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Q5F4B3 (TMLH_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Trimethyllysine dioxygenase, mitochondrial
EC=1.14.11.8
Alternative name(s):
Epsilon-trimethyllysine 2-oxoglutarate dioxygenase
TML hydroxylase
TML-alpha-ketoglutarate dioxygenase
Short name=TML dioxygenase
Short name=TMLD
Gene names
Name:TMLHE
ORF Names:RCJMB04_1d18
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML) By similarity.

Catalytic activity

N6,N6,N(6)-trimethyl-L-lysine + 2-oxoglutarate + O2 = 3-hydroxy-N6,N6,N(6)-trimethyl-L-lysine + succinate + CO2.

Cofactor

Binds 1 Fe2+ ion per subunit By similarity.

Ascorbate By similarity.

Pathway

Amine and polyamine biosynthesis; carnitine biosynthesis.

Subunit structure

Homodimer By similarity.

Subcellular location

Mitochondrion matrix.

Sequence similarities

Belongs to the gamma-BBH/TMLD family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 418Trimethyllysine dioxygenase, mitochondrialPRO_0000260157

Sites

Metal binding2391Iron; catalytic By similarity
Metal binding2411Iron; catalytic By similarity
Metal binding3861Iron; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5F4B3 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 01ABB6CF16BD31E5

FASTA41848,656
        10         20         30         40         50         60 
MWCRRLACLL SVPCQHTRHR LLGPSCGRRT FTAAVARWHH TAPESLSCAW QLHGDHLELR 

        70         80         90        100        110        120 
YADTLMRFDF VWLRDHCRSA SCYNAKTNQR SLDTASVDLS IKPKAVRVDE TTLFLTWPDG 

       130        140        150        160        170        180 
HVTRYGLQWL VKNSYEGQKQ QVMHPRILWN AEIYRQAQVP SVDCQSFLET DEGLKEFLQN 

       190        200        210        220        230        240 
FLLYGIAFVE NVTPTKEDTQ ILAERISLIR ETIYGRMWYF TSDFSRGDTA YTKLALDRHT 

       250        260        270        280        290        300 
DTTYFQEPCG IQVFHCLKHE GTGGRTLLVD GFYAAEQVLR QAPDQFELLS KVPLKHEYIE 

       310        320        330        340        350        360 
NVGDCHNHMI GVGPVLNVYP WNNELYLIRY NNYDRAVINT VPYDVVNRWY TAHRTLTTEL 

       370        380        390        400        410 
RRPENELWVK LKPGKALFID NWRVLHGREA FTGYRQLCGC YLTRDDVLNT ARLLGLQA

« Hide

References

[1]"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.
Genome Biol. 6:R6.1-R6.9(2005) [PubMed: 15642098] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CB.
Tissue: Bursa of Fabricius.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ851387 mRNA. Translation: CAH65021.1.
IPIIPI00598008.
RefSeqNP_001012593.1. NM_001012575.1.
UniGeneGga.18010.

3D structure databases

ProteinModelPortalQ5F4B3.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000012043; ENSGALP00000012029; ENSGALG00000007443.
GeneID422296.
KEGGgga:422296.

Organism-specific databases

CTD55217.

Phylogenomic databases

eggNOGveNOG13035.
GeneTreeENSGT00530000063582.
HOGENOMHBG445343.
HOVERGENHBG035650.
InParanoidQ5F4B3.
OMALCGCYLT.
OrthoDBEOG4QRH4C.
PhylomeDBQ5F4B3.

Family and domain databases

InterProIPR010376. DUF971.
IPR003819. Taurine_dOase.
IPR012776. Trimethyllysine_dOase.
[Graphical view]
KOK00474.
PfamPF06155. DUF971. 1 hit.
PF02668. TauD. 1 hit.
[Graphical view]
TIGRFAMsTIGR02410. Carnitine_TMLD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTMLH_CHICK
AccessionPrimary (citable) accession number: Q5F4B3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 15, 2005
Last modified: November 16, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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