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Protein
Submitted name:

Insulin II

Gene

Ins2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.SAAS annotation

GO - Molecular functioni

  1. hormone activity Source: MGI
  2. identical protein binding Source: MGI
  3. insulin-like growth factor receptor binding Source: MGI
  4. insulin receptor binding Source: MGI
  5. protease binding Source: MGI

GO - Biological processi

  1. activation of MAPK activity Source: MGI
  2. activation of protein kinase B activity Source: MGI
  3. acute-phase response Source: MGI
  4. alpha-beta T cell activation Source: MGI
  5. canonical Wnt signaling pathway Source: MGI
  6. ER overload response Source: MGI
  7. fatty acid homeostasis Source: MGI
  8. glucose homeostasis Source: MGI
  9. glucose metabolic process Source: MGI
  10. glucose transport Source: MGI
  11. G-protein coupled receptor signaling pathway Source: MGI
  12. insulin receptor signaling pathway Source: MGI
  13. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: MGI
  14. lipid catabolic process Source: MGI
  15. MAPK cascade Source: MGI
  16. myoblast fusion Source: MGI
  17. myotube differentiation Source: MGI
  18. negative regulation of acute inflammatory response Source: MGI
  19. negative regulation of fatty acid metabolic process Source: MGI
  20. negative regulation of feeding behavior Source: MGI
  21. negative regulation of glycogen catabolic process Source: MGI
  22. negative regulation of lipid catabolic process Source: MGI
  23. negative regulation of NAD(P)H oxidase activity Source: MGI
  24. negative regulation of protein catabolic process Source: MGI
  25. negative regulation of protein oligomerization Source: MGI
  26. negative regulation of protein secretion Source: MGI
  27. negative regulation of proteolysis Source: MGI
  28. negative regulation of respiratory burst involved in inflammatory response Source: MGI
  29. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  30. positive regulation of cell proliferation Source: MGI
  31. positive regulation of cellular protein metabolic process Source: MGI
  32. positive regulation of cytokine secretion Source: MGI
  33. positive regulation of DNA replication Source: MGI
  34. positive regulation of glucose import Source: MGI
  35. positive regulation of glycogen biosynthetic process Source: MGI
  36. positive regulation of glycolytic process Source: MGI
  37. positive regulation of insulin receptor signaling pathway Source: MGI
  38. positive regulation of MAPK cascade Source: MGI
  39. positive regulation of mitotic nuclear division Source: MGI
  40. positive regulation of NF-kappaB transcription factor activity Source: MGI
  41. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  42. positive regulation of phosphatidylinositol 3-kinase activity Source: MGI
  43. positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
  44. positive regulation of protein kinase B signaling Source: MGI
  45. positive regulation of protein localization to nucleus Source: MGI
  46. positive regulation of respiratory burst Source: MGI
  47. regulation of cellular amino acid metabolic process Source: MGI
  48. regulation of gene expression Source: MGI
  49. regulation of phosphorylation Source: MGI
  50. regulation of protein binding Source: MGI
  51. regulation of protein localization Source: MGI
  52. regulation of protein secretion Source: MGI
  53. regulation of transmembrane transporter activity Source: MGI
  54. wound healing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

HormoneSAAS annotation

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolismSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Insulin IIImported
Submitted name:
Insulin II, isoform CRA_aImported
Submitted name:
ProinsulinImported
Gene namesi
Name:Ins2Imported
ORF Names:mCG_11077Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96573. Ins2.

Subcellular locationi

Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular space Source: MGI
  3. nucleus Source: MGI
  4. secretory granule Source: MGI
  5. small nucleolar ribonucleoprotein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiQ5EEX1.

Expressioni

Gene expression databases

BgeeiQ5EEX1.
ExpressionAtlasiQ5EEX1. differential.
GenevestigatoriQ5EEX1.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.SAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ5EEX1.
SMRiQ5EEX1. Positions 25-110.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000015440.
HOVERGENiHBG006137.
KOiK04526.
OMAiAPPQHLC.
PhylomeDBiQ5EEX1.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR004825. Insulin.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00277. INSULIN.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5EEX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWMRFLPL LALLFLWESH PTQAFVKQHL CGSHLVEALY LVCGERGFFY
60 70 80 90 100
TPMSRREVED PQVAQLELGG GPGAGDLQTL ALEVAQQKRG IVDQCCTSIC
110
SLYQLENYCN
Length:110
Mass (Da):12,364
Last modified:May 9, 2005 - v1
Checksum:i3554C8803D24FDAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099934 mRNA. Translation: AAH99934.1.
BC132650 mRNA. Translation: AAI32651.1.
BC132652 mRNA. Translation: AAI32653.1.
BC145554 mRNA. Translation: AAI45555.1.
AY899305 mRNA. Translation: AAW83742.1.
AK007612 mRNA. Translation: BAB25135.1.
CH466531 Genomic DNA. Translation: EDL18179.1.
CH466531 Genomic DNA. Translation: EDL18180.1.
RefSeqiNP_001172012.1. NM_001185083.1.
NP_001172013.1. NM_001185084.1.
NP_032413.1. NM_008387.4.
UniGeneiMm.4946.

Genome annotation databases

GeneIDi16334.
KEGGimmu:16334.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099934 mRNA. Translation: AAH99934.1.
BC132650 mRNA. Translation: AAI32651.1.
BC132652 mRNA. Translation: AAI32653.1.
BC145554 mRNA. Translation: AAI45555.1.
AY899305 mRNA. Translation: AAW83742.1.
AK007612 mRNA. Translation: BAB25135.1.
CH466531 Genomic DNA. Translation: EDL18179.1.
CH466531 Genomic DNA. Translation: EDL18180.1.
RefSeqiNP_001172012.1. NM_001185083.1.
NP_001172013.1. NM_001185084.1.
NP_032413.1. NM_008387.4.
UniGeneiMm.4946.

3D structure databases

ProteinModelPortaliQ5EEX1.
SMRiQ5EEX1. Positions 25-110.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5EEX1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16334.
KEGGimmu:16334.

Organism-specific databases

CTDi16334.
MGIiMGI:96573. Ins2.

Phylogenomic databases

GeneTreeiENSGT00390000015440.
HOVERGENiHBG006137.
KOiK04526.
OMAiAPPQHLC.
PhylomeDBiQ5EEX1.

Miscellaneous databases

ChiTaRSiIns2. mouse.
NextBioi289430.
SOURCEiSearch...

Gene expression databases

BgeeiQ5EEX1.
ExpressionAtlasiQ5EEX1. differential.
GenevestigatoriQ5EEX1.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR004825. Insulin.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00277. INSULIN.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PancreasImported.
  2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PancreasImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PancreasImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PancreasImported.
  5. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2000)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PancreasImported.
  6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PancreasImported.
  7. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported and PancreasImported.
  9. "Increased insulin translation from an insulin splice-variant overexpressed in diabetes, obesity, and insulin resistance."
    Minn A.H., Lan H., Rabaglia M.E., Harlan D.M., Peculis B.A., Attie A.D., Shalev A.
    Mol. Endocrinol. 19:794-803(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  10. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2004)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PancreasImported.
  11. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: PancreasImported.
  12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiQ5EEX1_MOUSE
AccessioniPrimary (citable) accession number: Q5EEX1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 9, 2005
Last sequence update: May 9, 2005
Last modified: March 31, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.