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Q5F3W3

- MK06_CHICK

UniProt

Q5F3W3 - MK06_CHICK

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Protein

Mitogen-activated protein kinase 6

Gene
MAPK6, RCJMB04_5i17
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium By similarity.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491ATP By similarity
Active sitei152 – 1521Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 349ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 6 (EC:2.7.11.24)
Short name:
MAP kinase 6
Short name:
MAPK 6
Gene namesi
Name:MAPK6
ORF Names:RCJMB04_5i17
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 10

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 721721Mitogen-activated protein kinase 6PRO_0000249010Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei626 – 6261Phosphothreonine By similarity
Modified residuei628 – 6281Phosphotyrosine By similarity

Post-translational modificationi

Dually phosphorylated on Thr-626 and Tyr-628, which activates the enzyme By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5F3W3.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000007460.

Structurei

3D structure databases

ProteinModelPortaliQ5F3W3.
SMRiQ5F3W3. Positions 13-321.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 316297Protein kinaseAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi626 – 6283TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00550000074298.
HOGENOMiHOG000233020.
HOVERGENiHBG104376.
InParanoidiQ5F3W3.
KOiK06855.
OMAiKYLACIE.
OrthoDBiEOG780RKS.
PhylomeDBiQ5F3W3.
TreeFamiTF105098.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR008350. MAPK_ERK3/4.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01771. ERK3ERK4MAPK.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5F3W3-1 [UniParc]FASTAAdd to Basket

« Hide

MAEKFESLMN IHGFDLGSRY MDLKPLGCGG NGLVFSAVDN DCDKRVAVKK    50
IVLTDPQSVK HALREIKIIR RLDHDNIVKV FEILGPSGSQ LTDDVGSLTE 100
LNCVYIVQEY METDLANLLE QGPLLEDHAR LFMYQLLRGL KYIHSANVLH 150
RDLKPANLFI NTEDLVLKIG DFGLARIMDP HYSHKGHLSE GLVTKWYRSP 200
RLLLSPNNYT KAIDMWAAGC IFAEMLTGKT LFAGAHELEQ MQLILESIPV 250
VHEEDRQELL NVIPVYIRND MTEPHKPLTQ LLPGISPEAL DFLEQILTFS 300
PMDRLTAEEA LSHPYMSIYS FPTDEPISSH PFHIEDEVDD ILLMDESHSH 350
IYNWERYHES QFSDHDWPIH NNYEADEVQR DPRALSDVTD EEEVQVDPRK 400
YLDGDREKYL EDPAFDTHFS TEPCWQYSDH HENKYCDLEC SHTCNYKMRS 450
SSYLDNLVWR DSEVNHYYEP KLIIDLSNWK EQSKEKSDKK GKSKCEKNGL 500
VKAQIALEEA SQQLVEKERE KNQGFDFDSF IAETIQLSLQ HEPTDVDKLN 550
DLNSSVSQME SKGLISKSVS REKQEKGMAN LAQLGALYQT SWESQFVSNG 600
EECFLIDQFC CEVRKDEQVE KENTYTSYLD KFFSKKEDAE MLEPEPVEEG 650
KLGEKERGES FLSNSGELFF NKQLEAIGIP QFHSPVGSPL KSIQATLTPS 700
AMKSSPQIPH KTYSSILKHL N 721
Length:721
Mass (Da):82,747
Last modified:March 15, 2005 - v1
Checksum:iCC605A2282F16E43
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ851537 mRNA. Translation: CAH65171.1.
RefSeqiNP_001025720.1. NM_001030549.1.
UniGeneiGga.3411.

Genome annotation databases

EnsembliENSGALT00000007472; ENSGALP00000007460; ENSGALG00000004690.
GeneIDi415419.
KEGGigga:415419.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ851537 mRNA. Translation: CAH65171.1 .
RefSeqi NP_001025720.1. NM_001030549.1.
UniGenei Gga.3411.

3D structure databases

ProteinModelPortali Q5F3W3.
SMRi Q5F3W3. Positions 13-321.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000007460.

Proteomic databases

PaxDbi Q5F3W3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000007472 ; ENSGALP00000007460 ; ENSGALG00000004690 .
GeneIDi 415419.
KEGGi gga:415419.

Organism-specific databases

CTDi 5597.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00550000074298.
HOGENOMi HOG000233020.
HOVERGENi HBG104376.
InParanoidi Q5F3W3.
KOi K06855.
OMAi KYLACIE.
OrthoDBi EOG780RKS.
PhylomeDBi Q5F3W3.
TreeFami TF105098.

Miscellaneous databases

NextBioi 20819031.
PROi Q5F3W3.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR008350. MAPK_ERK3/4.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
PRINTSi PR01771. ERK3ERK4MAPK.
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiMK06_CHICK
AccessioniPrimary (citable) accession number: Q5F3W3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 15, 2005
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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