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Protein

Mitogen-activated protein kinase 6

Gene

MAPK6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei49ATPPROSITE-ProRule annotation1
Active sitei152Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 34ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-5687128 MAPK6/MAPK4 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 6 (EC:2.7.11.24)
Short name:
MAP kinase 6
Short name:
MAPK 6
Gene namesi
Name:MAPK6
ORF Names:RCJMB04_5i17
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002490101 – 721Mitogen-activated protein kinase 6Add BLAST721

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei626PhosphothreonineBy similarity1
Modified residuei628PhosphotyrosineBy similarity1

Post-translational modificationi

Dually phosphorylated on Thr-626 and Tyr-628, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5F3W3
PRIDEiQ5F3W3

Expressioni

Gene expression databases

BgeeiENSGALG00000004690

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000007460

Structurei

3D structure databases

ProteinModelPortaliQ5F3W3
SMRiQ5F3W3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 316Protein kinasePROSITE-ProRule annotationAdd BLAST297

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi626 – 628TXY3

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0660 Eukaryota
ENOG410XNY0 LUCA
GeneTreeiENSGT00910000144035
HOGENOMiHOG000233020
HOVERGENiHBG104376
InParanoidiQ5F3W3
KOiK06855
OMAiSEHDWPI
OrthoDBiEOG091G03RQ
PhylomeDBiQ5F3W3
TreeFamiTF105098

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR008350 MAPK_ERK3/4
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PRINTSiPR01771 ERK3ERK4MAPK
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q5F3W3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKFESLMN IHGFDLGSRY MDLKPLGCGG NGLVFSAVDN DCDKRVAVKK
60 70 80 90 100
IVLTDPQSVK HALREIKIIR RLDHDNIVKV FEILGPSGSQ LTDDVGSLTE
110 120 130 140 150
LNCVYIVQEY METDLANLLE QGPLLEDHAR LFMYQLLRGL KYIHSANVLH
160 170 180 190 200
RDLKPANLFI NTEDLVLKIG DFGLARIMDP HYSHKGHLSE GLVTKWYRSP
210 220 230 240 250
RLLLSPNNYT KAIDMWAAGC IFAEMLTGKT LFAGAHELEQ MQLILESIPV
260 270 280 290 300
VHEEDRQELL NVIPVYIRND MTEPHKPLTQ LLPGISPEAL DFLEQILTFS
310 320 330 340 350
PMDRLTAEEA LSHPYMSIYS FPTDEPISSH PFHIEDEVDD ILLMDESHSH
360 370 380 390 400
IYNWERYHES QFSDHDWPIH NNYEADEVQR DPRALSDVTD EEEVQVDPRK
410 420 430 440 450
YLDGDREKYL EDPAFDTHFS TEPCWQYSDH HENKYCDLEC SHTCNYKMRS
460 470 480 490 500
SSYLDNLVWR DSEVNHYYEP KLIIDLSNWK EQSKEKSDKK GKSKCEKNGL
510 520 530 540 550
VKAQIALEEA SQQLVEKERE KNQGFDFDSF IAETIQLSLQ HEPTDVDKLN
560 570 580 590 600
DLNSSVSQME SKGLISKSVS REKQEKGMAN LAQLGALYQT SWESQFVSNG
610 620 630 640 650
EECFLIDQFC CEVRKDEQVE KENTYTSYLD KFFSKKEDAE MLEPEPVEEG
660 670 680 690 700
KLGEKERGES FLSNSGELFF NKQLEAIGIP QFHSPVGSPL KSIQATLTPS
710 720
AMKSSPQIPH KTYSSILKHL N
Length:721
Mass (Da):82,747
Last modified:March 15, 2005 - v1
Checksum:iCC605A2282F16E43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851537 mRNA Translation: CAH65171.1
RefSeqiNP_001025720.1, NM_001030549.1
XP_015147391.1, XM_015291905.1
XP_015147392.1, XM_015291906.1
XP_015147393.1, XM_015291907.1
XP_015147394.1, XM_015291908.1
XP_015147395.1, XM_015291909.1
XP_015147396.1, XM_015291910.1
XP_015147397.1, XM_015291911.1
XP_015147399.1, XM_015291913.1
UniGeneiGga.3411

Genome annotation databases

EnsembliENSGALT00000061654; ENSGALP00000057521; ENSGALG00000031448
GeneIDi415419
KEGGigga:415419

Similar proteinsi

Entry informationi

Entry nameiMK06_CHICK
AccessioniPrimary (citable) accession number: Q5F3W3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 15, 2005
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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