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Q5F3N1

- PIMT_CHICK

UniProt

Q5F3N1 - PIMT_CHICK

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Protein

Protein-L-isoaspartate(D-aspartate) O-methyltransferase

Gene
PCMT1, RCJMB04_11o11
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins By similarity.

Catalytic activityi

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei60 – 601 By similarity

GO - Molecular functioni

  1. protein-L-isoaspartate (D-aspartate) O-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (EC:2.1.1.77)
Short name:
PIMT
Alternative name(s):
L-isoaspartyl protein carboxyl methyltransferase
Protein L-isoaspartyl/D-aspartyl methyltransferase
Protein-beta-aspartate methyltransferase
Gene namesi
Name:PCMT1
ORF Names:RCJMB04_11o11
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 228227Protein-L-isoaspartate(D-aspartate) O-methyltransferasePRO_0000253635Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5F3N1.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036798.

Structurei

3D structure databases

ProteinModelPortaliQ5F3N1.
SMRiQ5F3N1. Positions 3-225.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2518.
HOGENOMiHOG000257189.
HOVERGENiHBG004483.
InParanoidiQ5F3N1.
KOiK00573.
PhylomeDBiQ5F3N1.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR000682. PCMT.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR11579. PTHR11579. 1 hit.
PfamiPF01135. PCMT. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.
PROSITEiPS01279. PCMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5F3N1-1 [UniParc]FASTAAdd to Basket

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MAWKSGGASH SELIHNLRKN GIIKSDKVFE VMLATDRCHY AKYNPYMDSP    50
QSIGFQATIS APHMHAYALE LLSDQLHEGA KALDVGSGSG ILTACFSRMV 100
GPKGQVVGID HIKELVDDSI NNVKKDDPTL LSSGRVKLIV GDGRMGYAEE 150
APYDAIHVGA AAPVVPQALI DQLKPGGRLI LPVGPAGGNQ MLEQYDKLED 200
GSVKMKPLMG VIYVPLTDKE KQWSRDEL 228
Length:228
Mass (Da):24,691
Last modified:January 23, 2007 - v3
Checksum:i5F65A50FA1739916
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ851619 mRNA. Translation: CAH65253.1.
RefSeqiNP_001026696.1. NM_001031525.1.
UniGeneiGga.16623.

Genome annotation databases

GeneIDi428607.
KEGGigga:428607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ851619 mRNA. Translation: CAH65253.1 .
RefSeqi NP_001026696.1. NM_001031525.1.
UniGenei Gga.16623.

3D structure databases

ProteinModelPortali Q5F3N1.
SMRi Q5F3N1. Positions 3-225.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000036798.

Proteomic databases

PaxDbi Q5F3N1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 428607.
KEGGi gga:428607.

Organism-specific databases

CTDi 5110.

Phylogenomic databases

eggNOGi COG2518.
HOGENOMi HOG000257189.
HOVERGENi HBG004483.
InParanoidi Q5F3N1.
KOi K00573.
PhylomeDBi Q5F3N1.

Miscellaneous databases

NextBioi 20829551.
PROi Q5F3N1.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR000682. PCMT.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR11579. PTHR11579. 1 hit.
Pfami PF01135. PCMT. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00080. pimt. 1 hit.
PROSITEi PS01279. PCMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiPIMT_CHICK
AccessioniPrimary (citable) accession number: Q5F3N1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 57 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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