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Q5EEX1

- Q5EEX1_MOUSE

UniProt

Q5EEX1 - Q5EEX1_MOUSE

Protein
Submitted name:

Insulin II

Gene

Ins2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.SAAS annotation

    GO - Biological processi

    1. activation of MAPK activity Source: MGI
    2. canonical Wnt signaling pathway Source: MGI
    3. ER overload response Source: MGI
    4. glucose metabolic process Source: MGI
    5. glucose transport Source: MGI
    6. insulin receptor signaling pathway Source: MGI
    7. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: MGI
    8. lipid catabolic process Source: MGI
    9. myoblast fusion Source: MGI
    10. myotube differentiation Source: MGI
    11. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    12. positive regulation of phosphatidylinositol 3-kinase activity Source: MGI
    13. regulation of gene expression Source: MGI
    14. regulation of phosphorylation Source: MGI
    15. regulation of protein binding Source: MGI

    Keywords - Molecular functioni

    HormoneSAAS annotation

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolismSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Insulin IIImported
    Submitted name:
    Insulin II, isoform CRA_aImported
    Submitted name:
    ProinsulinImported
    Gene namesi
    Name:Ins2Imported
    ORF Names:mCG_11077Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:96573. Ins2.

    Subcellular locationi

    Secreted UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. extracellular space Source: Ensembl
    3. nucleus Source: MGI
    4. secretory granule Source: MGI
    5. small nucleolar ribonucleoprotein complex Source: MGI

    Keywords - Cellular componenti

    SecretedSAAS annotation

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ5EEX1.

    Interactioni

    Subunit structurei

    Heterodimer of a B chain and an A chain linked by two disulfide bonds.SAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the insulin family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000015440.
    HOVERGENiHBG006137.
    InParanoidiQ5EEX1.
    KOiK04526.
    OMAiVEQCCHN.

    Family and domain databases

    Gene3Di1.10.100.10. 1 hit.
    InterProiIPR004825. Insulin.
    IPR016179. Insulin-like.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view]
    PfamiPF00049. Insulin. 1 hit.
    [Graphical view]
    PRINTSiPR00277. INSULIN.
    PR00276. INSULINFAMLY.
    SMARTiSM00078. IlGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF56994. SSF56994. 1 hit.
    PROSITEiPS00262. INSULIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5EEX1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALWMRFLPL LALLFLWESH PTQAFVKQHL CGSHLVEALY LVCGERGFFY    50
    TPMSRREVED PQVAQLELGG GPGAGDLQTL ALEVAQQKRG IVDQCCTSIC 100
    SLYQLENYCN 110
    Length:110
    Mass (Da):12,364
    Last modified:May 10, 2005 - v1
    Checksum:i3554C8803D24FDAD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC099934 mRNA. Translation: AAH99934.1.
    BC132650 mRNA. Translation: AAI32651.1.
    BC132652 mRNA. Translation: AAI32653.1.
    BC145554 mRNA. Translation: AAI45555.1.
    AY899305 mRNA. Translation: AAW83742.1.
    AK007612 mRNA. Translation: BAB25135.1.
    CH466531 Genomic DNA. Translation: EDL18179.1.
    CH466531 Genomic DNA. Translation: EDL18180.1.
    RefSeqiNP_001172012.1. NM_001185083.1.
    NP_001172013.1. NM_001185084.1.
    NP_032413.1. NM_008387.4.
    UniGeneiMm.4946.

    Genome annotation databases

    GeneIDi16334.
    KEGGimmu:16334.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC099934 mRNA. Translation: AAH99934.1 .
    BC132650 mRNA. Translation: AAI32651.1 .
    BC132652 mRNA. Translation: AAI32653.1 .
    BC145554 mRNA. Translation: AAI45555.1 .
    AY899305 mRNA. Translation: AAW83742.1 .
    AK007612 mRNA. Translation: BAB25135.1 .
    CH466531 Genomic DNA. Translation: EDL18179.1 .
    CH466531 Genomic DNA. Translation: EDL18180.1 .
    RefSeqi NP_001172012.1. NM_001185083.1.
    NP_001172013.1. NM_001185084.1.
    NP_032413.1. NM_008387.4.
    UniGenei Mm.4946.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 16334.
    KEGGi mmu:16334.

    Organism-specific databases

    CTDi 16334.
    MGIi MGI:96573. Ins2.

    Phylogenomic databases

    GeneTreei ENSGT00390000015440.
    HOVERGENi HBG006137.
    InParanoidi Q5EEX1.
    KOi K04526.
    OMAi VEQCCHN.

    Miscellaneous databases

    ChiTaRSi Ins2. mouse.
    NextBioi 289430.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q5EEX1.

    Family and domain databases

    Gene3Di 1.10.100.10. 1 hit.
    InterProi IPR004825. Insulin.
    IPR016179. Insulin-like.
    IPR022353. Insulin_CS.
    IPR022352. Insulin_family.
    [Graphical view ]
    Pfami PF00049. Insulin. 1 hit.
    [Graphical view ]
    PRINTSi PR00277. INSULIN.
    PR00276. INSULINFAMLY.
    SMARTi SM00078. IlGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56994. SSF56994. 1 hit.
    PROSITEi PS00262. INSULIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: PancreasImported.
    2. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: PancreasImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: PancreasImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: PancreasImported.
    5. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: PancreasImported.
    6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: PancreasImported.
    7. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported and PancreasImported.
    9. "Increased insulin translation from an insulin splice-variant overexpressed in diabetes, obesity, and insulin resistance."
      Minn A.H., Lan H., Rabaglia M.E., Harlan D.M., Peculis B.A., Attie A.D., Shalev A.
      Mol. Endocrinol. 19:794-803(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    10. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: PancreasImported.
    11. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: PancreasImported.
    12. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.

    Entry informationi

    Entry nameiQ5EEX1_MOUSE
    AccessioniPrimary (citable) accession number: Q5EEX1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)