Ubiquitin carboxyl-terminal hydrolase BAP1

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Q5F3N6 (BAP1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 42. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Ubiquitin carboxyl-terminal hydrolase BAP1
EC=3.4.19.12

Alternative name(s):
BRCA1-associated protein 1

Gene names

Name:	BAP1
ORF Names:	RCJMB04_11f19

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	700 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) By similarity.
Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Subunit structure	Component of the PR-DUB complex By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity. Note: Mainly nuclear. Binds to chromatin By similarity.
Sequence similarities	Belongs to the peptidase C12 family. BAP1 subfamily.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Cytoplasm Nucleus
Domain	Coiled coil
Molecular function	Chromatin regulator Hydrolase Protease Thiol protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	monoubiquitinated histone H2A deubiquitination Inferred from sequence or structural similarity. Source: UniProtKB protein K48-linked deubiquitination Inferred from sequence or structural similarity. Source: UniProtKB regulation of cell cycle Inferred from sequence or structural similarity. Source: UniProtKB regulation of cell growth Inferred from sequence or structural similarity. Source: UniProtKB ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	PR-DUB complex Inferred from sequence or structural similarity. Source: UniProtKB cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	chromatin binding Inferred from sequence or structural similarity. Source: UniProtKB ubiquitin thiolesterase activity Inferred from sequence or structural similarity. Source: UniProtKB ubiquitin-specific protease activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 700

700

Ubiquitin carboxyl-terminal hydrolase BAP1

PRO_0000395818

Regions

Coiled coil

598 – 632

Potential

Sites

Active site

Nucleophile By similarity

Active site

169

Proton donor By similarity

Site

184

Important for enzyme activity By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q5F3N6 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: A279A342674F4DCA
Show »

FASTA

700

77,704

        10         20         30         40         50         60 
MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ GPVYGFIFLF KWIEESRSRR 

        70         80         90        100        110        120 
KVSTLVDETS VIDDDIVNNM FFAHQLIPNS CATHALLSVL LNCNNVDLGP TLSRMKDFTK 

       130        140        150        160        170        180 
GFSPESKGYA IGNAPELAKA RNSHARPEPR HLPEKQNGIS AVRTMEAFHF VSYVPIKGRL 

       190        200        210        220        230        240 
FELDGLKVYP IDHGPWADDE EWTDKARRVI MERIGLATAG EPYHDIRFNL MAVVPDRRMK 

       250        260        270        280        290        300 
YESKLHILKM NRQTVLEALQ QLIRVTQPEL IQSQKSQESQ SPEEAKPANS KTVAPESTHP 

       310        320        330        340        350        360 
DGADEPASQG HTTATQSPPT KSKPVAKASA SSINGVPPAN PNPIVQRLPA FLDNHNYAKS 

       370        380        390        400        410        420 
PMQEEEDLAA GVGRSRVPVR QHQQYSDDED DYDDDEEEEV RNTNSAIRYK RKGQVKQEHA 

       430        440        450        460        470        480 
AGAADGQLSV LQPNTINVLA EKLKESQKDL SIPLSIKTTG GGAAVAIVTH SQPSPTPSNE 

       490        500        510        520        530        540 
STDTASEIGS AFNSPLRSPI RSANPTRPSS PVTSHISKVL FGEEDGLLRI DCLRYNRAVR 

       550        560        570        580        590        600 
DLGPIISSGL LHLTEDGVFC PLAAADGGKS SPPSIKPGEE AQVTIKLDEK EGSEASGSKE 

       610        620        630        640        650        660 
KELLALLKCV EAEIANYEAC LKEEVEKRKK FKIDDQRRTH NYDEFICTFI SMLAQEGMLA 

       670        680        690        700 
SLVEQNISVR RRQGVSIGRL HKQRKPDRRK RSRPYKAKRQ

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References

[1]

"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.
Genome Biol. 6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CB.
Tissue: Bursa of Fabricius.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ851614 mRNA. Translation: CAH65248.1.
IPI	IPI00572217.
RefSeq	NP_001025761.1. NM_001030590.1.
UniGene	Gga.5871.
3D structure databases
ProteinModelPortal	Q5F3N6.
ModBase	Search...
Protein-protein interaction databases
STRING	9031.ENSGALP00000006954.
Protein family/group databases
MEROPS	C12.004.
Proteomic databases
PaxDb	Q5F3N6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	415944.
KEGG	gga:415944.
Organism-specific databases
CTD	8314.
Phylogenomic databases
eggNOG	NOG249036.
HOGENOM	HOG000013189.
HOVERGEN	HBG054042.
InParanoid	Q5F3N6.
KO	K08588.
OrthoDB	EOG4XPQFC.
Family and domain databases
Gene3D	3.40.532.10. 1 hit.
InterPro	IPR001578. Peptidase_C12. [Graphical view]
PANTHER	PTHR10589. PTHR10589. 1 hit.
Pfam	PF01088. Peptidase_C12. 1 hit. [Graphical view]
PRINTS	PR00707. UBCTHYDRLASE.
PROSITE	PS00140. UCH_1. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	20819470.

Entry information

Entry name

BAP1_CHICK

Accession

Primary (citable) accession number: Q5F3N6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 13, 2010
Last sequence update:	March 15, 2005
Last modified:	April 3, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Other

Entry information

Relevant documents