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Protein

Ras-related protein Rab-18

Gene

Rab18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 23GTPBy similarity9
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi122 – 125GTPBy similarity4
Nucleotide bindingi151 – 153GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-6798695. Neutrophil degranulation.
R-RNO-6811436. COPI-independent Golgi-to-ER retrograde traffic.
R-RNO-8876198. RAB GEFs exchange GTP for GDP on RABs.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-18
Gene namesi
Name:Rab18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1308905. Rab18.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211961 – 203Ras-related protein Rab-18Add BLAST203
PropeptideiPRO_0000370764204 – 206Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei144PhosphoserineBy similarity1
Lipidationi199S-palmitoyl cysteineSequence analysis1
Modified residuei203Cysteine methyl esterSequence analysis1
Lipidationi203S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ5EB77.
PRIDEiQ5EB77.

PTM databases

iPTMnetiQ5EB77.
PhosphoSitePlusiQ5EB77.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018972.
GenevisibleiQ5EB77. RN.

Interactioni

Protein-protein interaction databases

IntActiQ5EB77. 2 interactors.
MINTiMINT-4542670.
STRINGi10116.ENSRNOP00000025828.

Structurei

3D structure databases

ProteinModelPortaliQ5EB77.
SMRiQ5EB77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0080. Eukaryota.
ENOG410XPD0. LUCA.
GeneTreeiENSGT00890000139424.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ5EB77.
KOiK07910.
OMAiCCFEELV.
OrthoDBiEOG091G0MOO.
PhylomeDBiQ5EB77.
TreeFamiTF313448.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51419. RAB. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5EB77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEDVLTTLK ILIIGESGVG KSSLLLRFTD DTFDPELAAT IGVDFKVKTI
60 70 80 90 100
SVDGNKAKLA IWDTAGQERF RTLTPSYYRG AQGVILVYDV TRRDTFVKLD
110 120 130 140 150
NWLNELETYC TRNDIVNMLV GNKIDKENRE VDRNEGLKFA RKHSMLFIEA
160 170 180 190 200
SAKTCDGVQC AFEELVEKII QTPGLWESEN QNKGVKLSPR EESHGGGACG

GYCSVL
Length:206
Mass (Da):22,976
Last modified:March 15, 2005 - v1
Checksum:iD1A398067A6B9B77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089957 mRNA. Translation: AAH89957.1.
RefSeqiNP_001012486.1. NM_001012468.1.
UniGeneiRn.221766.

Genome annotation databases

EnsembliENSRNOT00000025828; ENSRNOP00000025828; ENSRNOG00000018972.
GeneIDi307039.
KEGGirno:307039.
UCSCiRGD:1308905. rat.

Similar proteinsi

Entry informationi

Entry nameiRAB18_RAT
AccessioniPrimary (citable) accession number: Q5EB77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 15, 2005
Last modified: August 30, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families