Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Septin-1

Gene

Sept1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).By similarityCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei66GTPBy similarity1
Binding sitei92GTP; via amide nitrogenBy similarity1
Binding sitei229GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei244GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 39GTPBy similarity8
Nucleotide bindingi171 – 179GTPBy similarity9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-1
Gene namesi
Name:Sept1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1307216. Sept1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003632191 – 366Septin-1Add BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei206PhosphoserineCombined sources1
Modified residuei247Phosphoserine; by AURKBBy similarity1
Modified residuei250PhosphothreonineBy similarity1
Modified residuei306Phosphoserine; by AURKBBy similarity1
Modified residuei314Phosphoserine; by AURKBBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5EB96.
PRIDEiQ5EB96.

PTM databases

iPTMnetiQ5EB96.
PhosphoSitePlusiQ5EB96.

Expressioni

Gene expression databases

BgeeiENSRNOG00000017804.
GenevisibleiQ5EB96. RN.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with AURKB (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051893.

Structurei

3D structure databases

ProteinModelPortaliQ5EB96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 295Septin-type GAdd BLAST274

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00860000133688.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
InParanoidiQ5EB96.
KOiK13737.
OMAiVEVENPH.
OrthoDBiEOG091G07TS.
PhylomeDBiQ5EB96.
TreeFamiTF101079.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5EB96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKEYVGFAA LPNQLHRKSV KKGFDFTLMV AGESGLGKST LINSLFLTNL
60 70 80 90 100
YEDRQVPDAS ARTTQTLTIE RRGVEIEEGG IKVKLTLVDT PGFGDSVDCS
110 120 130 140 150
DCWLPVVRFI EEQFEQYLRD ESGLNRKNIQ DSRVHCCLYF ISPFGRGLRP
160 170 180 190 200
LDVAFLRAVH EKVNIIPVIG KADALLPRET QVLKQKIRDQ LKEEEINIYQ
210 220 230 240 250
FPECDSDEDE EFKKQNEEMK ENIPFAVVGS SEVVREGTRP VRGRRYSWGT
260 270 280 290 300
VEVENPHHCD FLNLRRMLVQ THLQDLKEVT HDLLYEGYRA RCLQSLARPG
310 320 330 340 350
ARDRASRSKL SRQSATEIPL PMLPLADTEK LIREKDEELR RMQEMLEKMQ
360
AQMQQSQAQG EQSDVL
Length:366
Mass (Da):42,058
Last modified:March 15, 2005 - v1
Checksum:iD5C552D3716A0038
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089897 mRNA. Translation: AAH89897.1.
RefSeqiNP_001012478.1. NM_001012460.1.
UniGeneiRn.68675.

Genome annotation databases

EnsembliENSRNOT00000055012; ENSRNOP00000051893; ENSRNOG00000017804.
GeneIDi293507.
KEGGirno:293507.
UCSCiRGD:1307216. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089897 mRNA. Translation: AAH89897.1.
RefSeqiNP_001012478.1. NM_001012460.1.
UniGeneiRn.68675.

3D structure databases

ProteinModelPortaliQ5EB96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051893.

PTM databases

iPTMnetiQ5EB96.
PhosphoSitePlusiQ5EB96.

Proteomic databases

PaxDbiQ5EB96.
PRIDEiQ5EB96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000055012; ENSRNOP00000051893; ENSRNOG00000017804.
GeneIDi293507.
KEGGirno:293507.
UCSCiRGD:1307216. rat.

Organism-specific databases

CTDi1731.
RGDi1307216. Sept1.

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00860000133688.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
InParanoidiQ5EB96.
KOiK13737.
OMAiVEVENPH.
OrthoDBiEOG091G07TS.
PhylomeDBiQ5EB96.
TreeFamiTF101079.

Miscellaneous databases

PROiQ5EB96.

Gene expression databases

BgeeiENSRNOG00000017804.
GenevisibleiQ5EB96. RN.

Family and domain databases

CDDicd01850. CDC_Septin. 1 hit.
Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEPT1_RAT
AccessioniPrimary (citable) accession number: Q5EB96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: March 15, 2005
Last modified: November 30, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.