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Protein

WD repeat-containing protein 48

Gene

WDR48

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes.By similarity

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-GGA-110314 Recognition of DNA damage by PCNA-containing replication complex
R-GGA-5689880 Ub-specific processing proteases
R-GGA-6783310 Fanconi Anemia Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 48
Alternative name(s):
USP1-associated factor 1
Gene namesi
Name:WDR48
Synonyms:UAF1
ORF Names:RCJMB04_14o15
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Lysosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000514031 – 678WD repeat-containing protein 48Add BLAST678

Proteomic databases

PaxDbiQ5F3K4

Expressioni

Gene expression databases

BgeeiENSGALG00000006052

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000030646

Structurei

3D structure databases

ProteinModelPortaliQ5F3K4
SMRiQ5F3K4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati28 – 67WD 1Add BLAST40
Repeati73 – 112WD 2Add BLAST40
Repeati115 – 154WD 3Add BLAST40
Repeati166 – 205WD 4Add BLAST40
Repeati208 – 247WD 5Add BLAST40
Repeati250 – 289WD 6Add BLAST40
Repeati292 – 334WD 7Add BLAST43
Repeati358 – 452WD 8Add BLAST95

Domaini

The WD repeats are required for the interaction with deubiquitinating enzymes USP1, USP12 and USP46.By similarity

Sequence similaritiesi

Belongs to the WD repeat WDR48 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0308 Eukaryota
ENOG410XRJ5 LUCA
GeneTreeiENSGT00890000139394
HOGENOMiHOG000007343
HOVERGENiHBG079413
InParanoidiQ5F3K4
KOiK15361
OMAiYVPNWFN
OrthoDBiEOG091G03SS
PhylomeDBiQ5F3K4
TreeFamiTF315205

Family and domain databases

Gene3Di2.130.10.102 hits
InterProiView protein in InterPro
IPR021772 DUF3337
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF11816 DUF3337, 1 hit
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q5F3K4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAHHRQNTA GRRKVQVSYV IRDEVEKYNR NGVNALQLDP ALNRLFTAGR
60 70 80 90 100
DSIIRIWSVN QHKQDPYIAS MEHHTDWVND IVLCCNGKTL ISASSDTTVK
110 120 130 140 150
VWNAHKGFCM STLRTHKDYV KALAYAKDKE LVASAGLDRQ IFLWDVNTLT
160 170 180 190 200
ALTASNNTVT TSSLSGNKDS IYSLAMNQMG TVIVSGSTEK VLRVWDPRTC
210 220 230 240 250
AKLMKLKGHT DNVKALLLNR DGTQCLSGSS DGTIRLWSLG QQRCIATYRV
260 270 280 290 300
HDEGVWALQV NEAFTHVYSG GRDRKIYCTD LRNPDIRVLI CEEKAPVLKM
310 320 330 340 350
ELDRSADPPP AIWVATTKSS VNKWTLKGIH NFRASGDYDN DCTNPIPPLC
360 370 380 390 400
TQPDQVIKGG ASIIQCHILN DKRHILTKDT NNNVAYWDVL KACKVEDLGK
410 420 430 440 450
VDFEEEIKKR FKMVYVPNWF SVDLKTGMLT ITLDESDCFA AWVSAKDAGF
460 470 480 490 500
SSPDGSDPKL NLGGLLLQAL LEYWPRTHIN PMDEEENEIN HAVNGEQENR
510 520 530 540 550
VQKGNGYFQV PPHTPVIFGE AGGRTLFRLL CRDSGGETES MLLNETVPQW
560 570 580 590 600
VIDITVDKNM PKFNKIPFYL QPHSSSGAKT LKKDRLSASD MLQVRKVMEH
610 620 630 640 650
VYEKIINLDN ESQTTSSSNN EKAGEQEKEE DIAVLAEEKI ELLCQDQVLD
660 670
PNMDLRTVKH FIWKSGGDLT LHYRQKST
Length:678
Mass (Da):76,314
Last modified:March 15, 2005 - v1
Checksum:i3EA3E0009DDEA18E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851646 mRNA Translation: CAH65280.1
RefSeqiNP_001026135.1, NM_001030964.1
UniGeneiGga.3234

Genome annotation databases

EnsembliENSGALT00000031283; ENSGALP00000030646; ENSGALG00000006052
GeneIDi420427
KEGGigga:420427

Similar proteinsi

Entry informationi

Entry nameiWDR48_CHICK
AccessioniPrimary (citable) accession number: Q5F3K4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: March 15, 2005
Last modified: March 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome