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Protein

Histone-lysine N-methyltransferase SUV39H2

Gene

SUV39H2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi187 – 1871Zinc 1By similarity
Metal bindingi187 – 1871Zinc 2By similarity
Metal bindingi189 – 1891Zinc 1By similarity
Metal bindingi192 – 1921Zinc 1By similarity
Metal bindingi192 – 1921Zinc 3By similarity
Metal bindingi197 – 1971Zinc 1By similarity
Metal bindingi198 – 1981Zinc 1By similarity
Metal bindingi198 – 1981Zinc 2By similarity
Metal bindingi225 – 2251Zinc 2By similarity
Metal bindingi225 – 2251Zinc 3By similarity
Metal bindingi229 – 2291Zinc 2By similarity
Metal bindingi231 – 2311Zinc 3By similarity
Metal bindingi235 – 2351Zinc 3By similarity
Binding sitei300 – 3001S-adenosyl-L-methioninePROSITE-ProRule annotation
Metal bindingi329 – 3291Zinc 4By similarity
Metal bindingi395 – 3951Zinc 4By similarity
Metal bindingi397 – 3971Zinc 4By similarity
Metal bindingi402 – 4021Zinc 4By similarity

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. histone methyltransferase activity (H3-K9 specific) Source: Ensembl
  3. transcription regulatory region sequence-specific DNA binding Source: Ensembl
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. chromatin assembly or disassembly Source: Ensembl
  3. chromatin remodeling Source: Ensembl
  4. histone H3-K9 dimethylation Source: Ensembl
  5. histone H3-K9 trimethylation Source: Ensembl
  6. male meiosis Source: Ensembl
  7. negative regulation of circadian rhythm Source: Ensembl
  8. negative regulation of transcription, DNA-templated Source: Ensembl
  9. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Cell cycle, Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SUV39H2 (EC:2.1.1.43)
Alternative name(s):
Suppressor of variegation 3-9 homolog 2
Short name:
Su(var)3-9 homolog 2
Gene namesi
Name:SUV39H2
ORF Names:RCJMB04_5f7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 1

Subcellular locationi

Nucleus By similarity. Chromosomecentromere By similarity
Note: Associates with centromeric constitutive heterochromatin.By similarity

GO - Cellular componenti

  1. chromosome, centromeric region Source: UniProtKB-SubCell
  2. nuclear heterochromatin Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Histone-lysine N-methyltransferase SUV39H2PRO_0000281815Add
BLAST

Proteomic databases

PaxDbiQ5F3W5.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000028525.

Structurei

3D structure databases

ProteinModelPortaliQ5F3W5.
SMRiQ5F3W5. Positions 120-407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 10159ChromoPROSITE-ProRule annotationAdd
BLAST
Domaini185 – 24359Pre-SETPROSITE-ProRule annotationAdd
BLAST
Domaini246 – 369124SETPROSITE-ProRule annotationAdd
BLAST
Domaini391 – 40717Post-SETPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni257 – 2593S-adenosyl-L-methionine bindingBy similarity
Regioni326 – 3272S-adenosyl-L-methionine bindingBy similarity

Domaini

Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates to stable binding to heterochromatin (By similarity).By similarity
In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.By similarity

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.PROSITE-ProRule annotation
Contains 1 chromo domain.PROSITE-ProRule annotation
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 pre-SET domain.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2940.
GeneTreeiENSGT00780000121845.
HOGENOMiHOG000231244.
HOVERGENiHBG055621.
InParanoidiQ5F3W5.
KOiK11419.
OMAiAWCVPCL.
OrthoDBiEOG7RJPR0.
PhylomeDBiQ5F3W5.
TreeFamiTF106452.

Family and domain databases

InterProiIPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR011381. Histone_H3-K9_MeTrfase.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF009343. SUV39_SET. 1 hit.
SMARTiSM00298. CHROMO. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51579. SAM_MT43_SUVAR39_3. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5F3W5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGWRGAWYV PCLASHETLQ ELCRKENLRC KSIGITNKSL KSYEVEYLCD
60 70 80 90 100
YKVEEGKEYY LVKWKGWPES SNTWEPQKNL KCPKLLENFL SDKDEYLSRM
110 120 130 140 150
KEGRALKVRN SVKALKPAVA DYIVKKAKQR IALQRWKEEL NRKKNHKGMI
160 170 180 190 200
LVENTVDLEG PPIDFYYINE YKPAPGINVI NGITTGCECS DCPAEKCCPK
210 220 230 240 250
EAGFILAYNK QKKLKIQPGL PIYECNSFCR CGPDCPNRIV QKGTQYSLCI
260 270 280 290 300
FRTNNGRGWG VKTLQKIKTN SFVMEYVGEV ITSEEAERRG QFYDNQGNTY
310 320 330 340 350
LFDLDYDSDE FTVDAARYGN VSHFVNHSCD PNLQVFNVFI DNLDLRLPRI
360 370 380 390 400
ALFSTRTIKA GEELTFDYQM KGSIDLTSDS ADGLSSSRKR IRTVCKCGAV

CCRGYLN
Length:407
Mass (Da):46,659
Last modified:March 15, 2005 - v1
Checksum:i430C980EB03AC627
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851535 mRNA. Translation: CAH65169.1.
RefSeqiNP_001026541.1. NM_001031370.2.
UniGeneiGga.13450.

Genome annotation databases

EnsembliENSGALT00000029187; ENSGALP00000028525; ENSGALG00000013920.
GeneIDi426314.
KEGGigga:426314.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851535 mRNA. Translation: CAH65169.1.
RefSeqiNP_001026541.1. NM_001031370.2.
UniGeneiGga.13450.

3D structure databases

ProteinModelPortaliQ5F3W5.
SMRiQ5F3W5. Positions 120-407.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000028525.

Proteomic databases

PaxDbiQ5F3W5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000029187; ENSGALP00000028525; ENSGALG00000013920.
GeneIDi426314.
KEGGigga:426314.

Organism-specific databases

CTDi79723.

Phylogenomic databases

eggNOGiCOG2940.
GeneTreeiENSGT00780000121845.
HOGENOMiHOG000231244.
HOVERGENiHBG055621.
InParanoidiQ5F3W5.
KOiK11419.
OMAiAWCVPCL.
OrthoDBiEOG7RJPR0.
PhylomeDBiQ5F3W5.
TreeFamiTF106452.

Miscellaneous databases

NextBioi20827954.
PROiQ5F3W5.

Family and domain databases

InterProiIPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR011381. Histone_H3-K9_MeTrfase.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF009343. SUV39_SET. 1 hit.
SMARTiSM00298. CHROMO. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51579. SAM_MT43_SUVAR39_3. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiSUV92_CHICK
AccessioniPrimary (citable) accession number: Q5F3W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 15, 2005
Last modified: February 4, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.