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Q5F3W3

- MK06_CHICK

UniProt

Q5F3W3 - MK06_CHICK

Protein

Mitogen-activated protein kinase 6

Gene

MAPK6

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Activated by threonine and tyrosine phosphorylation.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei49 – 491ATPPROSITE-ProRule annotation
    Active sitei152 – 1521Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi26 – 349ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. MAP kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Cell cycle

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitogen-activated protein kinase 6 (EC:2.7.11.24)
    Short name:
    MAP kinase 6
    Short name:
    MAPK 6
    Gene namesi
    Name:MAPK6
    ORF Names:RCJMB04_5i17
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 10

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 721721Mitogen-activated protein kinase 6PRO_0000249010Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei626 – 6261PhosphothreonineBy similarity
    Modified residuei628 – 6281PhosphotyrosineBy similarity

    Post-translational modificationi

    Dually phosphorylated on Thr-626 and Tyr-628, which activates the enzyme.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ5F3W3.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000007460.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5F3W3.
    SMRiQ5F3W3. Positions 13-321.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 316297Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi626 – 6283TXY

    Domaini

    The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00550000074298.
    HOGENOMiHOG000233020.
    HOVERGENiHBG104376.
    InParanoidiQ5F3W3.
    KOiK06855.
    OMAiKYLACIE.
    OrthoDBiEOG780RKS.
    PhylomeDBiQ5F3W3.
    TreeFamiTF105098.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR008350. MAPK_ERK3/4.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    PRINTSiPR01771. ERK3ERK4MAPK.
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5F3W3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEKFESLMN IHGFDLGSRY MDLKPLGCGG NGLVFSAVDN DCDKRVAVKK    50
    IVLTDPQSVK HALREIKIIR RLDHDNIVKV FEILGPSGSQ LTDDVGSLTE 100
    LNCVYIVQEY METDLANLLE QGPLLEDHAR LFMYQLLRGL KYIHSANVLH 150
    RDLKPANLFI NTEDLVLKIG DFGLARIMDP HYSHKGHLSE GLVTKWYRSP 200
    RLLLSPNNYT KAIDMWAAGC IFAEMLTGKT LFAGAHELEQ MQLILESIPV 250
    VHEEDRQELL NVIPVYIRND MTEPHKPLTQ LLPGISPEAL DFLEQILTFS 300
    PMDRLTAEEA LSHPYMSIYS FPTDEPISSH PFHIEDEVDD ILLMDESHSH 350
    IYNWERYHES QFSDHDWPIH NNYEADEVQR DPRALSDVTD EEEVQVDPRK 400
    YLDGDREKYL EDPAFDTHFS TEPCWQYSDH HENKYCDLEC SHTCNYKMRS 450
    SSYLDNLVWR DSEVNHYYEP KLIIDLSNWK EQSKEKSDKK GKSKCEKNGL 500
    VKAQIALEEA SQQLVEKERE KNQGFDFDSF IAETIQLSLQ HEPTDVDKLN 550
    DLNSSVSQME SKGLISKSVS REKQEKGMAN LAQLGALYQT SWESQFVSNG 600
    EECFLIDQFC CEVRKDEQVE KENTYTSYLD KFFSKKEDAE MLEPEPVEEG 650
    KLGEKERGES FLSNSGELFF NKQLEAIGIP QFHSPVGSPL KSIQATLTPS 700
    AMKSSPQIPH KTYSSILKHL N 721
    Length:721
    Mass (Da):82,747
    Last modified:March 15, 2005 - v1
    Checksum:iCC605A2282F16E43
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ851537 mRNA. Translation: CAH65171.1.
    RefSeqiNP_001025720.1. NM_001030549.1.
    UniGeneiGga.3411.

    Genome annotation databases

    EnsembliENSGALT00000007472; ENSGALP00000007460; ENSGALG00000004690.
    GeneIDi415419.
    KEGGigga:415419.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ851537 mRNA. Translation: CAH65171.1 .
    RefSeqi NP_001025720.1. NM_001030549.1.
    UniGenei Gga.3411.

    3D structure databases

    ProteinModelPortali Q5F3W3.
    SMRi Q5F3W3. Positions 13-321.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000007460.

    Proteomic databases

    PaxDbi Q5F3W3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000007472 ; ENSGALP00000007460 ; ENSGALG00000004690 .
    GeneIDi 415419.
    KEGGi gga:415419.

    Organism-specific databases

    CTDi 5597.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00550000074298.
    HOGENOMi HOG000233020.
    HOVERGENi HBG104376.
    InParanoidi Q5F3W3.
    KOi K06855.
    OMAi KYLACIE.
    OrthoDBi EOG780RKS.
    PhylomeDBi Q5F3W3.
    TreeFami TF105098.

    Miscellaneous databases

    NextBioi 20819031.
    PROi Q5F3W3.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR008350. MAPK_ERK3/4.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PRINTSi PR01771. ERK3ERK4MAPK.
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: CB.
      Tissue: Bursa of Fabricius.

    Entry informationi

    Entry nameiMK06_CHICK
    AccessioniPrimary (citable) accession number: Q5F3W3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3