Q5F2J0 (PTP1_ENCIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Polar tube protein 1

Alternative name(s):
Major polar tube protein
Short name=Major PTP

Gene names

Name:

PTP1

Organism

Encephalitozoon intestinalis (Microsporidian parasite)

Taxonomic identifier

58839 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Microsporidia › Apansporoblastina › Unikaryonidae › Encephalitozoon

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved with PTP2 and PTP3 in formation of a polar tube through which the infectious agent is passed on to the host cell By similarity.
Subcellular location	Spore polar tube By similarity.
Post-translational modification	Glycosylated. Ref.2
Miscellaneous	The host antibody response is directed against the post-translational carbohydrate modification.

Ontologies

Keywords
Biological process	Sporulation
Domain	Signal
PTM	Glycoprotein
Gene Ontology (GO)
Biological_process	sporulation resulting in formation of a cellular spore Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	polar tube Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 371	349	Polar tube protein 1		PRO_0000377522

Sequences

	Sequence		Length	Mass (Da)
	Q5F2J0 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 1A9733EB8B5B6625	FASTA	371	37,520
	10 20 30 40 50 60 MKGISKVLSA SIVLMKLKGV YSTTVLCGDS TQGLQGTTQP SYVLVPSAPE TIANCGYSPQ 70 80 90 100 110 120 NMYVPSTPTT MPSTVPGTTG ESETPTSPTS SPTEDVGTCK IAVVKHCDAP GTSSTPCEPE 130 140 150 160 170 180 QTLAPSQPVA ATIATPLVVA SVQTPQAAVT ILTPKAVSAQ PATIISPFNQ APGYYNSAIP 190 200 210 220 230 240 GQILTGNVLS PSASSCQVVP GTTGSSTPQQ LPGAVSSGTI PCQIVQGTQS SGNTPGQQFL 250 260 270 280 290 300 PGIVPVGSLQ PDQATSGTPT PSVSQSQSGQ QCCCTPPITN PVMPTPMGIS SNGYPSSTAY 310 320 330 340 350 360 APTLGQLGPC IDTQKSTSSC EPKEKPVAQY GMEACAAPTP TAVLGNAEYL LSPGMYNSLN 370 SPCNACCQQQ C

References

[1]	"Microsporidian invasion apparatus: identification of a novel polar tube protein and evidence for clustering of ptp1 and ptp2 genes in three Encephalitozoon species." Delbac F., Peuvel I., Metenier G., Peyretaillade E., Vivares C.P. Infect. Immun. 69:1016-1024(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Carbohydrate moieties of microsporidian polar tube proteins are targeted by immunoglobulin G in immunocompetent individuals." Peek R., Delbac F., Speijer D., Polonais V., Greve S., Wentink-Bonnema E., Ringrose J., van Gool T. Infect. Immun. 73:7906-7913(2005) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION AS AN ANTIGEN, GLYCOSYLATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AX007051 Genomic DNA. No translation available. AJ880382 Genomic DNA. Translation: CAI54279.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

PTP1_ENCIN

Accession

Primary (citable) accession number: Q5F2J0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2009
Last sequence update:	March 15, 2005
Last modified:	April 3, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program