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Protein

Protocadherin Fat 2

Gene

Fat2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the migration of epidermal cells. May modulate the extracellular space surronding parallel fibers of cerebellar during development.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin Fat 2
Alternative name(s):
FAT tumor suppressor homolog 2
Gene namesi
Name:Fat2
Synonyms:Fath2, Kiaa0811
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2685369. Fat2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 4050ExtracellularSequence analysisAdd BLAST4032
Transmembranei4051 – 4071HelicalSequence analysisAdd BLAST21
Topological domaini4072 – 4351CytoplasmicSequence analysisAdd BLAST280

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000040660119 – 4351Protocadherin Fat 2Add BLAST4333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...)Sequence analysis1
Glycosylationi210N-linked (GlcNAc...)Sequence analysis1
Glycosylationi280N-linked (GlcNAc...)Sequence analysis1
Glycosylationi330N-linked (GlcNAc...)Sequence analysis1
Glycosylationi459N-linked (GlcNAc...)Sequence analysis1
Glycosylationi568N-linked (GlcNAc...)Sequence analysis1
Glycosylationi627N-linked (GlcNAc...)Sequence analysis1
Glycosylationi789N-linked (GlcNAc...)Sequence analysis1
Glycosylationi996N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1175N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1276N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1417N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1899N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1998N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2007N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2102N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2165N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2183N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2325N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2368N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2387N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2430N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2470N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2547N-linked (GlcNAc...)Sequence analysis1
Glycosylationi2597N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3127N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3278N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3312N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3432N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3603N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3770N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3774N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3815N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3842N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3875N-linked (GlcNAc...)Sequence analysis1
Glycosylationi3906N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi3914 ↔ 3946By similarity
Disulfide bondi3953 ↔ 3964By similarity
Disulfide bondi3958 ↔ 3974By similarity
Disulfide bondi3976 ↔ 3985By similarity
Glycosylationi3991N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi3992 ↔ 4003By similarity
Disulfide bondi3997 ↔ 4012By similarity
Disulfide bondi4014 ↔ 4023By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ5F226.
PaxDbiQ5F226.
PeptideAtlasiQ5F226.
PRIDEiQ5F226.

PTM databases

iPTMnetiQ5F226.
PhosphoSitePlusiQ5F226.

Expressioni

Gene expression databases

BgeeiENSMUSG00000055333.
GenevisibleiQ5F226. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ5F226. 1 interactor.
STRINGi10090.ENSMUSP00000067556.

Structurei

3D structure databases

ProteinModelPortaliQ5F226.
SMRiQ5F226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 148Cadherin 1PROSITE-ProRule annotationAdd BLAST115
Domaini149 – 256Cadherin 2PROSITE-ProRule annotationAdd BLAST108
Domaini363 – 458Cadherin 3PROSITE-ProRule annotationAdd BLAST96
Domaini459 – 564Cadherin 4PROSITE-ProRule annotationAdd BLAST106
Domaini565 – 669Cadherin 5PROSITE-ProRule annotationAdd BLAST105
Domaini716 – 820Cadherin 6PROSITE-ProRule annotationAdd BLAST105
Domaini821 – 925Cadherin 7PROSITE-ProRule annotationAdd BLAST105
Domaini926 – 1032Cadherin 8PROSITE-ProRule annotationAdd BLAST107
Domaini1033 – 1142Cadherin 9PROSITE-ProRule annotationAdd BLAST110
Domaini1138 – 1242Cadherin 10PROSITE-ProRule annotationAdd BLAST105
Domaini1243 – 1346Cadherin 11PROSITE-ProRule annotationAdd BLAST104
Domaini1350 – 1448Cadherin 12PROSITE-ProRule annotationAdd BLAST99
Domaini1449 – 1555Cadherin 13PROSITE-ProRule annotationAdd BLAST107
Domaini1556 – 1660Cadherin 14PROSITE-ProRule annotationAdd BLAST105
Domaini1661 – 1758Cadherin 15PROSITE-ProRule annotationAdd BLAST98
Domaini1759 – 1872Cadherin 16PROSITE-ProRule annotationAdd BLAST114
Domaini1873 – 1968Cadherin 17PROSITE-ProRule annotationAdd BLAST96
Domaini1969 – 2070Cadherin 18PROSITE-ProRule annotationAdd BLAST102
Domaini2071 – 2171Cadherin 19PROSITE-ProRule annotationAdd BLAST101
Domaini2172 – 2272Cadherin 20PROSITE-ProRule annotationAdd BLAST101
Domaini2273 – 2379Cadherin 21PROSITE-ProRule annotationAdd BLAST107
Domaini2380 – 2481Cadherin 22PROSITE-ProRule annotationAdd BLAST102
Domaini2482 – 2585Cadherin 23PROSITE-ProRule annotationAdd BLAST104
Domaini2586 – 2692Cadherin 24PROSITE-ProRule annotationAdd BLAST107
Domaini2693 – 2799Cadherin 25PROSITE-ProRule annotationAdd BLAST107
Domaini2800 – 2908Cadherin 26PROSITE-ProRule annotationAdd BLAST109
Domaini2909 – 3013Cadherin 27PROSITE-ProRule annotationAdd BLAST105
Domaini3014 – 3115Cadherin 28PROSITE-ProRule annotationAdd BLAST102
Domaini3116 – 3220Cadherin 29PROSITE-ProRule annotationAdd BLAST105
Domaini3221 – 3323Cadherin 30PROSITE-ProRule annotationAdd BLAST103
Domaini3324 – 3428Cadherin 31PROSITE-ProRule annotationAdd BLAST105
Domaini3429 – 3533Cadherin 32PROSITE-ProRule annotationAdd BLAST105
Domaini3534 – 3631Cadherin 33PROSITE-ProRule annotationAdd BLAST98
Domaini3775 – 3946Laminin G-likePROSITE-ProRule annotationAdd BLAST172
Domaini3949 – 3986EGF-like 1PROSITE-ProRule annotationAdd BLAST38
Domaini3988 – 4024EGF-like 2PROSITE-ProRule annotationAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4147 – 4261Pro-richAdd BLAST115
Compositional biasi4286 – 4289Poly-Gly4

Sequence similaritiesi

Contains 33 cadherin domains.PROSITE-ProRule annotation
Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1219. Eukaryota.
ENOG410XPEI. LUCA.
GeneTreeiENSGT00760000118805.
HOGENOMiHOG000046499.
HOVERGENiHBG005641.
InParanoidiQ5F226.
KOiK16506.
OMAiEPLYTFS.
OrthoDBiEOG091G00A0.
PhylomeDBiQ5F226.
TreeFamiTF316403.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
2.60.40.60. 33 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00028. Cadherin. 28 hits.
PF00008. EGF. 2 hits.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 33 hits.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 33 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS00232. CADHERIN_1. 13 hits.
PS50268. CADHERIN_2. 32 hits.
PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5F226-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLVLLGVAM VLLHRAACEK PLEETITPLT WRFTHSLYNA TIYENSAPKT
60 70 80 90 100
YVESPVKMGM YLAEPHWVVK YRIISGDAAG VFKTEEHVVG NFCFLRIRTK
110 120 130 140 150
SSNTALLNRE VRDSYTLVVQ ASDKSLEFEA LTQVVVHILD QNDLKPLFSP
160 170 180 190 200
PSYRFTISED RPLKSPICKV TATDADLGQN AEFYYAFNAR SEVFAIHPTS
210 220 230 240 250
GVVTVAGKLN VTWRGKYELQ VLAVDRMRKI SEGNGFGNLA PLVIYVEPVH
260 270 280 290 300
RKPPVITLVV LNPPEGDEGD IYATVTVDTN GSGAEVDSLE VVGGDPGKYF
310 320 330 340 350
KVLKSYAQGN EFNLVAVRDI NWAEHLHGFN ISLQTHSRSR FPSRSIIRAF
360 370 380 390 400
HLPPYTLANL RFEKAVYRVK LSEFSPPGSR VALVRVTTAL PTLRYALKPS
410 420 430 440 450
SGSTVFKLNA RTGLITTTKP VDFHEQNQYQ LHVKTSLGQA TTTVIIDIVD
460 470 480 490 500
CNNHAPVFNR SSYEGTLDEN IPPGTSVLTV TATDQDHGDN GHITYSIAGP
510 520 530 540 550
KAVPFSIDPY LGVISTTKSM DYELMKRIYT FRVRASDWGS PFRQEKEVSV
560 570 580 590 600
SLRLKNLNDN QPMFEEVNCT VSLRQDAPVG KSIMAVSAID MDELQNLKYE
610 620 630 640 650
IVSGNEQDYF HLNHFSGVIS LKRSFMNLTA VRPTVYSLKI TASDGKNYAS
660 670 680 690 700
PTTLKVTVVK DPRSEVPVQC DKTGVLTHIT KTILQSAGLQ GQEMGEEDFT
710 720 730 740 750
SLGNYQINHH APQFEDHFPQ SIDILEQVPV NTPLAHLAAT DPDPGFHGRL
760 770 780 790 800
VYVIADGNEE GCFDIELETG LLTVAAALDY ETTSFYVLNV TVYDLGTPPK
810 820 830 840 850
SSWKLLTVTV KDWNDKPPRF PPGGYQLTIS EDTEVGTTVA ELKTRDTDSE
860 870 880 890 900
DNGRVRYTLL TPTEKFSLHP LTGELVVTGQ LDRESEPQYI LKAEARDQPT
910 920 930 940 950
KGHQLFSVTD VIVTLEDIND NPPQCITEHS SLKVPEDMPL GTVLTFLDAS
960 970 980 990 1000
DPDLGPAGEV KYILVDDVHG TFRVDPMTGA LSLEKELDFE RRAGYNLSFW
1010 1020 1030 1040 1050
ASDSGRPLAR RTLCHVEVLV MDVNENLHSP HFSSFVYQGQ VQENSPAGTQ
1060 1070 1080 1090 1100
VMVVTAQDDD SGLDGELQYF LRAGTGLEAF SINQDTGMLE TLAPLDREFT
1110 1120 1130 1140 1150
PYYWLTVLAV DRGSVPLSAV TEVYIEVTDI NDNIPSMSRP VFYPSVKEDA
1160 1170 1180 1190 1200
PLGTSVLQLE AWDPDFSSQG KLTFNLTSGN HMGHFIVHPF TGLLSTAKQL
1210 1220 1230 1240 1250
DRENKDEYVL EVTVQDNGDP PLRSTSRVVV CVLDVNDNSP MFSHKLFNVR
1260 1270 1280 1290 1300
LSERLSPLSP EPVYRLVASD PDEGLNGSIT YSIEESDEES FRIDPVTGVV
1310 1320 1330 1340 1350
SSSSTFAAGE YNILTIKATD SGQPALSTSV RLHIEWIPQP RPSSIPLSFD
1360 1370 1380 1390 1400
ESHYSFAVME TDPVNHMLGV ISVEGRPGLF WFHISDGDKD MDFDIEKTTG
1410 1420 1430 1440 1450
SIVIARPLDT RRKSSYNLTV EVTDGFHTIA TQVHILMIAN INHHRPQFLQ
1460 1470 1480 1490 1500
DHYDIRVPQD TLPGVELLRV QATDQDHGKG LIYTIHSSRD PGSANLFQLD
1510 1520 1530 1540 1550
PSSGVLVTVG TLDLHSGPSQ HILTVMVRDQ EMPIKRNFVW VTIHVEDGNL
1560 1570 1580 1590 1600
HSPHFTQPRY EANVPDTTTP GTELLQVRAV DADRGANAEV HYSFLKGNSE
1610 1620 1630 1640 1650
GFFNIDSLLG IITVAQRLDH VHLNRHALTV KAEDQGSPQR HDLAMVVVHV
1660 1670 1680 1690 1700
HPSDSSAPIF SKDEYFIEIP ESVPIGSPIL LISAASSSDV TYELREGNKN
1710 1720 1730 1740 1750
SVFSMNSYSG LISTQKRLDH EKVSSYQLKI RGSNMAGVFT EVVALVYIID
1760 1770 1780 1790 1800
ENDNAPAFLK STFVGHISEA APLHSLILGE DNSPLVIRAS DSDQEANSLL
1810 1820 1830 1840 1850
VYKILEPEAL KFFKIDPSMG TLTITSELDY ETTPLFQFSI YVHDQGTPIL
1860 1870 1880 1890 1900
FAPRSARVII HVRDVNDSPP RFSEQIYEVA VVEPIHPGME LLTVQAEDND
1910 1920 1930 1940 1950
SKVTYSIKTS NTDEAVTIHP ITGQISVVNP AALRLFPKLN IRAFDGLYQD
1960 1970 1980 1990 2000
TAVVKISLTQ ALDKSLQFDQ DIYRARVTEN TPHSNVLVIL GVHGNHLNDT
2010 2020 2030 2040 2050
LSYFLLNGTD LFHMVKSAGV LQTRGVTFDR EQQDTHEVAV EVRDNRVPRR
2060 2070 2080 2090 2100
VAQALVRVSV EDVNDNIPEF QHLPYYTVIQ DGTEPGDVLF QVSATDKDLG
2110 2120 2130 2140 2150
ANGTVTYGFA EDYAYFRIDP YVGDISLKKP FDYQALNKYH LRVTARDAGT
2160 2170 2180 2190 2200
PPLQTEVEVH VTVRNKSNPL FQSPYYKVKV PENITLYTPI LHTQARSPEG
2210 2220 2230 2240 2250
LRLIYNIVEE EPLMLFTTDF KTGVLTVTGP LDYESKNKHV FTVRATDTAL
2260 2270 2280 2290 2300
GSFSEATVEV LVEDINDNPP TFSQLVYSTS VSEGSPAQTP VIQLLASDQD
2310 2320 2330 2340 2350
SGQNQDVSYQ IVEDGSDVSK FFRINGSTGE MFTIQELDYE AHQHFRVKVR
2360 2370 2380 2390 2400
ATDRGDPPLT GETLVVVNVS DINDNPPEFR EPQYEANVSE LATCGHLVLK
2410 2420 2430 2440 2450
VQALDPDIGD TSRLEYLILS GNQDRHFSIN STSGIISMFN LCKKQLDSSY
2460 2470 2480 2490 2500
NLRVGASDGV FQATVPVYIN TTNANKYSPE FQQNVYEAEL AENAKVGTKV
2510 2520 2530 2540 2550
IELLAIDKDS GPYGTVDYTI INKLAGERFF INPSGQITTL QKLDRENSTE
2560 2570 2580 2590 2600
RVIAIKIMAR DGGGKVAFCT VKIILTDEND NAPQFKASGY TVSIPSNVSR
2610 2620 2630 2640 2650
DSPIIQVLAY DADEGRNADV TYSVDSTEDL AEEIIEVNPT TGVVKVKESL
2660 2670 2680 2690 2700
VGLENKAVDF NIKAQDGGPP HWDSLVPVRL QVVPNEIPLP KFSEPLYTFS
2710 2720 2730 2740 2750
ASEDLPEGSE IGSVKAVAAQ DPIIYSLVQG TTPESNSDDV FSLDQDTGVL
2760 2770 2780 2790 2800
KVKKAMDHES TKWYQIDLMA HCPHEDTDLV SLVSVNIQVE DVNDNRPVFE
2810 2820 2830 2840 2850
ADPYKAFLTE NMPGGTTVIQ VTANDQDTGS DGQVSYRLSV EPGSNIHQLF
2860 2870 2880 2890 2900
AVDSESGWIT TLQELDCETQ QTYRFYVVAF DHGQTIQLSS QALVEVSITD
2910 2920 2930 2940 2950
ENDNPPRFAS EDYRGSVVEN NEPGELVATL KTLDADISEQ NRQVTCYITE
2960 2970 2980 2990 3000
GDPLGQFSIS QVGDEWRITS RKTLDREHIA KYLLRITASD GKFQASVPVE
3010 3020 3030 3040 3050
VFVLDINDNS PQCSQLLYTG KVREDVTPGH FILKVSAIDV DMDTNAQITY
3060 3070 3080 3090 3100
SLHGPGAQEF KLDPHTGELT TLSVLDRERK DVYNLVAKAT DGGGQSCQAE
3110 3120 3130 3140 3150
VTLHIEDVND NAPRFFPSHC AVAVFDNTTV KTPVAVVFAR DPDQGVNAQV
3160 3170 3180 3190 3200
VYSLTDSADG QFSIDATSGV IRLEKPLQVR SSSAVELTVR ASDLGTPIPL
3210 3220 3230 3240 3250
STLGTVTVSI VGLEDYLPIF LNSEHSTQVP EDALIDMEVL YLATLTRPGS
3260 3270 3280 3290 3300
EKTGYHITGG NEQGKFRLDA HTGILYVNGS LDFETNPKYF LSIECSRKSS
3310 3320 3330 3340 3350
SSLSDVTTIV INVTDVNEHH PRFTHDLYTV RVLENAIVGD VILTVSASDD
3360 3370 3380 3390 3400
DGPVNSVITY SLVGGNQLGH FTIDPKKGKL QVAKALDWEQ TPSYSLRIRA
3410 3420 3430 3440 3450
TDSGQPPLHE DTEVAVEVVD VNDNPPRFFQ LNYSTAVQEN SPIGIKVLQL
3460 3470 3480 3490 3500
ILDDPDSPQN GPPYFFRITE GNTGSVFRVT PDGWLVTAGS LSRRAQEWYQ
3510 3520 3530 3540 3550
LHIEVSDSGL PPLSSSTLVR VHITEQSRYP PSTLPLEIFI TKGEEEFQGG
3560 3570 3580 3590 3600
MVGKIHATDR DPQDTLTYSL DREGSLGKYF TVGASDGKII ASQGLPRGRY
3610 3620 3630 3640 3650
LFNVTVSDGT FTTTTGVHVH VWHMGQEAPQ QAVWLGFHQL TPEELVSDHW
3660 3670 3680 3690 3700
RNLQRFLSNI LDIKRANIHL ASLQPAEVTA GVDVLLAFEG HSGTSYDLQE
3710 3720 3730 3740 3750
LASAIAHSAK EMEHSVGIQM RSALPVVPCQ GPSCQDQTCQ ETVSLEPRVG
3760 3770 3780 3790 3800
PSYSTARLSI LTPRHHLGKN CSCNGTTWRF SGQSYMRYRP LEAQNWQIHF
3810 3820 3830 3840 3850
YLKTLQPWAL LMFTNETASI SLKLANGFLH LEYRCPGGFY GNLSSHRPVN
3860 3870 3880 3890 3900
DGQWHSMLLE ERDTSVHLLV DITDNTSLVI PEECQGLRTE RHLLLGGLVP
3910 3920 3930 3940 3950
SNPSSNVSLG FEGCLDAVVV NSERLELLGH RKKMAGYLET WALSQCCWPG
3960 3970 3980 3990 4000
TTCSQNPCLN GGSCSPALGS GYLCRCPPLF SGRNCELGRE NCTSAPCQEG
4010 4020 4030 4040 4050
GTCVSSPEGT SCSCPHPYTG DRCEMEARGC SGGHCLITPE IKRGDWGQQE
4060 4070 4080 4090 4100
FLVIIVALPL LIIATVGLLL YCRRCKSHKP VAMEDPDLLA RSIGVDTQAS
4110 4120 4130 4140 4150
PAIELDPLNA GSCNDLNQLE PSKTSVPNEL VTFGPSSKQR PMVCSVPPRL
4160 4170 4180 4190 4200
PPAVVSSHPG HEPIIKRTWS GEELVYPSGA AVWPPTYSRK EHWEYPHPEA
4210 4220 4230 4240 4250
MQGPLPPSPR RHVSPAVMPD PAGLYGGFPF PLELENKRAP LPPRYSNQNL
4260 4270 4280 4290 4300
EDLIPPRPPS PREHLLAPCL NEYTAISYYH SQFRQGGGGP CLAEGGYKGV
4310 4320 4330 4340 4350
SMRLSRAGPS YADCEVNGGP APGRSQPRAP PNYEGSDMVE SDYGSCEEVM

F
Length:4,351
Mass (Da):480,109
Last modified:March 15, 2005 - v1
Checksum:i72F9DADAAA5467D5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4010T → N in BAE21217 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL713870 Genomic DNA. Translation: CAI52049.1.
CH466575 Genomic DNA. Translation: EDL33495.1.
AK173031 mRNA. Translation: BAD32309.1.
AK132523 mRNA. Translation: BAE21217.1.
CCDSiCCDS36157.1.
RefSeqiNP_001025159.1. NM_001029988.2.
XP_006533385.1. XM_006533322.3.
XP_006533386.1. XM_006533323.3.
UniGeneiMm.339363.

Genome annotation databases

EnsembliENSMUST00000068853; ENSMUSP00000067556; ENSMUSG00000055333.
ENSMUST00000108864; ENSMUSP00000104492; ENSMUSG00000055333.
GeneIDi245827.
KEGGimmu:245827.
UCSCiuc007izf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL713870 Genomic DNA. Translation: CAI52049.1.
CH466575 Genomic DNA. Translation: EDL33495.1.
AK173031 mRNA. Translation: BAD32309.1.
AK132523 mRNA. Translation: BAE21217.1.
CCDSiCCDS36157.1.
RefSeqiNP_001025159.1. NM_001029988.2.
XP_006533385.1. XM_006533322.3.
XP_006533386.1. XM_006533323.3.
UniGeneiMm.339363.

3D structure databases

ProteinModelPortaliQ5F226.
SMRiQ5F226.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5F226. 1 interactor.
STRINGi10090.ENSMUSP00000067556.

PTM databases

iPTMnetiQ5F226.
PhosphoSitePlusiQ5F226.

Proteomic databases

MaxQBiQ5F226.
PaxDbiQ5F226.
PeptideAtlasiQ5F226.
PRIDEiQ5F226.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068853; ENSMUSP00000067556; ENSMUSG00000055333.
ENSMUST00000108864; ENSMUSP00000104492; ENSMUSG00000055333.
GeneIDi245827.
KEGGimmu:245827.
UCSCiuc007izf.1. mouse.

Organism-specific databases

CTDi2196.
MGIiMGI:2685369. Fat2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1219. Eukaryota.
ENOG410XPEI. LUCA.
GeneTreeiENSGT00760000118805.
HOGENOMiHOG000046499.
HOVERGENiHBG005641.
InParanoidiQ5F226.
KOiK16506.
OMAiEPLYTFS.
OrthoDBiEOG091G00A0.
PhylomeDBiQ5F226.
TreeFamiTF316403.

Miscellaneous databases

PROiQ5F226.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055333.
GenevisibleiQ5F226. MM.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
2.60.40.60. 33 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00028. Cadherin. 28 hits.
PF00008. EGF. 2 hits.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 33 hits.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 33 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS00232. CADHERIN_1. 13 hits.
PS50268. CADHERIN_2. 32 hits.
PS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFAT2_MOUSE
AccessioniPrimary (citable) accession number: Q5F226
Secondary accession number(s): Q3V1D4, Q69ZY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: March 15, 2005
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.