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Q5F3W5

- SUV92_CHICK

UniProt

Q5F3W5 - SUV92_CHICK

Protein

Histone-lysine N-methyltransferase SUV39H2

Gene

SUV39H2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi187 – 1871Zinc 1By similarity
    Metal bindingi187 – 1871Zinc 2By similarity
    Metal bindingi189 – 1891Zinc 1By similarity
    Metal bindingi192 – 1921Zinc 1By similarity
    Metal bindingi192 – 1921Zinc 3By similarity
    Metal bindingi197 – 1971Zinc 1By similarity
    Metal bindingi198 – 1981Zinc 1By similarity
    Metal bindingi198 – 1981Zinc 2By similarity
    Metal bindingi225 – 2251Zinc 2By similarity
    Metal bindingi225 – 2251Zinc 3By similarity
    Metal bindingi229 – 2291Zinc 2By similarity
    Metal bindingi231 – 2311Zinc 3By similarity
    Metal bindingi235 – 2351Zinc 3By similarity
    Binding sitei300 – 3001S-adenosyl-L-methioninePROSITE-ProRule annotation
    Metal bindingi329 – 3291Zinc 4By similarity
    Metal bindingi395 – 3951Zinc 4By similarity
    Metal bindingi397 – 3971Zinc 4By similarity
    Metal bindingi402 – 4021Zinc 4By similarity

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. histone methyltransferase activity (H3-K9 specific) Source: Ensembl
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. chromatin assembly or disassembly Source: Ensembl
    3. chromatin remodeling Source: Ensembl
    4. male meiosis Source: Ensembl
    5. regulation of transcription, DNA-templated Source: UniProtKB-KW
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Methyltransferase, Repressor, Transferase

    Keywords - Biological processi

    Cell cycle, Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, S-adenosyl-L-methionine, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase SUV39H2 (EC:2.1.1.43)
    Alternative name(s):
    Suppressor of variegation 3-9 homolog 2
    Short name:
    Su(var)3-9 homolog 2
    Gene namesi
    Name:SUV39H2
    ORF Names:RCJMB04_5f7
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 1

    Subcellular locationi

    Nucleus By similarity. Chromosomecentromere By similarity
    Note: Associates with centromeric constitutive heterochromatin.By similarity

    GO - Cellular componenti

    1. chromosome, centromeric region Source: UniProtKB-SubCell
    2. nuclear heterochromatin Source: Ensembl

    Keywords - Cellular componenti

    Centromere, Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 407407Histone-lysine N-methyltransferase SUV39H2PRO_0000281815Add
    BLAST

    Proteomic databases

    PaxDbiQ5F3W5.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000028525.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5F3W5.
    SMRiQ5F3W5. Positions 120-407.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 10159ChromoPROSITE-ProRule annotationAdd
    BLAST
    Domaini185 – 24359Pre-SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini246 – 369124SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini391 – 40717Post-SETPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni257 – 2593S-adenosyl-L-methionine bindingBy similarity
    Regioni326 – 3272S-adenosyl-L-methionine bindingBy similarity

    Domaini

    Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates to stable binding to heterochromatin By similarity.By similarity
    In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.By similarity

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.PROSITE-ProRule annotation
    Contains 1 chromo domain.PROSITE-ProRule annotation
    Contains 1 post-SET domain.PROSITE-ProRule annotation
    Contains 1 pre-SET domain.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2940.
    GeneTreeiENSGT00750000117355.
    HOGENOMiHOG000231244.
    HOVERGENiHBG055621.
    InParanoidiQ5F3W5.
    KOiK11419.
    OMAiAWCVPCL.
    OrthoDBiEOG7RJPR0.
    PhylomeDBiQ5F3W5.
    TreeFamiTF106452.

    Family and domain databases

    InterProiIPR023780. Chromo_domain.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR023779. Chromodomain_CS.
    IPR011381. Histone_H3-K9_MeTrfase.
    IPR003616. Post-SET_dom.
    IPR007728. Pre-SET_dom.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF00385. Chromo. 1 hit.
    PF05033. Pre-SET. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009343. SUV39_SET. 1 hit.
    SMARTiSM00298. CHROMO. 1 hit.
    SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    SUPFAMiSSF54160. SSF54160. 1 hit.
    PROSITEiPS00598. CHROMO_1. 1 hit.
    PS50013. CHROMO_2. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50867. PRE_SET. 1 hit.
    PS51579. SAM_MT43_SUVAR39_3. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5F3W5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGWRGAWYV PCLASHETLQ ELCRKENLRC KSIGITNKSL KSYEVEYLCD    50
    YKVEEGKEYY LVKWKGWPES SNTWEPQKNL KCPKLLENFL SDKDEYLSRM 100
    KEGRALKVRN SVKALKPAVA DYIVKKAKQR IALQRWKEEL NRKKNHKGMI 150
    LVENTVDLEG PPIDFYYINE YKPAPGINVI NGITTGCECS DCPAEKCCPK 200
    EAGFILAYNK QKKLKIQPGL PIYECNSFCR CGPDCPNRIV QKGTQYSLCI 250
    FRTNNGRGWG VKTLQKIKTN SFVMEYVGEV ITSEEAERRG QFYDNQGNTY 300
    LFDLDYDSDE FTVDAARYGN VSHFVNHSCD PNLQVFNVFI DNLDLRLPRI 350
    ALFSTRTIKA GEELTFDYQM KGSIDLTSDS ADGLSSSRKR IRTVCKCGAV 400
    CCRGYLN 407
    Length:407
    Mass (Da):46,659
    Last modified:March 15, 2005 - v1
    Checksum:i430C980EB03AC627
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ851535 mRNA. Translation: CAH65169.1.
    RefSeqiNP_001026541.1. NM_001031370.2.
    UniGeneiGga.13450.

    Genome annotation databases

    EnsembliENSGALT00000029187; ENSGALP00000028525; ENSGALG00000013920.
    GeneIDi426314.
    KEGGigga:426314.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ851535 mRNA. Translation: CAH65169.1 .
    RefSeqi NP_001026541.1. NM_001031370.2.
    UniGenei Gga.13450.

    3D structure databases

    ProteinModelPortali Q5F3W5.
    SMRi Q5F3W5. Positions 120-407.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000028525.

    Proteomic databases

    PaxDbi Q5F3W5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000029187 ; ENSGALP00000028525 ; ENSGALG00000013920 .
    GeneIDi 426314.
    KEGGi gga:426314.

    Organism-specific databases

    CTDi 79723.

    Phylogenomic databases

    eggNOGi COG2940.
    GeneTreei ENSGT00750000117355.
    HOGENOMi HOG000231244.
    HOVERGENi HBG055621.
    InParanoidi Q5F3W5.
    KOi K11419.
    OMAi AWCVPCL.
    OrthoDBi EOG7RJPR0.
    PhylomeDBi Q5F3W5.
    TreeFami TF106452.

    Miscellaneous databases

    NextBioi 20827954.
    PROi Q5F3W5.

    Family and domain databases

    InterProi IPR023780. Chromo_domain.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR023779. Chromodomain_CS.
    IPR011381. Histone_H3-K9_MeTrfase.
    IPR003616. Post-SET_dom.
    IPR007728. Pre-SET_dom.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF00385. Chromo. 1 hit.
    PF05033. Pre-SET. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009343. SUV39_SET. 1 hit.
    SMARTi SM00298. CHROMO. 1 hit.
    SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54160. SSF54160. 1 hit.
    PROSITEi PS00598. CHROMO_1. 1 hit.
    PS50013. CHROMO_2. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50867. PRE_SET. 1 hit.
    PS51579. SAM_MT43_SUVAR39_3. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: CB.
      Tissue: Bursa of Fabricius.

    Entry informationi

    Entry nameiSUV92_CHICK
    AccessioniPrimary (citable) accession number: Q5F3W5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3