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Protein

Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

Gene

PIP4K2A

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation (By similarity).By similarity

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-1660499. Synthesis of PIPs at the plasma membrane.
R-GGA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC:2.7.1.149)
Alternative name(s):
1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha
Diphosphoinositide kinase 2-alpha
Phosphatidylinositol 5-phosphate 4-kinase type II alpha
Short name:
PI(5)P 4-kinase type II alpha
Short name:
PIP4KII-alpha
PtdIns(5)P-4-kinase isoform 2-alpha
Gene namesi
Name:PIP4K2A
Synonyms:PIP5K2A
ORF Names:RCJMB04_33l24
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity
  • Cell membrane By similarity

  • Note: May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Phosphatidylinositol 5-phosphate 4-kinase type-2 alphaPRO_0000185469Add
BLAST

Proteomic databases

PaxDbiQ5F356.

Expressioni

Gene expression databases

ExpressionAtlasiQ5F356. baseline and differential.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012779.

Structurei

3D structure databases

ProteinModelPortaliQ5F356.
SMRiQ5F356. Positions 28-405.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 404373PIPKPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PIPK domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0229. Eukaryota.
COG5253. LUCA.
HOGENOMiHOG000007832.
HOVERGENiHBG000072.
InParanoidiQ5F356.
KOiK00920.
PhylomeDBiQ5F356.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 1 hit.
InterProiIPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF01504. PIP5K. 1 hit.
[Graphical view]
SMARTiSM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5F356-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPGTVASV MASKTKTKKK HFVVQKVKLF RASDPLLSVL MWGVNHSINE
60 70 80 90 100
LSHVQIPVML MPDDFKAYSK IKVDNHLFNK ENMPSHFKFK EYCPMVFRNL
110 120 130 140 150
RERFGIDDQD FQNSLTRSAP LANDSQARSG ARFHTSYDKR YIIKTITSED
160 170 180 190 200
VAEMHNILKK YHQFIVECHG NTLLPQFLGM YRLTVDGVEI YMIVTRNVFS
210 220 230 240 250
HRLSVYRKYD LKGSTVAREA SDKEKAKELP TFKDNDFIND GQKIHIDENN
260 270 280 290 300
KRMFLEKLKK DVEFLAQLKL MDYSLLVGIH DVERAEQEEV ECEENDGEDE
310 320 330 340 350
GESDGTHPIG TPPDSPGNTL NSSLPLAPGE FDPAIDVYGI KSHESAPRKE
360 370 380 390 400
VYFMAIIDIL THYDAKKKAA HAAKTVKHGA GAEISTVNPE QYSKRFLDFI

ANILT
Length:405
Mass (Da):46,092
Last modified:March 15, 2005 - v1
Checksum:i14331C226B3C6DB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851794 mRNA. Translation: CAH65428.1.
RefSeqiNP_001026142.1. NM_001030971.1.
UniGeneiGga.22009.

Genome annotation databases

GeneIDi420504.
KEGGigga:420504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851794 mRNA. Translation: CAH65428.1.
RefSeqiNP_001026142.1. NM_001030971.1.
UniGeneiGga.22009.

3D structure databases

ProteinModelPortaliQ5F356.
SMRiQ5F356. Positions 28-405.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012779.

Proteomic databases

PaxDbiQ5F356.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi420504.
KEGGigga:420504.

Organism-specific databases

CTDi5305.

Phylogenomic databases

eggNOGiKOG0229. Eukaryota.
COG5253. LUCA.
HOGENOMiHOG000007832.
HOVERGENiHBG000072.
InParanoidiQ5F356.
KOiK00920.
PhylomeDBiQ5F356.

Enzyme and pathway databases

ReactomeiR-GGA-1660499. Synthesis of PIPs at the plasma membrane.
R-GGA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Miscellaneous databases

PROiQ5F356.

Gene expression databases

ExpressionAtlasiQ5F356. baseline and differential.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 1 hit.
InterProiIPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF01504. PIP5K. 1 hit.
[Graphical view]
SMARTiSM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiPI42A_CHICK
AccessioniPrimary (citable) accession number: Q5F356
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: March 15, 2005
Last modified: June 8, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.