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Protein

Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

Gene

C1GALT1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.By similarity

Catalytic activityi

UDP-alpha-D-galactose + glycoprotein N-acetyl-D-galactosamine = UDP + glycoprotein D-galactosyl-(1->3)-N-acetyl-D-galactosamine.

Cofactori

Mg2+By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-GGA-913709. O-linked glycosylation of mucins.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (EC:2.4.1.122)
Alternative name(s):
Core 1 O-glycan T-synthase
Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1
Core 1 beta1,3-galactosyltransferase 1
Short name:
C1GalT1
Short name:
Core 1 beta3-Gal-T1
Gene namesi
Name:C1GALT1
ORF Names:RCJMB04_17i7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini32 – 366LumenalSequence analysisAdd BLAST335

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002850671 – 366Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1Add BLAST366

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ5F3G7.

Expressioni

Gene expression databases

BgeeiENSGALG00000009752.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015853.

Structurei

3D structure databases

ProteinModelPortaliQ5F3G7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2246. Eukaryota.
ENOG410YRJG. LUCA.
GeneTreeiENSGT00530000063264.
HOGENOMiHOG000021316.
HOVERGENiHBG097900.
InParanoidiQ5F3G7.
KOiK00731.
OMAiQYVHEHY.
OrthoDBiEOG091G0BLV.
PhylomeDBiQ5F3G7.
TreeFamiTF317293.

Family and domain databases

InterProiIPR026842. C1GALT1.
IPR003378. Fringe-like.
[Graphical view]
PANTHERiPTHR23033:SF13. PTHR23033:SF13. 1 hit.
PfamiPF02434. Fringe. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5F3G7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSKSLMNL LTFSFGSAIG FFLCYLLFSM ILEEQVEIQP HILHNDPHGQ
60 70 80 90 100
HSEDTDNNQL QGQMNFNADS GQHRDENRNI ADGLYEKVKI LCWVMTGPQN
110 120 130 140 150
LEKKARHVKA TWAQRCNKIL FMSSEENKDF PTVGLETKEG RDQLYWKTIK
160 170 180 190 200
AFQYVYDHYF DDADWFMKAD DDTYVILDNL RWLLSKYSPE QPIYFGRRFK
210 220 230 240 250
PYVKQGYMSG GAGYVLSKEA LKRFVTAFKT NKCSHSSSIE DLALGKCMEI
260 270 280 290 300
INVQAGDSRD TSGRETFHPF VPEHLLIRGY LPKTFWYWNY NYYPAVEGPG
310 320 330 340 350
CCSDLAVSFH YVDSMTMYHL EYLVYHLRPY GYSYRYDPDS AKGLEEQNKN
360
EAQEDNPKLK QKTSEN
Length:366
Mass (Da):42,620
Last modified:March 15, 2005 - v1
Checksum:iADA197C8002E4C61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851683 mRNA. Translation: CAH65317.1.
RefSeqiNP_001012575.1. NM_001012557.1.
XP_015136885.1. XM_015281399.1.
UniGeneiGga.1326.

Genome annotation databases

EnsembliENSGALT00000015869; ENSGALP00000015853; ENSGALG00000009752.
GeneIDi420575.
KEGGigga:420575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851683 mRNA. Translation: CAH65317.1.
RefSeqiNP_001012575.1. NM_001012557.1.
XP_015136885.1. XM_015281399.1.
UniGeneiGga.1326.

3D structure databases

ProteinModelPortaliQ5F3G7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015853.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Proteomic databases

PaxDbiQ5F3G7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000015869; ENSGALP00000015853; ENSGALG00000009752.
GeneIDi420575.
KEGGigga:420575.

Organism-specific databases

CTDi56913.

Phylogenomic databases

eggNOGiKOG2246. Eukaryota.
ENOG410YRJG. LUCA.
GeneTreeiENSGT00530000063264.
HOGENOMiHOG000021316.
HOVERGENiHBG097900.
InParanoidiQ5F3G7.
KOiK00731.
OMAiQYVHEHY.
OrthoDBiEOG091G0BLV.
PhylomeDBiQ5F3G7.
TreeFamiTF317293.

Enzyme and pathway databases

UniPathwayiUPA00378.
ReactomeiR-GGA-913709. O-linked glycosylation of mucins.

Miscellaneous databases

PROiQ5F3G7.

Gene expression databases

BgeeiENSGALG00000009752.

Family and domain databases

InterProiIPR026842. C1GALT1.
IPR003378. Fringe-like.
[Graphical view]
PANTHERiPTHR23033:SF13. PTHR23033:SF13. 1 hit.
PfamiPF02434. Fringe. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC1GLT_CHICK
AccessioniPrimary (citable) accession number: Q5F3G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: March 15, 2005
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.