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Q5F363 (JARD2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein Jumonji
Alternative name(s):
Jumonji/ARID domain-containing protein 2
Gene names
Name:JARID2
Synonyms:JMJ
ORF Names:RCJMB04_32g20
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length1233 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Regulator of histone methyltransferase complexes that plays an essential role in embryonic development. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development By similarity.

Subunit structure

Associates with the PRC2 complex By similarity.

Subcellular location

Nucleus. Note: Colocalizes with the PRC2 complex on chromatin.

Domain

The ARID domain is required to target the PRC2 complex to its target genes By similarity.

Sequence similarities

Belongs to the JARID2 family.

Contains 1 ARID domain.

Contains 1 JmjC domain.

Contains 1 JmjN domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12331233Protein Jumonji
PRO_0000391907

Regions

Domain546 – 58742JmjN
Domain610 – 70293ARID
Domain873 – 1037165JmjC
Motif102 – 1087Nuclear localization signal By similarity
Motif863 – 8675GSGFP motif
Compositional bias181 – 19111Poly-Glu
Compositional bias788 – 7936Poly-Glu
Compositional bias1223 – 123311Poly-Ser

Sequences

Sequence LengthMass (Da)Tools
Q5F363 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: 6386F8A089BBA7B7

FASTA1,233138,110
        10         20         30         40         50         60 
MSKERPKRNI IQKEYDDSDG IPWSEERVVR KVLYLSLKEF KNAQKRQHGD GISGSLKAVN 

        70         80         90        100        110        120 
GLLTNGQSKG LESEQLENEK DDASQVSSTS NDISSSDFEE GPSRKRPRLQ AQRKFAQSQP 

       130        140        150        160        170        180 
NSPSTTPIKI VEPLLPPPAT QISDLSKRKP KTEDFLTFLC LRGSPALPSN MVYFGSSQDD 

       190        200        210        220        230        240 
EDEEEEEEET EDTKTATNNA SSSCQSTPRK GKTHKQVPNG QVFNGSSKSL KEKEPAQKHK 

       250        260        270        280        290        300 
SKEATPGKEK NSEHKAESRK DQAAANHHPT TNTGSSTKGL TANNHHTLHR SAQDLRKQVS 

       310        320        330        340        350        360 
KVNGITRMSS PSANAASAKK MRDVRPSPSK TVKYTATVTK GTVTYTKAKK ELVKETKLNH 

       370        380        390        400        410        420 
HKPSSPVNHT ISGKLESSNA KTRKQVLSLG ASKSNNTAVN GVKVNGKLNQ KTCTKEVGRQ 

       430        440        450        460        470        480 
LREGLRNSKR RLEETNHIDK IQSPTKRMKG AVNLAEAASK KAVVEKPLLN GHLKKEVPEK 

       490        500        510        520        530        540 
NLERNRPKRA TAGKSTPGKQ AHGKTENASC ENRSTSQAES LHKPQDSMGK HEKGSSKSGW 

       550        560        570        580        590        600 
GMLGEIPILR PSTKEFHDPL IYIESVRAQV EKYGMCRVIP PPDWRPECKL NDEMRFVTQI 

       610        620        630        640        650        660 
QHIHKLGRRW GPNVQRLACI KKHLKSQGIT MDELPLIGGC ELDLACFVQL INEMGGMQQV 

       670        680        690        700        710        720 
TDLKKWNKLA DMLRIPKTAQ DRLAKLQEAY CQYLLSYDSL SPEEHKKLEK EVLLEKEILE 

       730        740        750        760        770        780 
KRKGPLEGHS ENAYKFHSLP RFEPKNGLIN GVVHKNGFRN KLKEVDVPLK TGRRRLFAQE 

       790        800        810        820        830        840 
KETTKDDEEE EEEGVLSDLH KCIYKGRSVS LTTFYRTARN IMNMCFTKEP TVAEVEQEYW 

       850        860        870        880        890        900 
RLVEQKDSHV AVHCGKVDTN THGSGFPVGK SEPFSRHGWN LTVLPNNTGS ILRHLGAVPG 

       910        920        930        940        950        960 
VTIPWLNIGM VFSTSCWSRD QNHLPYIDYL HTGADCIWYC IPAAEENKLD DVVHTLLQAN 

       970        980        990       1000       1010       1020 
GTPGLEMLES NVMISPEILC KEGIRVHRTV QQSGQFVVCF PGSFVSKVCC GYSVSETVHF 

      1030       1040       1050       1060       1070       1080 
ATTQWTSMGF KTAKEMKRRR IAKPFSMEKL LYQIATAEAK KENGPTLSTI SSLLGELRDT 

      1090       1100       1110       1120       1130       1140 
ELRQRRQLYE AGLHSSARYG SHDSSSTAMD GKKKPRKWLQ LETSERRCQI CQHLCYLSMV 

      1150       1160       1170       1180       1190       1200 
VQENENVVFC LECALRHVEK QKSCRGLKMM YRYDEEQIIS LVNQICGKVS GKNGSIENCI 

      1210       1220       1230 
SKPTPKRGPR KRATVDVPSS RLSSSSSSKS ASS

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References

[1]"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.
Genome Biol. 6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CB.
Tissue: Bursa of Fabricius.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ851787 mRNA. Translation: CAH65421.1.
IPIIPI00597467.
RefSeqNP_001012880.1. NM_001012862.1.
UniGeneGga.12117.

3D structure databases

ProteinModelPortalQ5F363.
ModBaseSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000020711.

Proteomic databases

PaxDbQ5F363.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID420839.
KEGGgga:420839.

Organism-specific databases

CTD3720.

Phylogenomic databases

eggNOGNOG327026.
HOGENOMHOG000013203.
HOVERGENHBG052160.
InParanoidQ5F363.
KOK11478.
OrthoDBEOG4KKZ26.

Family and domain databases

Gene3D1.10.150.60. 1 hit.
InterProIPR001606. ARID/BRIGHT_DNA-bd.
IPR003347. JmjC_dom.
IPR003349. TF_JmjN.
IPR004198. Znf_C5HC2.
[Graphical view]
PfamPF01388. ARID. 1 hit.
PF02373. JmjC. 1 hit.
PF02375. JmjN. 1 hit.
PF02928. zf-C5HC2. 1 hit.
[Graphical view]
SMARTSM00501. BRIGHT. 1 hit.
SM00558. JmjC. 1 hit.
SM00545. JmjN. 1 hit.
[Graphical view]
SUPFAMSSF46774. ARID. 1 hit.
PROSITEPS51011. ARID. 1 hit.
PS51184. JMJC. 1 hit.
PS51183. JMJN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20823696.

Entry information

Entry nameJARD2_CHICK
AccessionPrimary (citable) accession number: Q5F363
Entry history
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: March 15, 2005
Last modified: April 3, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents