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Reviewed, UniProtKB/Swiss-Prot Q5EBG2 (T23O_XENTR)

Last modified June 16, 2009. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Tryptophan 2,3-dioxygenase
      Short name=TDO
    EC=1.13.11.11
Alternative name(s):
    Tryptophan pyrrolase
      Short name=Tryptophanase
    Tryptophan oxygenase
      Short name=TRPO
      Short name=TO
    Tryptamin 2,3-dioxygenase
Gene names
Name: tdo2
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraMesobatrachiaPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring By similarity.

Catalytic activity

L-tryptophan + O2 = N-formyl-L-kynurenine.

Cofactor

Binds 2 heme groups per tetramer By similarity.

Pathway

Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the tryptophan 2,3-dioxygenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 406406Tryptophan 2,3-dioxygenase
PRO_0000247477

Regions

Region42 – 465Substrate binding By similarity
Region72 – 765Substrate binding By similarity
Coiled coil246 – 27025 Potential

Sites

Metal binding3281Iron (heme axial ligand) By similarity
Binding site1441Substrate By similarity
Binding site1511Heme By similarity
Binding site3421Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5EBG2-1 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: EEF95FDF71884F8C

FASTA40647,700
        10         20         30         40         50         60 
MSGCPFMGKK HHFNFSELSL EDKNEDSSQE GLNKASKGGL IYGDYLQLDK VLNAQELQSE 

        70         80         90        100        110        120 
KKGNKIHDEH LFIVTHQAYE LWFKQILWEL DSVREIFQNG HVRDERNMLK VVTRIHRISM 

       130        140        150        160        170        180 
ILKLLVEQFS VLETMTAMDF FDFRDYLSPA SGFQSLQFRL LENKIGVPEI LRVPYNRRHY 

       190        200        210        220        230        240 
RDNFKGETNE LLLKSEQELT LLGLVEAWLE RTPGLEEEGF HFWGKLEANI FRGLEEELQT 

       250        260        270        280        290        300 
VKTKPDSEEK EEQLAELQKQ KELFGALFDE RRHEHLLSKG ERRLSYKALK GALMIYFYRE 

       310        320        330        340        350        360 
EPRFQVPFQL LTSLMDIDTL MTKWRYNHVC MVHRMIGSKA GTGGSSGYQY LRSTVSDRYK 

       370        380        390        400 
VFVDLFNLST YLVPRHWVPR LNPSIHKFLY TAECCDSSYF SSDDSD 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

BC089667 mRNA. Translation: AAH89667.1.
RefSeqNP_001015733.1.
UniGeneStr.37472

3D structure databases

ModBaseSearch...

Genome annotation databases

EnsemblENSXETG00000022396. Xenopus tropicalis. [Contig view]
GeneID548450.
KEGGxtr:548450.

Organism-specific databases

XenbaseXB-FEAT-976711. tdo2.

Phylogenomic databases

HOVERGENQ5EBG2.
OMAQ5EBG2. HYRDNFR.

Enzyme and pathway databases

BRENDA1.13.11.11. 279072.

Gene expression databases

BgeeQ5EBG2.

Family and domain databases

InterProIPR004981. Trp_2_3_dOase.
[Graphical view]
PANTHERPTHR10138. Trp_2_3_dOase. 1 hit.
PfamPF03301. Trp_dioxygenase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameT23O_XENTR
AccessionPrimary (citable) accession number: Q5EBG2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 15, 2005
Last modified: June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectXenopus annotation project

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents