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Q5F3N6 (BAP1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase BAP1

EC=3.4.19.12
Alternative name(s):
BRCA1-associated protein 1
Gene names
Name:BAP1
ORF Names:RCJMB04_11f19
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length700 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Component of the PR-DUB complex By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: Mainly nuclear. Binds to chromatin By similarity.

Sequence similarities

Belongs to the peptidase C12 family. BAP1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 700700Ubiquitin carboxyl-terminal hydrolase BAP1
PRO_0000395818

Regions

Coiled coil598 – 63235 Potential

Sites

Active site911Nucleophile By similarity
Active site1691Proton donor By similarity
Site1841Important for enzyme activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5F3N6 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: A279A342674F4DCA

FASTA70077,704
        10         20         30         40         50         60 
MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ GPVYGFIFLF KWIEESRSRR 

        70         80         90        100        110        120 
KVSTLVDETS VIDDDIVNNM FFAHQLIPNS CATHALLSVL LNCNNVDLGP TLSRMKDFTK 

       130        140        150        160        170        180 
GFSPESKGYA IGNAPELAKA RNSHARPEPR HLPEKQNGIS AVRTMEAFHF VSYVPIKGRL 

       190        200        210        220        230        240 
FELDGLKVYP IDHGPWADDE EWTDKARRVI MERIGLATAG EPYHDIRFNL MAVVPDRRMK 

       250        260        270        280        290        300 
YESKLHILKM NRQTVLEALQ QLIRVTQPEL IQSQKSQESQ SPEEAKPANS KTVAPESTHP 

       310        320        330        340        350        360 
DGADEPASQG HTTATQSPPT KSKPVAKASA SSINGVPPAN PNPIVQRLPA FLDNHNYAKS 

       370        380        390        400        410        420 
PMQEEEDLAA GVGRSRVPVR QHQQYSDDED DYDDDEEEEV RNTNSAIRYK RKGQVKQEHA 

       430        440        450        460        470        480 
AGAADGQLSV LQPNTINVLA EKLKESQKDL SIPLSIKTTG GGAAVAIVTH SQPSPTPSNE 

       490        500        510        520        530        540 
STDTASEIGS AFNSPLRSPI RSANPTRPSS PVTSHISKVL FGEEDGLLRI DCLRYNRAVR 

       550        560        570        580        590        600 
DLGPIISSGL LHLTEDGVFC PLAAADGGKS SPPSIKPGEE AQVTIKLDEK EGSEASGSKE 

       610        620        630        640        650        660 
KELLALLKCV EAEIANYEAC LKEEVEKRKK FKIDDQRRTH NYDEFICTFI SMLAQEGMLA 

       670        680        690        700 
SLVEQNISVR RRQGVSIGRL HKQRKPDRRK RSRPYKAKRQ 

« Hide

References

[1]"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.
Genome Biol. 6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CB.
Tissue: Bursa of Fabricius.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ851614 mRNA. Translation: CAH65248.1.
RefSeqNP_001025761.1. NM_001030590.1.
UniGeneGga.5871.

3D structure databases

ProteinModelPortalQ5F3N6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000006954.

Protein family/group databases

MEROPSC12.004.

Proteomic databases

PaxDbQ5F3N6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID415944.
KEGGgga:415944.

Organism-specific databases

CTD8314.

Phylogenomic databases

eggNOGNOG249036.
HOGENOMHOG000013189.
HOVERGENHBG054042.
InParanoidQ5F3N6.
KOK08588.
PhylomeDBQ5F3N6.

Family and domain databases

Gene3D3.40.532.10. 1 hit.
InterProIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERPTHR10589. PTHR10589. 1 hit.
PfamPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSPR00707. UBCTHYDRLASE.
ProtoNetSearch...

Other

NextBio20819470.
PROQ5F3N6.

Entry information

Entry nameBAP1_CHICK
AccessionPrimary (citable) accession number: Q5F3N6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: March 15, 2005
Last modified: April 16, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries