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Protein

GTPase NRas

Gene

NRAS

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Enzyme regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTPBy similarity8
Nucleotide bindingi57 – 61GTPBy similarity5
Nucleotide bindingi116 – 119GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-1169092 Activation of RAS in B cells
R-GGA-1250347 SHC1 events in ERBB4 signaling
R-GGA-1433557 Signaling by SCF-KIT
R-GGA-179812 GRB2 events in EGFR signaling
R-GGA-180336 SHC1 events in EGFR signaling
R-GGA-186763 Downstream signal transduction
R-GGA-1963640 GRB2 events in ERBB2 signaling
R-GGA-210993 Tie2 Signaling
R-GGA-2179392 EGFR Transactivation by Gastrin
R-GGA-2424491 DAP12 signaling
R-GGA-2871796 FCERI mediated MAPK activation
R-GGA-375165 NCAM signaling for neurite out-growth
R-GGA-5218921 VEGFR2 mediated cell proliferation
R-GGA-5621575 CD209 (DC-SIGN) signaling
R-GGA-5654688 SHC-mediated cascade:FGFR1
R-GGA-5654693 FRS-mediated FGFR1 signaling
R-GGA-5654699 SHC-mediated cascade:FGFR2
R-GGA-5654700 FRS-mediated FGFR2 signaling
R-GGA-5654704 SHC-mediated cascade:FGFR3
R-GGA-5654706 FRS-mediated FGFR3 signaling
R-GGA-5654712 FRS-mediated FGFR4 signaling
R-GGA-5654719 SHC-mediated cascade:FGFR4
R-GGA-5658442 Regulation of RAS by GAPs
R-GGA-5673000 RAF activation
R-GGA-5673001 RAF/MAP kinase cascade
R-GGA-5674135 MAP2K and MAPK activation
R-GGA-5675221 Negative regulation of MAPK pathway
R-GGA-6798695 Neutrophil degranulation
R-GGA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-GGA-8851805 MET activates RAS signaling

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase NRas
Alternative name(s):
Transforming protein N-Ras
Gene namesi
Name:NRAS
ORF Names:RCJMB04_34f10
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000430161 – 186GTPase NRasAdd BLAST186
PropeptideiPRO_0000043017187 – 189Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi181S-palmitoyl cysteineBy similarity1
Modified residuei186Cysteine methyl esterBy similarity1
Lipidationi186S-farnesyl cysteineBy similarity1

Post-translational modificationi

Palmitoylated by the ZDHHC9-GOLGA7 complex. Depalmitoylated by ABHD17A, ABHD17B and ABHD17C. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PaxDbiQ5F352
PRIDEiQ5F352

Expressioni

Gene expression databases

BgeeiENSGALG00000026692

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000003258

Structurei

3D structure databases

ProteinModelPortaliQ5F352
SMRiQ5F352
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni166 – 185Hypervariable regionBy similarityAdd BLAST20

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiQ5F352
KOiK07828
OMAiTIEXEQI
OrthoDBiEOG091G0UAU
PhylomeDBiQ5F352

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5F352-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET
60 70 80 90 100
CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNSKSF ADINLYREQI
110 120 130 140 150
KRVKDSDDVP MVLVGNKCDL PTRTVDTKQA QELAKSYGIP FIETSAKTRQ
160 170 180
GVEDAFYTLV REIRQYRMKK LNSNEDGNQG CMGLSCIVM
Length:189
Mass (Da):21,278
Last modified:March 15, 2005 - v1
Checksum:i52A8D86371920698
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ851798 mRNA Translation: CAH65432.1
RefSeqiNP_001012567.1, NM_001012549.1
UniGeneiGga.22051

Genome annotation databases

GeneIDi419885
KEGGigga:419885

Similar proteinsi

Entry informationi

Entry nameiRASN_CHICK
AccessioniPrimary (citable) accession number: Q5F352
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 15, 2005
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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