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Protein

Protein-L-isoaspartate(D-aspartate) O-methyltransferase

Gene

PCMT1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei60 – 601By similarity

GO - Molecular functioni

  1. protein-L-isoaspartate (D-aspartate) O-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (EC:2.1.1.77)
Short name:
PIMT
Alternative name(s):
L-isoaspartyl protein carboxyl methyltransferase
Protein L-isoaspartyl/D-aspartyl methyltransferase
Protein-beta-aspartate methyltransferase
Gene namesi
Name:PCMT1
ORF Names:RCJMB04_11o11
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

  1. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 228227Protein-L-isoaspartate(D-aspartate) O-methyltransferasePRO_0000253635Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5F3N1.

Expressioni

Gene expression databases

ExpressionAtlasiQ5F3N1. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036798.

Structurei

3D structure databases

ProteinModelPortaliQ5F3N1.
SMRiQ5F3N1. Positions 3-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2518.
HOGENOMiHOG000257189.
HOVERGENiHBG004483.
InParanoidiQ5F3N1.
KOiK00573.
PhylomeDBiQ5F3N1.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR000682. PCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11579. PTHR11579. 1 hit.
PfamiPF01135. PCMT. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.
PROSITEiPS01279. PCMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5F3N1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWKSGGASH SELIHNLRKN GIIKSDKVFE VMLATDRCHY AKYNPYMDSP
60 70 80 90 100
QSIGFQATIS APHMHAYALE LLSDQLHEGA KALDVGSGSG ILTACFSRMV
110 120 130 140 150
GPKGQVVGID HIKELVDDSI NNVKKDDPTL LSSGRVKLIV GDGRMGYAEE
160 170 180 190 200
APYDAIHVGA AAPVVPQALI DQLKPGGRLI LPVGPAGGNQ MLEQYDKLED
210 220
GSVKMKPLMG VIYVPLTDKE KQWSRDEL
Length:228
Mass (Da):24,691
Last modified:January 23, 2007 - v3
Checksum:i5F65A50FA1739916
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851619 mRNA. Translation: CAH65253.1.
RefSeqiNP_001026696.1. NM_001031525.1.
UniGeneiGga.16623.

Genome annotation databases

GeneIDi428607.
KEGGigga:428607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851619 mRNA. Translation: CAH65253.1.
RefSeqiNP_001026696.1. NM_001031525.1.
UniGeneiGga.16623.

3D structure databases

ProteinModelPortaliQ5F3N1.
SMRiQ5F3N1. Positions 3-225.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036798.

Proteomic databases

PaxDbiQ5F3N1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi428607.
KEGGigga:428607.

Organism-specific databases

CTDi5110.

Phylogenomic databases

eggNOGiCOG2518.
HOGENOMiHOG000257189.
HOVERGENiHBG004483.
InParanoidiQ5F3N1.
KOiK00573.
PhylomeDBiQ5F3N1.

Miscellaneous databases

NextBioi20829551.
PROiQ5F3N1.

Gene expression databases

ExpressionAtlasiQ5F3N1. baseline.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR000682. PCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11579. PTHR11579. 1 hit.
PfamiPF01135. PCMT. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.
PROSITEiPS01279. PCMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiPIMT_CHICK
AccessioniPrimary (citable) accession number: Q5F3N1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: January 23, 2007
Last modified: February 4, 2015
This is version 62 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.