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Protein

Purine nucleoside phosphorylase DeoD-type

Gene

deoD

Organism
Bacillus cereus
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation
Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei4Purine nucleoside; shared with dimeric partnerBy similarity1
Binding sitei20Phosphate; via amide nitrogenBy similarity1
Binding sitei24PhosphateBy similarity1
Binding sitei43Phosphate; shared with dimeric partnerBy similarity1
Binding sitei162Purine nucleosideBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylase DeoD-typeUniRule annotation (EC:2.4.2.1UniRule annotation)
Short name:
PNPUniRule annotation
Gene namesi
Name:deoDUniRule annotation
OrganismiBacillus cereus
Taxonomic identifieri1396 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000631151 – 235Purine nucleoside phosphorylase DeoD-typeAdd BLAST235

Interactioni

Subunit structurei

Homohexamer.UniRule annotation

Structurei

Secondary structure

1235
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi14 – 18Combined sources5
Helixi22 – 32Combined sources11
Beta strandi34 – 40Combined sources7
Helixi42 – 44Combined sources3
Beta strandi47 – 52Combined sources6
Beta strandi55 – 60Combined sources6
Helixi66 – 80Combined sources15
Beta strandi84 – 93Combined sources10
Beta strandi95 – 98Combined sources4
Beta strandi103 – 112Combined sources10
Helixi115 – 119Combined sources5
Helixi131 – 144Combined sources14
Beta strandi148 – 155Combined sources8
Helixi165 – 172Combined sources8
Beta strandi177 – 181Combined sources5
Helixi182 – 192Combined sources11
Beta strandi195 – 205Combined sources11
Turni206 – 208Combined sources3
Helixi215 – 217Combined sources3
Helixi218 – 232Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UAVX-ray1.40A1-235[»]
3UAWX-ray1.20A1-235[»]
3UAXX-ray1.20A1-235[»]
3UAYX-ray1.40A1-235[»]
3UAZX-ray1.40A1-235[»]
ProteinModelPortaliQ5EEL8
SMRiQ5EEL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni87 – 90Phosphate bindingBy similarity4
Regioni179 – 181Purine nucleoside bindingBy similarity3
Regioni203 – 204Purine nucleoside bindingBy similarity2

Sequence similaritiesi

Belongs to the PNP/UDP phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D3A Bacteria
COG0813 LUCA

Family and domain databases

HAMAPiMF_01627 Pur_nucleosid_phosp, 1 hit
InterProiView protein in InterPro
IPR004402 DeoD-type
IPR018016 Nucleoside_phosphorylase_CS
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
PANTHERiPTHR43691:SF2 PTHR43691:SF2, 1 hit
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR00107 deoD, 1 hit
PROSITEiView protein in PROSITE
PS01232 PNP_UDP_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q5EEL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVHIEAKQG EIAESILLPG DPLRAKYIAE TFLEDVTCYN NVRGMLGFTG
60 70 80 90 100
TYKGKRVSVQ GTGMGVPSIS IYVNELIQSY GVKNLIRVGT CGAIQKDVKV
110 120 130 140 150
RDVIIAMTAC TDSNMNRLTF PGFDFAPAAN FDLLKKAYDA GTEKGLHVRV
160 170 180 190 200
GNVLTADVFY RESMDMVKKL GDYGVLAVEM ETTALYTLAA KYGVNALSVL
210 220 230
TVSDHIFTGE ETTSEERQTT FNEMIEIALD AAIQQ
Length:235
Mass (Da):25,675
Last modified:April 14, 2009 - v2
Checksum:i41A138A380CA3C31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY900166 Genomic DNA Translation: AAW82755.2
RefSeqiWP_000110707.1, NZ_PIYQ01000024.1

Genome annotation databases

GeneIDi31630975

Similar proteinsi

Entry informationi

Entry nameiDEOD_BACCE
AccessioniPrimary (citable) accession number: Q5EEL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: April 14, 2009
Last modified: March 28, 2018
This is version 56 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure
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Main funding by: National Institutes of Health