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Q5EB77

- RAB18_RAT

UniProt

Q5EB77 - RAB18_RAT

Protein

Ras-related protein Rab-18

Gene

Rab18

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 239GTPBy similarity
    Nucleotide bindingi63 – 675GTPBy similarity
    Nucleotide bindingi122 – 1254GTPBy similarity
    Nucleotide bindingi151 – 1533GTPBy similarity

    GO - Molecular functioni

    1. GDP binding Source: UniProtKB
    2. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. brain development Source: UniProtKB
    2. eye development Source: UniProtKB
    3. protein transport Source: UniProtKB-KW
    4. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-18
    Gene namesi
    Name:Rab18
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 17

    Organism-specific databases

    RGDi1308905. Rab18.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 203203Ras-related protein Rab-18PRO_0000121196Add
    BLAST
    Propeptidei204 – 2063Removed in mature formSequence AnalysisPRO_0000370764

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Lipidationi199 – 1991S-palmitoyl cysteineSequence Analysis
    Modified residuei203 – 2031Cysteine methyl esterSequence Analysis
    Lipidationi203 – 2031S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Methylation, Palmitate, Prenylation

    Proteomic databases

    PaxDbiQ5EB77.
    PRIDEiQ5EB77.

    Expressioni

    Gene expression databases

    GenevestigatoriQ5EB77.

    Interactioni

    Protein-protein interaction databases

    IntActiQ5EB77. 2 interactions.
    MINTiMINT-4542670.
    STRINGi10116.ENSRNOP00000025828.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5EB77.
    SMRiQ5EB77. Positions 2-178.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi37 – 459Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    GeneTreeiENSGT00740000115017.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiQ5EB77.
    KOiK07910.
    OMAiTYTTRND.
    OrthoDBiEOG7CVQ04.
    PhylomeDBiQ5EB77.
    TreeFamiTF313448.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR025662. Sigma_54_int_dom_ATP-bd_1.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5EB77-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDEDVLTTLK ILIIGESGVG KSSLLLRFTD DTFDPELAAT IGVDFKVKTI    50
    SVDGNKAKLA IWDTAGQERF RTLTPSYYRG AQGVILVYDV TRRDTFVKLD 100
    NWLNELETYC TRNDIVNMLV GNKIDKENRE VDRNEGLKFA RKHSMLFIEA 150
    SAKTCDGVQC AFEELVEKII QTPGLWESEN QNKGVKLSPR EESHGGGACG 200
    GYCSVL 206
    Length:206
    Mass (Da):22,976
    Last modified:March 15, 2005 - v1
    Checksum:iD1A398067A6B9B77
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC089957 mRNA. Translation: AAH89957.1.
    RefSeqiNP_001012486.1. NM_001012468.1.
    XP_006254194.1. XM_006254132.1.
    UniGeneiRn.221766.

    Genome annotation databases

    EnsembliENSRNOT00000025828; ENSRNOP00000025828; ENSRNOG00000018972.
    GeneIDi307039.
    KEGGirno:307039.
    UCSCiRGD:1308905. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC089957 mRNA. Translation: AAH89957.1 .
    RefSeqi NP_001012486.1. NM_001012468.1.
    XP_006254194.1. XM_006254132.1.
    UniGenei Rn.221766.

    3D structure databases

    ProteinModelPortali Q5EB77.
    SMRi Q5EB77. Positions 2-178.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q5EB77. 2 interactions.
    MINTi MINT-4542670.
    STRINGi 10116.ENSRNOP00000025828.

    Proteomic databases

    PaxDbi Q5EB77.
    PRIDEi Q5EB77.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000025828 ; ENSRNOP00000025828 ; ENSRNOG00000018972 .
    GeneIDi 307039.
    KEGGi rno:307039.
    UCSCi RGD:1308905. rat.

    Organism-specific databases

    CTDi 22931.
    RGDi 1308905. Rab18.

    Phylogenomic databases

    eggNOGi COG1100.
    GeneTreei ENSGT00740000115017.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi Q5EB77.
    KOi K07910.
    OMAi TYTTRND.
    OrthoDBi EOG7CVQ04.
    PhylomeDBi Q5EB77.
    TreeFami TF313448.

    Miscellaneous databases

    NextBioi 656875.
    PROi Q5EB77.

    Gene expression databases

    Genevestigatori Q5EB77.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR025662. Sigma_54_int_dom_ATP-bd_1.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiRAB18_RAT
    AccessioniPrimary (citable) accession number: Q5EB77
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3