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Protein

Ubiquitin carboxyl-terminal hydrolase BAP1

Gene

BAP1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei91 – 911NucleophileBy similarity
Active sitei169 – 1691Proton donorBy similarity
Sitei184 – 1841Important for enzyme activityBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC12.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase BAP1 (EC:3.4.19.12)
Alternative name(s):
BRCA1-associated protein 1
Gene namesi
Name:BAP1
ORF Names:RCJMB04_11f19
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Mainly nuclear. Binds to chromatin (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 700700Ubiquitin carboxyl-terminal hydrolase BAP1PRO_0000395818Add
BLAST

Proteomic databases

PaxDbiQ5F3N6.

Interactioni

Subunit structurei

Component of the PR-DUB complex.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006954.

Structurei

3D structure databases

ProteinModelPortaliQ5F3N6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili598 – 63235Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C12 family. BAP1 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG249036.
HOGENOMiHOG000013189.
HOVERGENiHBG054042.
InParanoidiQ5F3N6.
KOiK08588.
PhylomeDBiQ5F3N6.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.

Sequencei

Sequence statusi: Complete.

Q5F3N6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ GPVYGFIFLF
60 70 80 90 100
KWIEESRSRR KVSTLVDETS VIDDDIVNNM FFAHQLIPNS CATHALLSVL
110 120 130 140 150
LNCNNVDLGP TLSRMKDFTK GFSPESKGYA IGNAPELAKA RNSHARPEPR
160 170 180 190 200
HLPEKQNGIS AVRTMEAFHF VSYVPIKGRL FELDGLKVYP IDHGPWADDE
210 220 230 240 250
EWTDKARRVI MERIGLATAG EPYHDIRFNL MAVVPDRRMK YESKLHILKM
260 270 280 290 300
NRQTVLEALQ QLIRVTQPEL IQSQKSQESQ SPEEAKPANS KTVAPESTHP
310 320 330 340 350
DGADEPASQG HTTATQSPPT KSKPVAKASA SSINGVPPAN PNPIVQRLPA
360 370 380 390 400
FLDNHNYAKS PMQEEEDLAA GVGRSRVPVR QHQQYSDDED DYDDDEEEEV
410 420 430 440 450
RNTNSAIRYK RKGQVKQEHA AGAADGQLSV LQPNTINVLA EKLKESQKDL
460 470 480 490 500
SIPLSIKTTG GGAAVAIVTH SQPSPTPSNE STDTASEIGS AFNSPLRSPI
510 520 530 540 550
RSANPTRPSS PVTSHISKVL FGEEDGLLRI DCLRYNRAVR DLGPIISSGL
560 570 580 590 600
LHLTEDGVFC PLAAADGGKS SPPSIKPGEE AQVTIKLDEK EGSEASGSKE
610 620 630 640 650
KELLALLKCV EAEIANYEAC LKEEVEKRKK FKIDDQRRTH NYDEFICTFI
660 670 680 690 700
SMLAQEGMLA SLVEQNISVR RRQGVSIGRL HKQRKPDRRK RSRPYKAKRQ
Length:700
Mass (Da):77,704
Last modified:March 15, 2005 - v1
Checksum:iA279A342674F4DCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851614 mRNA. Translation: CAH65248.1.
RefSeqiNP_001025761.1. NM_001030590.1.
UniGeneiGga.5871.

Genome annotation databases

GeneIDi415944.
KEGGigga:415944.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851614 mRNA. Translation: CAH65248.1.
RefSeqiNP_001025761.1. NM_001030590.1.
UniGeneiGga.5871.

3D structure databases

ProteinModelPortaliQ5F3N6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006954.

Protein family/group databases

MEROPSiC12.004.

Proteomic databases

PaxDbiQ5F3N6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi415944.
KEGGigga:415944.

Organism-specific databases

CTDi8314.

Phylogenomic databases

eggNOGiNOG249036.
HOGENOMiHOG000013189.
HOVERGENiHBG054042.
InParanoidiQ5F3N6.
KOiK08588.
PhylomeDBiQ5F3N6.

Miscellaneous databases

NextBioi20819470.
PROiQ5F3N6.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiBAP1_CHICK
AccessioniPrimary (citable) accession number: Q5F3N6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: March 15, 2005
Last modified: March 4, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.