Reviewed,
UniProtKB/Swiss-Prot Q5F3T9 (UGDH_CHICK)
Last modified
November 25, 2008.
Version 30.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: UDP-glucose 6-dehydrogenase Short name=UDP-Glc dehydrogenase Short name=UDP-GlcDH Short name=UDPGDH EC=1.1.1.22 | ||||
| Gene names |
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| Organism | Gallus gallus (Chicken) | ||||
| Taxonomic identifier | 9031 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus |
Protein attributes
| Sequence length | 494 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate By similarity. |
| Catalytic activity | UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH. |
| Pathway | |
| Sequence similarities | Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. |
Ontologies
Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
Gene Ontology (GO) | |
| Biological process | gastrulation with mouth forming second Inferred from sequence or structural similarity. Source: AgBase oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | NAD binding Inferred from electronic annotation. Source: InterPro UDP-glucose 6-dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 494 | 494 | UDP-glucose 6-dehydrogenase | PRO_0000317478 | |||||
Regions | |||||||||
| Nucleotide binding | 6 – 23 | 18 | NAD By similarity | ||||||
| Region | 162 – 165 | 4 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Active site | 276 | 1 | Nucleophile By similarity | ||||||
| Binding site | 36 | 1 | NAD By similarity | ||||||
| Binding site | 41 | 1 | NAD By similarity | ||||||
| Binding site | 93 | 1 | NAD By similarity | ||||||
| Binding site | 131 | 1 | NAD; via amide nitrogen By similarity | ||||||
| Binding site | 165 | 1 | NAD By similarity | ||||||
| Binding site | 220 | 1 | Substrate By similarity | ||||||
| Binding site | 273 | 1 | Substrate; via amide nitrogen By similarity | ||||||
| Binding site | 279 | 1 | NAD By similarity | ||||||
| Binding site | 339 | 1 | Substrate By similarity | ||||||
| Binding site | 346 | 1 | NAD By similarity | ||||||
Sequences
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References
| [1] | "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:RESEARCH006.1-RESEARCH006.9(2005) [PubMed: 15642098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius. |
Cross-references
Sequence databases | |
|---|---|
| AJ851561 mRNA. Translation: CAH65195.1. | |
| RefSeq | NP_001012599.1. |
| UniGene | Gga.8846 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSGALG00000014320. Gallus gallus. [Contig view] |
| GeneID | 422792. |
| KEGG | gga:422792. |
Phylogenomic databases | |
| HOGENOM | Q5F3T9. |
| HOVERGEN | Q5F3T9. |
Family and domain databases | |
| InterPro | IPR016040. NAD(P)-bd. IPR017476. Nucleotide_sugar_DH. IPR014027. UDP-Glc/GDP-Man_DHase_C. IPR014026. UDP-Glc/GDP-Man_DHase_dimer. IPR014028. UDP-Glc/GDP-Man_DHase_dimer-bd. IPR001732. UDP-Glc/GDP-Man_DHase_N. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:3.40.50.1870. UDP-Glc/GDP-Man_DH_C. 1 hit. |
| PANTHER | PTHR11374. UDPG_MGDP_DH_Creg. 1 hit. |
| Pfam | PF00984. UDPG_MGDP_dh. 1 hit. PF03720. UDPG_MGDP_dh_C. 1 hit. PF03721. UDPG_MGDP_dh_N. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | UGDH_CHICK | ||||||||
| Accession | Primary (citable) accession number: Q5F3T9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


