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Protein

Heat shock protein beta-6

Gene

Hspb6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein beta-6
Short name:
HspB6
Gene namesi
Name:Hspb6
Synonyms:Gm479
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2685325. Hspb6.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Translocates to nuclear foci during heat shock.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 162162Heat shock protein beta-6PRO_0000246077Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161PhosphoserineBy similarity
Modified residuei157 – 1571PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ5EBG6.
PaxDbiQ5EBG6.
PeptideAtlasiQ5EBG6.
PRIDEiQ5EBG6.

PTM databases

iPTMnetiQ5EBG6.
PhosphoSiteiQ5EBG6.

Expressioni

Gene expression databases

BgeeiQ5EBG6.
CleanExiMM_HSPB6.
GenevisibleiQ5EBG6. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039172.

Structurei

3D structure databases

ProteinModelPortaliQ5EBG6.
SMRiQ5EBG6. Positions 5-157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233954.
HOVERGENiHBG054766.
InParanoidiQ5EBG6.
KOiK09545.
OMAiAFAPYYL.
OrthoDBiEOG7WHHBK.
PhylomeDBiQ5EBG6.
TreeFamiTF105049.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR003090. Alpha-crystallin_N.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00525. Crystallin. 1 hit.
PF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5EBG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIPVPVQPS WLRRASAPLP GFSAPGRLFD QRFGEGLLEA ELASLCPAAI
60 70 80 90 100
APYYLRAPSV ALPTAQVSTD SGYFSVLLDV KHFLPEEISV KVVDDHVEVH
110 120 130 140 150
ARHEERPDEH GFIAREFHRR YRLPPGVDPA AVTSALSPEG VLSIQATPAS
160
AQAQLPSPPA AK
Length:162
Mass (Da):17,521
Last modified:March 15, 2005 - v1
Checksum:iD4CA1685AEBD3337
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089621 mRNA. Translation: AAH89621.1.
CCDSiCCDS21097.1.
RefSeqiNP_001012401.1. NM_001012401.2.
UniGeneiMm.34885.

Genome annotation databases

EnsembliENSMUST00000044048; ENSMUSP00000039172; ENSMUSG00000036854.
GeneIDi243912.
KEGGimmu:243912.
UCSCiuc009gew.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089621 mRNA. Translation: AAH89621.1.
CCDSiCCDS21097.1.
RefSeqiNP_001012401.1. NM_001012401.2.
UniGeneiMm.34885.

3D structure databases

ProteinModelPortaliQ5EBG6.
SMRiQ5EBG6. Positions 5-157.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000039172.

PTM databases

iPTMnetiQ5EBG6.
PhosphoSiteiQ5EBG6.

Proteomic databases

MaxQBiQ5EBG6.
PaxDbiQ5EBG6.
PeptideAtlasiQ5EBG6.
PRIDEiQ5EBG6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044048; ENSMUSP00000039172; ENSMUSG00000036854.
GeneIDi243912.
KEGGimmu:243912.
UCSCiuc009gew.1. mouse.

Organism-specific databases

CTDi126393.
MGIiMGI:2685325. Hspb6.

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233954.
HOVERGENiHBG054766.
InParanoidiQ5EBG6.
KOiK09545.
OMAiAFAPYYL.
OrthoDBiEOG7WHHBK.
PhylomeDBiQ5EBG6.
TreeFamiTF105049.

Miscellaneous databases

PROiQ5EBG6.
SOURCEiSearch...

Gene expression databases

BgeeiQ5EBG6.
CleanExiMM_HSPB6.
GenevisibleiQ5EBG6. MM.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR003090. Alpha-crystallin_N.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00525. Crystallin. 1 hit.
PF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart and Lung.

Entry informationi

Entry nameiHSPB6_MOUSE
AccessioniPrimary (citable) accession number: Q5EBG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 15, 2005
Last modified: July 6, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.