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Protein

Multidrug resistance-associated protein 1

Gene

ABCC1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi675 – 682ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1321 – 1328ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 1
Alternative name(s):
ATP-binding cassette sub-family C member 1
Leukotriene C(4) transporter
Short name:
LTC4 transporter
Gene namesi
Name:ABCC1
Synonyms:MRP1
ORF Names:RCJMB04_32d20
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularBy similarityAdd BLAST33
Transmembranei34 – 54Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini55 – 74CytoplasmicBy similarityAdd BLAST20
Transmembranei75 – 95Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini96 – 100ExtracellularBy similarity5
Transmembranei101 – 121Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini122 – 133CytoplasmicBy similarityAdd BLAST12
Transmembranei134 – 154Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini155 – 172ExtracellularBy similarityAdd BLAST18
Transmembranei173 – 193Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini194 – 315CytoplasmicBy similarityAdd BLAST122
Transmembranei316 – 336Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini337 – 362ExtracellularBy similarityAdd BLAST26
Transmembranei363 – 383Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini384 – 439CytoplasmicBy similarityAdd BLAST56
Transmembranei440 – 460Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini461 – 463ExtracellularBy similarity3
Transmembranei464 – 484Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini485 – 546CytoplasmicBy similarityAdd BLAST62
Transmembranei547 – 567Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini568 – 589ExtracellularBy similarityAdd BLAST22
Transmembranei590 – 610Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini611 – 961CytoplasmicBy similarityAdd BLAST351
Transmembranei962 – 982Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini983 – 1019ExtracellularBy similarityAdd BLAST37
Transmembranei1020 – 1040Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1041 – 1083CytoplasmicBy similarityAdd BLAST43
Transmembranei1084 – 1104Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1105ExtracellularBy similarity1
Transmembranei1106 – 1126Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1127 – 1197CytoplasmicBy similarityAdd BLAST71
Transmembranei1198 – 1218Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
Topological domaini1219 – 1220ExtracellularBy similarity2
Transmembranei1221 – 1241Helical; Name=17PROSITE-ProRule annotationAdd BLAST21
Topological domaini1242 – 1525CytoplasmicBy similarityAdd BLAST284

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933551 – 1525Multidrug resistance-associated protein 1Add BLAST1525

Proteomic databases

PaxDbiQ5F364.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010735.

Structurei

3D structure databases

ProteinModelPortaliQ5F364.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini324 – 607ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST284
Domaini641 – 865ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
Domaini969 – 1250ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST282
Domaini1289 – 1521ABC transporter 2PROSITE-ProRule annotationAdd BLAST233

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
HOVERGENiHBG108314.
InParanoidiQ5F364.
KOiK05665.
PhylomeDBiQ5F364.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030241. ABCC1.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF241. PTHR24223:SF241. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5F364-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIESLCSAD ASEPFWDWNL TWHTENPDFT QCFQNTVLVW VPCIYLWVCF
60 70 80 90 100
PAYFLYLRSH DRGYIQMSIL NKAKTALGLI LWIVCWADLF YSFWERSQNI
110 120 130 140 150
FRAPFFLISP TVLGITMLLA TFLIQHERLK GVQSSGVMMI FWLISLLCAT
160 170 180 190 200
VIFRSKIMLA LNTDTEVDAF RYVTFCTYFI LLLVQLILSC FPEKPPLFSE
210 220 230 240 250
AVNDPKPCPE FSASFLSRIT FWWITGLMIQ GHRRPLEAKD LWSLNKEDTS
260 270 280 290 300
EEIVPGLAKN WAKEWAKTKR QPLNMLYSSK KQQKSSDSNG EVMEEAEALI
310 320 330 340 350
IKPSQRSSEA SLSKVLYKTF GPYFLMSFLF KAAHDLLMFT GPEILKLLIN
360 370 380 390 400
FVNNKSAPNW QGYFYTGLLF VCACLQTLIL HQYFHICFVT GMRLKTAIVG
410 420 430 440 450
VIYRKALVIT NSARKTSTVG EIVNLMSVDA QRFMDLATYI NMIWSAPLQV
460 470 480 490 500
ILALYLLWRN LGPSVLAGVA VMILLVPINA VMAMKTKTYQ VAQMKSKDNR
510 520 530 540 550
IKLMNEILNG IKVLKLYAWE LAFREKVLEI RQKELKVLKK SAYLAAMGTF
560 570 580 590 600
TWVCAPFLVA LSTFAVYVKV NKNNILDAQK AFVSLALFNI LRFPLNILPM
610 620 630 640 650
VISSIVEASV SLKRLRVFLS HEELDPDSII RGPITNAEGS IVVKNATFSW
660 670 680 690 700
SKTDPPSLNS INFTVPEGSL IAVVGQVGCG KSSLLSALLG EMDKKEGYVV
710 720 730 740 750
VKGSIAYVPQ QAWIQNATLE DNIIFGREMN ESRYKRVIEA CALLPDLEIL
760 770 780 790 800
PMGDRTEIGE KGVNLSGGQK QRVSLARAVY CNADTYLFDD PLSAVDAHVG
810 820 830 840 850
KHIFEKVIGP KGILKNKTRV LVTHAVNYLP QMDTILVMTD GEISEMGSYQ
860 870 880 890 900
ELLKQDGAFA EFLRTYANAE QSMESSDASS PSGKEGKPVE NGVLVNDATG
910 920 930 940 950
KLMHRQLSNS STYSRETGKS QHQSSTAELQ KPLAEKNSWK LTEADTAKTG
960 970 980 990 1000
RVKATVYWEY MKAIGLYISF LSVFLFMCNH IASLASNYWL SLWTDDPVVN
1010 1020 1030 1040 1050
GTQQYTNVRL GVYGALGISQ GIAVFGYSMA VSIGGIFASR HLHLDLLHNV
1060 1070 1080 1090 1100
LRSPMSFFER TPSGNLVSRF SKEIDTIDST IPPIIKMFMG STFNVIGACI
1110 1120 1130 1140 1150
IILLATPIAA VVIPPLGLVY LLVQRFYVAT SRQLKRLESV SRSPVYSHFN
1160 1170 1180 1190 1200
ETLLGVSVIR AFEEQKRFIK QNDMKVDENQ KAYYPSIVAN RWLAVRLEFV
1210 1220 1230 1240 1250
GNCIVLFAAL FAVIARNKLS PGLIGLSVSY SLQITAYLNW LVRMTSDLET
1260 1270 1280 1290 1300
NIVAVERVKE YAEMEKEAEW SIEETAPAST WPQEGKVEFR GFGLRYREDL
1310 1320 1330 1340 1350
DLVLKNINIT INGGEKVGIV GRTGAGKSSL TLGLFRINEA AEGEIIIDGI
1360 1370 1380 1390 1400
NIAKIGLHDL RFKITIIPQD PILFSGSLRM NLDPFDQHSD EDIWRSLELA
1410 1420 1430 1440 1450
HLKNFVSSLP DKLNHECSEG GENLSVGQRQ LVCLARALLR KSKILVLDEA
1460 1470 1480 1490 1500
TAAVDLETDN LIQSTIKSQF EECTVLTIAH RLNTIMDYTR VLVLDRGEVV
1510 1520
ECDSPDNLLQ AKGLFYSMAK DSGLA
Length:1,525
Mass (Da):170,972
Last modified:March 15, 2005 - v1
Checksum:i38724B6711B878FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851786 mRNA. Translation: CAH65420.1.
RefSeqiNP_001012540.1. NM_001012522.1.
UniGeneiGga.1310.

Genome annotation databases

GeneIDi395416.
KEGGigga:395416.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851786 mRNA. Translation: CAH65420.1.
RefSeqiNP_001012540.1. NM_001012522.1.
UniGeneiGga.1310.

3D structure databases

ProteinModelPortaliQ5F364.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010735.

Proteomic databases

PaxDbiQ5F364.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395416.
KEGGigga:395416.

Organism-specific databases

CTDi4363.

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
HOVERGENiHBG108314.
InParanoidiQ5F364.
KOiK05665.
PhylomeDBiQ5F364.

Miscellaneous databases

PROiQ5F364.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030241. ABCC1.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24223:SF241. PTHR24223:SF241. 2 hits.
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRP1_CHICK
AccessioniPrimary (citable) accession number: Q5F364
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 15, 2005
Last modified: October 5, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.