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Protein

WW domain-containing oxidoreductase

Gene

WWOX

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development. Inhibits Wnt signaling (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei260 – 2601SubstrateBy similarity
Active sitei293 – 2931Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi131 – 1377NADPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Apoptosis, Wnt signaling pathway

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
WW domain-containing oxidoreductase (EC:1.1.1.-)
Gene namesi
Name:WWOX
ORF Names:RCJMB04_28b1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414WW domain-containing oxidoreductasePRO_0000054818Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5F389.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000008618.

Structurei

3D structure databases

ProteinModelPortaliQ5F389.
SMRiQ5F389. Positions 49-101.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 4934WW 1PROSITE-ProRule annotationAdd
BLAST
Domaini57 – 9034WW 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi50 – 556Nuclear localization signalBy similarity

Sequence similaritiesi

Contains 2 WW domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
COG5021. LUCA.
HOVERGENiHBG078800.
InParanoidiQ5F389.
KOiK19329.
PhylomeDBiQ5F389.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
PF00397. WW. 2 hits.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SMARTiSM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS01159. WW_DOMAIN_1. 2 hits.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5F389-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALKYAGLE DTDSEEELPP GWEERTTKDG WVYYANHLEE KTQWEHPKSG
60 70 80 90 100
KRKRVAGGLP YGWEQETDEN GQVYFVDHIN KRTTYLDPRL AFTVEDNPAK
110 120 130 140 150
PPTRQKYDGN STAMEILQGR DLSGKVIIIT GANSGIGFET AKSFALHGAY
160 170 180 190 200
VILACRNMSR GNDAVQRILE EWHKAKVEAM TLDLASLRSV QNFAEAFKSK
210 220 230 240 250
NMPLHILVCN AAIFGSSWCL TEDGLESTFQ VNHLGHFYLV QLLEDILRRS
260 270 280 290 300
SPARVVVVSS ESHRFTEIKD SSGKLDFSLL SPSKKEYWAM LAYNRSKLCN
310 320 330 340 350
ILFSNELNRR LSPHGVTSNS VHPGNMIYSS IHRNWWVYTL LFTLARPFTK
360 370 380 390 400
SMQQGAATTV YCATAAELEG LGGMYFNNCC RCLPSAEARN ELTAVALWEL
410
SERLIREQLG RRSP
Length:414
Mass (Da):46,730
Last modified:November 22, 2005 - v2
Checksum:i8752D52FBDA29837
GO

Sequence cautioni

The sequence CAH65395 differs from that shown. Reason: Frameshift at position 377. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851761 mRNA. Translation: CAH65395.1. Frameshift.
RefSeqiNP_001025745.2. NM_001030574.2.
UniGeneiGga.22968.
Gga.50350.

Genome annotation databases

GeneIDi415801.
KEGGigga:415801.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851761 mRNA. Translation: CAH65395.1. Frameshift.
RefSeqiNP_001025745.2. NM_001030574.2.
UniGeneiGga.22968.
Gga.50350.

3D structure databases

ProteinModelPortaliQ5F389.
SMRiQ5F389. Positions 49-101.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000008618.

Proteomic databases

PaxDbiQ5F389.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi415801.
KEGGigga:415801.

Organism-specific databases

CTDi51741.

Phylogenomic databases

eggNOGiKOG1208. Eukaryota.
COG1028. LUCA.
COG5021. LUCA.
HOVERGENiHBG078800.
InParanoidiQ5F389.
KOiK19329.
PhylomeDBiQ5F389.

Miscellaneous databases

PROiQ5F389.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
PF00397. WW. 2 hits.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SMARTiSM00456. WW. 2 hits.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiPS01159. WW_DOMAIN_1. 2 hits.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWWOX_CHICK
AccessioniPrimary (citable) accession number: Q5F389
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 22, 2005
Last modified: June 8, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.