Q5EU83 (Q5EU83_9ENTR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase HAMAP MF_00222
EC=1.1.1.25 HAMAP MF_00222

Gene names

Name:

aroE HAMAP MF_00222 EMBL AAW72678.1

Organism

Buchnera aphidicola (Cinara cedri) EMBL AAW72678.1

Taxonomic identifier

261318 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Buchnera

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222 SAAS SAAS011342
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222 SAAS SAAS011342
Sequence similarities	Belongs to the shikimate dehydrogenase family. HAMAP MF_00222

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00222 SAAS SAAS011342
Ligand	NADP HAMAP MF_00222 SAAS SAAS011342
Molecular function	Oxidoreductase HAMAP MF_00222 RuleBase RU004037 SAAS SAAS011342
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	135 – 139	5	NADP By similarity HAMAP MF_00222
Sites
	Active site	74	1	Proton acceptor By similarity HAMAP MF_00222

Sequences

	Sequence		Length	Mass (Da)
	Q5EU83 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: F8E9EDC4A8A2A713	FASTA	280	32,079
	10 20 30 40 50 60 MQNSKYCEKK IHIALFGNPI EHSLSPLIHK NFSKEIKINY NYNSFLCTKS NFFVIVKNFF 70 80 90 100 110 120 QNGGFGCNIT VPFKKKSFQI SNKNTKYVKI SNSVNVLKKS SNNNIIGYNT DGIGLIYDLN 130 140 150 160 170 180 RLKYITENSF ILILGSGGAV YSIVYHLLKK KCCIFILNRT ISKSCILVNK FKKFGKIFVF 190 200 210 220 230 240 DKNLYTKKFD IIINATSCGL YNFSPKFPKN LIFPNTKCYD ISYSKNKKLT PFLSTCRDLG 250 260 270 280 SRKYSDGLGM LVAQAAYSCY IWFNILPNIK KNINLLKSII

References

[1]	"Comparative analysis of two genomic regions among four strains of Buchnera aphidicola, primary endosymbiont of aphids." Perez-Brocal V., Latorre A., Gil R., Moya A. Gene 345:73-80(2005) [PubMed: 15716086] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY744382 Genomic DNA. Translation: AAW72678.1.
3D structure databases
ProteinModelPortal	Q5EU83.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q5EU83_9ENTR

Accession

Primary (citable) accession number: Q5EU83

Entry history

Integrated into UniProtKB/TrEMBL:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	December 14, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)