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Protein

Carboxypeptidase inhibitor

Gene
N/A
Organism
Rhipicephalus bursa (Tick)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potent competitive inhibitor of metallo-carboxypeptidases CPA1, CPA2, CPB, CPN and TAF1a. Accelerates fibrinolysis in vitro and may contribute to the maintenance of host blood liquidity during feeding.1 Publication

GO - Molecular functioni

  • enzyme inhibitor activity Source: UniProtKB
  • metalloendopeptidase inhibitor activity Source: UniProtKB

GO - Biological processi

  • acquisition of nutrients from host Source: UniProtKB
  • blood coagulation Source: UniProtKB-KW
  • fibrinolysis Source: UniProtKB-KW

Keywordsi

Molecular functionMetalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor
Biological processBlood coagulation, Fibrinolysis, Hemostasis

Protein family/group databases

MEROPSiI68.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase inhibitor
Alternative name(s):
TCI
OrganismiRhipicephalus bursa (Tick)
Taxonomic identifieri67831 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAcariParasitiformesIxodidaIxodoideaIxodidaeRhipicephalinaeRhipicephalusRhipicephalus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000022752923 – 97Carboxypeptidase inhibitor1 PublicationAdd BLAST75

Structurei

Secondary structure

197
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 27Combined sources4
Beta strandi31 – 33Combined sources3
Helixi35 – 37Combined sources3
Helixi40 – 42Combined sources3
Beta strandi50 – 54Combined sources5
Helixi56 – 58Combined sources3
Helixi63 – 65Combined sources3
Beta strandi68 – 71Combined sources4
Beta strandi76 – 78Combined sources3
Helixi80 – 86Combined sources7
Beta strandi90 – 93Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZLHX-ray1.70B23-97[»]
1ZLIX-ray2.09B23-97[»]
2JTONMR-A23-97[»]
2K2XNMR-A23-97[»]
2K2YNMR-A23-61[»]
2K2ZNMR-A59-97[»]
3D4UX-ray1.70B23-96[»]
3LMSX-ray2.50B23-96[»]
3OSLX-ray6.00B/D23-96[»]
ProteinModelPortaliQ5EPH2.
SMRiQ5EPH2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5EPH2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR019509. Carboxypeptidase_inhibitor_I68.
PfamiView protein in Pfam
PF10468. Inhibitor_I68. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5EPH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATLPVFAV VFFAMVLASS QANECVSKGF GCLPQSDCPQ EARLSYGGCS
60 70 80 90
TVCCDLSKLT GCKGKGGECN PLDRQCKELQ AESASCGKGQ KCCVWLH
Length:97
Mass (Da):10,189
Last modified:March 15, 2005 - v1
Checksum:i22A8B710821B0C0E
GO

Mass spectrometryi

Molecular mass is 7798 Da from positions 23 - 97. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY794405 mRNA. Translation: AAW72225.1.

Similar proteinsi

Entry informationi

Entry nameiTCI1_RHIBU
AccessioniPrimary (citable) accession number: Q5EPH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 15, 2005
Last modified: November 2, 2016
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families