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Q5F3N6

- BAP1_CHICK

UniProt

Q5F3N6 - BAP1_CHICK

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Protein

Ubiquitin carboxyl-terminal hydrolase BAP1

Gene

BAP1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei91 – 911NucleophileBy similarity
Active sitei169 – 1691Proton donorBy similarity
Sitei184 – 1841Important for enzyme activityBy similarity

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. ubiquitin-specific protease activity Source: UniProtKB
  3. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. monoubiquitinated histone H2A deubiquitination Source: UniProtKB
  2. protein deubiquitination Source: UniProtKB
  3. protein K48-linked deubiquitination Source: UniProtKB
  4. regulation of cell cycle Source: UniProtKB
  5. regulation of cell growth Source: UniProtKB
  6. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC12.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase BAP1 (EC:3.4.19.12)
Alternative name(s):
BRCA1-associated protein 1
Gene namesi
Name:BAP1
ORF Names:RCJMB04_11f19
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Mainly nuclear. Binds to chromatin (By similarity).By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
  3. PR-DUB complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 700700Ubiquitin carboxyl-terminal hydrolase BAP1PRO_0000395818Add
BLAST

Proteomic databases

PaxDbiQ5F3N6.

Interactioni

Subunit structurei

Component of the PR-DUB complex.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006954.

Structurei

3D structure databases

ProteinModelPortaliQ5F3N6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili598 – 63235Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C12 family. BAP1 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG249036.
HOGENOMiHOG000013189.
HOVERGENiHBG054042.
InParanoidiQ5F3N6.
KOiK08588.
PhylomeDBiQ5F3N6.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.

Sequencei

Sequence statusi: Complete.

Q5F3N6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ GPVYGFIFLF
60 70 80 90 100
KWIEESRSRR KVSTLVDETS VIDDDIVNNM FFAHQLIPNS CATHALLSVL
110 120 130 140 150
LNCNNVDLGP TLSRMKDFTK GFSPESKGYA IGNAPELAKA RNSHARPEPR
160 170 180 190 200
HLPEKQNGIS AVRTMEAFHF VSYVPIKGRL FELDGLKVYP IDHGPWADDE
210 220 230 240 250
EWTDKARRVI MERIGLATAG EPYHDIRFNL MAVVPDRRMK YESKLHILKM
260 270 280 290 300
NRQTVLEALQ QLIRVTQPEL IQSQKSQESQ SPEEAKPANS KTVAPESTHP
310 320 330 340 350
DGADEPASQG HTTATQSPPT KSKPVAKASA SSINGVPPAN PNPIVQRLPA
360 370 380 390 400
FLDNHNYAKS PMQEEEDLAA GVGRSRVPVR QHQQYSDDED DYDDDEEEEV
410 420 430 440 450
RNTNSAIRYK RKGQVKQEHA AGAADGQLSV LQPNTINVLA EKLKESQKDL
460 470 480 490 500
SIPLSIKTTG GGAAVAIVTH SQPSPTPSNE STDTASEIGS AFNSPLRSPI
510 520 530 540 550
RSANPTRPSS PVTSHISKVL FGEEDGLLRI DCLRYNRAVR DLGPIISSGL
560 570 580 590 600
LHLTEDGVFC PLAAADGGKS SPPSIKPGEE AQVTIKLDEK EGSEASGSKE
610 620 630 640 650
KELLALLKCV EAEIANYEAC LKEEVEKRKK FKIDDQRRTH NYDEFICTFI
660 670 680 690 700
SMLAQEGMLA SLVEQNISVR RRQGVSIGRL HKQRKPDRRK RSRPYKAKRQ
Length:700
Mass (Da):77,704
Last modified:March 15, 2005 - v1
Checksum:iA279A342674F4DCA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ851614 mRNA. Translation: CAH65248.1.
RefSeqiNP_001025761.1. NM_001030590.1.
UniGeneiGga.5871.

Genome annotation databases

GeneIDi415944.
KEGGigga:415944.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ851614 mRNA. Translation: CAH65248.1 .
RefSeqi NP_001025761.1. NM_001030590.1.
UniGenei Gga.5871.

3D structure databases

ProteinModelPortali Q5F3N6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000006954.

Protein family/group databases

MEROPSi C12.004.

Proteomic databases

PaxDbi Q5F3N6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 415944.
KEGGi gga:415944.

Organism-specific databases

CTDi 8314.

Phylogenomic databases

eggNOGi NOG249036.
HOGENOMi HOG000013189.
HOVERGENi HBG054042.
InParanoidi Q5F3N6.
KOi K08588.
PhylomeDBi Q5F3N6.

Miscellaneous databases

NextBioi 20819470.
PROi Q5F3N6.

Family and domain databases

Gene3Di 3.40.532.10. 1 hit.
InterProi IPR001578. Peptidase_C12_UCH.
[Graphical view ]
PANTHERi PTHR10589. PTHR10589. 1 hit.
Pfami PF01088. Peptidase_C12. 1 hit.
[Graphical view ]
PRINTSi PR00707. UBCTHYDRLASE.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiBAP1_CHICK
AccessioniPrimary (citable) accession number: Q5F3N6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: March 15, 2005
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3