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Protein

Centromere protein W

Gene

CENPW

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPW has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis.By similarity5 Publications

Caution

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • CENP-A containing nucleosome assembly Source: UniProtKB
  • chromosome organization Source: UniProtKB
  • chromosome segregation Source: UniProtKB
  • kinetochore assembly Source: UniProtKB
  • mitotic cell cycle Source: UniProtKB

Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein W
Short name:
CENP-W
Alternative name(s):
Cancer-up-regulated gene 2 protein
Gene namesi
Name:CENPW
Synonyms:C6orf173, CUG2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000203760.8
HGNCiHGNC:21488 CENPW
MIMi611264 gene
neXtProtiNX_Q5EE01

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi387103
OpenTargetsiENSG00000203760
PharmGKBiPA165617841

Polymorphism and mutation databases

BioMutaiCENPW
DMDMi74741448

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003111831 – 88Centromere protein WAdd BLAST88

Proteomic databases

EPDiQ5EE01
MaxQBiQ5EE01
PaxDbiQ5EE01
PeptideAtlasiQ5EE01
PRIDEiQ5EE01
TopDownProteomicsiQ5EE01-1 [Q5EE01-1]

PTM databases

iPTMnetiQ5EE01
PhosphoSitePlusiQ5EE01

Expressioni

Tissue specificityi

Highly expressed in ovary, liver, lung and pancreas and to a lower extent in breast and gastrointestinal tract cancers; such as those of the colon, rectum and stomach. Overexpressed in high grade breast invasive tumors. Expressed in many cancer cell types.2 Publications

Gene expression databases

BgeeiENSG00000203760
CleanExiHS_C6orf173
ExpressionAtlasiQ5EE01 baseline and differential
GenevisibleiQ5EE01 HS

Organism-specific databases

HPAiHPA067285

Interactioni

Subunit structurei

Heterodimer with CENPT; this dimer coassembles with CENPS-CENPX heterodimers at centromeres to form the tetrameric CENP-T-W-S-X complex, which is a subcomplex of the large constitutive centromere-associated network (CCAN, also known as the interphase centromere complex or ICEN) (PubMed:19070575, PubMed:19533040, PubMed:21695110, PubMed:22304917). Interacts with NPM1 (PubMed:22002061).5 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1322406 interactors.
CORUMiQ5EE01
IntActiQ5EE01 3 interactors.
STRINGi9606.ENSP00000357311

Structurei

3D structure databases

ProteinModelPortaliQ5EE01
SMRiQ5EE01
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CENP-W/WIP1 family.Curated

Phylogenomic databases

eggNOGiENOG410J16U Eukaryota
ENOG411155P LUCA
GeneTreeiENSGT00390000010369
HOGENOMiHOG000060251
InParanoidiQ5EE01
OMAiTNACESK
OrthoDBiEOG091G1B79
PhylomeDBiQ5EE01
TreeFamiTF343285

Family and domain databases

Gene3Di1.10.20.101 hit
InterProiView protein in InterPro
IPR028847 CENP-W
IPR009072 Histone-fold
PfamiView protein in Pfam
PF15510 CENP-W, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5EE01-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALSTIVSQR KQIKRKAPRG FLKRVFKRKK PQLRLEKSGD LLVHLNCLLF
60 70 80
VHRLAEESRT NACASKCRVI NKEHVLAAAK VILKKSRG
Length:88
Mass (Da):10,061
Last modified:March 15, 2005 - v1
Checksum:i3BC0A6F158B1E6D9
GO
Isoform 2 (identifier: Q5EE01-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     43-43: V → VRFHPFSGWEWGTGEV

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:103
Mass (Da):11,835
Checksum:i5363AD93990CA973
GO

Sequence cautioni

The sequence EAW48122 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAW48123 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05570843V → VRFHPFSGWEWGTGEV in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY902475 mRNA Translation: AAW82474.1
AC020559 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48121.1
CH471051 Genomic DNA Translation: EAW48122.1 Sequence problems.
CH471051 Genomic DNA Translation: EAW48123.1 Sequence problems.
BC017928 mRNA Translation: AAH17928.1
BC039556 mRNA Translation: AAH39556.1
BC046178 mRNA Translation: AAH46178.1
BC062798 mRNA Translation: AAH62798.1
CCDSiCCDS34529.1 [Q5EE01-1]
CCDS69196.1 [Q5EE01-2]
RefSeqiNP_001012525.1, NM_001012507.3 [Q5EE01-1]
NP_001273453.1, NM_001286524.1 [Q5EE01-2]
NP_001273454.1, NM_001286525.1
XP_016866334.1, XM_017010845.1
UniGeneiHs.486401

Genome annotation databases

EnsembliENST00000368325; ENSP00000357308; ENSG00000203760 [Q5EE01-2]
ENST00000368328; ENSP00000357311; ENSG00000203760 [Q5EE01-1]
GeneIDi387103
KEGGihsa:387103
UCSCiuc003qao.5 human [Q5EE01-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCENPW_HUMAN
AccessioniPrimary (citable) accession number: Q5EE01
Secondary accession number(s): A6NIR0, A6NJC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 15, 2005
Last modified: April 25, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome