Reviewed, UniProtKB/Swiss-Prot Q5EMU8 (MTLD_MAGGR)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
      Short name=M1PDH
      Short name=MPDH
      Short name=MPD
    EC=1.1.1.17

Gene names

ORF Names:

MGG_10503

Organism

Magnaporthe grisea (Rice blast fungus) (Pyricularia grisea) [Complete proteome]

Taxonomic identifier

148305 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Sordariomycetidae › Magnaporthales › Magnaporthaceae › Magnaporthe

Protein attributes

Sequence length	400 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the NAD(H)-dependent interconversion of D-fructose 6-phosphate and D-mannitol 1-phosphate in the mannitol metabolic pathway By similarity.
Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 400	400	Mannitol-1-phosphate 5-dehydrogenase		PRO_0000371528
Regions
	Nucleotide binding	12 – 23	12	NAD By similarity
Sites
	Active site	221	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5EMU8-1 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: AAB005CB5590EADE	FASTA	400	44,518
	10 20 30 40 50 60 MSQTNGTHTK KAVHFGAGNI GRGFVACFLH NSGYEVVFAD VTDRTCDALN NQTSYKVIEV 70 80 90 100 110 120 GAEGTEEKTI TNYRAINSKT KEDELLQEIA TADVVTCSVG PNILKFIAPV IAKGLDMRSE 130 140 150 160 170 180 ELKPAAVIAC ENAIGATDTL AEHIKEHLPA TRVEDLSTRA RFANSAIDRI VPAQDPNSGL 190 200 210 220 230 240 DVKLEKFYEW VVDRTPFADH EVPSIEGIHW VDNLEPYIER KLYTVNTGHA TAAYHGYNRQ 250 260 270 280 290 300 KRTVYDALQD REIQSEVRRA LENTSKLITA KHGINPEEQQ AYVRKIMTRI GNPHLEDAVE 310 320 330 340 350 360 RVGRAPLRKL SRKERFVGPA AELAEKGEDC SALLDAAEMA LRFQNVEEDA ESKELAKIMA 370 380 390 400 ENSAEQVVSQ VCGLQPSEKL YPKMVEIVHR VQQDSMDDTE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Dong H.-T., Peng Y.-L., Chen B.-S., Li Y.-Z., Li D.-B. Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Y34.
[2]	"The genome sequence of the rice blast fungus Magnaporthe grisea." Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K., Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D., Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S., Soanes D.M. , Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M., Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E., Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W. Nature 434:980-986(2005) [PubMed: 15846337] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 70-15 / FGSC 8958.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY849685 mRNA. Translation: AAX07705.1. CH476786 Genomic DNA. Translation: EDK06587.1.
RefSeq	XP_366284.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2682115.
KEGG	mgr:MGG_10503.
NMPDR	fig|242507.1.peg.8023.
Phylogenomic databases
OMA	VDRIVPN.
Family and domain databases
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_MAGGR

Accession

Primary (citable) accession number: Q5EMU8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	March 15, 2005
Last modified:	November 3, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)