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Q5F2E8

- TAOK1_MOUSE

UniProt

Q5F2E8 - TAOK1_MOUSE

Protein

Serine/threonine-protein kinase TAO1

Gene

Taok1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Serine/threonine-protein kinase activity is inhibited by SPRED1.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei57 – 571ATPPROSITE-ProRule annotation
    Active sitei151 – 1511Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi34 – 429ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB

    GO - Biological processi

    1. cellular response to DNA damage stimulus Source: UniProtKB
    2. DNA repair Source: UniProtKB-KW
    3. execution phase of apoptosis Source: UniProtKB
    4. G2 DNA damage checkpoint Source: UniProtKB
    5. positive regulation of JNK cascade Source: UniProtKB
    6. positive regulation of stress-activated MAPK cascade Source: UniProtKB
    7. regulation of cytoskeleton organization Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Apoptosis, DNA damage, DNA repair

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_207679. Separation of Sister Chromatids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase TAO1 (EC:2.7.11.1)
    Alternative name(s):
    Thousand and one amino acid protein 1
    Gene namesi
    Name:Taok1
    Synonyms:Kiaa1361
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1914490. Taok1.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10011001Serine/threonine-protein kinase TAO1PRO_0000086729Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei9 – 91PhosphoserineBy similarity
    Modified residuei421 – 4211Phosphoserine1 Publication
    Modified residuei445 – 4451PhosphoserineBy similarity
    Modified residuei669 – 6691PhosphothreonineBy similarity
    Modified residuei965 – 9651PhosphoserineBy similarity

    Post-translational modificationi

    Proteolytically processed by caspase-3 (CASP3).
    Autophosphorylated By similarity. Phosphorylated by ATM in response to DNA damage. Phosphorylated by LRRK2.By similarity1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ5F2E8.
    PRIDEiQ5F2E8.

    PTM databases

    PhosphoSiteiQ5F2E8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ5F2E8.
    BgeeiQ5F2E8.
    CleanExiMM_TAOK1.
    GenevestigatoriQ5F2E8.

    Interactioni

    Subunit structurei

    Self-associates. Interacts with MAP2K3. Interacts with SPRED1 and TESK1. Interacts with MAP3K7 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi229824. 2 interactions.
    IntActiQ5F2E8. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5F2E8.
    SMRiQ5F2E8. Positions 12-376.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 281254Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili458 – 651194Sequence AnalysisAdd
    BLAST
    Coiled coili754 – 877124Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi330 – 3345Poly-Glu

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00740000114927.
    HOGENOMiHOG000236358.
    HOVERGENiHBG088996.
    InParanoidiQ5F2E8.
    KOiK04429.
    OMAiAGPHWGH.
    OrthoDBiEOG74XS5S.
    PhylomeDBiQ5F2E8.
    TreeFamiTF351444.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5F2E8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSTNRAGSL KDPEIAELFF KEDPEKLFTD LREIGHGSFG AVYFARDVRT     50
    NEVVAIKKMS YSGKQSTEKW QDIIKEVKFL QRIKHPNSIE YKGCYLREHT 100
    AWLVMEYCLG SASDLLEVHK KPLQEVEIAA ITHGALQGLA YLHSHTMIHR 150
    DIKAGNILLT EPGQVKLADF GSASMASPAN SFVGTPYWMA PEVILAMDEG 200
    QYDGKVDVWS LGITCIELAE RKPPLFNMNA MSALYHIAQN ESPTLQSNEW 250
    SDYFRNFVDS CLQKIPQDRP TSEELLKHMF VLRERPETVL IDLIQRTKDA 300
    VRELDNLQYR KMKKLLFQEA HNGPAVEAQE EEEEQDHGVG RTGTVNSVGS 350
    NQSIPSMSIS ASSQSSSVNS LPDASDDKSE LDMMEGDHTV MSNSSVIHLK 400
    PEEENYQEEG DPRTRASDPQ SPPQVSRHKS HYRNREHFAT IRTASLVTRQ 450
    MQEHEQDSEL REQMSGYKRM RRQHQKQLMT LENKLKAEMD EHRLRLDKDL 500
    ETQRNNFAAE MEKLIKKHQA AMEKEAKVMA NEEKKFQQHI QAQQKKELNS 550
    FLESQKREYK LRKEQLKEEL NENQSTPKKE KQEWLSKQKE NIQHFQAEEE 600
    ANLLRRQRQY LELECRRFKR RMLLGRHNLE QDLVREELNK RQTQKDLEHA 650
    MLLRQHESMQ ELEFRHLNTI QKMRCELIRL QHQTELTNQL EYNKRREREL 700
    RRKHVMEVRQ QPKSLKSKEL QIKKQFQDTC KIQTRQYKAL RNHLLETTPK 750
    SEHKAVLKRL KEEQTRKLAI LAEQYDHSIN EMLSTQALRL DEAQEAECQV 800
    LKMQLQQELE LLNAYQSKIK MQAEAQHDRE LRELEQRVSL RRALLEQKIE 850
    EEMLALQNER TERIRSLLER QAREIEAFDS ESMRLGFSNM VLSNLSPEAF 900
    SHSYPGASSW SHNPTGGPGP HWGHPMGGTP QAWGHPMQGG PQPWGHPSGP 950
    MQGVPRGSSM GVRNSPQALR RTASGGRTEQ GMSRSTSVTS QISNGSHMSY 1000
    T 1001
    Length:1,001
    Mass (Da):116,050
    Last modified:March 15, 2005 - v1
    Checksum:i59DF437EAB8127C2
    GO

    Sequence cautioni

    The sequence AAH16522.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAD32434.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591136 Genomic DNA. Translation: CAI51877.1.
    BC016522 mRNA. Translation: AAH16522.1. Different initiation.
    BC034906 mRNA. Translation: AAH34906.1.
    AK173156 mRNA. Translation: BAD32434.1. Different initiation.
    CCDSiCCDS36235.1.
    RefSeqiNP_659074.2. NM_144825.2.
    XP_006533020.1. XM_006532957.1.
    XP_006533021.1. XM_006532958.1.
    XP_006533022.1. XM_006532959.1.
    UniGeneiMm.340436.

    Genome annotation databases

    EnsembliENSMUST00000017435; ENSMUSP00000017435; ENSMUSG00000017291.
    ENSMUST00000058496; ENSMUSP00000055470; ENSMUSG00000017291.
    GeneIDi216965.
    KEGGimmu:216965.
    UCSCiuc007khc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591136 Genomic DNA. Translation: CAI51877.1 .
    BC016522 mRNA. Translation: AAH16522.1 . Different initiation.
    BC034906 mRNA. Translation: AAH34906.1 .
    AK173156 mRNA. Translation: BAD32434.1 . Different initiation.
    CCDSi CCDS36235.1.
    RefSeqi NP_659074.2. NM_144825.2.
    XP_006533020.1. XM_006532957.1.
    XP_006533021.1. XM_006532958.1.
    XP_006533022.1. XM_006532959.1.
    UniGenei Mm.340436.

    3D structure databases

    ProteinModelPortali Q5F2E8.
    SMRi Q5F2E8. Positions 12-376.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 229824. 2 interactions.
    IntActi Q5F2E8. 1 interaction.

    PTM databases

    PhosphoSitei Q5F2E8.

    Proteomic databases

    PaxDbi Q5F2E8.
    PRIDEi Q5F2E8.

    Protocols and materials databases

    DNASUi 216965.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000017435 ; ENSMUSP00000017435 ; ENSMUSG00000017291 .
    ENSMUST00000058496 ; ENSMUSP00000055470 ; ENSMUSG00000017291 .
    GeneIDi 216965.
    KEGGi mmu:216965.
    UCSCi uc007khc.1. mouse.

    Organism-specific databases

    CTDi 57551.
    MGIi MGI:1914490. Taok1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00740000114927.
    HOGENOMi HOG000236358.
    HOVERGENi HBG088996.
    InParanoidi Q5F2E8.
    KOi K04429.
    OMAi AGPHWGH.
    OrthoDBi EOG74XS5S.
    PhylomeDBi Q5F2E8.
    TreeFami TF351444.

    Enzyme and pathway databases

    Reactomei REACT_198961. Resolution of Sister Chromatid Cohesion.
    REACT_207679. Separation of Sister Chromatids.

    Miscellaneous databases

    ChiTaRSi TAOK1. mouse.
    NextBioi 375476.
    PROi Q5F2E8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q5F2E8.
    Bgeei Q5F2E8.
    CleanExi MM_TAOK1.
    Genevestigatori Q5F2E8.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 437-1001.
      Strain: FVB/N.
      Tissue: Mammary gland and Thymus.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
      DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 657-1001.
      Tissue: Brain.
    4. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    5. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
      Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain cortex.
    6. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-421, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTAOK1_MOUSE
    AccessioniPrimary (citable) accession number: Q5F2E8
    Secondary accession number(s): Q69ZL2, Q8JZX2, Q91VG7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3