Q5EB77 (RAB18_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-18

Gene names

Name:

Rab18

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration By similarity.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Biological process	Protein transport Transport
Ligand	GTP-binding Nucleotide-binding
Molecular function	Developmental protein
PTM	Acetylation Lipoprotein Methylation Palmitate Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	brain development Inferred from sequence or structural similarity. Source: UniProtKB eye development Inferred from sequence or structural similarity. Source: UniProtKB protein transport Inferred from electronic annotation. Source: UniProtKB-KW small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	intracellular Inferred from electronic annotation. Source: Compara
Molecular_function	GDP binding Inferred from sequence or structural similarity. Source: UniProtKB GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 203	203	Ras-related protein Rab-18		PRO_0000121196
	Propeptide	204 – 206	3	Removed in mature form Potential		PRO_0000370764
Regions
	Nucleotide binding	15 – 23	9	GTP By similarity
	Nucleotide binding	63 – 67	5	GTP By similarity
	Nucleotide binding	122 – 125	4	GTP By similarity
	Nucleotide binding	151 – 153	3	GTP By similarity
	Motif	37 – 45	9	Effector region By similarity
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine By similarity
	Modified residue	203	1	Cysteine methyl ester Potential
	Lipidation	199	1	S-palmitoyl cysteine Potential
	Lipidation	203	1	S-geranylgeranyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5EB77 [UniParc]. Last modified March 15, 2005. Version 1. Checksum: D1A398067A6B9B77	FASTA	206	22,976
	10 20 30 40 50 60 MDEDVLTTLK ILIIGESGVG KSSLLLRFTD DTFDPELAAT IGVDFKVKTI SVDGNKAKLA 70 80 90 100 110 120 IWDTAGQERF RTLTPSYYRG AQGVILVYDV TRRDTFVKLD NWLNELETYC TRNDIVNMLV 130 140 150 160 170 180 GNKIDKENRE VDRNEGLKFA RKHSMLFIEA SAKTCDGVQC AFEELVEKII QTPGLWESEN 190 200 QNKGVKLSPR EESHGGGACG GYCSVL

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC089957 mRNA. Translation: AAH89957.1.
IPI	IPI00198316.
RefSeq	NP_001012486.1. NM_001012468.1.
UniGene	Rn.221766.
3D structure databases
ProteinModelPortal	Q5EB77.
SMR	Q5EB77. Positions 2-178.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q5EB77. 1 interaction.
STRING	10116.ENSRNOP00000025828.
Proteomic databases
PaxDb	Q5EB77.
PRIDE	Q5EB77.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000025828; ENSRNOP00000025828; ENSRNOG00000018972.
GeneID	307039.
KEGG	rno:307039.
UCSC	RGD:1308905. rat.
Organism-specific databases
CTD	22931.
RGD	1308905. Rab18.
Phylogenomic databases
eggNOG	COG1100.
GeneTree	ENSGT00700000104044.
HOGENOM	HOG000233968.
HOVERGEN	HBG009351.
InParanoid	Q5EB77.
KO	K07910.
OMA	LETYTTR.
OrthoDB	EOG4VT5Z6.
Gene expression databases
Genevestigator	Q5EB77.
GermOnline	ENSRNOG00000018972. Rattus norvegicus.
Family and domain databases
InterPro	IPR025662. Sigma_54_int_dom_ATP-bd_1. IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	656875.

Entry information

Entry name

RAB18_RAT

Accession

Primary (citable) accession number: Q5EB77

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	March 15, 2005
Last modified:	April 3, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program