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Q5EEX1 (Q5EEX1_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Insulin II, isoform CRA_a EMBL EDL18179.1

Proinsulin EMBL AAW83742.1
Gene names
Name:Ins2 MGI 96573 EMBL AAH99934.1
ORF Names:mCG_11077 EMBL EDL18179.1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length110 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver By similarity. SAAS SAAS016179

Subunit structure

Heterodimer of a B chain and an A chain linked by two disulfide bonds By similarity. SAAS SAAS016179

Subcellular location

Secreted By similarity SAAS SAAS016179 RuleBase RU000406.

Sequence similarities

Belongs to the insulin family. RuleBase RU000406

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism SAAS SAAS016179
   Cellular componentSecreted SAAS SAAS016179
   Molecular functionHormone SAAS SAAS016179
   PTMDisulfide bond SAAS SAAS016179
Gene Ontology (GO)
   Biological_processER overload response

Inferred from mutant phenotype PubMed 11854325. Source: MGI

activation of MAPK activity

Inferred from direct assay PubMed 12059784. Source: MGI

canonical Wnt signaling pathway

Inferred from genetic interaction PubMed 15282335. Source: MGI

glucose metabolic process

Inferred from mutant phenotype PubMed 11854325. Source: MGI

glucose transport

Traceable author statement PubMed 12297296. Source: MGI

insulin receptor signaling pathway

Inferred from direct assay PubMed 12805218. Source: MGI

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Inferred from mutant phenotype PubMed 11854325. Source: MGI

lipid catabolic process

Inferred from direct assay PubMed 12805218. Source: MGI

myoblast fusion

Inferred from genetic interaction PubMed 15282335. Source: MGI

myotube differentiation

Inferred from genetic interaction PubMed 15282335. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 9689059. Source: MGI

positive regulation of phosphatidylinositol 3-kinase activity

Inferred from direct assay PubMed 11375348. Source: MGI

regulation of gene expression

Inferred from direct assay PubMed 19293336. Source: MGI

regulation of phosphorylation

Inferred from direct assay PubMed 12059784. Source: MGI

regulation of protein binding

Inferred from direct assay PubMed 9507006. Source: MGI

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 15793245. Source: MGI

extracellular space

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from direct assay PubMed 12488434. Source: MGI

secretory granule

Inferred from direct assay PubMed 15788565. Source: MGI

small nucleolar ribonucleoprotein complex

Inferred from direct assay PubMed 12488434. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q5EEX1 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 3554C8803D24FDAD

FASTA11012,364
        10         20         30         40         50         60 
MALWMRFLPL LALLFLWESH PTQAFVKQHL CGSHLVEALY LVCGERGFFY TPMSRREVED 

        70         80         90        100        110 
PQVAQLELGG GPGAGDLQTL ALEVAQQKRG IVDQCCTSIC SLYQLENYCN 

« Hide

References

« Hide 'large scale' references
[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB25135.1.
Tissue: Pancreas EMBL BAB25135.1.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB25135.1.
Tissue: Pancreas EMBL BAB25135.1.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB25135.1.
Tissue: Pancreas EMBL BAB25135.1.
[4]Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., Arakawa T., Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., Hanagaki T., Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F. expand/collapse author list , Imotani K., Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., Kawai J., Kojima Y., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Nishi K., Nomura K., Numazaki R., Ohno M., Okazaki Y., Okido T., Owa C., Saito H., Saito R., Sakai C., Sakai K., Sano H., Sasaki D., Shibata K., Shibata Y., Shinagawa A., Shiraki T., Sogabe Y., Suzuki H., Tagami M., Tagawa A., Takahashi F., Tanaka T., Tejima Y., Toya T., Yamamura T., Yasunishi A., Yoshida K., Yoshino M., Muramatsu M., Hayashizaki Y.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB25135.1.
Tissue: Pancreas EMBL BAB25135.1.
[5]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB25135.1.
Tissue: Pancreas EMBL BAB25135.1.
[6]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB25135.1.
Tissue: Pancreas EMBL BAB25135.1.
[7]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL18179.1.
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain EMBL AAI32651.1 and Pancreas EMBL AAH99934.1.
[9]"Increased insulin translation from an insulin splice-variant overexpressed in diabetes, obesity, and insulin resistance."
Minn A.H., Lan H., Rabaglia M.E., Harlan D.M., Peculis B.A., Attie A.D., Shalev A.
Mol. Endocrinol. 19:794-803(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[10]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB25135.1.
Tissue: Pancreas EMBL BAB25135.1.
[11]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB25135.1.
Tissue: Pancreas EMBL BAB25135.1.
[12]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL18179.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC099934 mRNA. Translation: AAH99934.1.
BC132650 mRNA. Translation: AAI32651.1.
BC132652 mRNA. Translation: AAI32653.1.
BC145554 mRNA. Translation: AAI45555.1.
AY899305 mRNA. Translation: AAW83742.1.
AK007612 mRNA. Translation: BAB25135.1.
CH466531 Genomic DNA. Translation: EDL18179.1.
CH466531 Genomic DNA. Translation: EDL18180.1.
RefSeqNP_001172012.1. NM_001185083.1.
NP_001172013.1. NM_001185084.1.
NP_032413.1. NM_008387.4.
UniGeneMm.4946.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID16334.
KEGGmmu:16334.

Organism-specific databases

CTD16334.
MGIMGI:96573. Ins2.

Phylogenomic databases

GeneTreeENSGT00390000015440.
HOVERGENHBG006137.
InParanoidQ5EEX1.
KOK04526.
OMAAPPQHLC.

Gene expression databases

GenevestigatorQ5EEX1.

Family and domain databases

Gene3D1.10.100.10. 1 hit.
InterProIPR004825. Insulin.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSPR00277. INSULIN.
PR00276. INSULINFAMLY.
SMARTSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMSSF56994. SSF56994. 1 hit.
PROSITEPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIns2. mouse.
NextBio289430.
SOURCESearch...

Entry information

Entry nameQ5EEX1_MOUSE
AccessionPrimary (citable) accession number: Q5EEX1
Entry history
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)