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Q5F2E8

- TAOK1_MOUSE

UniProt

Q5F2E8 - TAOK1_MOUSE

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Protein
Serine/threonine-protein kinase TAO1
Gene
Taok1, Kiaa1361
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Serine/threonine-protein kinase activity is inhibited by SPRED1 By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei57 – 571ATP By similarity
Active sitei151 – 1511Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi34 – 429ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase kinase kinase activity Source: RefGenome
  3. protein serine/threonine kinase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. DNA repair Source: UniProtKB-KW
  2. G2 DNA damage checkpoint Source: UniProtKB
  3. MAPK cascade Source: GOC
  4. activation of MAPKK activity Source: GOC
  5. cellular response to DNA damage stimulus Source: UniProtKB
  6. execution phase of apoptosis Source: UniProtKB
  7. intracellular signal transduction Source: RefGenome
  8. positive regulation of JNK cascade Source: UniProtKB
  9. positive regulation of stress-activated MAPK cascade Source: UniProtKB
  10. regulation of cytoskeleton organization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Apoptosis, DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase TAO1 (EC:2.7.11.1)
Alternative name(s):
Thousand and one amino acid protein 1
Gene namesi
Name:Taok1
Synonyms:Kiaa1361
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1914490. Taok1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10011001Serine/threonine-protein kinase TAO1
PRO_0000086729Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91Phosphoserine By similarity
Modified residuei421 – 4211Phosphoserine1 Publication
Modified residuei445 – 4451Phosphoserine By similarity
Modified residuei669 – 6691Phosphothreonine By similarity
Modified residuei965 – 9651Phosphoserine By similarity

Post-translational modificationi

Proteolytically processed by caspase-3 (CASP3).
Autophosphorylated By similarity. Phosphorylated by ATM in response to DNA damage. Phosphorylated by LRRK2.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5F2E8.
PRIDEiQ5F2E8.

PTM databases

PhosphoSiteiQ5F2E8.

Expressioni

Gene expression databases

ArrayExpressiQ5F2E8.
BgeeiQ5F2E8.
CleanExiMM_TAOK1.
GenevestigatoriQ5F2E8.

Interactioni

Subunit structurei

Self-associates. Interacts with MAP2K3. Interacts with SPRED1 and TESK1. Interacts with MAP3K7 By similarity.

Protein-protein interaction databases

BioGridi229824. 2 interactions.
IntActiQ5F2E8. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ5F2E8.
SMRiQ5F2E8. Positions 12-376.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 281254Protein kinase
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili458 – 651194 Reviewed prediction
Add
BLAST
Coiled coili754 – 877124 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi330 – 3345Poly-Glu

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00740000114927.
HOGENOMiHOG000236358.
HOVERGENiHBG088996.
InParanoidiQ5F2E8.
KOiK04429.
OMAiAGPHWGH.
OrthoDBiEOG74XS5S.
PhylomeDBiQ5F2E8.
TreeFamiTF351444.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5F2E8-1 [UniParc]FASTAAdd to Basket

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MPSTNRAGSL KDPEIAELFF KEDPEKLFTD LREIGHGSFG AVYFARDVRT     50
NEVVAIKKMS YSGKQSTEKW QDIIKEVKFL QRIKHPNSIE YKGCYLREHT 100
AWLVMEYCLG SASDLLEVHK KPLQEVEIAA ITHGALQGLA YLHSHTMIHR 150
DIKAGNILLT EPGQVKLADF GSASMASPAN SFVGTPYWMA PEVILAMDEG 200
QYDGKVDVWS LGITCIELAE RKPPLFNMNA MSALYHIAQN ESPTLQSNEW 250
SDYFRNFVDS CLQKIPQDRP TSEELLKHMF VLRERPETVL IDLIQRTKDA 300
VRELDNLQYR KMKKLLFQEA HNGPAVEAQE EEEEQDHGVG RTGTVNSVGS 350
NQSIPSMSIS ASSQSSSVNS LPDASDDKSE LDMMEGDHTV MSNSSVIHLK 400
PEEENYQEEG DPRTRASDPQ SPPQVSRHKS HYRNREHFAT IRTASLVTRQ 450
MQEHEQDSEL REQMSGYKRM RRQHQKQLMT LENKLKAEMD EHRLRLDKDL 500
ETQRNNFAAE MEKLIKKHQA AMEKEAKVMA NEEKKFQQHI QAQQKKELNS 550
FLESQKREYK LRKEQLKEEL NENQSTPKKE KQEWLSKQKE NIQHFQAEEE 600
ANLLRRQRQY LELECRRFKR RMLLGRHNLE QDLVREELNK RQTQKDLEHA 650
MLLRQHESMQ ELEFRHLNTI QKMRCELIRL QHQTELTNQL EYNKRREREL 700
RRKHVMEVRQ QPKSLKSKEL QIKKQFQDTC KIQTRQYKAL RNHLLETTPK 750
SEHKAVLKRL KEEQTRKLAI LAEQYDHSIN EMLSTQALRL DEAQEAECQV 800
LKMQLQQELE LLNAYQSKIK MQAEAQHDRE LRELEQRVSL RRALLEQKIE 850
EEMLALQNER TERIRSLLER QAREIEAFDS ESMRLGFSNM VLSNLSPEAF 900
SHSYPGASSW SHNPTGGPGP HWGHPMGGTP QAWGHPMQGG PQPWGHPSGP 950
MQGVPRGSSM GVRNSPQALR RTASGGRTEQ GMSRSTSVTS QISNGSHMSY 1000
T 1001
Length:1,001
Mass (Da):116,050
Last modified:March 15, 2005 - v1
Checksum:i59DF437EAB8127C2
GO

Sequence cautioni

The sequence AAH16522.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAD32434.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591136 Genomic DNA. Translation: CAI51877.1.
BC016522 mRNA. Translation: AAH16522.1. Different initiation.
BC034906 mRNA. Translation: AAH34906.1.
AK173156 mRNA. Translation: BAD32434.1. Different initiation.
CCDSiCCDS36235.1.
RefSeqiNP_659074.2. NM_144825.2.
XP_006533020.1. XM_006532957.1.
XP_006533021.1. XM_006532958.1.
XP_006533022.1. XM_006532959.1.
UniGeneiMm.340436.

Genome annotation databases

EnsembliENSMUST00000017435; ENSMUSP00000017435; ENSMUSG00000017291.
ENSMUST00000058496; ENSMUSP00000055470; ENSMUSG00000017291.
GeneIDi216965.
KEGGimmu:216965.
UCSCiuc007khc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591136 Genomic DNA. Translation: CAI51877.1 .
BC016522 mRNA. Translation: AAH16522.1 . Different initiation.
BC034906 mRNA. Translation: AAH34906.1 .
AK173156 mRNA. Translation: BAD32434.1 . Different initiation.
CCDSi CCDS36235.1.
RefSeqi NP_659074.2. NM_144825.2.
XP_006533020.1. XM_006532957.1.
XP_006533021.1. XM_006532958.1.
XP_006533022.1. XM_006532959.1.
UniGenei Mm.340436.

3D structure databases

ProteinModelPortali Q5F2E8.
SMRi Q5F2E8. Positions 12-376.
ModBasei Search...

Protein-protein interaction databases

BioGridi 229824. 2 interactions.
IntActi Q5F2E8. 1 interaction.

PTM databases

PhosphoSitei Q5F2E8.

Proteomic databases

PaxDbi Q5F2E8.
PRIDEi Q5F2E8.

Protocols and materials databases

DNASUi 216965.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000017435 ; ENSMUSP00000017435 ; ENSMUSG00000017291 .
ENSMUST00000058496 ; ENSMUSP00000055470 ; ENSMUSG00000017291 .
GeneIDi 216965.
KEGGi mmu:216965.
UCSCi uc007khc.1. mouse.

Organism-specific databases

CTDi 57551.
MGIi MGI:1914490. Taok1.
Rougei Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00740000114927.
HOGENOMi HOG000236358.
HOVERGENi HBG088996.
InParanoidi Q5F2E8.
KOi K04429.
OMAi AGPHWGH.
OrthoDBi EOG74XS5S.
PhylomeDBi Q5F2E8.
TreeFami TF351444.

Enzyme and pathway databases

Reactomei REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.

Miscellaneous databases

ChiTaRSi TAOK1. mouse.
NextBioi 375476.
PROi Q5F2E8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q5F2E8.
Bgeei Q5F2E8.
CleanExi MM_TAOK1.
Genevestigatori Q5F2E8.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 437-1001.
    Strain: FVB/N.
    Tissue: Mammary gland and Thymus.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 657-1001.
    Tissue: Brain.
  4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  5. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-421, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTAOK1_MOUSE
AccessioniPrimary (citable) accession number: Q5F2E8
Secondary accession number(s): Q69ZL2, Q8JZX2, Q91VG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: March 15, 2005
Last modified: September 3, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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