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Q5F3N6

- BAP1_CHICK

UniProt

Q5F3N6 - BAP1_CHICK

Protein

Ubiquitin carboxyl-terminal hydrolase BAP1

Gene

BAP1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei91 – 911NucleophileBy similarity
    Active sitei169 – 1691Proton donorBy similarity
    Sitei184 – 1841Important for enzyme activityBy similarity

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB
    2. ubiquitin-specific protease activity Source: UniProtKB
    3. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. monoubiquitinated histone H2A deubiquitination Source: UniProtKB
    2. protein deubiquitination Source: UniProtKB
    3. protein K48-linked deubiquitination Source: UniProtKB
    4. regulation of cell cycle Source: UniProtKB
    5. regulation of cell growth Source: UniProtKB
    6. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC12.004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase BAP1 (EC:3.4.19.12)
    Alternative name(s):
    BRCA1-associated protein 1
    Gene namesi
    Name:BAP1
    ORF Names:RCJMB04_11f19
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Mainly nuclear. Binds to chromatin By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. PR-DUB complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 700700Ubiquitin carboxyl-terminal hydrolase BAP1PRO_0000395818Add
    BLAST

    Proteomic databases

    PaxDbiQ5F3N6.

    Interactioni

    Subunit structurei

    Component of the PR-DUB complex.By similarity

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000006954.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5F3N6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili598 – 63235Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C12 family. BAP1 subfamily.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG249036.
    HOGENOMiHOG000013189.
    HOVERGENiHBG054042.
    InParanoidiQ5F3N6.
    KOiK08588.
    PhylomeDBiQ5F3N6.

    Family and domain databases

    Gene3Di3.40.532.10. 1 hit.
    InterProiIPR001578. Peptidase_C12_UCH.
    [Graphical view]
    PANTHERiPTHR10589. PTHR10589. 1 hit.
    PfamiPF01088. Peptidase_C12. 1 hit.
    [Graphical view]
    PRINTSiPR00707. UBCTHYDRLASE.

    Sequencei

    Sequence statusi: Complete.

    Q5F3N6-1 [UniParc]FASTAAdd to Basket

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    MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ GPVYGFIFLF    50
    KWIEESRSRR KVSTLVDETS VIDDDIVNNM FFAHQLIPNS CATHALLSVL 100
    LNCNNVDLGP TLSRMKDFTK GFSPESKGYA IGNAPELAKA RNSHARPEPR 150
    HLPEKQNGIS AVRTMEAFHF VSYVPIKGRL FELDGLKVYP IDHGPWADDE 200
    EWTDKARRVI MERIGLATAG EPYHDIRFNL MAVVPDRRMK YESKLHILKM 250
    NRQTVLEALQ QLIRVTQPEL IQSQKSQESQ SPEEAKPANS KTVAPESTHP 300
    DGADEPASQG HTTATQSPPT KSKPVAKASA SSINGVPPAN PNPIVQRLPA 350
    FLDNHNYAKS PMQEEEDLAA GVGRSRVPVR QHQQYSDDED DYDDDEEEEV 400
    RNTNSAIRYK RKGQVKQEHA AGAADGQLSV LQPNTINVLA EKLKESQKDL 450
    SIPLSIKTTG GGAAVAIVTH SQPSPTPSNE STDTASEIGS AFNSPLRSPI 500
    RSANPTRPSS PVTSHISKVL FGEEDGLLRI DCLRYNRAVR DLGPIISSGL 550
    LHLTEDGVFC PLAAADGGKS SPPSIKPGEE AQVTIKLDEK EGSEASGSKE 600
    KELLALLKCV EAEIANYEAC LKEEVEKRKK FKIDDQRRTH NYDEFICTFI 650
    SMLAQEGMLA SLVEQNISVR RRQGVSIGRL HKQRKPDRRK RSRPYKAKRQ 700
    Length:700
    Mass (Da):77,704
    Last modified:March 15, 2005 - v1
    Checksum:iA279A342674F4DCA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ851614 mRNA. Translation: CAH65248.1.
    RefSeqiNP_001025761.1. NM_001030590.1.
    UniGeneiGga.5871.

    Genome annotation databases

    GeneIDi415944.
    KEGGigga:415944.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ851614 mRNA. Translation: CAH65248.1 .
    RefSeqi NP_001025761.1. NM_001030590.1.
    UniGenei Gga.5871.

    3D structure databases

    ProteinModelPortali Q5F3N6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000006954.

    Protein family/group databases

    MEROPSi C12.004.

    Proteomic databases

    PaxDbi Q5F3N6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 415944.
    KEGGi gga:415944.

    Organism-specific databases

    CTDi 8314.

    Phylogenomic databases

    eggNOGi NOG249036.
    HOGENOMi HOG000013189.
    HOVERGENi HBG054042.
    InParanoidi Q5F3N6.
    KOi K08588.
    PhylomeDBi Q5F3N6.

    Miscellaneous databases

    NextBioi 20819470.
    PROi Q5F3N6.

    Family and domain databases

    Gene3Di 3.40.532.10. 1 hit.
    InterProi IPR001578. Peptidase_C12_UCH.
    [Graphical view ]
    PANTHERi PTHR10589. PTHR10589. 1 hit.
    Pfami PF01088. Peptidase_C12. 1 hit.
    [Graphical view ]
    PRINTSi PR00707. UBCTHYDRLASE.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: CB.
      Tissue: Bursa of Fabricius.

    Entry informationi

    Entry nameiBAP1_CHICK
    AccessioniPrimary (citable) accession number: Q5F3N6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3