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Q5F3T9

- UGDH_CHICK

UniProt

Q5F3T9 - UGDH_CHICK

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Protein

UDP-glucose 6-dehydrogenase

Gene

UGDH

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.By similarity

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361NADBy similarity
Binding sitei41 – 411NADBy similarity
Binding sitei165 – 1651NADBy similarity
Active sitei276 – 2761NucleophileBy similarity
Binding sitei346 – 3461NADBy similarity
Binding sitei442 – 4421SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 166NADBy similarity
Nucleotide bindingi89 – 935NADBy similarity
Nucleotide bindingi130 – 1312NADBy similarity
Nucleotide bindingi276 – 2794NADBy similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. UDP-glucose 6-dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. gastrulation with mouth forming second Source: AgBase
  2. UDP-glucuronate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_247059. Formation of the active cofactor, UDP-glucuronate.
UniPathwayiUPA00038; UER00491.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
Short name:
UDP-Glc dehydrogenase
Short name:
UDP-GlcDH
Short name:
UDPGDH
Gene namesi
Name:UGDH
ORF Names:RCJMB04_7d7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 4

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494UDP-glucose 6-dehydrogenasePRO_0000317478Add
BLAST

Proteomic databases

PaxDbiQ5F3T9.
PRIDEiQ5F3T9.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023101.

Structurei

3D structure databases

ProteinModelPortaliQ5F3T9.
SMRiQ5F3T9. Positions 1-466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni161 – 1655Substrate bindingBy similarity
Regioni220 – 2278Substrate bindingBy similarity
Regioni260 – 27314Substrate bindingBy similarityAdd
BLAST
Regioni338 – 3392Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1004.
GeneTreeiENSGT00390000015355.
HOGENOMiHOG000153773.
HOVERGENiHBG003512.
InParanoidiQ5F3T9.
KOiK00012.
PhylomeDBiQ5F3T9.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028356. UDPglc_DH_euk.
[Graphical view]
PANTHERiPTHR11374. PTHR11374. 1 hit.
PTHR11374:SF3. PTHR11374:SF3. 1 hit.
PfamiPF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF500133. UDPglc_DH_euk. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5F3T9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFEIKKICCI GAGYVGGPTC SVIAQMCPKI QVTVVDVNEA RINAWNSDTL
60 70 80 90 100
PIYEPGLKEV VESCRGRNLF FSTSIDDAIR EADLVFISVN TPTKTYGMGK
110 120 130 140 150
GRAADLKYIE ACARRIVQNS NGYKIVTEKS TVPVRAAESI RRIFDANTKP
160 170 180 190 200
NLDLQVLSNP EFLAEGTAIK DLKNPDRVLI GGDDSPEGQK AVRALCAVYE
210 220 230 240 250
HWVPKEKILT TNTWSSELSK LAANAFLAQR ISSINSISAL CEATGADVEE
260 270 280 290 300
VARAIGTDQR IGNKFLKASV GFGGSCFQKD VLNLVYLCEA LNLPEVARYW
310 320 330 340 350
QQVIDMNDYQ RRRFASRIID SLFNTVTDKK IAILGFAFKK DTGDTRESSS
360 370 380 390 400
IYISKYLMDE GAKLHIYDPK VPKEQIILDL SHPGVSEDNQ VSRLVTISQD
410 420 430 440 450
PYEACDGAHA LVICTEWDMF KELDYERIHK KMLKPAFIFD GRRVLDDLHN
460 470 480 490
ELQVIGFQIE TIGKKVSAKR IPFASSCEIP KFSLQDPPVK KPRV
Length:494
Mass (Da):55,064
Last modified:March 15, 2005 - v1
Checksum:iB5D9F2590D366122
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851561 mRNA. Translation: CAH65195.1.
RefSeqiNP_001012599.1. NM_001012581.1.
UniGeneiGga.48631.
Gga.8846.

Genome annotation databases

EnsembliENSGALT00000023144; ENSGALP00000023101; ENSGALG00000014320.
GeneIDi422792.
KEGGigga:422792.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851561 mRNA. Translation: CAH65195.1 .
RefSeqi NP_001012599.1. NM_001012581.1.
UniGenei Gga.48631.
Gga.8846.

3D structure databases

ProteinModelPortali Q5F3T9.
SMRi Q5F3T9. Positions 1-466.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000023101.

Proteomic databases

PaxDbi Q5F3T9.
PRIDEi Q5F3T9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000023144 ; ENSGALP00000023101 ; ENSGALG00000014320 .
GeneIDi 422792.
KEGGi gga:422792.

Organism-specific databases

CTDi 7358.

Phylogenomic databases

eggNOGi COG1004.
GeneTreei ENSGT00390000015355.
HOGENOMi HOG000153773.
HOVERGENi HBG003512.
InParanoidi Q5F3T9.
KOi K00012.
PhylomeDBi Q5F3T9.

Enzyme and pathway databases

UniPathwayi UPA00038 ; UER00491 .
Reactomei REACT_247059. Formation of the active cofactor, UDP-glucuronate.

Miscellaneous databases

NextBioi 20825373.
PROi Q5F3T9.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR016040. NAD(P)-bd_dom.
IPR017476. UDP-Glc/GDP-Man.
IPR014027. UDP-Glc/GDP-Man_DH_C.
IPR014026. UDP-Glc/GDP-Man_DH_dimer.
IPR001732. UDP-Glc/GDP-Man_DH_N.
IPR028356. UDPglc_DH_euk.
[Graphical view ]
PANTHERi PTHR11374. PTHR11374. 1 hit.
PTHR11374:SF3. PTHR11374:SF3. 1 hit.
Pfami PF00984. UDPG_MGDP_dh. 1 hit.
PF03720. UDPG_MGDP_dh_C. 1 hit.
PF03721. UDPG_MGDP_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF500133. UDPglc_DH_euk. 1 hit.
PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMARTi SM00984. UDPG_MGDP_dh_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
SSF52413. SSF52413. 1 hit.
TIGRFAMsi TIGR03026. NDP-sugDHase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiUGDH_CHICK
AccessioniPrimary (citable) accession number: Q5F3T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 15, 2005
Last modified: November 26, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3