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Q5EF78

- ICA_APICA

UniProt

Q5EF78 - ICA_APICA

Protein

Icarapin

Gene
N/A
Organism
Apis mellifera carnica (Carniolan bee)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 2 (30 Nov 2010)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Icarapin
    Alternative name(s):
    Venom protein 2
    Allergen: Api m 10
    OrganismiApis mellifera carnica (Carniolan bee)
    Taxonomic identifieri88217 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataApoideaApidaeApis

    Subcellular locationi

    Secreted 2 Publications

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.

    Keywords - Diseasei

    Allergen

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 223204IcarapinPRO_5000095342Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ5EF78.

    Expressioni

    Tissue specificityi

    Expressed by the venom duct.1 Publication

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG83101.
    InParanoidiQ5EF78.

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform variant 1 (identifier: Q5EF78-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKTLGVLFIA AWFIACTHSF PGAHDEDSKE ERKNVDTVLV LPSIERDQMM    50
    AATFDFPSLS FEDSDEGSNW NWNTLLRPNF LDGWYQTLQS AISAHMKKVR 100
    EQMAGILSRI PEQGVVNWNK IPEGANTTST TKIIDGHVVT INETTYTDGS 150
    DDYSTLIRVR VIDVRPQNET ILTTVSSEAD SDVTTLPTLI GKNETSTQSS 200
    RSVESVEDFD NEIPKNQGDV LTA 223
    Length:223
    Mass (Da):24,819
    Last modified:November 30, 2010 - v2
    Checksum:i9BD51D084DFBFB28
    GO
    Isoform variant 2 (identifier: Q5EF78-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         90-94: SAISA → T

    Note: fragment, sequence of 45-223.

    Show »
    Length:219
    Mass (Da):24,490
    Checksum:iD0441FFB07784974
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti140 – 1401T → A in AAW81036. (PubMed:16914147)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei90 – 945SAISA → T in isoform variant 2. CuratedVSP_040198

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY897570 mRNA. Translation: AAW81036.1.
    DQ485318 mRNA. Translation: ABF21077.1.
    DQ485319 mRNA. Translation: ABF21078.1.
    UniGeneiAme.1095.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY897570 mRNA. Translation: AAW81036.1 .
    DQ485318 mRNA. Translation: ABF21077.1 .
    DQ485319 mRNA. Translation: ABF21078.1 .
    UniGenei Ame.1095.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q5EF78.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG83101.
    InParanoidi Q5EF78.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The protein composition of honeybee venom reconsidered by a proteomic approach."
      Peiren N., Vanrobaeys F., de Graaf D.C., Devreese B., Van Beeumen J., Jacobs F.J.
      Biochim. Biophys. Acta 1752:1-5(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 33-46 AND 99-109, SUBCELLULAR LOCATION, TISSUE SPECIFICITY (ISOFORM VARIANT 1).
      Tissue: Venom and Venom duct.
    2. "Molecular cloning and expression of icarapin, a novel IgE-binding bee venom protein."
      Peiren N., de Graaf D.C., Brunain M., Bridts C.H., Ebo D.G., Stevens W.J., Jacobs F.J.
      FEBS Lett. 580:4895-4899(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, TISSUE SPECIFICITY, ALLERGEN (ISOFORMS VARIANT 1 AND VARIANT 2).
      Tissue: Venom duct.

    Entry informationi

    Entry nameiICA_APICA
    AccessioniPrimary (citable) accession number: Q5EF78
    Secondary accession number(s): Q1HHN7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 30, 2010
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 23 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries

    External Data

    Dasty 3