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Protein

GTPase NRas

Gene

NRAS

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Enzyme regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178GTPBy similarity
Nucleotide bindingi57 – 615GTPBy similarity
Nucleotide bindingi116 – 1194GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-1169092. Activation of RAS in B cells.
R-GGA-1250347. SHC1 events in ERBB4 signaling.
R-GGA-1433557. Signaling by SCF-KIT.
R-GGA-171007. p38MAPK events.
R-GGA-179812. GRB2 events in EGFR signaling.
R-GGA-180336. SHC1 events in EGFR signaling.
R-GGA-186763. Downstream signal transduction.
R-GGA-1963640. GRB2 events in ERBB2 signaling.
R-GGA-210993. Tie2 Signaling.
R-GGA-2179392. EGFR Transactivation by Gastrin.
R-GGA-2424491. DAP12 signaling.
R-GGA-2871796. FCERI mediated MAPK activation.
R-GGA-375165. NCAM signaling for neurite out-growth.
R-GGA-5218921. VEGFR2 mediated cell proliferation.
R-GGA-5621575. CD209 (DC-SIGN) signaling.
R-GGA-5654688. SHC-mediated cascade:FGFR1.
R-GGA-5654693. FRS-mediated FGFR1 signaling.
R-GGA-5654699. SHC-mediated cascade:FGFR2.
R-GGA-5654700. FRS-mediated FGFR2 signaling.
R-GGA-5654704. SHC-mediated cascade:FGFR3.
R-GGA-5654706. FRS-mediated FGFR3 signaling.
R-GGA-5654712. FRS-mediated FGFR4 signaling.
R-GGA-5654719. SHC-mediated cascade:FGFR4.
R-GGA-5658442. Regulation of RAS by GAPs.
R-GGA-5673000. RAF activation.
R-GGA-5673001. RAF/MAP kinase cascade.
R-GGA-5674135. MAP2K and MAPK activation.
R-GGA-5675221. Negative regulation of MAPK pathway.
R-GGA-8849471. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase NRas
Alternative name(s):
Transforming protein N-Ras
Gene namesi
Name:NRAS
ORF Names:RCJMB04_34f10
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 26

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186GTPase NRasPRO_0000043016Add
BLAST
Propeptidei187 – 1893Removed in mature formBy similarityPRO_0000043017

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi181 – 1811S-palmitoyl cysteineBy similarity
Modified residuei186 – 1861Cysteine methyl esterBy similarity
Lipidationi186 – 1861S-farnesyl cysteineBy similarity

Post-translational modificationi

Palmitoylated by the ZDHHC9-GOLGA7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi (By similarity).By similarity

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PaxDbiQ5F352.
PRIDEiQ5F352.

Expressioni

Gene expression databases

ExpressionAtlasiQ5F352. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000003258.

Structurei

3D structure databases

ProteinModelPortaliQ5F352.
SMRiQ5F352. Positions 1-166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni166 – 18520Hypervariable regionBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi32 – 409Effector region

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121849.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ5F352.
KOiK07828.
OMAiFAVNNAK.
PhylomeDBiQ5F352.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5F352-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET
60 70 80 90 100
CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNSKSF ADINLYREQI
110 120 130 140 150
KRVKDSDDVP MVLVGNKCDL PTRTVDTKQA QELAKSYGIP FIETSAKTRQ
160 170 180
GVEDAFYTLV REIRQYRMKK LNSNEDGNQG CMGLSCIVM
Length:189
Mass (Da):21,278
Last modified:March 15, 2005 - v1
Checksum:i52A8D86371920698
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851798 mRNA. Translation: CAH65432.1.
RefSeqiNP_001012567.1. NM_001012549.1.
UniGeneiGga.22051.

Genome annotation databases

EnsembliENSGALT00000043422; ENSGALP00000043468; ENSGALG00000026692.
GeneIDi419885.
KEGGigga:419885.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851798 mRNA. Translation: CAH65432.1.
RefSeqiNP_001012567.1. NM_001012549.1.
UniGeneiGga.22051.

3D structure databases

ProteinModelPortaliQ5F352.
SMRiQ5F352. Positions 1-166.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000003258.

Proteomic databases

PaxDbiQ5F352.
PRIDEiQ5F352.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000043422; ENSGALP00000043468; ENSGALG00000026692.
GeneIDi419885.
KEGGigga:419885.

Organism-specific databases

CTDi4893.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121849.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ5F352.
KOiK07828.
OMAiFAVNNAK.
PhylomeDBiQ5F352.

Enzyme and pathway databases

ReactomeiR-GGA-1169092. Activation of RAS in B cells.
R-GGA-1250347. SHC1 events in ERBB4 signaling.
R-GGA-1433557. Signaling by SCF-KIT.
R-GGA-171007. p38MAPK events.
R-GGA-179812. GRB2 events in EGFR signaling.
R-GGA-180336. SHC1 events in EGFR signaling.
R-GGA-186763. Downstream signal transduction.
R-GGA-1963640. GRB2 events in ERBB2 signaling.
R-GGA-210993. Tie2 Signaling.
R-GGA-2179392. EGFR Transactivation by Gastrin.
R-GGA-2424491. DAP12 signaling.
R-GGA-2871796. FCERI mediated MAPK activation.
R-GGA-375165. NCAM signaling for neurite out-growth.
R-GGA-5218921. VEGFR2 mediated cell proliferation.
R-GGA-5621575. CD209 (DC-SIGN) signaling.
R-GGA-5654688. SHC-mediated cascade:FGFR1.
R-GGA-5654693. FRS-mediated FGFR1 signaling.
R-GGA-5654699. SHC-mediated cascade:FGFR2.
R-GGA-5654700. FRS-mediated FGFR2 signaling.
R-GGA-5654704. SHC-mediated cascade:FGFR3.
R-GGA-5654706. FRS-mediated FGFR3 signaling.
R-GGA-5654712. FRS-mediated FGFR4 signaling.
R-GGA-5654719. SHC-mediated cascade:FGFR4.
R-GGA-5658442. Regulation of RAS by GAPs.
R-GGA-5673000. RAF activation.
R-GGA-5673001. RAF/MAP kinase cascade.
R-GGA-5674135. MAP2K and MAPK activation.
R-GGA-5675221. Negative regulation of MAPK pathway.
R-GGA-8849471. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.

Miscellaneous databases

PROiQ5F352.

Gene expression databases

ExpressionAtlasiQ5F352. baseline.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiRASN_CHICK
AccessioniPrimary (citable) accession number: Q5F352
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 15, 2005
Last modified: July 6, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.