Q5F339 (CCHL_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c-type heme lyase
Short name=CCHL
EC=4.4.1.17

Alternative name(s):
Holocytochrome c-type synthase

Gene names

Name:	HCCS
ORF Names:	RCJMB04_37l21

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Links covalently the heme group to the apoprotein of cytochrome c By similarity.
Catalytic activity	Holocytochrome c = apocytochrome c + heme.
Subcellular location	Mitochondrion inner membrane Potential.
Sequence similarities	Belongs to the cytochrome c-type heme lyase family. Contains 2 HRM (heme regulatory motif) repeats.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Repeat
Ligand	Heme Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	holocytochrome-c synthase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	Cytochrome c-type heme lyase		PRO_0000331126
Regions
	Repeat	30 – 35	6	HRM 1
	Repeat	40 – 45	6	HRM 2

Sequences

	Sequence		Length	Mass (Da)
	Q5F339 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: B38205DFF1E3E32D	FASTA	273	31,438
	10 20 30 40 50 60 MGLSASSPAA TAQSAAEPSK QHQVASPPSE CPMHQEKMRG CPMHMKASDR RAENTDDVPA 70 80 90 100 110 120 HQERAYEYVA CPVKSGASQV NDDIDPSNMM PPPNQLPSPD QPFPLSTVRE ESSIPRAHSD 130 140 150 160 170 180 KKWVYPSEQM FWNAMLRKGW RWKDDDITSE DMTNIIKIHN QNNEQAWKEI LKWEALHAME 190 200 210 220 230 240 CPCGPSLMRF GGKAKEYSPR ARIRSWMGYE LPFDRHDWIV DRCGKEVRYV IDYYDGGAVD 250 260 270 KNYQFTILDV RPAFDSLSAV WDRMKVAWWR WTS

References

[1]

"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:R6.1-R6.9(2005) [PubMed: 15642098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ851811 mRNA. Translation: CAH65445.1.
IPI	IPI00651481.
RefSeq	NP_001026446.1. NM_001031275.1.
UniGene	Gga.9645.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5F339.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	424482.
KEGG	gga:424482.
Organism-specific databases
CTD	3052.
Phylogenomic databases
eggNOG	veNOG06130.
GeneTree	ENSGT00390000004175.
HOGENOM	HBG627179.
HOVERGEN	HBG001566.
InParanoid	Q5F339.
OrthoDB	EOG4RJG2H.
PhylomeDB	Q5F339.
Family and domain databases
InterPro	IPR000511. Cyt_C/C1_haem_lyase. [Graphical view]
KO	K01764.
PANTHER	PTHR12743. Cyto_heme_lyase. 1 hit.
Pfam	PF01265. Cyto_heme_lyase. 1 hit. [Graphical view]
PROSITE	PS00821. CYTO_HEME_LYASE_1. 1 hit. PS00822. CYTO_HEME_LYASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCHL_CHICK

Accession

Primary (citable) accession number: Q5F339

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	March 15, 2005
Last modified:	November 16, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program