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Q5F3T9

- UGDH_CHICK

UniProt

Q5F3T9 - UGDH_CHICK

Protein

UDP-glucose 6-dehydrogenase

Gene

UGDH

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.By similarity

    Catalytic activityi

    UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei36 – 361NADBy similarity
    Binding sitei41 – 411NADBy similarity
    Binding sitei165 – 1651NADBy similarity
    Active sitei276 – 2761NucleophileBy similarity
    Binding sitei346 – 3461NADBy similarity
    Binding sitei442 – 4421SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 166NADBy similarity
    Nucleotide bindingi89 – 935NADBy similarity
    Nucleotide bindingi130 – 1312NADBy similarity
    Nucleotide bindingi276 – 2794NADBy similarity

    GO - Molecular functioni

    1. NAD binding Source: InterPro
    2. UDP-glucose 6-dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. gastrulation with mouth forming second Source: AgBase
    2. UDP-glucuronate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00038; UER00491.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucose 6-dehydrogenase (EC:1.1.1.22)
    Short name:
    UDP-Glc dehydrogenase
    Short name:
    UDP-GlcDH
    Short name:
    UDPGDH
    Gene namesi
    Name:UGDH
    ORF Names:RCJMB04_7d7
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 4

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 494494UDP-glucose 6-dehydrogenasePRO_0000317478Add
    BLAST

    Proteomic databases

    PaxDbiQ5F3T9.
    PRIDEiQ5F3T9.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000023101.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5F3T9.
    SMRiQ5F3T9. Positions 1-466.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni161 – 1655Substrate bindingBy similarity
    Regioni220 – 2278Substrate bindingBy similarity
    Regioni260 – 27314Substrate bindingBy similarityAdd
    BLAST
    Regioni338 – 3392Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1004.
    GeneTreeiENSGT00390000015355.
    HOGENOMiHOG000153773.
    HOVERGENiHBG003512.
    InParanoidiQ5F3T9.
    KOiK00012.
    PhylomeDBiQ5F3T9.

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR016040. NAD(P)-bd_dom.
    IPR017476. UDP-Glc/GDP-Man.
    IPR014027. UDP-Glc/GDP-Man_DH_C.
    IPR014026. UDP-Glc/GDP-Man_DH_dimer.
    IPR001732. UDP-Glc/GDP-Man_DH_N.
    IPR028356. UDPglc_DH_euk.
    [Graphical view]
    PANTHERiPTHR11374. PTHR11374. 1 hit.
    PTHR11374:SF3. PTHR11374:SF3. 1 hit.
    PfamiPF00984. UDPG_MGDP_dh. 1 hit.
    PF03720. UDPG_MGDP_dh_C. 1 hit.
    PF03721. UDPG_MGDP_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF500133. UDPglc_DH_euk. 1 hit.
    PIRSF000124. UDPglc_GDPman_dh. 1 hit.
    SMARTiSM00984. UDPG_MGDP_dh_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    SSF52413. SSF52413. 1 hit.
    TIGRFAMsiTIGR03026. NDP-sugDHase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5F3T9-1 [UniParc]FASTAAdd to Basket

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    MFEIKKICCI GAGYVGGPTC SVIAQMCPKI QVTVVDVNEA RINAWNSDTL    50
    PIYEPGLKEV VESCRGRNLF FSTSIDDAIR EADLVFISVN TPTKTYGMGK 100
    GRAADLKYIE ACARRIVQNS NGYKIVTEKS TVPVRAAESI RRIFDANTKP 150
    NLDLQVLSNP EFLAEGTAIK DLKNPDRVLI GGDDSPEGQK AVRALCAVYE 200
    HWVPKEKILT TNTWSSELSK LAANAFLAQR ISSINSISAL CEATGADVEE 250
    VARAIGTDQR IGNKFLKASV GFGGSCFQKD VLNLVYLCEA LNLPEVARYW 300
    QQVIDMNDYQ RRRFASRIID SLFNTVTDKK IAILGFAFKK DTGDTRESSS 350
    IYISKYLMDE GAKLHIYDPK VPKEQIILDL SHPGVSEDNQ VSRLVTISQD 400
    PYEACDGAHA LVICTEWDMF KELDYERIHK KMLKPAFIFD GRRVLDDLHN 450
    ELQVIGFQIE TIGKKVSAKR IPFASSCEIP KFSLQDPPVK KPRV 494
    Length:494
    Mass (Da):55,064
    Last modified:March 15, 2005 - v1
    Checksum:iB5D9F2590D366122
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ851561 mRNA. Translation: CAH65195.1.
    RefSeqiNP_001012599.1. NM_001012581.1.
    UniGeneiGga.48631.
    Gga.8846.

    Genome annotation databases

    EnsembliENSGALT00000023144; ENSGALP00000023101; ENSGALG00000014320.
    GeneIDi422792.
    KEGGigga:422792.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ851561 mRNA. Translation: CAH65195.1 .
    RefSeqi NP_001012599.1. NM_001012581.1.
    UniGenei Gga.48631.
    Gga.8846.

    3D structure databases

    ProteinModelPortali Q5F3T9.
    SMRi Q5F3T9. Positions 1-466.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000023101.

    Proteomic databases

    PaxDbi Q5F3T9.
    PRIDEi Q5F3T9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000023144 ; ENSGALP00000023101 ; ENSGALG00000014320 .
    GeneIDi 422792.
    KEGGi gga:422792.

    Organism-specific databases

    CTDi 7358.

    Phylogenomic databases

    eggNOGi COG1004.
    GeneTreei ENSGT00390000015355.
    HOGENOMi HOG000153773.
    HOVERGENi HBG003512.
    InParanoidi Q5F3T9.
    KOi K00012.
    PhylomeDBi Q5F3T9.

    Enzyme and pathway databases

    UniPathwayi UPA00038 ; UER00491 .

    Miscellaneous databases

    NextBioi 20825373.
    PROi Q5F3T9.

    Family and domain databases

    Gene3Di 3.40.50.720. 2 hits.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR016040. NAD(P)-bd_dom.
    IPR017476. UDP-Glc/GDP-Man.
    IPR014027. UDP-Glc/GDP-Man_DH_C.
    IPR014026. UDP-Glc/GDP-Man_DH_dimer.
    IPR001732. UDP-Glc/GDP-Man_DH_N.
    IPR028356. UDPglc_DH_euk.
    [Graphical view ]
    PANTHERi PTHR11374. PTHR11374. 1 hit.
    PTHR11374:SF3. PTHR11374:SF3. 1 hit.
    Pfami PF00984. UDPG_MGDP_dh. 1 hit.
    PF03720. UDPG_MGDP_dh_C. 1 hit.
    PF03721. UDPG_MGDP_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF500133. UDPglc_DH_euk. 1 hit.
    PIRSF000124. UDPglc_GDPman_dh. 1 hit.
    SMARTi SM00984. UDPG_MGDP_dh_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    SSF52413. SSF52413. 1 hit.
    TIGRFAMsi TIGR03026. NDP-sugDHase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: CB.
      Tissue: Bursa of Fabricius.

    Entry informationi

    Entry nameiUGDH_CHICK
    AccessioniPrimary (citable) accession number: Q5F3T9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3