Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Septin-1

Gene

Sept1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).By similarityCurated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei66 – 661GTPBy similarity
Binding sitei92 – 921GTP; via amide nitrogenBy similarity
Binding sitei229 – 2291GTP; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei244 – 2441GTPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi32 – 398GTPBy similarity
Nucleotide bindingi171 – 1799GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-1
Gene namesi
Name:Sept1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1307216. Sept1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Septin-1PRO_0000363219Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei206 – 2061PhosphoserineCombined sources
Modified residuei247 – 2471Phosphoserine; by AURKBBy similarity
Modified residuei250 – 2501PhosphothreonineBy similarity
Modified residuei306 – 3061Phosphoserine; by AURKBBy similarity
Modified residuei314 – 3141Phosphoserine; by AURKBBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5EB96.
PRIDEiQ5EB96.

Expressioni

Gene expression databases

GenevisibleiQ5EB96. RN.

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with AURKB (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051893.

Structurei

3D structure databases

ProteinModelPortaliQ5EB96.
SMRiQ5EB96. Positions 8-293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 295274Septin-type GAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00760000118899.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
InParanoidiQ5EB96.
KOiK13737.
OMAiPVRGRCY.
OrthoDBiEOG79KPF0.
PhylomeDBiQ5EB96.
TreeFamiTF101079.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5EB96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKEYVGFAA LPNQLHRKSV KKGFDFTLMV AGESGLGKST LINSLFLTNL
60 70 80 90 100
YEDRQVPDAS ARTTQTLTIE RRGVEIEEGG IKVKLTLVDT PGFGDSVDCS
110 120 130 140 150
DCWLPVVRFI EEQFEQYLRD ESGLNRKNIQ DSRVHCCLYF ISPFGRGLRP
160 170 180 190 200
LDVAFLRAVH EKVNIIPVIG KADALLPRET QVLKQKIRDQ LKEEEINIYQ
210 220 230 240 250
FPECDSDEDE EFKKQNEEMK ENIPFAVVGS SEVVREGTRP VRGRRYSWGT
260 270 280 290 300
VEVENPHHCD FLNLRRMLVQ THLQDLKEVT HDLLYEGYRA RCLQSLARPG
310 320 330 340 350
ARDRASRSKL SRQSATEIPL PMLPLADTEK LIREKDEELR RMQEMLEKMQ
360
AQMQQSQAQG EQSDVL
Length:366
Mass (Da):42,058
Last modified:March 15, 2005 - v1
Checksum:iD5C552D3716A0038
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089897 mRNA. Translation: AAH89897.1.
RefSeqiNP_001012478.1. NM_001012460.1.
UniGeneiRn.68675.

Genome annotation databases

EnsembliENSRNOT00000055012; ENSRNOP00000051893; ENSRNOG00000017804.
GeneIDi293507.
KEGGirno:293507.
UCSCiRGD:1307216. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089897 mRNA. Translation: AAH89897.1.
RefSeqiNP_001012478.1. NM_001012460.1.
UniGeneiRn.68675.

3D structure databases

ProteinModelPortaliQ5EB96.
SMRiQ5EB96. Positions 8-293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051893.

Proteomic databases

PaxDbiQ5EB96.
PRIDEiQ5EB96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000055012; ENSRNOP00000051893; ENSRNOG00000017804.
GeneIDi293507.
KEGGirno:293507.
UCSCiRGD:1307216. rat.

Organism-specific databases

CTDi1731.
RGDi1307216. Sept1.

Phylogenomic databases

eggNOGiKOG2655. Eukaryota.
COG5019. LUCA.
GeneTreeiENSGT00760000118899.
HOGENOMiHOG000233586.
HOVERGENiHBG065093.
InParanoidiQ5EB96.
KOiK13737.
OMAiPVRGRCY.
OrthoDBiEOG79KPF0.
PhylomeDBiQ5EB96.
TreeFamiTF101079.

Miscellaneous databases

NextBioi636270.
PROiQ5EB96.

Gene expression databases

GenevisibleiQ5EB96. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030379. G_SEPTIN_dom.
IPR027417. P-loop_NTPase.
IPR016491. Septin.
[Graphical view]
PANTHERiPTHR18884. PTHR18884. 1 hit.
PfamiPF00735. Septin. 1 hit.
[Graphical view]
PIRSFiPIRSF006698. Septin. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51719. G_SEPTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSEPT1_RAT
AccessioniPrimary (citable) accession number: Q5EB96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: March 15, 2005
Last modified: November 11, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.