Q5EBY4 (Q5EBY4_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Erbb2 EMBL AAX09341.1

Gene names

Name:

erbb2 ZFIN ZDB-GENE-031118-121

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) EMBL AAX09341.1

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	1275 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS009030
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. RuleBase RU000307 Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS009030 Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase RuleBase RU000307 SAAS SAAS009030
PTM	Phosphoprotein SAAS SAAS009030
Gene Ontology (GO)
Biological_process	Schwann cell development Inferred from mutant phenotype PubMed 16875686. Source: ZFIN axonal fasciculation Inferred from mutant phenotype PubMed 16875686. Source: ZFIN epithelial to mesenchymal transition Inferred from mutant phenotype PubMed 19911055. Source: ZFIN fin regeneration Inferred from mutant phenotype PubMed 19133254. Source: ZFIN myelination of anterior lateral line nerve axons Inferred from mutant phenotype PubMed 16875686. Source: ZFIN myelination of posterior lateral line nerve axons Inferred from mutant phenotype PubMed 16875686. Source: ZFIN neural crest cell migration Inferred from mutant phenotype PubMed 18599505. Source: ZFIN non-myelinated axon ensheathment Inferred from mutant phenotype PubMed 16875686. Source: ZFIN posterior lateral line neuromast development Inferred from mutant phenotype PubMed 16875686. Source: ZFIN signal transduction by phosphorylation Inferred from electronic annotation. Source: GOC transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW receptor signaling protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5EBY4 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: 67462B4F1B68492F	FASTA	1,275	140,829
	10 20 30 40 50 60 MEADRSFGLA WVLLLLLGIT AATGREVCLG TDMKLALPSS LENHYEMLRL LYTGCQVVHG 70 80 90 100 110 120 NLEITHLQGN PDLSFLQEIV EVQGYVLIAH VSVRSLPLDN LRIIRGSQLY KSNYALAVHN 130 140 150 160 170 180 NSNSSQAGLG LRELRLRSLT EILLGGVYIW GNPQLCFPRN INWEDTVSKV QNKPLHLQDI 190 200 210 220 230 240 PKNCPRCSSA CKSGGCWGEK DQDCQTLTSV NCSSGCSRCK GPKPSDCCHV QCAAGCTGPK 250 260 270 280 290 300 DSDCLACRHF NDSGTCKDSC PPPTIYDPIT FQSKPNKDKK FSFGATCVKQ CPHNYLAMEV 310 320 330 340 350 360 ACTMVCPKAN KEVISVEPDG QETQKCEKCE GECPKVCYGL GMGNLQGVSV VNSTNIGMFT 370 380 390 400 410 420 GCEKIYGSLA FLSDSFKGNA DTNSSGLQPS DLEKLKTIEE ITGYLYIDAW SENLLDLSVF 430 440 450 460 470 480 ENLKVIRGQM LYKGVFSLGV QSLQIESLGL RSLRSVSGGL VLIHNNSRLC YTSSLPWTSL 490 500 510 520 530 540 LHPTQGPNLI SNNNKDQQTC VSEGKICDPL CGDSGCWGPG PSQCVSCLNY KRGTECVELC 550 560 570 580 590 600 NVLHGSVREF EDGFNCVPCH PECRPINGTA SCTGPGPDQC TDCMHFQDGD VCVERCPSGV 610 620 630 640 650 660 KEEQHTVWKY SNATGHCLPC ETNCTVSCPL DDRGCPIQQK TGPGTTVAIT VGGVLLFIIL 670 680 690 700 710 720 LALLVFYLRR QKHQKKKETI RRRLQEHELV EPLTPSGAMP NQAQMRILKE TELKKLRVLG 730 740 750 760 770 780 SGAFGTVFKG IWAPDGENVR IPVAIKVLRE NTSPKANKEI LDEAYVMAGV ASPYVCRLLG 790 800 810 820 830 840 ICLTSTVQLV TQLMPYGCLL DYVRENKDRI GSQYLLSWCV QIAKGMSYLE EVRLVHRDLA 850 860 870 880 890 900 ARNVLVKNPN HVKITDFGLA RLLDIDEKEY HADGGKVPIK WMALESILHR KFTHQSDVWS 910 920 930 940 950 960 YGVTVWELMT FGMKPYESFQ ARDIPELLEA GERLSQPCNC TKEVYMIMVK CWQIDPDNRP 970 980 990 1000 1010 1020 RFKDLVDEFT TMARDPSRYV VIQNEDQMSL SSPVDSEFFR ILMAEEGGNV KEFLDAEEYL 1030 1040 1050 1060 1070 1080 VPQPGSIFNT HGEMRANGPS RHHSHRSTDQ MVEVDGLPNG RELYSSVSMI EQSQYPTLPV 1090 1100 1110 1120 1130 1140 GATANGMWPG TQYPPLARSI SHRSAGGQSD SVFLDGYVED SCPPSSPCRY SKDPTMPNGI 1150 1160 1170 1180 1190 1200 DGDLETDGNM VFLSHTLPRG THTQPEYVNQ DMASERPSTL PRKASERRFI LNGLSTGNSV 1210 1220 1230 1240 1250 1260 ENPEYLVPIG SITPTSPAFD NPYYHDIAAK AQAVARVAIN GGTNHRQPNG FMTPTAENPE 1270 YLGLADTWSG HKEYT

References

[1]	"erbb3 and erbb2 are essential for schwann cell migration and myelination in zebrafish." Lyons D.A., Pogoda H.M., Voas M.G., Woods I.G., Diamond B., Nix R., Arana N., Jacobs J., Talbot W.S. Curr. Biol. 15:513-524(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Analysis of a zebrafish erbb2 gene." Pogoda H.-M., Voas M.G., Talbot W.S. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY914799 mRNA. Translation: AAX09341.1.
IPI	IPI00482529.
RefSeq	NP_956413.2. NM_200119.2.
UniGene	Dr.52559.
3D structure databases
ProteinModelPortal	Q5EBY4.
SMR	Q5EBY4. Positions 25-623, 670-1003.
ModBase	Search...
Protein-protein interaction databases
STRING	7955.ENSDARP00000010252.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	386966.
KEGG	dre:386966.
Organism-specific databases
CTD	2064.
ZFIN	ZDB-GENE-031118-121. erbb2.
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000230982.
HOVERGEN	HBG000490.
InParanoid	Q5EBY4.
KO	K05083.
OrthoDB	EOG461434.
Family and domain databases
InterPro	IPR000494. EGF_rcpt_L. IPR006211. Furin-like_Cys-rich_dom. IPR006212. Furin_repeat. IPR009030. Growth_fac_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt. [Graphical view]
Pfam	PF00757. Furin-like. 1 hit. PF07714. Pkinase_Tyr. 1 hit. PF01030. Recep_L_domain. 2 hits. [Graphical view]
PIRSF	PIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTS	PR00109. TYRKINASE.
SMART	SM00261. FU. 3 hits. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF57184. Grow_fac_recept. 2 hits. SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20814093.

Entry information

Entry name

Q5EBY4_DANRE

Accession

Primary (citable) accession number: Q5EBY4

Entry history

Integrated into UniProtKB/TrEMBL:	March 15, 2005
Last sequence update:	March 15, 2005
Last modified:	April 3, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)