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Q5EB77 (RAB18_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-related protein Rab-18
Gene names
Name:Rab18
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length206 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration By similarity.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 203203Ras-related protein Rab-18
PRO_0000121196
Propeptide204 – 2063Removed in mature form Potential
PRO_0000370764

Regions

Nucleotide binding15 – 239GTP By similarity
Nucleotide binding63 – 675GTP By similarity
Nucleotide binding122 – 1254GTP By similarity
Nucleotide binding151 – 1533GTP By similarity
Motif37 – 459Effector region By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue2031Cysteine methyl ester Potential
Lipidation1991S-palmitoyl cysteine Potential
Lipidation2031S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5EB77 [UniParc].

Last modified March 15, 2005. Version 1.
Checksum: D1A398067A6B9B77

FASTA20622,976
        10         20         30         40         50         60 
MDEDVLTTLK ILIIGESGVG KSSLLLRFTD DTFDPELAAT IGVDFKVKTI SVDGNKAKLA 

        70         80         90        100        110        120 
IWDTAGQERF RTLTPSYYRG AQGVILVYDV TRRDTFVKLD NWLNELETYC TRNDIVNMLV 

       130        140        150        160        170        180 
GNKIDKENRE VDRNEGLKFA RKHSMLFIEA SAKTCDGVQC AFEELVEKII QTPGLWESEN 

       190        200 
QNKGVKLSPR EESHGGGACG GYCSVL 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC089957 mRNA. Translation: AAH89957.1.
RefSeqNP_001012486.1. NM_001012468.1.
XP_006254194.1. XM_006254132.1.
UniGeneRn.221766.

3D structure databases

ProteinModelPortalQ5EB77.
SMRQ5EB77. Positions 2-178.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ5EB77. 2 interactions.
MINTMINT-4542670.
STRING10116.ENSRNOP00000025828.

Proteomic databases

PaxDbQ5EB77.
PRIDEQ5EB77.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000025828; ENSRNOP00000025828; ENSRNOG00000018972.
GeneID307039.
KEGGrno:307039.
UCSCRGD:1308905. rat.

Organism-specific databases

CTD22931.
RGD1308905. Rab18.

Phylogenomic databases

eggNOGCOG1100.
GeneTreeENSGT00740000115017.
HOGENOMHOG000233968.
HOVERGENHBG009351.
InParanoidQ5EB77.
KOK07910.
OMATYTTRND.
OrthoDBEOG7CVQ04.
PhylomeDBQ5EB77.
TreeFamTF313448.

Gene expression databases

GenevestigatorQ5EB77.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio656875.
PROQ5EB77.

Entry information

Entry nameRAB18_RAT
AccessionPrimary (citable) accession number: Q5EB77
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 15, 2005
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families