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Q5F3N1

- PIMT_CHICK

UniProt

Q5F3N1 - PIMT_CHICK

Protein

Protein-L-isoaspartate(D-aspartate) O-methyltransferase

Gene

PCMT1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei60 – 601By similarity

    GO - Molecular functioni

    1. protein-L-isoaspartate (D-aspartate) O-methyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein-L-isoaspartate(D-aspartate) O-methyltransferase (EC:2.1.1.77)
    Short name:
    PIMT
    Alternative name(s):
    L-isoaspartyl protein carboxyl methyltransferase
    Protein L-isoaspartyl/D-aspartyl methyltransferase
    Protein-beta-aspartate methyltransferase
    Gene namesi
    Name:PCMT1
    ORF Names:RCJMB04_11o11
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 228227Protein-L-isoaspartate(D-aspartate) O-methyltransferasePRO_0000253635Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ5F3N1.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000036798.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5F3N1.
    SMRiQ5F3N1. Positions 3-225.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2518.
    HOGENOMiHOG000257189.
    HOVERGENiHBG004483.
    InParanoidiQ5F3N1.
    KOiK00573.
    PhylomeDBiQ5F3N1.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR000682. PCMT.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR11579. PTHR11579. 1 hit.
    PfamiPF01135. PCMT. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00080. pimt. 1 hit.
    PROSITEiPS01279. PCMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5F3N1-1 [UniParc]FASTAAdd to Basket

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    MAWKSGGASH SELIHNLRKN GIIKSDKVFE VMLATDRCHY AKYNPYMDSP    50
    QSIGFQATIS APHMHAYALE LLSDQLHEGA KALDVGSGSG ILTACFSRMV 100
    GPKGQVVGID HIKELVDDSI NNVKKDDPTL LSSGRVKLIV GDGRMGYAEE 150
    APYDAIHVGA AAPVVPQALI DQLKPGGRLI LPVGPAGGNQ MLEQYDKLED 200
    GSVKMKPLMG VIYVPLTDKE KQWSRDEL 228
    Length:228
    Mass (Da):24,691
    Last modified:January 23, 2007 - v3
    Checksum:i5F65A50FA1739916
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ851619 mRNA. Translation: CAH65253.1.
    RefSeqiNP_001026696.1. NM_001031525.1.
    UniGeneiGga.16623.

    Genome annotation databases

    GeneIDi428607.
    KEGGigga:428607.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ851619 mRNA. Translation: CAH65253.1 .
    RefSeqi NP_001026696.1. NM_001031525.1.
    UniGenei Gga.16623.

    3D structure databases

    ProteinModelPortali Q5F3N1.
    SMRi Q5F3N1. Positions 3-225.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000036798.

    Proteomic databases

    PaxDbi Q5F3N1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 428607.
    KEGGi gga:428607.

    Organism-specific databases

    CTDi 5110.

    Phylogenomic databases

    eggNOGi COG2518.
    HOGENOMi HOG000257189.
    HOVERGENi HBG004483.
    InParanoidi Q5F3N1.
    KOi K00573.
    PhylomeDBi Q5F3N1.

    Miscellaneous databases

    NextBioi 20829551.
    PROi Q5F3N1.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR000682. PCMT.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR11579. PTHR11579. 1 hit.
    Pfami PF01135. PCMT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00080. pimt. 1 hit.
    PROSITEi PS01279. PCMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: CB.
      Tissue: Bursa of Fabricius.

    Entry informationi

    Entry nameiPIMT_CHICK
    AccessioniPrimary (citable) accession number: Q5F3N1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3