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Protein

Insulin

Gene

Ins2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.UniRule annotationSAAS annotation

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HormoneUniRule annotationSAAS annotation

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolismUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
InsulinUniRule annotation
Gene namesi
Name:Ins2Imported
ORF Names:mCG_11077Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:96573. Ins2.

Subcellular locationi

  • Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 11086InsulinSequence analysisPRO_5007924748Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000000215.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000220.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 10982IlGFInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the insulin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410J0XC. Eukaryota.
ENOG4111VJB. LUCA.
GeneTreeiENSGT00390000015440.
HOVERGENiHBG006137.
KOiK04526.
OMAiDPQVGQV.
OrthoDBiEOG091G0H56.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR004825. Insulin.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00277. INSULIN.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5EEX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWMRFLPL LALLFLWESH PTQAFVKQHL CGSHLVEALY LVCGERGFFY
60 70 80 90 100
TPMSRREVED PQVAQLELGG GPGAGDLQTL ALEVAQQKRG IVDQCCTSIC
110
SLYQLENYCN
Length:110
Mass (Da):12,364
Last modified:May 10, 2005 - v1
Checksum:i3554C8803D24FDAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099934 mRNA. Translation: AAH99934.1.
BC132650 mRNA. Translation: AAI32651.1.
BC132652 mRNA. Translation: AAI32653.1.
BC145554 mRNA. Translation: AAI45555.1.
AY899305 mRNA. Translation: AAW83742.1.
AK007612 mRNA. Translation: BAB25135.1.
CH466531 Genomic DNA. Translation: EDL18179.1.
CH466531 Genomic DNA. Translation: EDL18180.1.
RefSeqiNP_001172012.1. NM_001185083.2.
NP_001172013.1. NM_001185084.2.
NP_032413.1. NM_008387.5.
UniGeneiMm.4946.

Genome annotation databases

GeneIDi16334.
KEGGimmu:16334.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC099934 mRNA. Translation: AAH99934.1.
BC132650 mRNA. Translation: AAI32651.1.
BC132652 mRNA. Translation: AAI32653.1.
BC145554 mRNA. Translation: AAI45555.1.
AY899305 mRNA. Translation: AAW83742.1.
AK007612 mRNA. Translation: BAB25135.1.
CH466531 Genomic DNA. Translation: EDL18179.1.
CH466531 Genomic DNA. Translation: EDL18180.1.
RefSeqiNP_001172012.1. NM_001185083.2.
NP_001172013.1. NM_001185084.2.
NP_032413.1. NM_008387.5.
UniGeneiMm.4946.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000220.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16334.
KEGGimmu:16334.

Organism-specific databases

CTDi16334.
MGIiMGI:96573. Ins2.

Phylogenomic databases

eggNOGiENOG410J0XC. Eukaryota.
ENOG4111VJB. LUCA.
GeneTreeiENSGT00390000015440.
HOVERGENiHBG006137.
KOiK04526.
OMAiDPQVGQV.
OrthoDBiEOG091G0H56.

Miscellaneous databases

ChiTaRSiIns2. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000215.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR004825. Insulin.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00277. INSULIN.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5EEX1_MOUSE
AccessioniPrimary (citable) accession number: Q5EEX1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.