Q5EBG2 (T23O_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tryptophan 2,3-dioxygenase
Short name=TDO
EC=1.13.11.11

Alternative name(s):
Tryptamin 2,3-dioxygenase
Tryptophan oxygenase
Short name=TO
Short name=TRPO
Tryptophan pyrrolase
Tryptophanase

Gene names

Name:

tdo2

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	406 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring By similarity.
Catalytic activity	L-tryptophan + O2 = N-formyl-L-kynurenine.
Cofactor	Binds 2 heme groups per tetramer By similarity.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the tryptophan 2,3-dioxygenase family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Domain	Coiled coil
Ligand	Heme Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tryptophan catabolic process to kynurenine Inferred from electronic annotation. Source: InterPro
Molecular function	iron ion binding Inferred from electronic annotation. Source: InterPro tryptophan 2,3-dioxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 406	406	Tryptophan 2,3-dioxygenase		PRO_0000247477
Regions
	Region	42 – 46	5	Substrate binding By similarity
	Region	72 – 76	5	Substrate binding By similarity
	Coiled coil	246 – 270	25	Potential
Sites
	Metal binding	328	1	Iron (heme axial ligand) By similarity
	Binding site	144	1	Substrate By similarity
	Binding site	151	1	Heme By similarity
	Binding site	342	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5EBG2 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: EEF95FDF71884F8C	FASTA	406	47,700
	10 20 30 40 50 60 MSGCPFMGKK HHFNFSELSL EDKNEDSSQE GLNKASKGGL IYGDYLQLDK VLNAQELQSE 70 80 90 100 110 120 KKGNKIHDEH LFIVTHQAYE LWFKQILWEL DSVREIFQNG HVRDERNMLK VVTRIHRISM 130 140 150 160 170 180 ILKLLVEQFS VLETMTAMDF FDFRDYLSPA SGFQSLQFRL LENKIGVPEI LRVPYNRRHY 190 200 210 220 230 240 RDNFKGETNE LLLKSEQELT LLGLVEAWLE RTPGLEEEGF HFWGKLEANI FRGLEEELQT 250 260 270 280 290 300 VKTKPDSEEK EEQLAELQKQ KELFGALFDE RRHEHLLSKG ERRLSYKALK GALMIYFYRE 310 320 330 340 350 360 EPRFQVPFQL LTSLMDIDTL MTKWRYNHVC MVHRMIGSKA GTGGSSGYQY LRSTVSDRYK 370 380 390 400 VFVDLFNLST YLVPRHWVPR LNPSIHKFLY TAECCDSSYF SSDDSD

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC089667 mRNA. Translation: AAH89667.1.
RefSeq	NP_001015733.1. NM_001015733.1.
UniGene	Str.37472.
3D structure databases
ProteinModelPortal	Q5EBG2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5EBG2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSXETT00000048482; ENSXETP00000048482; ENSXETG00000022396.
GeneID	548450.
KEGG	xtr:548450.
Organism-specific databases
CTD	6999.
Xenbase	XB-GENE-976712. tdo2.
Phylogenomic databases
eggNOG	veNOG06399.
GeneTree	ENSGT00390000008593.
HOGENOM	HBG647485.
HOVERGEN	HBG003043.
InParanoid	Q5EBG2.
OMA	KLLVDQV.
OrthoDB	EOG4933J4.
Gene expression databases
Bgee	Q5EBG2.
Family and domain databases
InterPro	IPR004981. Trp_2_3_dOase. [Graphical view]
KO	K00453.
PANTHER	PTHR10138. Trp_2_3_dOase. 1 hit.
Pfam	PF03301. Trp_dioxygenase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

T23O_XENTR

Accession

Primary (citable) accession number: Q5EBG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	March 15, 2005
Last modified:	November 16, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program