Q5F4A3 (AN32E_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acidic leucine-rich nuclear phosphoprotein 32 family member E

Gene names

Name:	ANP32E
ORF Names:	RCJMB04_1l3

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis process by modulating PP2A activity By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the ANP32 family. Contains 3 LRR (leucine-rich) repeats. Contains 1 LRRCT domain.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Domain	Leucine-rich repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasmic membrane-bounded vesicle Inferred from sequence or structural similarity. Source: AgBase nucleus Inferred from sequence or structural similarity. Source: AgBase
Molecular function	phosphatase inhibitor activity Inferred from sequence or structural similarity. Source: AgBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 256	256	Acidic leucine-rich nuclear phosphoprotein 32 family member E		PRO_0000280065
Regions
	Repeat	43 – 64	22	LRR 1
	Repeat	65 – 87	23	LRR 2
	Repeat	89 – 110	22	LRR 3
	Domain	123 – 161	39	LRRCT
	Compositional bias	130 – 254	125	Asp/Glu-rich (highly acidic)

Sequences

	Sequence		Length	Mass (Da)
	Q5F4A3 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 50380963AB9C0F43	FASTA	256	28,926
	10 20 30 40 50 60 MEMKKRINLE LRNQAPEEVT ELVLDNCKSS NGEIEGLNDS FKELEFLSMA NVQLTSLAKL 70 80 90 100 110 120 PTLSKLRKLE LSDNIISGGL EVLAERCPNL TYLNLSGNKI KDLGTVEALQ NLKNLKSLDL 130 140 150 160 170 180 FNCEITNLED YRDSIFDLLQ QITYLDGFDQ EDNEAPDSED DDDEGDEDDN DEDEDEAGPP 190 200 210 220 230 240 GEYEEEDDED DGGSDLGEGE EEEEVGLSYL MKEEIQDEDD DDDYVEEGGD EEEEAEGIRG 250 EKRKRDPEDE GEEEDD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:R6.1-R6.9(2005) [PubMed: 15642098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.
[2]	"The Anp32 family of proteins containing leucine-rich repeats." Matilla A., Radrizzani M. Cerebellum 4:7-18(2005) [PubMed: 15895553] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ851397 mRNA. Translation: CAH65031.1.
IPI	IPI00596060.
RefSeq	NP_001006564.2. NM_001006564.2.
UniGene	Gga.22580.
3D structure databases
HSSP	HSSP built from PDB template 1D0B based on UniProtKB P25147.
ProteinModelPortal	Q5F4A3.
SMR	Q5F4A3. Positions 1-159.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	426109.
KEGG	gga:426109.
Organism-specific databases
CTD	81611.
Phylogenomic databases
eggNOG	veNOG15750.
HOVERGEN	HBG053102.
Family and domain databases
InterPro	IPR001611. Leu-rich_rpt. IPR003603. U2A'_phosphoprotein32A_C. [Graphical view]
SMART	SM00446. LRRcap. 1 hit. [Graphical view]
PROSITE	PS51450. LRR. 4 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AN32E_CHICK

Accession

Primary (citable) accession number: Q5F4A3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 6, 2007
Last sequence update:	March 15, 2005
Last modified:	September 21, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program