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Protein

Interferon regulatory factor 2-binding protein-like

Gene

Irf2bpl

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May contribute to the control of female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri702 – 74948RING-type; degenerateAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • development of secondary female sexual characteristics Source: ParkinsonsUK-UCL
  • negative regulation of transcription from RNA polymerase II promoter Source: ParkinsonsUK-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon regulatory factor 2-binding protein-like
Alternative name(s):
Enhanced at puberty protein 1
Polyglutamine-containing protein
Gene namesi
Name:Irf2bpl
Synonyms:Eap1, Pqcp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310994. Irf2bpl.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 783783Interferon regulatory factor 2-binding protein-likePRO_0000323512Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei203 – 2031PhosphoserineCombined sources
Modified residuei506 – 5061PhosphoserineBy similarity
Modified residuei534 – 5341PhosphoserineCombined sources
Modified residuei644 – 6441PhosphoserineBy similarity
Modified residuei645 – 6451PhosphoserineBy similarity
Modified residuei646 – 6461PhosphoserineBy similarity
Modified residuei649 – 6491PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5EIC4.
PRIDEiQ5EIC4.

PTM databases

iPTMnetiQ5EIC4.
PhosphoSiteiQ5EIC4.

Expressioni

Tissue specificityi

Expressed in the regions of the hypothalamus involved in reproductive control, such as medial preoptic area, arcuate nucleus and ventromedial nucleus.1 Publication

Developmental stagei

Up-regulated during puberty in the hypothalamus, but not in the cerebral cortex.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064525.

Structurei

3D structure databases

ProteinModelPortaliQ5EIC4.
SMRiQ5EIC4. Positions 693-773.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili85 – 11228Sequence analysisAdd
BLAST
Coiled coili323 – 35836Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi70 – 756Poly-Pro
Compositional biasi88 – 958Poly-Ala
Compositional biasi96 – 11520Gln-richAdd
BLAST
Compositional biasi141 – 15212Poly-AlaAdd
BLAST
Compositional biasi162 – 290129Pro-richAdd
BLAST
Compositional biasi583 – 61028Pro-richAdd
BLAST
Compositional biasi672 – 6754Poly-Pro

Sequence similaritiesi

Belongs to the IRF2BP family.Curated
Contains 1 RING-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri702 – 74948RING-type; degenerateAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG3579. Eukaryota.
ENOG410Z1AW. LUCA.
HOVERGENiHBG108364.
InParanoidiQ5EIC4.
PhylomeDBiQ5EIC4.

Family and domain databases

InterProiIPR022750. Interferon_reg_fac2-bd1_2_Znf.
[Graphical view]
PfamiPF11261. IRF-2BP1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5EIC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAAQVSSSR RQSCYLCDLP RMPWAMIWDF SEPVCRGCVN YEGADRIEFV
60 70 80 90 100
IETARQLKRA HGCFQDGRSP GPPPPVGVKT VALSAKEAAA AAAAAQQQQQ
110 120 130 140 150
QQQQQQQQQQ QQPQQLNHVD GSTKPAVLPA PSGLERYGLS AAAAAAAAAA
160 170 180 190 200
AAVEQRSRFE YPPPPVSLGS SSHAARLPNG LGGPNGFPKP APEEGPPELN
210 220 230 240 250
RQSPNSSSAA TSVASRRGTH SGLVTGLPNP GGGGGPQLTV PPNLLPQTLL
260 270 280 290 300
NGPASAAVLP PPHGLGGSRG PPTPAPPGAP GGPACLGGPP GVSATVSSAP
310 320 330 340 350
SSTSSTVAEV GVGAAGKRPG SVSSTDQERE LKEKQRNAEA LAELSESLRN
360 370 380 390 400
RAEEWANKPK MVRDTLLTLA GCTPYEVRFK KDHSLLGRVF AFDAVSKPGM
410 420 430 440 450
DYELKLFIEY PTGSGNVYSS ASGVAKQMYQ DCMKDFGRGL SSGFKYLEYE
460 470 480 490 500
KKHGSGDWRL LGDLLPEAVR FFKEGVPGAD MLPQPYLDAS CPMLPTALVS
510 520 530 540 550
LSRAPSAPPG TGALPPAAPT GRGAAASLRK RKASPEPPDS AESALKLGEE
560 570 580 590 600
QQRQQWMANQ SEALKLTMSA GGFAAPGHAA GGPPPPPPPL GPHSNRTTPP
610 620 630 640 650
ESAPQNGPSP MAALMSVADT LGTAHSPKDG SSVHSTTASA RRNSSSPVSP
660 670 680 690 700
ASVPGQRRLA SRNGDLNLQV APPPPSAHPG MDQVHPQNIP DSPMANSGPL
710 720 730 740 750
CCTICHERLE DTHFVQCPSV PSHKFCFPCS RESIKAQGAT GEVYCPSGEK
760 770 780
CPLVGSNVPW AFMQGEIATI LAGDVKVKKE RDP
Length:783
Mass (Da):81,496
Last modified:March 15, 2005 - v1
Checksum:i27BB8D21D8EA85FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY879229 Genomic DNA. Translation: AAW72780.1.
BC098759 mRNA. Translation: AAH98759.1.
RefSeqiNP_001012488.1. NM_001012470.1.
UniGeneiRn.15682.

Genome annotation databases

GeneIDi314329.
KEGGirno:314329.
UCSCiRGD:1310994. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY879229 Genomic DNA. Translation: AAW72780.1.
BC098759 mRNA. Translation: AAH98759.1.
RefSeqiNP_001012488.1. NM_001012470.1.
UniGeneiRn.15682.

3D structure databases

ProteinModelPortaliQ5EIC4.
SMRiQ5EIC4. Positions 693-773.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064525.

PTM databases

iPTMnetiQ5EIC4.
PhosphoSiteiQ5EIC4.

Proteomic databases

PaxDbiQ5EIC4.
PRIDEiQ5EIC4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi314329.
KEGGirno:314329.
UCSCiRGD:1310994. rat.

Organism-specific databases

CTDi64207.
RGDi1310994. Irf2bpl.

Phylogenomic databases

eggNOGiKOG3579. Eukaryota.
ENOG410Z1AW. LUCA.
HOVERGENiHBG108364.
InParanoidiQ5EIC4.
PhylomeDBiQ5EIC4.

Miscellaneous databases

PROiQ5EIC4.

Family and domain databases

InterProiIPR022750. Interferon_reg_fac2-bd1_2_Znf.
[Graphical view]
PfamiPF11261. IRF-2BP1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Enhanced at puberty 1 (EAP1) is a new transcriptional regulator of the female neuroendocrine reproductive axis."
    Heger S., Mastronardi C., Dissen G.A., Lomniczi A., Cabrera R., Roth C.L., Jung H., Galimi F., Sippell W., Ojeda S.R.
    J. Clin. Invest. 117:2145-2154(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 434-783.
    Tissue: Liver.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203 AND SER-534, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiI2BPL_RAT
AccessioniPrimary (citable) accession number: Q5EIC4
Secondary accession number(s): Q4G048
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 15, 2005
Last modified: June 8, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.