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Protein

Histone-lysine N-methyltransferase SUV39H2

Gene

SUV39H2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi187Zinc 1By similarity1
Metal bindingi187Zinc 2By similarity1
Metal bindingi189Zinc 1By similarity1
Metal bindingi192Zinc 1By similarity1
Metal bindingi192Zinc 3By similarity1
Metal bindingi197Zinc 1By similarity1
Metal bindingi198Zinc 1By similarity1
Metal bindingi198Zinc 2By similarity1
Metal bindingi225Zinc 2By similarity1
Metal bindingi225Zinc 3By similarity1
Metal bindingi229Zinc 2By similarity1
Metal bindingi231Zinc 3By similarity1
Metal bindingi235Zinc 3By similarity1
Binding sitei300S-adenosyl-L-methioninePROSITE-ProRule annotation1
Metal bindingi329Zinc 4By similarity1
Metal bindingi395Zinc 4By similarity1
Metal bindingi397Zinc 4By similarity1
Metal bindingi402Zinc 4By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Repressor, Transferase

Keywords - Biological processi

Cell cycle, Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SUV39H2 (EC:2.1.1.43)
Alternative name(s):
Suppressor of variegation 3-9 homolog 2
Short name:
Su(var)3-9 homolog 2
Gene namesi
Name:SUV39H2
ORF Names:RCJMB04_5f7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

  • Nucleus By similarity
  • Chromosomecentromere By similarity

  • Note: Associates with centromeric constitutive heterochromatin.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002818151 – 407Histone-lysine N-methyltransferase SUV39H2Add BLAST407

Proteomic databases

PaxDbiQ5F3W5.

Expressioni

Gene expression databases

BgeeiENSGALG00000013920.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000028525.

Structurei

3D structure databases

ProteinModelPortaliQ5F3W5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 101ChromoPROSITE-ProRule annotationAdd BLAST59
Domaini185 – 243Pre-SETPROSITE-ProRule annotationAdd BLAST59
Domaini246 – 369SETPROSITE-ProRule annotationAdd BLAST124
Domaini391 – 407Post-SETPROSITE-ProRule annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni257 – 259S-adenosyl-L-methionine bindingBy similarity3
Regioni326 – 327S-adenosyl-L-methionine bindingBy similarity2

Domaini

Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates in stable binding to heterochromatin (By similarity).By similarity
In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.By similarity

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.PROSITE-ProRule annotation
Contains 1 chromo domain.PROSITE-ProRule annotation
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 pre-SET domain.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1082. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00780000121845.
HOGENOMiHOG000231244.
HOVERGENiHBG055621.
InParanoidiQ5F3W5.
KOiK11419.
OMAiAWCVPCL.
OrthoDBiEOG091G0Y4N.
PhylomeDBiQ5F3W5.
TreeFamiTF106452.

Family and domain databases

InterProiIPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR011381. Histone_H3-K9_MeTrfase.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF009343. SUV39_SET. 1 hit.
SMARTiSM00298. CHROMO. 1 hit.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51579. SAM_MT43_SUVAR39_3. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5F3W5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGWRGAWYV PCLASHETLQ ELCRKENLRC KSIGITNKSL KSYEVEYLCD
60 70 80 90 100
YKVEEGKEYY LVKWKGWPES SNTWEPQKNL KCPKLLENFL SDKDEYLSRM
110 120 130 140 150
KEGRALKVRN SVKALKPAVA DYIVKKAKQR IALQRWKEEL NRKKNHKGMI
160 170 180 190 200
LVENTVDLEG PPIDFYYINE YKPAPGINVI NGITTGCECS DCPAEKCCPK
210 220 230 240 250
EAGFILAYNK QKKLKIQPGL PIYECNSFCR CGPDCPNRIV QKGTQYSLCI
260 270 280 290 300
FRTNNGRGWG VKTLQKIKTN SFVMEYVGEV ITSEEAERRG QFYDNQGNTY
310 320 330 340 350
LFDLDYDSDE FTVDAARYGN VSHFVNHSCD PNLQVFNVFI DNLDLRLPRI
360 370 380 390 400
ALFSTRTIKA GEELTFDYQM KGSIDLTSDS ADGLSSSRKR IRTVCKCGAV

CCRGYLN
Length:407
Mass (Da):46,659
Last modified:March 15, 2005 - v1
Checksum:i430C980EB03AC627
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851535 mRNA. Translation: CAH65169.1.
RefSeqiNP_001026541.1. NM_001031370.2.
UniGeneiGga.13450.

Genome annotation databases

EnsembliENSGALT00000029187; ENSGALP00000028525; ENSGALG00000013920.
GeneIDi426314.
KEGGigga:426314.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851535 mRNA. Translation: CAH65169.1.
RefSeqiNP_001026541.1. NM_001031370.2.
UniGeneiGga.13450.

3D structure databases

ProteinModelPortaliQ5F3W5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000028525.

Proteomic databases

PaxDbiQ5F3W5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000029187; ENSGALP00000028525; ENSGALG00000013920.
GeneIDi426314.
KEGGigga:426314.

Organism-specific databases

CTDi79723.

Phylogenomic databases

eggNOGiKOG1082. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00780000121845.
HOGENOMiHOG000231244.
HOVERGENiHBG055621.
InParanoidiQ5F3W5.
KOiK11419.
OMAiAWCVPCL.
OrthoDBiEOG091G0Y4N.
PhylomeDBiQ5F3W5.
TreeFamiTF106452.

Miscellaneous databases

PROiQ5F3W5.

Gene expression databases

BgeeiENSGALG00000013920.

Family and domain databases

InterProiIPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR011381. Histone_H3-K9_MeTrfase.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF009343. SUV39_SET. 1 hit.
SMARTiSM00298. CHROMO. 1 hit.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51579. SAM_MT43_SUVAR39_3. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUV92_CHICK
AccessioniPrimary (citable) accession number: Q5F3W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 15, 2005
Last modified: November 30, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.