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Q5F3T9

- UGDH_CHICK

UniProt

Q5F3T9 - UGDH_CHICK

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Protein
UDP-glucose 6-dehydrogenase
Gene
UGDH, RCJMB04_7d7
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate By similarity.

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361NAD By similarity
Binding sitei41 – 411NAD By similarity
Binding sitei165 – 1651NAD By similarity
Active sitei276 – 2761Nucleophile By similarity
Binding sitei346 – 3461NAD By similarity
Binding sitei442 – 4421Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NAD By similarity
Nucleotide bindingi89 – 935NAD By similarity
Nucleotide bindingi130 – 1312NAD By similarity
Nucleotide bindingi276 – 2794NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. UDP-glucose 6-dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. UDP-glucuronate biosynthetic process Source: UniProtKB-UniPathway
  2. gastrulation with mouth forming second Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00038; UER00491.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase
Short name:
UDP-GlcDH
Short name:
UDPGDH
Gene namesi
Name:UGDH
ORF Names:RCJMB04_7d7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 4

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494UDP-glucose 6-dehydrogenase
PRO_0000317478Add
BLAST

Proteomic databases

PaxDbiQ5F3T9.
PRIDEiQ5F3T9.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023101.

Structurei

3D structure databases

ProteinModelPortaliQ5F3T9.
SMRiQ5F3T9. Positions 1-466.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni161 – 1655Substrate binding By similarity
Regioni220 – 2278Substrate binding By similarity
Regioni260 – 27314Substrate binding By similarity
Add
BLAST
Regioni338 – 3392Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1004.
GeneTreeiENSGT00390000015355.
HOGENOMiHOG000153773.
HOVERGENiHBG003512.
InParanoidiQ5F3T9.
KOiK00012.
PhylomeDBiQ5F3T9.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028356. UDPglc_DH_euk.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PTHR11374:SF3. PTHR11374:SF3. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500133. UDPglc_DH_euk. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5F3T9-1 [UniParc]FASTAAdd to Basket

« Hide

MFEIKKICCI GAGYVGGPTC SVIAQMCPKI QVTVVDVNEA RINAWNSDTL    50
PIYEPGLKEV VESCRGRNLF FSTSIDDAIR EADLVFISVN TPTKTYGMGK 100
GRAADLKYIE ACARRIVQNS NGYKIVTEKS TVPVRAAESI RRIFDANTKP 150
NLDLQVLSNP EFLAEGTAIK DLKNPDRVLI GGDDSPEGQK AVRALCAVYE 200
HWVPKEKILT TNTWSSELSK LAANAFLAQR ISSINSISAL CEATGADVEE 250
VARAIGTDQR IGNKFLKASV GFGGSCFQKD VLNLVYLCEA LNLPEVARYW 300
QQVIDMNDYQ RRRFASRIID SLFNTVTDKK IAILGFAFKK DTGDTRESSS 350
IYISKYLMDE GAKLHIYDPK VPKEQIILDL SHPGVSEDNQ VSRLVTISQD 400
PYEACDGAHA LVICTEWDMF KELDYERIHK KMLKPAFIFD GRRVLDDLHN 450
ELQVIGFQIE TIGKKVSAKR IPFASSCEIP KFSLQDPPVK KPRV 494
Length:494
Mass (Da):55,064
Last modified:March 15, 2005 - v1
Checksum:iB5D9F2590D366122
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ851561 mRNA. Translation: CAH65195.1.
RefSeqiNP_001012599.1. NM_001012581.1.
UniGeneiGga.48631.
Gga.8846.

Genome annotation databases

EnsembliENSGALT00000023144; ENSGALP00000023101; ENSGALG00000014320.
GeneIDi422792.
KEGGigga:422792.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ851561 mRNA. Translation: CAH65195.1 .
RefSeqi NP_001012599.1. NM_001012581.1.
UniGenei Gga.48631.
Gga.8846.

3D structure databases

ProteinModelPortali Q5F3T9.
SMRi Q5F3T9. Positions 1-466.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000023101.

Proteomic databases

PaxDbi Q5F3T9.
PRIDEi Q5F3T9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000023144 ; ENSGALP00000023101 ; ENSGALG00000014320 .
GeneIDi 422792.
KEGGi gga:422792.

Organism-specific databases

CTDi 7358.

Phylogenomic databases

eggNOGi COG1004.
GeneTreei ENSGT00390000015355.
HOGENOMi HOG000153773.
HOVERGENi HBG003512.
InParanoidi Q5F3T9.
KOi K00012.
PhylomeDBi Q5F3T9.

Enzyme and pathway databases

UniPathwayi UPA00038 ; UER00491 .

Miscellaneous databases

NextBioi 20825373.
PROi Q5F3T9.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028356. UDPglc_DH_euk.
[Graphical view ]
PANTHERi PTHR11374. PTHR11374. 1 hit.
PTHR11374:SF3. PTHR11374:SF3. 1 hit.
Pfami PF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF500133. UDPglc_DH_euk. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTi SM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsi TIGR03026. NDP-sugDHase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiUGDH_CHICK
AccessioniPrimary (citable) accession number: Q5F3T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 15, 2005
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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