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Protein

Zinc finger protein 628

Gene

ZNF628

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription activator. Binds DNA on GT-box consensus sequence 5'-TTGGTT-3' (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri36 – 5823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri64 – 8623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri92 – 11423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri120 – 14223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri148 – 17023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri176 – 19823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri204 – 22623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri356 – 37823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri454 – 47623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri482 – 50423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri510 – 53223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri538 – 56023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri566 – 58823C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri594 – 61623C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri622 – 64423C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 628
Gene namesi
Name:ZNF628
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28054. ZNF628.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670507.

Polymorphism and mutation databases

BioMutaiZNF628.
DMDMi476007835.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10591059Zinc finger protein 628PRO_0000246070Add
BLAST

Proteomic databases

MaxQBiQ5EBL2.
PaxDbiQ5EBL2.
PRIDEiQ5EBL2.

PTM databases

iPTMnetiQ5EBL2.
PhosphoSiteiQ5EBL2.

Expressioni

Gene expression databases

BgeeiQ5EBL2.
CleanExiHS_ZNF628.
ExpressionAtlasiQ5EBL2. baseline and differential.
GenevisibleiQ5EBL2. HS.

Organism-specific databases

HPAiHPA044451.

Interactioni

Protein-protein interaction databases

BioGridi124638. 2 interactions.
STRINGi9606.ENSP00000375598.

Structurei

3D structure databases

ProteinModelPortaliQ5EBL2.
SMRiQ5EBL2. Positions 36-114, 452-506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati818 – 831141Add
BLAST
Repeati832 – 842112Add
BLAST
Repeati843 – 853113Add
BLAST
Repeati854 – 864114Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni818 – 864474 X approximate tandem repeatsAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi230 – 354125Pro-richAdd
BLAST
Compositional biasi417 – 44731Pro-richAdd
BLAST
Compositional biasi646 – 74095Pro-richAdd
BLAST
Compositional biasi751 – 81161Gly-richAdd
BLAST

Sequence similaritiesi

Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri36 – 5823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri64 – 8623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri92 – 11423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri120 – 14223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri148 – 17023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri176 – 19823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri204 – 22623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri356 – 37823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri454 – 47623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri482 – 50423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri510 – 53223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri538 – 56023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri566 – 58823C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri594 – 61623C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri622 – 64423C2H2-type 16PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129911.
HOGENOMiHOG000155804.
HOVERGENiHBG018163.
InParanoidiQ5EBL2.
OMAiEHQPCPG.
OrthoDBiEOG7KSX7Q.
TreeFamiTF350841.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 7 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 17 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5EBL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGVMVGSHA DMAPASTAEG AGEKPGPAAP APAAQYECGE CGKSFRWSSR
60 70 80 90 100
LLHHQRTHTG ERPYKCPDCP KAFKGSSALL YHQRGHTGER PYQCPDCPKA
110 120 130 140 150
FKRSSLLQIH RSVHTGLRAF ICGQCGLAFK WSSHYQYHLR QHTGERPYPC
160 170 180 190 200
PDCPKAFKNS SSLRRHRHVH TGERPYTCGV CGKSFTQSTN LRQHQRVHTG
210 220 230 240 250
ERPFRCPLCP KTFTHSSNLL LHQRTHGAAP APGTASAAPP PQSREPGKVF
260 270 280 290 300
VCDAYLQRHL QPHSPPAPPA PPPPPPPVVP ELFLAAAETT VELVYRCDGC
310 320 330 340 350
EQGFSSEELL LEHQPCPGPD AAPQPQEAPA EAPKADQPPS PLPQPPPPAA
360 370 380 390 400
APAPGFACLP CGKSFRTVAG LSRHQHSHGA AGGQAFRCGS CDGSFPQLAS
410 420 430 440 450
LLAHQQCHVE EAAAGRPPPQ AEAAEVTCPQ EPLAPAAPVP PPPPSAPASA
460 470 480 490 500
ERPYKCAECG KSFKGSSGLR YHLRDHTGER PYQCGECGKA FKRSSLLAIH
510 520 530 540 550
QRVHTGLRAF TCGQCGLTFK WSSHYQYHLR LHSGERPYAC GECGKAFRNT
560 570 580 590 600
SCLRRHRHVH TGERPHACGV CGKSFAQTSN LRQHQRVHTG ERPFRCPLCP
610 620 630 640 650
KTFTHSSNLL LHQRTHSAER PFTCPICGRG FVMAAYLQRH LRTHAPANTP
660 670 680 690 700
PSTTAPAAGP QPPAPLAAAR APPATQDVHV LPHLQATLSL EVAGGTAQAP
710 720 730 740 750
SLGPAAPNSQ TFLLVQTAQG LQLIPSSVQP PTPPPPPAPP KLILLPSSSA
760 770 780 790 800
GAGGGRARQG PRAVGKAGQG AGVVWLPGPG GLGVQGAASA GASGTGQSLI
810 820 830 840 850
VLQNVGGGEA GPQEMSGVQL QPLRPAPEVT TVQLQPAQEV TTVQLQPAQE
860 870 880 890 900
VTTVQLQPAQ EVTTVQLQPV AGQLSNSSGG AVATEAPNLL VVQSGAAEEL
910 920 930 940 950
LTGPGPGEAG DGEASTGVVQ DVLFETLQTD EGLQSVLVLS GADGEQTRLC
960 970 980 990 1000
VQEVETLPPG LTEPPATGPP GQKLLIIRSA PATELLDSSN TGGGTATLQL
1010 1020 1030 1040 1050
LAPPPSGPAS GPAGLPGAPA SQMVQVVPAG AGPGVMTPQG LPSIQIVQTL

PAVQLVHTF
Length:1,059
Mass (Da):110,887
Last modified:April 3, 2013 - v3
Checksum:iF05F6265E9336D0C
GO

Sequence cautioni

The sequence AAH89449.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti234 – 2341T → A in AAH89449 (PubMed:15489334).Curated
Sequence conflicti439 – 4391V → A in AAH89449 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008735 Genomic DNA. No translation available.
BC047332 mRNA. Translation: AAH47332.1.
BC089449 mRNA. Translation: AAH89449.1. Different initiation.
CCDSiCCDS33116.3.
RefSeqiNP_149104.3. NM_033113.2.
UniGeneiHs.525209.

Genome annotation databases

EnsembliENST00000598519; ENSP00000469591; ENSG00000197483.
GeneIDi89887.
KEGGihsa:89887.
UCSCiuc002qld.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008735 Genomic DNA. No translation available.
BC047332 mRNA. Translation: AAH47332.1.
BC089449 mRNA. Translation: AAH89449.1. Different initiation.
CCDSiCCDS33116.3.
RefSeqiNP_149104.3. NM_033113.2.
UniGeneiHs.525209.

3D structure databases

ProteinModelPortaliQ5EBL2.
SMRiQ5EBL2. Positions 36-114, 452-506.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124638. 2 interactions.
STRINGi9606.ENSP00000375598.

PTM databases

iPTMnetiQ5EBL2.
PhosphoSiteiQ5EBL2.

Polymorphism and mutation databases

BioMutaiZNF628.
DMDMi476007835.

Proteomic databases

MaxQBiQ5EBL2.
PaxDbiQ5EBL2.
PRIDEiQ5EBL2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000598519; ENSP00000469591; ENSG00000197483.
GeneIDi89887.
KEGGihsa:89887.
UCSCiuc002qld.3. human.

Organism-specific databases

CTDi89887.
GeneCardsiZNF628.
HGNCiHGNC:28054. ZNF628.
HPAiHPA044451.
MIMi610671. gene.
neXtProtiNX_Q5EBL2.
PharmGKBiPA142670507.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129911.
HOGENOMiHOG000155804.
HOVERGENiHBG018163.
InParanoidiQ5EBL2.
OMAiEHQPCPG.
OrthoDBiEOG7KSX7Q.
TreeFamiTF350841.

Miscellaneous databases

GenomeRNAii89887.
PROiQ5EBL2.
SOURCEiSearch...

Gene expression databases

BgeeiQ5EBL2.
CleanExiHS_ZNF628.
ExpressionAtlasiQ5EBL2. baseline and differential.
GenevisibleiQ5EBL2. HS.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 7 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 17 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 17 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Chondrosarcoma and Liver.

Entry informationi

Entry nameiZN628_HUMAN
AccessioniPrimary (citable) accession number: Q5EBL2
Secondary accession number(s): Q86X34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: April 3, 2013
Last modified: June 8, 2016
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.