Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

Gene

C1GALT1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.By similarity

Catalytic activityi

UDP-alpha-D-galactose + N-acetyl-alpha-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R.By similarity

Cofactori

Mg2+By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-GGA-913709 O-linked glycosylation of mucins
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT31 Glycosyltransferase Family 31

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC:2.4.1.122By similarity)
Alternative name(s):
Core 1 O-glycan T-synthase
Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1
Core 1 beta1,3-galactosyltransferase 1
Short name:
C1GalT1
Short name:
Core 1 beta3-Gal-T1
Gene namesi
Name:C1GALT1
ORF Names:RCJMB04_17i7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini32 – 366LumenalSequence analysisAdd BLAST335

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002850671 – 366Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1Add BLAST366

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ5F3G7

Expressioni

Gene expression databases

BgeeiENSGALG00000009752

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015853

Structurei

3D structure databases

ProteinModelPortaliQ5F3G7
SMRiQ5F3G7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2246 Eukaryota
ENOG410YRJG LUCA
GeneTreeiENSGT00530000063264
HOGENOMiHOG000021316
HOVERGENiHBG097900
InParanoidiQ5F3G7
KOiK00731
OMAiYQPTLPE
OrthoDBiEOG091G0BLV
PhylomeDBiQ5F3G7
TreeFamiTF317293

Family and domain databases

InterProiView protein in InterPro
IPR026842 C1GALT1
IPR003378 Fringe-like
PANTHERiPTHR23033:SF13 PTHR23033:SF13, 1 hit
PfamiView protein in Pfam
PF02434 Fringe, 1 hit

Sequencei

Sequence statusi: Complete.

Q5F3G7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSKSLMNL LTFSFGSAIG FFLCYLLFSM ILEEQVEIQP HILHNDPHGQ
60 70 80 90 100
HSEDTDNNQL QGQMNFNADS GQHRDENRNI ADGLYEKVKI LCWVMTGPQN
110 120 130 140 150
LEKKARHVKA TWAQRCNKIL FMSSEENKDF PTVGLETKEG RDQLYWKTIK
160 170 180 190 200
AFQYVYDHYF DDADWFMKAD DDTYVILDNL RWLLSKYSPE QPIYFGRRFK
210 220 230 240 250
PYVKQGYMSG GAGYVLSKEA LKRFVTAFKT NKCSHSSSIE DLALGKCMEI
260 270 280 290 300
INVQAGDSRD TSGRETFHPF VPEHLLIRGY LPKTFWYWNY NYYPAVEGPG
310 320 330 340 350
CCSDLAVSFH YVDSMTMYHL EYLVYHLRPY GYSYRYDPDS AKGLEEQNKN
360
EAQEDNPKLK QKTSEN
Length:366
Mass (Da):42,620
Last modified:March 15, 2005 - v1
Checksum:iADA197C8002E4C61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851683 mRNA Translation: CAH65317.1
RefSeqiNP_001012575.1, NM_001012557.1
XP_015136885.1, XM_015281399.1
UniGeneiGga.1326

Genome annotation databases

EnsembliENSGALT00000015869; ENSGALP00000015853; ENSGALG00000009752
GeneIDi420575
KEGGigga:420575

Similar proteinsi

Entry informationi

Entry nameiC1GLT_CHICK
AccessioniPrimary (citable) accession number: Q5F3G7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 15, 2005
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health