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Q5EP31

- Q5EP31_9INFA

UniProt

Q5EP31 - Q5EP31_9INFA

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Protein
Submitted name: Hemagglutinin
Gene
HA
Organism
Influenza A virus (A/Viet Nam/1203/2004(H5N1))
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore By similarity.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei237 – 2371Galactose; via carbonyl oxygenImported

GO - Biological processi

  1. clathrin-mediated endocytosis of virus by host cell Source: UniProtKB-KW
  2. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  3. fusion of virus membrane with host plasma membrane Source: InterPro
  4. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HemagglutininUniRule annotationSAAS annotations

Keywords - Biological processi

Clathrin- and caveolin-independent endocytosis of virus by hostSAAS annotations, Clathrin-mediated endocytosis of virus by hostSAAS annotations, Fusion of virus membrane with host endosomal membraneSAAS annotations, Fusion of virus membrane with host membrane, Host-virus interaction, Viral attachment to host cellSAAS annotations, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Submitted name:
HemagglutininImported
Submitted name:
Hemagglutinin HAImported
Gene namesi
Name:HAImported
OrganismiInfluenza A virus (A/Viet Nam/1203/2004(H5N1))Imported
Taxonomic identifieri284218 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A

Subcellular locationi

GO - Cellular componenti

  1. host cell plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
  3. viral envelope Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host cell membraneSAAS annotations, Host membrane, Membrane, Viral envelope proteinUniRule annotationSAAS annotations, Virion

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...)
Glycosylationi39 – 391N-linked (GlcNAc...)Imported
Glycosylationi181 – 1811N-linked (GlcNAc...)Imported

Keywords - PTMi

Disulfide bondSAAS annotations

Interactioni

Subunit structurei

Homotrimer of disulfide-linked HA1-HA2 By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

DIPiDIP-60227N.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BH2X-ray2.12A17-340[»]
B347-513[»]
4BH3X-ray2.00A17-340[»]
B347-513[»]
4BH4X-ray1.90A17-340[»]
B347-513[»]
4N5ZX-ray2.95A/C/E/G/I/K/M/O/Q/S/U/W/Y/a/c17-346[»]

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Family and domain databases

Gene3Di2.10.77.10. 1 hit.
3.90.20.10. 1 hit.
3.90.209.20. 1 hit.
InterProiIPR008980. Capsid_hemagglutn.
IPR013828. Hemagglutn_HA1_a/b_dom.
IPR013827. Hemagglutn_HA1_b-rbn_dom.
IPR000149. Hemagglutn_influenz_A.
IPR001364. Hemagglutn_influenz_A/B.
IPR013829. Hemagglutn_stalk.
[Graphical view]
PfamiPF00509. Hemagglutinin. 1 hit.
[Graphical view]
PRINTSiPR00330. HEMAGGLUTN1.
PR00329. HEMAGGLUTN12.
SUPFAMiSSF49818. SSF49818. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5EP31-1 [UniParc]FASTAAdd to Basket

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MEKIVLLFAI VSLVKSDQIC IGYHANNSTE QVDTIMEKNV TVTHAQDILE    50
KKHNGKLCDL DGVKPLILRD CSVAGWLLGN PMCDEFINVP EWSYIVEKAN 100
PVNDLCYPGD FNDYEELKHL LSRINHFEKI QIIPKSSWSS HEASLGVSSA 150
CPYQGKSSFF RNVVWLIKKN STYPTIKRSY NNTNQEDLLV LWGIHHPNDA 200
AEQTKLYQNP TTYISVGTST LNQRLVPRIA TRSKVNGQSG RMEFFWTILK 250
PNDAINFESN GNFIAPEYAY KIVKKGDSTI MKSELEYGNC NTKCQTPMGA 300
INSSMPFHNI HPLTIGECPK YVKSNRLVLA TGLRNSPQRE RRRKKRGLFG 350
AIAGFIEGGW QGMVDGWYGY HHSNEQGSGY AADKESTQKA IDGVTNKVNS 400
IIDKMNTQFE AVGREFNNLE RRIENLNKKM EDGFLDVWTY NAELLVLMEN 450
ERTLDFHDSN VKNLYDKVRL QLRDNAKELG NGCFEFYHKC DNECMESVRN 500
GTYDYPQYSE EARLKREEIS GVKLESIGIY QILSIYSTVA SSLALAIMVA 550
GLSLWMCSNG SLQCRICI 568
Length:568
Mass (Da):64,461
Last modified:March 15, 2005 - v1
Checksum:i1987CB02AB9C06CA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY818135 Genomic RNA. Translation: AAW80717.1.
EF541403 Viral cRNA. Translation: ABP51977.1.
HM006759 Viral cRNA. Translation: ADD97095.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY818135 Genomic RNA. Translation: AAW80717.1 .
EF541403 Viral cRNA. Translation: ABP51977.1 .
HM006759 Viral cRNA. Translation: ADD97095.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BH2 X-ray 2.12 A 17-340 [» ]
B 347-513 [» ]
4BH3 X-ray 2.00 A 17-340 [» ]
B 347-513 [» ]
4BH4 X-ray 1.90 A 17-340 [» ]
B 347-513 [» ]
4N5Z X-ray 2.95 A/C/E/G/I/K/M/O/Q/S/U/W/Y/a/c 17-346 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60227N.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.10.77.10. 1 hit.
3.90.20.10. 1 hit.
3.90.209.20. 1 hit.
InterProi IPR008980. Capsid_hemagglutn.
IPR013828. Hemagglutn_HA1_a/b_dom.
IPR013827. Hemagglutn_HA1_b-rbn_dom.
IPR000149. Hemagglutn_influenz_A.
IPR001364. Hemagglutn_influenz_A/B.
IPR013829. Hemagglutn_stalk.
[Graphical view ]
Pfami PF00509. Hemagglutinin. 1 hit.
[Graphical view ]
PRINTSi PR00330. HEMAGGLUTN1.
PR00329. HEMAGGLUTN12.
SUPFAMi SSF49818. SSF49818. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Evolution of H5N1 avian influenza viruses in Asia."
    World Health Organization Global Influenza Program Surveillance Network
    Emerg. Infect. Dis. 11:1515-1521(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/Viet Nam/1203/2004Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/Viet Nam/1203/2004Imported.
  3. Smith C.
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/Viet Nam/1203/2004Imported.
  4. "Acquisition of virulence mutations in avian H5N1 influenza virus during a single passage in ferrets."
    Butler J., Middleton D., Klippel J., Rockman S., Brown L., Sapats S.
    Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: A/Viet Nam/1203/2004Imported.
  5. "Receptor binding by a ferret-transmissible H5 avian influenza virus."
    Xiong X., Coombs P.J., Martin S.R., Liu J., Xiao H., McCauley J.W., Locher K., Walker P.A., Collins P.J., Kawaoka Y., Skehel J.J., Gamblin S.J.
    Nature 497:392-396(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 17-340 AND 347-513 IN COMPLEX WITH GALACTOSE, GLYCOSYLATION AT ASN-27; ASN-39 AND ASN-181.
  6. "Hemagglutinin receptor specificity and structural analyses of respiratory droplet-transmissible H5N1 viruses."
    de Vries R.P., Zhu X., McBride R., Rigter A., Hanson A., Zhong G., Hatta M., Xu R., Yu W., Kawaoka Y., de Haan C.A., Wilson I.A., Paulson J.C.
    J. Virol. 88:768-773(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.95 ANGSTROMS) OF 17-346, GLYCOSYLATION AT ASN-39 AND ASN-181.

Entry informationi

Entry nameiQ5EP31_9INFA
AccessioniPrimary (citable) accession number: Q5EP31
Entry historyi
Integrated into UniProtKB/TrEMBL: March 15, 2005
Last sequence update: March 15, 2005
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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