQELNHNSR DFGQLAVELL
710 720 730 740 750
DQSYKQDEQL AMKLLTYELK NWSNATCLQL AVAAKHRDFI AHTCSQMLLT
760 770 780 790 800
DMWMGRLRMR KNSGLKVILG ILLPPSILSL EFKNKDDMPY MTQAQEIHLQ
810 820 830 840 850
EKEPEEPEKP TKEKDEEDME LTAMLGRSNG ESSRKKDEEE VQSRHRLIPV
860 870 880 890 900
GRKIYEFYNA PIVKFWFYTL AYIGYLMLFN YIVLVKMERW PSTQEWIVIS
910 920 930 940 950
YIFTLGIEKM REILMSEPGK LLQKVKVWLQ EYWNVTDLIA ILLFSVGMIL
960 970 980 990 1000
RLQDQPFRSD GRVIYCVNII YWYIRLLDIF GVNKYLGPYV MMIGKMMIDM
1010 1020 1030 1040 1050
MYFVIIMLVV LMSFGVARQA ILFPNEEPSW KLAKNIFYMP YWMIYGEVFA
1060 1070 1080 1090 1100
DQIDPPCGQN ETREDGKTIQ LPPCKTGAWI VPAIMACYLL VANILLVNLL
1110 1120 1130 1140 1150
IAVFNNTFFE VKSISNQVWK FQRYQLIMTF HERPVLPPPL IIFSHMTMIF
1160 1170 1180 1190 1200
QHVCCRWRKH ESDQDERDYG LKLFITDDEL KKVHDFEEQC IEEYFREKDD
1210 1220 1230 1240 1250
RFNSSNDERI RVTSERVENM SMRLEEVNER EHSMKASLQT VDIRLAQLED
1260 1270 1280 1290 1300
LIGRMATALE RLTGLERAES NKIRSRTSSD CTDAAYIVRQ SSFNSQEGNT
1310 1320 1330 1340 1350
FKLQESIDPA GEETISPTSP TLMPRMRSHS FYSVNVKDKG GIEKLESIFK
1360 1370 1380 1390 1400
ERSLSLHRAT SSHSVAKEPK APAAPANTLA IVPDSRRPSS CIDIYVSAMD
1410 1420 1430 1440 1450
ELHCDIEPLD NSMNILGLGE PSFSALAPST TPSSSAYATL APTDRPPSRS
1460 1470 1480 1490 1500
IDFEDLTSMD TRSFSSDYTH LPECQNPWDT DPPTYHTIER SKSSRYLATT
1510 1520 1530 1540 1550
PFLLEEAPIV KSHSFMFSPS RSYYANFGVP VKTAEYTSIT DCIDTRCVNA
1560 1570 1580 1590 1600
PQAIADRATF PGGLGDKVED LSCCHPEREA ELSHPSSDSE ENEARGQRAA
1610 1620 1630 1640 1650
NPISSQEAEN ADRTLSNNIT VPKIERANSY SAEEPNVPYA HTRKSFSISD
1660 1670 1680 1690
KLDRQRNTAS LRNPFQRSKS SKPEGRGDSL SMRRLSRTSA FHSFESKHN
Length:1,699
Mass (Da):193,712
Last modified:March 15, 2005 - v1
Checksum:iBF1409BD9F0F216F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ544536 mRNA. Translation: CAD67496.1.
RefSeqiNP_001030316.1. NM_001035239.2.
NP_001030317.1. NM_001035240.2.
NP_001030318.1. NM_001035241.2.
NP_001030320.1. NM_001035243.2.
UniGeneiMm.131943.
Mm.397699.
Mm.440339.

Genome annotation databases

GeneIDi226025.
KEGGimmu:226025.
UCSCiuc008gzn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ544536 mRNA. Translation: CAD67496.1.
RefSeqiNP_001030316.1. NM_001035239.2.
NP_001030317.1. NM_001035240.2.
NP_001030318.1. NM_001035241.2.
NP_001030320.1. NM_001035243.2.
UniGeneiMm.131943.
Mm.397699.
Mm.440339.

3D structure databases

ProteinModelPortaliQ5F4S6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000084857.

Proteomic databases

PaxDbiQ5F4S6.
PRIDEiQ5F4S6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi226025.
KEGGimmu:226025.
UCSCiuc008gzn.1. mouse.

Organism-specific databases

CTDi80036.
MGIiMGI:2443101. Trpm3.

Phylogenomic databases

eggNOGiKOG3614. Eukaryota.
ENOG410XR5B. LUCA.
HOVERGENiHBG055663.
KOiK04978.

Miscellaneous databases

ChiTaRSiTrpm3. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiQ5F4S6.
GenevisibleiQ5F4S6. MM.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR029583. TRPM3.
IPR032415. TRPM_tetra.
[Graphical view]
PANTHERiPTHR13800:SF7. PTHR13800:SF7. 2 hits.
PfamiPF00520. Ion_trans. 1 hit.
PF16519. TRPM_tetra. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Alternative splicing switches the divalent cation selectivity of TRPM3 channels."
    Oberwinkler J., Lis A., Giehl K.M., Flockerzi V., Philipp S.E.
    J. Biol. Chem. 280:22540-22548(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvJ x C57BL/6JImported.

Entry informationi

Entry nameiQ5F4S6_MOUSE
AccessioniPrimary (citable) accession number: Q5F4S6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 15, 2005
Last sequence update: March 15, 2005
Last modified: July 6, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.