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Q5F3W5 (SUV92_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase SUV39H2

EC=2.1.1.43
Alternative name(s):
Suppressor of variegation 3-9 homolog 2
Short name=Su(var)3-9 homolog 2
Gene names
Name:SUV39H2
ORF Names:RCJMB04_5f7
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes By similarity.

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subcellular location

Nucleus By similarity. Chromosomecentromere By similarity. Note: Associates with centromeric constitutive heterochromatin By similarity.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.

Contains 1 chromo domain.

Contains 1 post-SET domain.

Contains 1 pre-SET domain.

Contains 1 SET domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 407407Histone-lysine N-methyltransferase SUV39H2
PRO_0000281815

Regions

Domain43 – 10159Chromo
Domain185 – 24359Pre-SET
Domain246 – 369124SET
Domain391 – 40717Post-SET

Sequences

Sequence LengthMass (Da)Tools
Q5F3W5 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 430C980EB03AC627

FASTA40746,659
        10         20         30         40         50         60 
MEGWRGAWYV PCLASHETLQ ELCRKENLRC KSIGITNKSL KSYEVEYLCD YKVEEGKEYY 

        70         80         90        100        110        120 
LVKWKGWPES SNTWEPQKNL KCPKLLENFL SDKDEYLSRM KEGRALKVRN SVKALKPAVA 

       130        140        150        160        170        180 
DYIVKKAKQR IALQRWKEEL NRKKNHKGMI LVENTVDLEG PPIDFYYINE YKPAPGINVI 

       190        200        210        220        230        240 
NGITTGCECS DCPAEKCCPK EAGFILAYNK QKKLKIQPGL PIYECNSFCR CGPDCPNRIV 

       250        260        270        280        290        300 
QKGTQYSLCI FRTNNGRGWG VKTLQKIKTN SFVMEYVGEV ITSEEAERRG QFYDNQGNTY 

       310        320        330        340        350        360 
LFDLDYDSDE FTVDAARYGN VSHFVNHSCD PNLQVFNVFI DNLDLRLPRI ALFSTRTIKA 

       370        380        390        400 
GEELTFDYQM KGSIDLTSDS ADGLSSSRKR IRTVCKCGAV CCRGYLN 

« Hide

References

[1]"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.
Genome Biol. 6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CB.
Tissue: Bursa of Fabricius.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ851535 mRNA. Translation: CAH65169.1.
RefSeqNP_001026541.1. NM_001031370.2.
UniGeneGga.13450.

3D structure databases

ProteinModelPortalQ5F3W5.
SMRQ5F3W5. Positions 120-407.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000028525.

Proteomic databases

PaxDbQ5F3W5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000029187; ENSGALP00000028525; ENSGALG00000013920.
GeneID426314.
KEGGgga:426314.

Organism-specific databases

CTD79723.

Phylogenomic databases

eggNOGCOG2940.
GeneTreeENSGT00750000117355.
HOGENOMHOG000231244.
HOVERGENHBG055621.
InParanoidQ5F3W5.
KOK11419.
OMAPGISLVN.
OrthoDBEOG7RJPR0.
PhylomeDBQ5F3W5.
TreeFamTF106452.

Family and domain databases

InterProIPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR011381. Histone_H3-K9_MeTrfase.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamPF00385. Chromo. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
PIRSFPIRSF009343. SUV39_SET. 1 hit.
SMARTSM00298. CHROMO. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMSSF54160. SSF54160. 1 hit.
PROSITEPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51579. SAM_MT43_SUVAR39_3. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20827954.
PROQ5F3W5.

Entry information

Entry nameSUV92_CHICK
AccessionPrimary (citable) accession number: Q5F3W5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 15, 2005
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families