Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5EB77

- RAB18_RAT

UniProt

Q5EB77 - RAB18_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ras-related protein Rab-18

Gene

Rab18

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 239GTPBy similarity
Nucleotide bindingi63 – 675GTPBy similarity
Nucleotide bindingi122 – 1254GTPBy similarity
Nucleotide bindingi151 – 1533GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: UniProtKB
  2. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. brain development Source: UniProtKB
  2. eye development Source: UniProtKB
  3. lipid particle organization Source: Ensembl
  4. protein transport Source: UniProtKB-KW
  5. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-18
Gene namesi
Name:Rab18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 17

Organism-specific databases

RGDi1308905. Rab18.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. intracellular Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 203203Ras-related protein Rab-18PRO_0000121196Add
BLAST
Propeptidei204 – 2063Removed in mature formSequence AnalysisPRO_0000370764

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Lipidationi199 – 1991S-palmitoyl cysteineSequence Analysis
Modified residuei203 – 2031Cysteine methyl esterSequence Analysis
Lipidationi203 – 2031S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PaxDbiQ5EB77.
PRIDEiQ5EB77.

Expressioni

Gene expression databases

GenevestigatoriQ5EB77.

Interactioni

Protein-protein interaction databases

IntActiQ5EB77. 2 interactions.
MINTiMINT-4542670.
STRINGi10116.ENSRNOP00000025828.

Structurei

3D structure databases

ProteinModelPortaliQ5EB77.
SMRiQ5EB77. Positions 2-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi37 – 459Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00740000115017.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ5EB77.
KOiK07910.
OMAiTYTTRND.
OrthoDBiEOG7CVQ04.
PhylomeDBiQ5EB77.
TreeFamiTF313448.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5EB77-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDEDVLTTLK ILIIGESGVG KSSLLLRFTD DTFDPELAAT IGVDFKVKTI
60 70 80 90 100
SVDGNKAKLA IWDTAGQERF RTLTPSYYRG AQGVILVYDV TRRDTFVKLD
110 120 130 140 150
NWLNELETYC TRNDIVNMLV GNKIDKENRE VDRNEGLKFA RKHSMLFIEA
160 170 180 190 200
SAKTCDGVQC AFEELVEKII QTPGLWESEN QNKGVKLSPR EESHGGGACG

GYCSVL
Length:206
Mass (Da):22,976
Last modified:March 15, 2005 - v1
Checksum:iD1A398067A6B9B77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089957 mRNA. Translation: AAH89957.1.
RefSeqiNP_001012486.1. NM_001012468.1.
XP_006254194.1. XM_006254132.2.
UniGeneiRn.221766.

Genome annotation databases

EnsembliENSRNOT00000025828; ENSRNOP00000025828; ENSRNOG00000018972.
GeneIDi307039.
KEGGirno:307039.
UCSCiRGD:1308905. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC089957 mRNA. Translation: AAH89957.1 .
RefSeqi NP_001012486.1. NM_001012468.1.
XP_006254194.1. XM_006254132.2.
UniGenei Rn.221766.

3D structure databases

ProteinModelPortali Q5EB77.
SMRi Q5EB77. Positions 2-178.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q5EB77. 2 interactions.
MINTi MINT-4542670.
STRINGi 10116.ENSRNOP00000025828.

Proteomic databases

PaxDbi Q5EB77.
PRIDEi Q5EB77.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000025828 ; ENSRNOP00000025828 ; ENSRNOG00000018972 .
GeneIDi 307039.
KEGGi rno:307039.
UCSCi RGD:1308905. rat.

Organism-specific databases

CTDi 22931.
RGDi 1308905. Rab18.

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00740000115017.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi Q5EB77.
KOi K07910.
OMAi TYTTRND.
OrthoDBi EOG7CVQ04.
PhylomeDBi Q5EB77.
TreeFami TF313448.

Miscellaneous databases

NextBioi 656875.
PROi Q5EB77.

Gene expression databases

Genevestigatori Q5EB77.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR025662. Sigma_54_int_dom_ATP-bd_1.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiRAB18_RAT
AccessioniPrimary (citable) accession number: Q5EB77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: March 15, 2005
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3