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Protein

Cilia- and flagella-associated protein 52

Gene

Cfap52

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in cell growth and/or survival.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Cilia- and flagella-associated protein 52Imported
Alternative name(s):
WD repeat-containing protein 16Imported
Gene namesi
Name:Cfap52Imported
Synonyms:Wdr16Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1919110. Cfap52.

Subcellular locationi

  • Cytoplasm By similarity
  • Cell projectionciliumflagellum By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 620620Cilia- and flagella-associated protein 52CuratedPRO_0000233155Add
BLAST

Proteomic databases

MaxQBiQ5F201.
PaxDbiQ5F201.
PRIDEiQ5F201.

PTM databases

iPTMnetiQ5F201.
PhosphoSiteiQ5F201.

Expressioni

Gene expression databases

BgeeiQ5F201.
CleanExiMM_WDR16.
ExpressionAtlasiQ5F201. baseline and differential.
GenevisibleiQ5F201. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021287.

Structurei

3D structure databases

ProteinModelPortaliQ5F201.
SMRiQ5F201. Positions 29-617.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati62 – 10645WD 1Add
BLAST
Repeati109 – 15042WD 2Add
BLAST
Repeati156 – 19540WD 3Add
BLAST
Repeati288 – 32740WD 4Add
BLAST
Repeati330 – 36940WD 5Add
BLAST
Repeati372 – 41140WD 6Add
BLAST
Repeati415 – 45440WD 7Add
BLAST
Repeati459 – 49840WD 8Add
BLAST
Repeati500 – 54142WD 9Add
BLAST
Repeati543 – 58240WD 10Add
BLAST
Repeati585 – 62036WD 11Add
BLAST

Sequence similaritiesi

Belongs to the CFAP52 family.Curated
Contains 11 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
GeneTreeiENSGT00840000129772.
HOGENOMiHOG000258436.
HOVERGENiHBG055224.
InParanoidiQ5F201.
OMAiMKRIVMS.
OrthoDBiEOG71P297.
PhylomeDBiQ5F201.
TreeFamiTF323254.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR033015. CFAP52.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR13720:SF14. PTHR13720:SF14. 1 hit.
PfamiPF00400. WD40. 5 hits.
[Graphical view]
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5F201-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEQVLPELD VAELELQAVI GFNGHVPNGL KCHPDQEHLI YPLGCTVLIQ
60 70 80 90 100
AINTNEQNFL HGHGNNVSCV TISKEGDYIA SGQVTFMGFK ADIILWDFKK
110 120 130 140 150
RELIARLSLH KGKIEALAFS PNDLYLVSLG GPDDGSVVVW SIAKRDAICG
160 170 180 190 200
SPAAGLNVGN ATSVVFSRCR DEMFVTAGNG TIRVWELDLP NRKIWPTECQ
210 220 230 240 250
TGQMKRIVLS TGMADDDSFF YLGTTTGDIL KMNPKTKLLA DTGPVKDKFS
260 270 280 290 300
LGVSALRCLK MGGLLVGSGA GLLIFCKSPS YKPIKKVQLQ GGITSITLRG
310 320 330 340 350
EGHQFFVGTE ESHIYRVNFT DFKETLIATC HFEAVQDIVF PFGTAELFAT
360 370 380 390 400
CAKKDIRVWH TMSKRELLRI TVPNMTCHGI DFMRDGKSII SAWDDGKIRA
410 420 430 440 450
FAPESGRLMY TINSAHRIGV TAIATTSDCK RIISGGGEGE VRVWQVGCQT
460 470 480 490 500
QKLEEALKEH KSSVSCIRVK KNNEECVTAS TDGTCIIWDL VRLRRNQMIL
510 520 530 540 550
ANTLFQCVCY HPEEFQIITS GTDRKIAYWE VFDGSVIREL EGSLSGSING
560 570 580 590 600
MDITQEGGHF VTGGHDHLVK VWDYNEGEVT HVGVGHSGNI MAMRISPGNQ
610 620
YIVSVSADGA ILRWKYPFAS
Note: No experimental confirmation available.
Length:620
Mass (Da):68,240
Last modified:March 15, 2005 - v1
Checksum:i85062659B988E2AC
GO
Isoform 2 (identifier: Q5F201-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     342-342: F → L
     343-620: Missing.

Note: No experimental confirmation available.
Show »
Length:342
Mass (Da):37,367
Checksum:i05E4075C2A0CDC30
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti309 – 3091T → A in BAB30457 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei342 – 3421F → L in isoform 2. 1 PublicationVSP_018069
Alternative sequencei343 – 620278Missing in isoform 2. 1 PublicationVSP_018070Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006118 mRNA. Translation: BAB24416.1.
AK016839 mRNA. Translation: BAB30457.1.
AL732570, AL663076 Genomic DNA. Translation: CAI51998.1.
AL732570, AL663076 Genomic DNA. Translation: CAI51999.1.
AL663076, AL732570 Genomic DNA. Translation: CAI52022.1.
AL663076, AL732570 Genomic DNA. Translation: CAI52023.1.
CCDSiCCDS24862.1. [Q5F201-1]
RefSeqiNP_082239.2. NM_027963.2. [Q5F201-1]
UniGeneiMm.441823.

Genome annotation databases

EnsembliENSMUST00000021287; ENSMUSP00000021287; ENSMUSG00000020904. [Q5F201-1]
ENSMUST00000126766; ENSMUSP00000116496; ENSMUSG00000020904. [Q5F201-2]
GeneIDi71860.
KEGGimmu:71860.
UCSCiuc007jnf.1. mouse. [Q5F201-1]
uc007jng.1. mouse. [Q5F201-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006118 mRNA. Translation: BAB24416.1.
AK016839 mRNA. Translation: BAB30457.1.
AL732570, AL663076 Genomic DNA. Translation: CAI51998.1.
AL732570, AL663076 Genomic DNA. Translation: CAI51999.1.
AL663076, AL732570 Genomic DNA. Translation: CAI52022.1.
AL663076, AL732570 Genomic DNA. Translation: CAI52023.1.
CCDSiCCDS24862.1. [Q5F201-1]
RefSeqiNP_082239.2. NM_027963.2. [Q5F201-1]
UniGeneiMm.441823.

3D structure databases

ProteinModelPortaliQ5F201.
SMRiQ5F201. Positions 29-617.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021287.

PTM databases

iPTMnetiQ5F201.
PhosphoSiteiQ5F201.

Proteomic databases

MaxQBiQ5F201.
PaxDbiQ5F201.
PRIDEiQ5F201.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021287; ENSMUSP00000021287; ENSMUSG00000020904. [Q5F201-1]
ENSMUST00000126766; ENSMUSP00000116496; ENSMUSG00000020904. [Q5F201-2]
GeneIDi71860.
KEGGimmu:71860.
UCSCiuc007jnf.1. mouse. [Q5F201-1]
uc007jng.1. mouse. [Q5F201-2]

Organism-specific databases

CTDi146845.
MGIiMGI:1919110. Cfap52.

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
GeneTreeiENSGT00840000129772.
HOGENOMiHOG000258436.
HOVERGENiHBG055224.
InParanoidiQ5F201.
OMAiMKRIVMS.
OrthoDBiEOG71P297.
PhylomeDBiQ5F201.
TreeFamiTF323254.

Miscellaneous databases

PROiQ5F201.
SOURCEiSearch...

Gene expression databases

BgeeiQ5F201.
CleanExiMM_WDR16.
ExpressionAtlasiQ5F201. baseline and differential.
GenevisibleiQ5F201. MM.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR033015. CFAP52.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR13720:SF14. PTHR13720:SF14. 1 hit.
PfamiPF00400. WD40. 5 hits.
[Graphical view]
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiCFA52_MOUSE
AccessioniPrimary (citable) accession number: Q5F201
Secondary accession number(s): Q5F200, Q9D432, Q9DA68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 15, 2005
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.