Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q5F3F2 (MYSM1_CHICK)

Last modified September 1, 2009. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Histone H2A deubiquitinase MYSM1
      Short name=2A-DUB
    EC=3.1.2.15
Alternative name(s):
    Myb-like, SWIRM and MPN domain-containing protein 1
Gene names
Name: MYSM1
ORF Names: RCJMB04_19a21
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Hide | Top

Protein attributes

Sequence length832 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

Hide | Top

General annotation (Comments)

Function

Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation By similarity.

Catalytic activity

Ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol.

Subcellular location

Nucleus Probable.

Domain

Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA By similarity.

Sequence similarities

Belongs to the peptidase M67A family. MYSM1 subfamily.

Contains 1 MPN (JAB/Mov34) domain.

Contains 1 SANT domain.

Contains 1 SWIRM domain.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 832832Histone H2A deubiquitinase MYSM1
PRO_0000234075

Regions

Domain117 – 16852SANT
Domain374 – 47299SWIRM
Domain574 – 684111MPN
Motif658 – 67114JAMM motif
Motif776 – 7805LXXLL motif

Sites

Metal binding6581Zinc; catalytic By similarity
Metal binding6601Zinc; catalytic By similarity
Metal binding6711Zinc; catalytic By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q5F3F2-1 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 757AE9CA3C19DC57

FASTA83294,556
        10         20         30         40         50         60 
MAAEEPEVDV EGDLAAAPGE AASEGHENTA SSLLQDHYLD SSWRTDNSLP WTLDSSISEE 

        70         80         90        100        110        120 
NRAVIEKMLL EEEYYLSNKS LSEKIWLSQK EAEKRSVKSP HKKTGKVMVR SPTKPGSYSL 

       130        140        150        160        170        180 
KWTSEEKELF EQGLVKYGRR WTKIAKLIGS RTVLQVKSYA RQYFKNKAKN DGSEREEQSQ 

       190        200        210        220        230        240 
HGGTLPTEDG VRVEAWSAGN LRGRADPNLN AVKIEKLSDD EEVDITDDMD ELFSPAFQQG 

       250        260        270        280        290        300 
VGKSELSIIS ESPAEETKGT EHPFPHVGHS SAVSLLKEDP QNTKQPTVDA LLFQDGAATC 

       310        320        330        340        350        360 
SQHVNGDKSV NLEYQQCNDF IEKAEQGRTG MSHGARQITD QELNEEQRDL ADNGLLFHPP 

       370        380        390        400        410        420 
CQVDEDHQEE AEALKPPDQE VEIDRSIILE EEKQAIPEFF EGRQAKTPER YLKIRNYILD 

       430        440        450        460        470        480 
QWERCKPKYL NKTSVRPGLK NCGDVNCIGR IHTYLELIGA INFGCEQAVY NRPQPADKTR 

       490        500        510        520        530        540 
SKEGKDTVEA YQLAQRLQSM RTRRRRVRDP WGNWCDAKDL EGQTFEHLSA EELARRREEE 

       550        560        570        580        590        600 
KLKPSKSSKG SRQIKSSFDP FQLIPCCLFT EEKQEPFQVK VSSEALLIMD LHSHVSMAEV 

       610        620        630        640        650        660 
IGLLGGRYSE ADKVVEVCAA EPCNSLSTGL QCEMDPVSQT QASETLAARG YSVIGWYHSH 

       670        680        690        700        710        720 
PAFDPNPSIR DIDTQAKYQS YFSRGGAMFI GMIVSPYNRN NPLPYSQITC LVISDEISSD 

       730        740        750        760        770        780 
GSYRLPYKFE IQQMLEEPQW ELIFEKTRWI IEKYRFCHSS VPMDKIFHRD SDLTCLQKLL 

       790        800        810        820        830 
ECMRKTLGKV TNCFIAEEFL TQIENLFVSM YKSEKKSNAE ENKNEHSSEL ES

« Hide

Hide | Top

References

[1]"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.
Genome Biol. 6:RESEARCH006.1-RESEARCH006.9(2005) [PubMed: 15642098] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CB.
Tissue: Bursa of Fabricius.

Hide | Top

Cross-references

Sequence databases

AJ851698 mRNA. Translation: CAH65332.1.
IPIIPI00820738.
RefSeqNP_001012945.1.
UniGeneGga.19362

3D structure databases

SMRQ5F3F2. Positions 120-183, 370-472.
ModBaseSearch...

Genome annotation databases

EnsemblENSGALT00000038040; ENSGALP00000037248; ENSGALG00000010869; Gallus gallus. [Genome view]
GeneID424671.
KEGGgga:424671.

Organism-specific databases

CTD424671.

Phylogenomic databases

HOVERGENQ5F3F2.

Family and domain databases

InterProIPR012287. Homeodomain-rel.
IPR000555. Mov34_MPN_PAD1.
IPR014778. Myb_DNA-bd.
IPR001005. SANT_DNA-bd.
IPR017884. SANT_eukarya.
IPR007526. SWIRM.
[Graphical view]
Gene3DG3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
PfamPF01398. Mov34. 1 hit.
PF00249. Myb_DNA-binding. 1 hit.
PF04433. SWIRM. 1 hit.
[Graphical view]
SMARTSM00232. JAB_MPN. 1 hit.
SM00717. SANT. 1 hit.
[Graphical view]
PROSITEPS51293. SANT. 1 hit.
PS50934. SWIRM. 1 hit.
[Graphical view]
ProtoNetSearch...

Hide | Top

Entry information

Entry nameMYSM1_CHICK
AccessionPrimary (citable) accession number: Q5F3F2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 15, 2005
Last modified: September 1, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Hide | Top

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents