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Protein

Cilia- and flagella-associated protein 52

Gene

Cfap52

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in cell growth and/or survival.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Cilia- and flagella-associated protein 52Imported
Alternative name(s):
WD repeat-containing protein 16Imported
Gene namesi
Name:Cfap52Imported
Synonyms:Wdr16Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1919110 Cfap52

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Flagellum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002331551 – 620Cilia- and flagella-associated protein 52CuratedAdd BLAST620

Proteomic databases

PaxDbiQ5F201
PRIDEiQ5F201

PTM databases

iPTMnetiQ5F201
PhosphoSitePlusiQ5F201

Expressioni

Gene expression databases

BgeeiENSMUSG00000020904
CleanExiMM_WDR16
ExpressionAtlasiQ5F201 baseline and differential
GenevisibleiQ5F201 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021287

Structurei

3D structure databases

ProteinModelPortaliQ5F201
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati62 – 106WD 1Add BLAST45
Repeati109 – 150WD 2Add BLAST42
Repeati156 – 195WD 3Add BLAST40
Repeati288 – 327WD 4Add BLAST40
Repeati330 – 369WD 5Add BLAST40
Repeati372 – 411WD 6Add BLAST40
Repeati415 – 454WD 7Add BLAST40
Repeati459 – 498WD 8Add BLAST40
Repeati500 – 541WD 9Add BLAST42
Repeati543 – 582WD 10Add BLAST40
Repeati585 – 620WD 11Add BLAST36

Sequence similaritiesi

Belongs to the CFAP52 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0266 Eukaryota
ENOG410XP3K LUCA
GeneTreeiENSGT00910000144186
HOGENOMiHOG000258436
HOVERGENiHBG055224
InParanoidiQ5F201
OMAiAIPNAHN
OrthoDBiEOG091G04IQ
PhylomeDBiQ5F201
TreeFamiTF323254

Family and domain databases

Gene3Di2.130.10.10, 3 hits
InterProiView protein in InterPro
IPR033015 CFAP52
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR13720:SF14 PTHR13720:SF14, 2 hits
PfamiView protein in Pfam
PF00400 WD40, 5 hits
SMARTiView protein in SMART
SM00320 WD40, 11 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5F201-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEQVLPELD VAELELQAVI GFNGHVPNGL KCHPDQEHLI YPLGCTVLIQ
60 70 80 90 100
AINTNEQNFL HGHGNNVSCV TISKEGDYIA SGQVTFMGFK ADIILWDFKK
110 120 130 140 150
RELIARLSLH KGKIEALAFS PNDLYLVSLG GPDDGSVVVW SIAKRDAICG
160 170 180 190 200
SPAAGLNVGN ATSVVFSRCR DEMFVTAGNG TIRVWELDLP NRKIWPTECQ
210 220 230 240 250
TGQMKRIVLS TGMADDDSFF YLGTTTGDIL KMNPKTKLLA DTGPVKDKFS
260 270 280 290 300
LGVSALRCLK MGGLLVGSGA GLLIFCKSPS YKPIKKVQLQ GGITSITLRG
310 320 330 340 350
EGHQFFVGTE ESHIYRVNFT DFKETLIATC HFEAVQDIVF PFGTAELFAT
360 370 380 390 400
CAKKDIRVWH TMSKRELLRI TVPNMTCHGI DFMRDGKSII SAWDDGKIRA
410 420 430 440 450
FAPESGRLMY TINSAHRIGV TAIATTSDCK RIISGGGEGE VRVWQVGCQT
460 470 480 490 500
QKLEEALKEH KSSVSCIRVK KNNEECVTAS TDGTCIIWDL VRLRRNQMIL
510 520 530 540 550
ANTLFQCVCY HPEEFQIITS GTDRKIAYWE VFDGSVIREL EGSLSGSING
560 570 580 590 600
MDITQEGGHF VTGGHDHLVK VWDYNEGEVT HVGVGHSGNI MAMRISPGNQ
610 620
YIVSVSADGA ILRWKYPFAS
Note: No experimental confirmation available.
Length:620
Mass (Da):68,240
Last modified:March 15, 2005 - v1
Checksum:i85062659B988E2AC
GO
Isoform 2 (identifier: Q5F201-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     342-342: F → L
     343-620: Missing.

Note: No experimental confirmation available.
Show »
Length:342
Mass (Da):37,367
Checksum:i05E4075C2A0CDC30
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti309T → A in BAB30457 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_018069342F → L in isoform 2. 1 Publication1
Alternative sequenceiVSP_018070343 – 620Missing in isoform 2. 1 PublicationAdd BLAST278

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006118 mRNA Translation: BAB24416.1
AK016839 mRNA Translation: BAB30457.1
AL732570, AL663076 Genomic DNA Translation: CAI51998.1
AL732570, AL663076 Genomic DNA Translation: CAI51999.1
AL663076, AL732570 Genomic DNA Translation: CAI52022.1
AL663076, AL732570 Genomic DNA Translation: CAI52023.1
CCDSiCCDS24862.1 [Q5F201-1]
RefSeqiNP_082239.2, NM_027963.2 [Q5F201-1]
UniGeneiMm.441823

Genome annotation databases

EnsembliENSMUST00000021287; ENSMUSP00000021287; ENSMUSG00000020904 [Q5F201-1]
ENSMUST00000126766; ENSMUSP00000116496; ENSMUSG00000020904 [Q5F201-2]
GeneIDi71860
KEGGimmu:71860
UCSCiuc007jnf.1 mouse [Q5F201-1]
uc007jng.1 mouse [Q5F201-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCFA52_MOUSE
AccessioniPrimary (citable) accession number: Q5F201
Secondary accession number(s): Q5F200, Q9D432, Q9DA68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 15, 2005
Last modified: April 25, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health