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Q5F3W5

- SUV92_CHICK

UniProt

Q5F3W5 - SUV92_CHICK

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Protein

Histone-lysine N-methyltransferase SUV39H2

Gene
SUV39H2, RCJMB04_5f7
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes By similarity.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi187 – 1871Zinc 1 By similarity
Metal bindingi187 – 1871Zinc 2 By similarity
Metal bindingi189 – 1891Zinc 1 By similarity
Metal bindingi192 – 1921Zinc 1 By similarity
Metal bindingi192 – 1921Zinc 3 By similarity
Metal bindingi197 – 1971Zinc 1 By similarity
Metal bindingi198 – 1981Zinc 1 By similarity
Metal bindingi198 – 1981Zinc 2 By similarity
Metal bindingi225 – 2251Zinc 2 By similarity
Metal bindingi225 – 2251Zinc 3 By similarity
Metal bindingi229 – 2291Zinc 2 By similarity
Metal bindingi231 – 2311Zinc 3 By similarity
Metal bindingi235 – 2351Zinc 3 By similarity
Binding sitei300 – 3001S-adenosyl-L-methionine By similarity
Metal bindingi329 – 3291Zinc 4 By similarity
Metal bindingi395 – 3951Zinc 4 By similarity
Metal bindingi397 – 3971Zinc 4 By similarity
Metal bindingi402 – 4021Zinc 4 By similarity

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. histone methyltransferase activity (H3-K9 specific) Source: Ensembl
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. chromatin assembly or disassembly Source: Ensembl
  3. chromatin remodeling Source: Ensembl
  4. male meiosis Source: Ensembl
  5. regulation of transcription, DNA-templated Source: UniProtKB-KW
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Cell cycle, Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SUV39H2 (EC:2.1.1.43)
Alternative name(s):
Suppressor of variegation 3-9 homolog 2
Short name:
Su(var)3-9 homolog 2
Gene namesi
Name:SUV39H2
ORF Names:RCJMB04_5f7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 1

Subcellular locationi

Nucleus By similarity. Chromosomecentromere By similarity
Note: Associates with centromeric constitutive heterochromatin By similarity.

GO - Cellular componenti

  1. chromosome, centromeric region Source: UniProtKB-SubCell
  2. nuclear heterochromatin Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Histone-lysine N-methyltransferase SUV39H2PRO_0000281815Add
BLAST

Proteomic databases

PaxDbiQ5F3W5.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000028525.

Structurei

3D structure databases

ProteinModelPortaliQ5F3W5.
SMRiQ5F3W5. Positions 120-407.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 10159ChromoAdd
BLAST
Domaini185 – 24359Pre-SETAdd
BLAST
Domaini246 – 369124SETAdd
BLAST
Domaini391 – 40717Post-SETAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni257 – 2593S-adenosyl-L-methionine binding By similarity
Regioni326 – 3272S-adenosyl-L-methionine binding By similarity

Domaini

Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates to stable binding to heterochromatin By similarity.
In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster By similarity.

Sequence similaritiesi

Contains 1 chromo domain.
Contains 1 post-SET domain.
Contains 1 pre-SET domain.
Contains 1 SET domain.

Phylogenomic databases

eggNOGiCOG2940.
GeneTreeiENSGT00750000117355.
HOGENOMiHOG000231244.
HOVERGENiHBG055621.
InParanoidiQ5F3W5.
KOiK11419.
OMAiAWCVPCL.
OrthoDBiEOG7RJPR0.
PhylomeDBiQ5F3W5.
TreeFamiTF106452.

Family and domain databases

InterProiIPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR011381. Histone_H3-K9_MeTrfase.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF009343. SUV39_SET. 1 hit.
SMARTiSM00298. CHROMO. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51579. SAM_MT43_SUVAR39_3. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5F3W5-1 [UniParc]FASTAAdd to Basket

« Hide

MEGWRGAWYV PCLASHETLQ ELCRKENLRC KSIGITNKSL KSYEVEYLCD    50
YKVEEGKEYY LVKWKGWPES SNTWEPQKNL KCPKLLENFL SDKDEYLSRM 100
KEGRALKVRN SVKALKPAVA DYIVKKAKQR IALQRWKEEL NRKKNHKGMI 150
LVENTVDLEG PPIDFYYINE YKPAPGINVI NGITTGCECS DCPAEKCCPK 200
EAGFILAYNK QKKLKIQPGL PIYECNSFCR CGPDCPNRIV QKGTQYSLCI 250
FRTNNGRGWG VKTLQKIKTN SFVMEYVGEV ITSEEAERRG QFYDNQGNTY 300
LFDLDYDSDE FTVDAARYGN VSHFVNHSCD PNLQVFNVFI DNLDLRLPRI 350
ALFSTRTIKA GEELTFDYQM KGSIDLTSDS ADGLSSSRKR IRTVCKCGAV 400
CCRGYLN 407
Length:407
Mass (Da):46,659
Last modified:March 15, 2005 - v1
Checksum:i430C980EB03AC627
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ851535 mRNA. Translation: CAH65169.1.
RefSeqiNP_001026541.1. NM_001031370.2.
UniGeneiGga.13450.

Genome annotation databases

EnsembliENSGALT00000029187; ENSGALP00000028525; ENSGALG00000013920.
GeneIDi426314.
KEGGigga:426314.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ851535 mRNA. Translation: CAH65169.1 .
RefSeqi NP_001026541.1. NM_001031370.2.
UniGenei Gga.13450.

3D structure databases

ProteinModelPortali Q5F3W5.
SMRi Q5F3W5. Positions 120-407.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000028525.

Proteomic databases

PaxDbi Q5F3W5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000029187 ; ENSGALP00000028525 ; ENSGALG00000013920 .
GeneIDi 426314.
KEGGi gga:426314.

Organism-specific databases

CTDi 79723.

Phylogenomic databases

eggNOGi COG2940.
GeneTreei ENSGT00750000117355.
HOGENOMi HOG000231244.
HOVERGENi HBG055621.
InParanoidi Q5F3W5.
KOi K11419.
OMAi AWCVPCL.
OrthoDBi EOG7RJPR0.
PhylomeDBi Q5F3W5.
TreeFami TF106452.

Miscellaneous databases

NextBioi 20827954.
PROi Q5F3W5.

Family and domain databases

InterProi IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR011381. Histone_H3-K9_MeTrfase.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF00385. Chromo. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
PIRSFi PIRSF009343. SUV39_SET. 1 hit.
SMARTi SM00298. CHROMO. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
SUPFAMi SSF54160. SSF54160. 1 hit.
PROSITEi PS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51579. SAM_MT43_SUVAR39_3. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiSUV92_CHICK
AccessioniPrimary (citable) accession number: Q5F3W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 15, 2005
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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