Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger and BTB domain-containing protein 38

Gene

Zbtb38

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner. Plays an important role in regulating DNA-replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (By similarity). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (PubMed:15713629).1 PublicationBy similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri341 – 36323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri370 – 39425C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri459 – 48123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri487 – 50923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri515 – 53824C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1017 – 103923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1045 – 106723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1073 – 109523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1101 – 112323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1132 – 115423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 38
Alternative name(s):
Zinc finger protein expressed in neurons
Short name:
Zenon
Gene namesi
Name:Zbtb38By similarity
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310136. Zbtb38.

Subcellular locationi

  • Nucleus 1 Publication
  • Chromosome By similarity

  • Note: Localizes to chromocenters.By similarity

GO - Cellular componenti

  • chromosome Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12031203Zinc finger and BTB domain-containing protein 38PRO_0000047743Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki43 – 43Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei130 – 1301PhosphoserineBy similarity
Cross-linki145 – 145Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki556 – 556Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki750 – 750Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki806 – 806Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki984 – 984Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationi

Ubiquitinated by RBBP6; leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5EXX3.
PRIDEiQ5EXX3.

PTM databases

PhosphoSiteiQ5EXX3.

Expressioni

Tissue specificityi

Widely expressed throughout the adult brain where it is found mainly in neurons. Also expressed in the adrenal medulla. Not detected in non-neural tissues including heart, spleen, liver and muscle. In the embryo, expressed in the developing brain and spinal cord but not in the migratory neural crest. Also expressed in the limbs, transiently in somites, and in the embryonic liver. In the embryonic neural tube, expression is restricted to late postmitotic neurons.1 Publication

Developmental stagei

Expressed in embryo and adult. Embryonic expression is detected from E12.1 Publication

Interactioni

Subunit structurei

Interacts with CBFA2T3, ZBTB4 and RBBP6.By similarity

Protein-protein interaction databases

BioGridi261189. 1 interaction.
STRINGi10116.ENSRNOP00000067350.

Structurei

3D structure databases

ProteinModelPortaliQ5EXX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 10068BTBPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni299 – 522224Interaction with CBFA2T3By similarityAdd
BLAST

Domaini

The BTB domain is not required for activation of transcription or self-association.1 Publication

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri341 – 36323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri370 – 39425C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri459 – 48123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri487 – 50923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri515 – 53824C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1017 – 103923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1045 – 106723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1073 – 109523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1101 – 112323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1132 – 115423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOVERGENiHBG084299.
InParanoidiQ5EXX3.
KOiK10510.
PhylomeDBiQ5EXX3.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5EXX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVMSLSRDL KDDFHSDTVL SILNEQRIRG ILCDVTIIVE DTKFKAHSNV
60 70 80 90 100
LAASSLYFKN IFWSHTICIS SHVLELDDLK AEVFTEILNY IYSSTVVVRR
110 120 130 140 150
QETVTDLAAA GKRLGISFLE DLSDRNFSNS PGPYVVCITE KGVVKEEKNE
160 170 180 190 200
KRHEEPAVTN GPRITNAFSI IETENSNSMF SPLDLRASFK KVSDAMRTTS
210 220 230 240 250
LCQERASVCP EAEPVRTLAE HSYAVSSITE AYRSQPLREH DSSSSSGKTG
260 270 280 290 300
KENGEALTTK AKPCRKPKTQ TQDSDSTTEN MPLPLVTCPE VNQERSPQPA
310 320 330 340 350
PILSHSEPPS SEGDVHFPRE DENQPSETPG PPAAEVPPLV YNCSCCSKSF
360 370 380 390 400
DSSTLLGAHM QLHKPTQDPF VCKYCNKQFT TLNRLDRHEQ ICMRSSHMPM
410 420 430 440 450
PGGNQPFLEN YPTIGQDGGS FTSPDSLVPE SRIGELSSAG SALSDADHMV
460 470 480 490 500
KFVNGQMLYS CVVCKRSYVT LSSLRRHANV HSWRRTYPCH YCNKVFALAE
510 520 530 540 550
YRTRHEIWHT GERRYQCIFC LETFMTYYIL KNHQKSFHAI DHRLSISKKT
560 570 580 590 600
ANGGLKPTVY PYKLYRLLPM RCKRAPYKSY RNSSYESAQG NRQRNESPPD
610 620 630 640 650
TFVIPNLPSS EMPTLNFQDG RNSLTSSPAI PVETPSWQGT PTSAKVKNAE
660 670 680 690 700
GLKWRKQALK TDLVDSAEVS ISSIGNSVST TLQAEPVCVS SGEHSASVIS
710 720 730 740 750
YSGLVPSVIV HSSQFSSVIK HSNAIACLAN SNHQSPSQPV ASPSLIKDSK
760 770 780 790 800
PEADKASKLA SRPKNSKEKK KTVPCNRGEI TEEAKYVADL GGSSGKTTNV
810 820 830 840 850
VEETSKIETY IAKPALPGTS TNSNVAPLCQ ITVKIGNEAI VKRHILGSKL
860 870 880 890 900
FYKRGRKPKY QMQEETLPRE SDPETRGDSP LGLCQADCVE MSEAFDEVSD
910 920 930 940 950
QDSTDKPWRP YYNYKPKKKS KQLRKIRKVK WRKERGSRSP VGRRRYPAEL
960 970 980 990 1000
DRAEMGRRRY PAELDRCAEV KLPPDKASEE EENKEMPKLQ CELCDGDKAA
1010 1020 1030 1040 1050
GAGAEGKPHQ HLTLKPYICE LCAKQFQSSS TLKMHMRCHT GEKPYQCKTC
1060 1070 1080 1090 1100
GRRFSVQGNL QKHERIHLGV KEFICQYCNK AFTLNETLKI HERIHTGEKR
1110 1120 1130 1140 1150
YHCQFCFQGF LYLSTKRNHE RRHVREHDGK GFACFQCPKI CKTAAALRMH
1160 1170 1180 1190 1200
QKKHLFKTLT KQEETDDLCH ENSDLLESQP CTDSEDSDQK DDIKKPLLKM

SFE
Length:1,203
Mass (Da):135,300
Last modified:March 15, 2005 - v1
Checksum:iE5E15AF3A487A12B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY623002 mRNA. Translation: AAT72920.1.
RefSeqiNP_001012489.1. NM_001012471.1.
UniGeneiRn.104538.

Genome annotation databases

GeneIDi315936.
KEGGirno:315936.
UCSCiRGD:1310136. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY623002 mRNA. Translation: AAT72920.1.
RefSeqiNP_001012489.1. NM_001012471.1.
UniGeneiRn.104538.

3D structure databases

ProteinModelPortaliQ5EXX3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi261189. 1 interaction.
STRINGi10116.ENSRNOP00000067350.

PTM databases

PhosphoSiteiQ5EXX3.

Proteomic databases

PaxDbiQ5EXX3.
PRIDEiQ5EXX3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi315936.
KEGGirno:315936.
UCSCiRGD:1310136. rat.

Organism-specific databases

CTDi253461.
RGDi1310136. Zbtb38.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOVERGENiHBG084299.
InParanoidiQ5EXX3.
KOiK10510.
PhylomeDBiQ5EXX3.

Miscellaneous databases

PROiQ5EXX3.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBT38_RAT
AccessioniPrimary (citable) accession number: Q5EXX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: March 15, 2005
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.