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Protein

Icarapin

Gene
N/A
Organism
Apis mellifera carnica (Carniolan honeybee)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Icarapin
Alternative name(s):
Venom protein 2
Allergen: Api m 10
OrganismiApis mellifera carnica (Carniolan honeybee)
Taxonomic identifieri88217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataApoideaApidaeApis

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500009534220 – 223IcarapinAdd BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi126N-linked (GlcNAc...)Sequence analysis1
Glycosylationi142N-linked (GlcNAc...)Sequence analysis1
Glycosylationi168N-linked (GlcNAc...)Sequence analysis1
Glycosylationi193N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ5EF78.

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Family & Domainsi

Keywords - Domaini

Signal

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform variant 1 (identifier: Q5EF78-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKTLGVLFIA AWFIACTHSF PGAHDEDSKE ERKNVDTVLV LPSIERDQMM
60 70 80 90 100
AATFDFPSLS FEDSDEGSNW NWNTLLRPNF LDGWYQTLQS AISAHMKKVR
110 120 130 140 150
EQMAGILSRI PEQGVVNWNK IPEGANTTST TKIIDGHVVT INETTYTDGS
160 170 180 190 200
DDYSTLIRVR VIDVRPQNET ILTTVSSEAD SDVTTLPTLI GKNETSTQSS
210 220
RSVESVEDFD NEIPKNQGDV LTA
Length:223
Mass (Da):24,819
Last modified:November 30, 2010 - v2
Checksum:i9BD51D084DFBFB28
GO
Isoform variant 2 (identifier: Q5EF78-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-94: SAISA → T

Note: fragment, sequence of 45-223.
Show »
Length:219
Mass (Da):24,490
Checksum:iD0441FFB07784974
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140T → A in AAW81036 (PubMed:16914147).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04019890 – 94SAISA → T in isoform variant 2. Curated5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY897570 mRNA. Translation: AAW81036.1.
DQ485318 mRNA. Translation: ABF21077.1.
DQ485319 mRNA. Translation: ABF21078.1.
UniGeneiAme.1095.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY897570 mRNA. Translation: AAW81036.1.
DQ485318 mRNA. Translation: ABF21077.1.
DQ485319 mRNA. Translation: ABF21078.1.
UniGeneiAme.1095.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5EF78.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiICA_APICA
AccessioniPrimary (citable) accession number: Q5EF78
Secondary accession number(s): Q1HHN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: November 30, 2010
Last modified: October 5, 2016
This is version 28 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Caution

Sequences and experimental results obtained from PubMed:16112630 and PubMed:16914147 are obtained from A.mellifera carnica and not A.mellifera.Curated

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.