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Q5F3W3 (MK06_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase 6

Short name=MAP kinase 6
Short name=MAPK 6
EC=2.7.11.24
Gene names
Name:MAPK6
ORF Names:RCJMB04_5i17
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length721 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Enzyme regulation

Activated by threonine and tyrosine phosphorylation By similarity.

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-626 and Tyr-628, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Biological processCell cycle
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

MAP kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 721721Mitogen-activated protein kinase 6
PRO_0000249010

Regions

Domain20 – 316297Protein kinase
Nucleotide binding26 – 349ATP By similarity
Motif626 – 6283TXY

Sites

Active site1521Proton acceptor By similarity
Binding site491ATP By similarity

Amino acid modifications

Modified residue6261Phosphothreonine By similarity
Modified residue6281Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5F3W3 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: CC605A2282F16E43

FASTA72182,747
        10         20         30         40         50         60 
MAEKFESLMN IHGFDLGSRY MDLKPLGCGG NGLVFSAVDN DCDKRVAVKK IVLTDPQSVK 

        70         80         90        100        110        120 
HALREIKIIR RLDHDNIVKV FEILGPSGSQ LTDDVGSLTE LNCVYIVQEY METDLANLLE 

       130        140        150        160        170        180 
QGPLLEDHAR LFMYQLLRGL KYIHSANVLH RDLKPANLFI NTEDLVLKIG DFGLARIMDP 

       190        200        210        220        230        240 
HYSHKGHLSE GLVTKWYRSP RLLLSPNNYT KAIDMWAAGC IFAEMLTGKT LFAGAHELEQ 

       250        260        270        280        290        300 
MQLILESIPV VHEEDRQELL NVIPVYIRND MTEPHKPLTQ LLPGISPEAL DFLEQILTFS 

       310        320        330        340        350        360 
PMDRLTAEEA LSHPYMSIYS FPTDEPISSH PFHIEDEVDD ILLMDESHSH IYNWERYHES 

       370        380        390        400        410        420 
QFSDHDWPIH NNYEADEVQR DPRALSDVTD EEEVQVDPRK YLDGDREKYL EDPAFDTHFS 

       430        440        450        460        470        480 
TEPCWQYSDH HENKYCDLEC SHTCNYKMRS SSYLDNLVWR DSEVNHYYEP KLIIDLSNWK 

       490        500        510        520        530        540 
EQSKEKSDKK GKSKCEKNGL VKAQIALEEA SQQLVEKERE KNQGFDFDSF IAETIQLSLQ 

       550        560        570        580        590        600 
HEPTDVDKLN DLNSSVSQME SKGLISKSVS REKQEKGMAN LAQLGALYQT SWESQFVSNG 

       610        620        630        640        650        660 
EECFLIDQFC CEVRKDEQVE KENTYTSYLD KFFSKKEDAE MLEPEPVEEG KLGEKERGES 

       670        680        690        700        710        720 
FLSNSGELFF NKQLEAIGIP QFHSPVGSPL KSIQATLTPS AMKSSPQIPH KTYSSILKHL 


N 

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References

[1]"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.
Genome Biol. 6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CB.
Tissue: Bursa of Fabricius.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ851537 mRNA. Translation: CAH65171.1.
RefSeqNP_001025720.1. NM_001030549.1.
UniGeneGga.3411.

3D structure databases

ProteinModelPortalQ5F3W3.
SMRQ5F3W3. Positions 13-321.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000007460.

Proteomic databases

PaxDbQ5F3W3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000007472; ENSGALP00000007460; ENSGALG00000004690.
GeneID415419.
KEGGgga:415419.

Organism-specific databases

CTD5597.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00550000074298.
HOGENOMHOG000233020.
HOVERGENHBG104376.
InParanoidQ5F3W3.
KOK06855.
OMAKYLACIE.
OrthoDBEOG780RKS.
PhylomeDBQ5F3W3.
TreeFamTF105098.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR008350. MAPK_ERK3/4.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSPR01771. ERK3ERK4MAPK.
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20819031.
PROQ5F3W3.

Entry information

Entry nameMK06_CHICK
AccessionPrimary (citable) accession number: Q5F3W3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 15, 2005
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families